Hcls1 cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Hcls1 |
| Entrez Gene ID | 15163 |
| Full Name | hematopoietic cell specific Lyn substrate 1 |
| Synonyms | AW213261,HS1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_008225.2 | NP_032251.2 | hematopoietic lineage cell-specific protein |
| Homo sapiens (human) | HCLS1 | NP_005326.2 |
| Mus musculus (house mouse) | Hcls1 | NP_032251.2 |
| Rattus norvegicus (Norway rat) | Hcls1 | NP_001011898.1 |
| Bos taurus (cattle) | HCLS1 | NP_001030229.1 |
| Gallus gallus (chicken) | HCLS1 | NP_001026572.1 |
| Pan troglodytes (chimpanzee) | HCLS1 | XP_516684.2 |
| HCLS1 | XP_001111514.1 | |
| Canis lupus familiaris (dog) | HCLS1 | XP_005639607.1 |
Related articles in PubMed
The Arp2/3 complex binding protein HS1 is required for efficient dendritic cell random migration and force generation.
Bendell AC, Williamson EK, Chen CS, Burkhardt JK, Hammer DA
Integrative biology : quantitative biosciences from nano to macro9(8)695-708(2017 Aug)
HS1 deficiency impairs neutrophil recruitment in vivo and activation of the small GTPases Rac1 and Rap1.
Latasiewicz J, Artz A, Jing D, Blanco MP, Currie SM, Avila MV, Schnoor M, Vestweber D
Journal of leukocyte biology101(5)1133-1142(2017 05)
Identification of RNA-binding Proteins in Macrophages by Interactome Capture.
Liepelt A, Naarmann-de Vries IS, Simons N, Eichelbaum K, F?hr S, Archer SK, Castello A, Usadel B, Krijgsveld J, Preiss T, Marx G, Hentze MW, Ostareck DH, Ostareck-Lederer A
Molecular & cellular proteomics : MCP15(8)2699-714(2016 08)
Phosphoproteome analyses reveal specific implications of Hcls1, p21-activated kinase 1 and Ezrin in proliferation of a myeloid progenitor cell line downstream of wild-type and ITD mutant Fms-like tyrosine kinase 3 receptors.
Habif G, Grasset MF, Kieffer-Jaquinod S, Kuhn L, Mouchiroud G, Gobert-Gosse S
Journal of proteomics78231-44(2013 Jan)
Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis.
Skokowa J, Klimiankou M, Klimenkova O, Lan D, Gupta K, Hussein K, Carrizosa E, Kusnetsova I, Li Z, Sustmann C, Ganser A, Zeidler C, Kreipe HH, Burkhardt J, Grosschedl R, Welte K
Nature medicine18(10)1550-9(2012 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
HS1 as an important regulator of proper Rac1 and Rap1 activation and neutrophil extravasation.
Title: HS1 deficiency impairs neutrophil recruitment in vivo and activation of the small GTPases Rac1 and Rap1.
Results identified two proteins P23 and HCLS1, which were not known as RNA-binding proteins, exhibiting RNA-binding activity.
Title: Identification of RNA-binding Proteins in Macrophages by Interactome Capture.
Phosphoproteome analyses reveal specific implications of Hcls1, p21-activated kinase 1 and Ezrin in proliferation of a myeloid progenitor cell line downstream of wild-type and ITD mutant Fms-like tyrosine kinase 3 receptors.
Title: Phosphoproteome analyses reveal specific implications of Hcls1, p21-activated kinase 1 and Ezrin in proliferation of a myeloid progenitor cell line downstream of wild-type and ITD mutant Fms-like tyrosine kinase 3 receptors.
studies show that HS1 promotes an early step in the endocytic pathway that is required for efficient Ag presentation of exogenous Ag by dendritic cells
Title: The actin regulatory protein HS1 is required for antigen uptake and presentation by dendritic cells.
Studies show that HS1 functions in concert with WASp to fine-tune DC cytoarchitecture and direct cell migration.
Title: Hematopoietic lineage cell-specific protein 1 functions in concert with the Wiskott-Aldrich syndrome protein to promote podosome array organization and chemotaxis in dendritic cells.
The following Hcls1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hcls1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu13465 | |
| Clone ID Related Accession (Same CDS sequence) | NM_008225.2 | |
| Accession Version | NM_008225.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1461bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-08-03 | |
| Organism | Mus musculus(house mouse) | |
| Product | hematopoietic lineage cell-specific protein | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC154763.2, AK040049.1, CA321698.1 and BX519502.1. On Aug 12, 2009 this sequence version replaced NM_008225.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC007469.1, AK088723.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGTGGAAGT CTGTAGTGGG GCATGATGTA TCGGTTTCCG TGGAGACCCA GGGTGATGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_032251.2 |
| CDS | 93..1553 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_008225.2 |
ORF Insert Sequence:
1 | ATGTGGAAGT CTGTAGTGGG GCATGATGTA TCGGTTTCCG TGGAGACCCA GGGTGATGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
The Arp2/3 complex binding protein HS1 is required for efficient dendritic cell random migration and force generation. |
|
HS1 deficiency impairs neutrophil recruitment in vivo and activation of the small GTPases Rac1 and Rap1. |
|
Identification of RNA-binding Proteins in Macrophages by Interactome Capture. |
|
Phosphoproteome analyses reveal specific implications of Hcls1, p21-activated kinase 1 and Ezrin in proliferation of a myeloid progenitor cell line downstream of wild-type and ITD mutant Fms-like tyrosine kinase 3 receptors. |
|
Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis. |