HGFAC cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HGFAC
Entrez Gene ID	3083
Full Name	HGF activator
Synonyms	HGFA
General protein information	Preferred Names HGF activator Names hepatocyte growth factor activator
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4p16.3
Summary	This gene encodes a member of the peptidase S1 protein family. The encoded protein is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Disorder MIM:	604552

mRNA and Protein(s)

mRNA	Protein	Name
NM_001297439.2	NP_001284368.1	hepatocyte growth factor activator isoform 1 preproprotein
NM_001297439.1	NP_001284368.1	hepatocyte growth factor activator isoform 1 preproprotein
NM_001528.3	NP_001519.1	hepatocyte growth factor activator isoform 2 preproprotein
NM_001528.4	NP_001519.1	hepatocyte growth factor activator isoform 2 preproprotein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	HGFAC	XP_001174601.2
Canis lupus familiaris (dog)	HGFAC	NP_001026985.1
Mus musculus (house mouse)	Hgfac	NP_062320.2
	HGFAC	XP_001114822.2
Bos taurus (cattle)	HGFAC	NP_001193958.1
Homo sapiens (human)	HGFAC	NP_001519.1
Rattus norvegicus (Norway rat)	Hgfac	NP_445772.1
Xenopus tropicalis (tropical clawed frog)	hgfac	XP_002939269.2
Gallus gallus (chicken)	HGFAC	XP_420819.4

Gene Ontology
Bibliography

Related articles in PubMed

Trans-ethnic meta-analysis identifies common and rare variants associated with hepatocyte growth factor levels in the Multi-Ethnic Study of Atherosclerosis (MESA).
Larson NB, Berardi C, Decker PA, Wassel CL, Kirsch PS, Pankow JS, Sale MM, de Andrade M, Sicotte H, Tang W, Hanson NQ, Tsai MY, Taylor KD, Bielinski SJ
Annals of human genetics79(4)264-74(2015 Jul)

L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
Yokoyama K, Urashima M, Ohkido I, Kono T, Yoshida T, Muramatsu M, Niu T, Hosoya T
Nephron. Clinical practice115(4)c237-43(2010)

Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein.
Kawaguchi M, Orikawa H, Baba T, Fukushima T, Kataoka H
The FEBS journal276(13)3481-90(2009 Jul)

Elevated serum concentrations of activated hepatocyte growth factor activator in patients with multiple myeloma.
Wader KF, Fagerli UM, Holt RU, Stordal B, B?rset M, Sundan A, Waage A
European journal of haematology81(5)380-3(2008 Nov)

Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer.
Kitajima Y, Ide T, Ohtsuka T, Miyazaki K
Cancer science99(7)1341-7(2008 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Based upon ethnicity-stratified single-variant association analysis and trans-ethnic meta-analysis of 6201 participants of the Multi-Ethnic Study of Atherosclerosis, discovered 5 common and low-frequency variants: HGF missense polymorphism rs5745687 (p.E299K) and 4 variants (rs16844364, rs4690098, rs114303452, rs3748034) within or in proximity to HGFAC.[Meta-analysis]
Title: Trans-ethnic meta-analysis identifies common and rare variants associated with hepatocyte growth factor levels in the Multi-Ethnic Study of Atherosclerosis (MESA).

Observational study of gene-disease association. (HuGE Navigator)
Title: L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.

Results suggest that hepatocyte growth factor activator is a major serum activator of pro-macrophage-stimulating protein.
Title: Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein.

the activated form of HGFA is present at high levels in serum and bone marrow of myeloma patients, thus providing a necessary prerequisite for the activation of HGF.
Title: Elevated serum concentrations of activated hepatocyte growth factor activator in patients with multiple myeloma.

Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer.
Title: Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer.

The following HGFAC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HGFAC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28748	NM_001528.4 Latest version!	Homo sapiens HGF activator (HGFAC), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu28747	NM_001297439.2 Latest version!	Homo sapiens HGF activator (HGFAC), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
View Old Accession Versions >>
OHu28747	NM_001297439.1	Homo sapiens HGF activator (HGFAC), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu28748	NM_001528.3	Homo sapiens HGF activator (HGFAC), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HGFAC ( NM_001528.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001519.1 Homo sapiens HGF activator (HGFAC), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu28748
Clone ID Related Accession (Same CDS sequence)	NM_001528.3 , NM_001528.4
Accession Version	NM_001528.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1968bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	hepatocyte growth factor activator isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC112190.1 and D14012.1. On Jul 2, 2014 this sequence version replaced NM_001528.2. Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC112190.1, BC112192.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145122, SAMEA2155590 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGCGCT GGGCCTGGGT CCCCAGCCCC TGGCCCCCAC CGGGGCTGGG CCCCTTCCTC 
CTCCTCCTCC TGCTGCTGCT GCTGCTGCCA CGGGGGTTCC AGCCCCAGCC TGGCGGGAAC 
CGTACGGAGT CCCCAGAACC TAATGCCACA GCGACCCCTG CGATCCCCAC TATCCTGGTG 
ACCTCTGTGA CCTCTGAGAC CCCAGCAACA AGTGCTCCAG AGGCAGAGGG ACCCCAAAGT 
GGGGGGCTCC CGCCCCCGCC CAGGGCAGTT CCCTCGAGCA GTAGCCCCCA GGCCCAAGCA 
CTCACCGAGG ACGGGAGGCC CTGCAGGTTC CCCTTCCGCT ACGGGGGCCG CATGCTGCAT 
GCCTGCACTT CGGAGGGCAG TGCACACAGG AAGTGGTGTG CCACAACTCA CAACTACGAC 
CGGGACAGGG CCTGGGGCTA CTGTGTGGAG GCCACCCCGC CTCCAGGGGG CCCAGCTGCC 
CTGGATCCCT GTGCCTCCGG CCCCTGCCTC AATGGAGGCT CCTGCTCCAA TACCCAGGAC 
CCCCAGTCCT ATCACTGCAG CTGCCCCCGG GCCTTCACCG GCAAGGACTG CGGCACAGAG 
AAATGCTTTG ATGAGACCCG CTACGAGTAC CTGGAGGGGG GCGACCGCTG GGCCCGCGTG 
CGCCAGGGCC ACGTGGAACA GTGCGAGTGC TTCGGGGGCC GGACCTGGTG CGAAGGCACC 
CGACATACAG CTTGTCTGAG CAGCCCTTGC CTGAACGGGG GCACCTGCCA CCTGATCGTG 
GCCACCGGGA CCACCGTGTG TGCCTGCCCA CCAGGCTTCG CTGGACGGCT CTGCAACATC 
GAGCCTGATG AGCGCTGCTT CTTGGGGAAC GGCACTGGGT ACCGTGGCGT GGCCAGCACC 
TCAGCCTCGG GCCTCAGCTG CCTGGCCTGG AACTCCGATC TGCTCTACCA GGAGCTGCAC 
GTGGACTCCG TGGGCGCCGC GGCCCTGCTG GGCCTGGGCC CCCATGCCTA CTGCCGGAAT 
CCGGACAATG ACGAGAGGCC CTGGTGCTAC GTGGTGAAGG ACAGCGCGCT CTCCTGGGAG 
TACTGCCGCC TGGAGGCCTG CGAATCCCTC ACCAGAGTCC AACTGTCACC GGATCTCCTG 
GCGACCCTGC CTGAGCCAGC CTCCCCGGGG CGCCAGGCCT GCGGCAGGAG GCACAAGAAG 
AGGACGTTCC TGCGGCCACG TATCATCGGC GGCTCCTCCT CGCTGCCCGG CTCGCACCCC 
TGGCTGGCCG CCATCTACAT CGGGGACAGC TTCTGCGCCG GGAGCCTGGT CCACACCTGC 
TGGGTGGTGT CGGCCGCCCA CTGCTTCTCC CACAGCCCCC CCAGGGACAG CGTCTCCGTG 
GTGCTGGGCC AGCACTTCTT CAACCGCACG ACGGACGTGA CGCAGACCTT CGGCATCGAG 
AAGTACATCC CGTACACCCT GTACTCGGTG TTCAACCCCA GCGACCACGA CCTCGTCCTG 
ATCCGGCTGA AGAAGAAAGG GGACCGCTGT GCCACACGCT CGCAGTTCGT GCAGCCCATC 
TGCCTGCCCG AGCCCGGCAG CACCTTCCCC GCAGGACACA AGTGCCAGAT TGCGGGCTGG 
GGCCACTTGG ATGAGAACGT GAGCGGCTAC TCCAGCTCCC TGCGGGAGGC CCTGGTCCCC 
CTGGTCGCCG ACCACAAGTG CAGCAGCCCT GAGGTCTACG GCGCCGACAT CAGCCCCAAC 
ATGCTCTGTG CCGGCTACTT CGACTGCAAG TCCGACGCCT GCCAGGGGGA CTCAGGGGGG 
CCCCTGGCCT GCGAGAAGAA CGGCGTGGCT TACCTCTACG GCATCATCAG CTGGGGTGAC 
GGCTGCGGGC GGCTCCACAA GCCGGGGGTC TACACCCGCG TGGCCAACTA TGTGGACTGG 
ATCAACGACC GGATACGGCC TCCCAGGCGG CTTGTGGCTC CCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001519.1
CDS	70..2037
Translation	MGRWAWVPSPWPPPGLGPFLLLLLLLLLLPRGFQPQPGGNRTESPEPNATATPAIPTILVTSVTSETPATSAPEAEGPQSGGLPPPPRAVPSSSSPQAQALTEDGRPCRFPFRYGGRMLHACTSEGSAHRKWCATTHNYDRDRAWGYCVEATPPPGGPAALDPCASGPCLNGGSCSNTQDPQSYHCSCPRAFTGKDCGTEKCFDETRYEYLEGGDRWARVRQGHVEQCECFGGRTWCEGTRHTACLSSPCLNGGTCHLIVATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVASTSASGLSCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYVVKDSALSWEYCRLEACESLTRVQLSPDLLATLPEPASPGRQACGRRHKKRTFLRPRIIGGSSSLPGSHPWLAAIYIGDSFCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQTFGIEKYIPYTLYSVFNPSDHDLVLIRLKKKGDRCATRSQFVQPICLPEPGSTFPAGHKCQIAGWGHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIRPPRRLVAPS

Target ORF information:

RefSeq Version	NM_001528.3
Organism	Homo sapiens(human)
Definition	Homo sapiens HGF activator (HGFAC), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001528.3

ORF Insert Sequence:

ATGGGGCGCT GGGCCTGGGT CCCCAGCCCC TGGCCCCCAC CGGGGCTGGG CCCCTTCCTC 
CTCCTCCTCC TGCTGCTGCT GCTGCTGCCA CGGGGGTTCC AGCCCCAGCC TGGCGGGAAC 
CGTACGGAGT CCCCAGAACC TAATGCCACA GCGACCCCTG CGATCCCCAC TATCCTGGTG 
ACCTCTGTGA CCTCTGAGAC CCCAGCAACA AGTGCTCCAG AGGCAGAGGG ACCCCAAAGT 
GGGGGGCTCC CGCCCCCGCC CAGGGCAGTT CCCTCGAGCA GTAGCCCCCA GGCCCAAGCA 
CTCACCGAGG ACGGGAGGCC CTGCAGGTTC CCCTTCCGCT ACGGGGGCCG CATGCTGCAT 
GCCTGCACTT CGGAGGGCAG TGCACACAGG AAGTGGTGTG CCACAACTCA CAACTACGAC 
CGGGACAGGG CCTGGGGCTA CTGTGTGGAG GCCACCCCGC CTCCAGGGGG CCCAGCTGCC 
CTGGATCCCT GTGCCTCCGG CCCCTGCCTC AATGGAGGCT CCTGCTCCAA TACCCAGGAC 
CCCCAGTCCT ATCACTGCAG CTGCCCCCGG GCCTTCACCG GCAAGGACTG CGGCACAGAG 
AAATGCTTTG ATGAGACCCG CTACGAGTAC CTGGAGGGGG GCGACCGCTG GGCCCGCGTG 
CGCCAGGGCC ACGTGGAACA GTGCGAGTGC TTCGGGGGCC GGACCTGGTG CGAAGGCACC 
CGACATACAG CTTGTCTGAG CAGCCCTTGC CTGAACGGGG GCACCTGCCA CCTGATCGTG 
GCCACCGGGA CCACCGTGTG TGCCTGCCCA CCAGGCTTCG CTGGACGGCT CTGCAACATC 
GAGCCTGATG AGCGCTGCTT CTTGGGGAAC GGCACTGGGT ACCGTGGCGT GGCCAGCACC 
TCAGCCTCGG GCCTCAGCTG CCTGGCCTGG AACTCCGATC TGCTCTACCA GGAGCTGCAC 
GTGGACTCCG TGGGCGCCGC GGCCCTGCTG GGCCTGGGCC CCCATGCCTA CTGCCGGAAT 
CCGGACAATG ACGAGAGGCC CTGGTGCTAC GTGGTGAAGG ACAGCGCGCT CTCCTGGGAG 
TACTGCCGCC TGGAGGCCTG CGAATCCCTC ACCAGAGTCC AACTGTCACC GGATCTCCTG 
GCGACCCTGC CTGAGCCAGC CTCCCCGGGG CGCCAGGCCT GCGGCAGGAG GCACAAGAAG 
AGGACGTTCC TGCGGCCACG TATCATCGGC GGCTCCTCCT CGCTGCCCGG CTCGCACCCC 
TGGCTGGCCG CCATCTACAT CGGGGACAGC TTCTGCGCCG GGAGCCTGGT CCACACCTGC 
TGGGTGGTGT CGGCCGCCCA CTGCTTCTCC CACAGCCCCC CCAGGGACAG CGTCTCCGTG 
GTGCTGGGCC AGCACTTCTT CAACCGCACG ACGGACGTGA CGCAGACCTT CGGCATCGAG 
AAGTACATCC CGTACACCCT GTACTCGGTG TTCAACCCCA GCGACCACGA CCTCGTCCTG 
ATCCGGCTGA AGAAGAAAGG GGACCGCTGT GCCACACGCT CGCAGTTCGT GCAGCCCATC 
TGCCTGCCCG AGCCCGGCAG CACCTTCCCC GCAGGACACA AGTGCCAGAT TGCGGGCTGG 
GGCCACTTGG ATGAGAACGT GAGCGGCTAC TCCAGCTCCC TGCGGGAGGC CCTGGTCCCC 
CTGGTCGCCG ACCACAAGTG CAGCAGCCCT GAGGTCTACG GCGCCGACAT CAGCCCCAAC 
ATGCTCTGTG CCGGCTACTT CGACTGCAAG TCCGACGCCT GCCAGGGGGA CTCAGGGGGG 
CCCCTGGCCT GCGAGAAGAA CGGCGTGGCT TACCTCTACG GCATCATCAG CTGGGGTGAC 
GGCTGCGGGC GGCTCCACAA GCCGGGGGTC TACACCCGCG TGGCCAACTA TGTGGACTGG 
ATCAACGACC GGATACGGCC TCCCAGGCGG CTTGTGGCTC CCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HGFAC ( NM_001528.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001519.1 Homo sapiens HGF activator (HGFAC), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu28748
Clone ID Related Accession (Same CDS sequence)	NM_001528.3 , NM_001528.4
Accession Version	NM_001528.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1968bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	hepatocyte growth factor activator isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC112190.1 and D14012.1. On Jun 2, 2019 this sequence version replaced NM_001528.3. Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D14012.1, BC112190.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145122, SAMEA2155590 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGGCGCT GGGCCTGGGT CCCCAGCCCC TGGCCCCCAC CGGGGCTGGG CCCCTTCCTC 
CTCCTCCTCC TGCTGCTGCT GCTGCTGCCA CGGGGGTTCC AGCCCCAGCC TGGCGGGAAC 
CGTACGGAGT CCCCAGAACC TAATGCCACA GCGACCCCTG CGATCCCCAC TATCCTGGTG 
ACCTCTGTGA CCTCTGAGAC CCCAGCAACA AGTGCTCCAG AGGCAGAGGG ACCCCAAAGT 
GGGGGGCTCC CGCCCCCGCC CAGGGCAGTT CCCTCGAGCA GTAGCCCCCA GGCCCAAGCA 
CTCACCGAGG ACGGGAGGCC CTGCAGGTTC CCCTTCCGCT ACGGGGGCCG CATGCTGCAT 
GCCTGCACTT CGGAGGGCAG TGCACACAGG AAGTGGTGTG CCACAACTCA CAACTACGAC 
CGGGACAGGG CCTGGGGCTA CTGTGTGGAG GCCACCCCGC CTCCAGGGGG CCCAGCTGCC 
CTGGATCCCT GTGCCTCCGG CCCCTGCCTC AATGGAGGCT CCTGCTCCAA TACCCAGGAC 
CCCCAGTCCT ATCACTGCAG CTGCCCCCGG GCCTTCACCG GCAAGGACTG CGGCACAGAG 
AAATGCTTTG ATGAGACCCG CTACGAGTAC CTGGAGGGGG GCGACCGCTG GGCCCGCGTG 
CGCCAGGGCC ACGTGGAACA GTGCGAGTGC TTCGGGGGCC GGACCTGGTG CGAAGGCACC 
CGACATACAG CTTGTCTGAG CAGCCCTTGC CTGAACGGGG GCACCTGCCA CCTGATCGTG 
GCCACCGGGA CCACCGTGTG TGCCTGCCCA CCAGGCTTCG CTGGACGGCT CTGCAACATC 
GAGCCTGATG AGCGCTGCTT CTTGGGGAAC GGCACTGGGT ACCGTGGCGT GGCCAGCACC 
TCAGCCTCGG GCCTCAGCTG CCTGGCCTGG AACTCCGATC TGCTCTACCA GGAGCTGCAC 
GTGGACTCCG TGGGCGCCGC GGCCCTGCTG GGCCTGGGCC CCCATGCCTA CTGCCGGAAT 
CCGGACAATG ACGAGAGGCC CTGGTGCTAC GTGGTGAAGG ACAGCGCGCT CTCCTGGGAG 
TACTGCCGCC TGGAGGCCTG CGAATCCCTC ACCAGAGTCC AACTGTCACC GGATCTCCTG 
GCGACCCTGC CTGAGCCAGC CTCCCCGGGG CGCCAGGCCT GCGGCAGGAG GCACAAGAAG 
AGGACGTTCC TGCGGCCACG TATCATCGGC GGCTCCTCCT CGCTGCCCGG CTCGCACCCC 
TGGCTGGCCG CCATCTACAT CGGGGACAGC TTCTGCGCCG GGAGCCTGGT CCACACCTGC 
TGGGTGGTGT CGGCCGCCCA CTGCTTCTCC CACAGCCCCC CCAGGGACAG CGTCTCCGTG 
GTGCTGGGCC AGCACTTCTT CAACCGCACG ACGGACGTGA CGCAGACCTT CGGCATCGAG 
AAGTACATCC CGTACACCCT GTACTCGGTG TTCAACCCCA GCGACCACGA CCTCGTCCTG 
ATCCGGCTGA AGAAGAAAGG GGACCGCTGT GCCACACGCT CGCAGTTCGT GCAGCCCATC 
TGCCTGCCCG AGCCCGGCAG CACCTTCCCC GCAGGACACA AGTGCCAGAT TGCGGGCTGG 
GGCCACTTGG ATGAGAACGT GAGCGGCTAC TCCAGCTCCC TGCGGGAGGC CCTGGTCCCC 
CTGGTCGCCG ACCACAAGTG CAGCAGCCCT GAGGTCTACG GCGCCGACAT CAGCCCCAAC 
ATGCTCTGTG CCGGCTACTT CGACTGCAAG TCCGACGCCT GCCAGGGGGA CTCAGGGGGG 
CCCCTGGCCT GCGAGAAGAA CGGCGTGGCT TACCTCTACG GCATCATCAG CTGGGGTGAC 
GGCTGCGGGC GGCTCCACAA GCCGGGGGTC TACACCCGCG TGGCCAACTA TGTGGACTGG 
ATCAACGACC GGATACGGCC TCCCAGGCGG CTTGTGGCTC CCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001519.1
CDS	35..2002
Translation	MGRWAWVPSPWPPPGLGPFLLLLLLLLLLPRGFQPQPGGNRTESPEPNATATPAIPTILVTSVTSETPATSAPEAEGPQSGGLPPPPRAVPSSSSPQAQALTEDGRPCRFPFRYGGRMLHACTSEGSAHRKWCATTHNYDRDRAWGYCVEATPPPGGPAALDPCASGPCLNGGSCSNTQDPQSYHCSCPRAFTGKDCGTEKCFDETRYEYLEGGDRWARVRQGHVEQCECFGGRTWCEGTRHTACLSSPCLNGGTCHLIVATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVASTSASGLSCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYVVKDSALSWEYCRLEACESLTRVQLSPDLLATLPEPASPGRQACGRRHKKRTFLRPRIIGGSSSLPGSHPWLAAIYIGDSFCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQTFGIEKYIPYTLYSVFNPSDHDLVLIRLKKKGDRCATRSQFVQPICLPEPGSTFPAGHKCQIAGWGHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIRPPRRLVAPS

Target ORF information:

RefSeq Version	NM_001528.4
Organism	Homo sapiens(human)
Definition	Homo sapiens HGF activator (HGFAC), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001528.4

ORF Insert Sequence:

ATGGGGCGCT GGGCCTGGGT CCCCAGCCCC TGGCCCCCAC CGGGGCTGGG CCCCTTCCTC 
CTCCTCCTCC TGCTGCTGCT GCTGCTGCCA CGGGGGTTCC AGCCCCAGCC TGGCGGGAAC 
CGTACGGAGT CCCCAGAACC TAATGCCACA GCGACCCCTG CGATCCCCAC TATCCTGGTG 
ACCTCTGTGA CCTCTGAGAC CCCAGCAACA AGTGCTCCAG AGGCAGAGGG ACCCCAAAGT 
GGGGGGCTCC CGCCCCCGCC CAGGGCAGTT CCCTCGAGCA GTAGCCCCCA GGCCCAAGCA 
CTCACCGAGG ACGGGAGGCC CTGCAGGTTC CCCTTCCGCT ACGGGGGCCG CATGCTGCAT 
GCCTGCACTT CGGAGGGCAG TGCACACAGG AAGTGGTGTG CCACAACTCA CAACTACGAC 
CGGGACAGGG CCTGGGGCTA CTGTGTGGAG GCCACCCCGC CTCCAGGGGG CCCAGCTGCC 
CTGGATCCCT GTGCCTCCGG CCCCTGCCTC AATGGAGGCT CCTGCTCCAA TACCCAGGAC 
CCCCAGTCCT ATCACTGCAG CTGCCCCCGG GCCTTCACCG GCAAGGACTG CGGCACAGAG 
AAATGCTTTG ATGAGACCCG CTACGAGTAC CTGGAGGGGG GCGACCGCTG GGCCCGCGTG 
CGCCAGGGCC ACGTGGAACA GTGCGAGTGC TTCGGGGGCC GGACCTGGTG CGAAGGCACC 
CGACATACAG CTTGTCTGAG CAGCCCTTGC CTGAACGGGG GCACCTGCCA CCTGATCGTG 
GCCACCGGGA CCACCGTGTG TGCCTGCCCA CCAGGCTTCG CTGGACGGCT CTGCAACATC 
GAGCCTGATG AGCGCTGCTT CTTGGGGAAC GGCACTGGGT ACCGTGGCGT GGCCAGCACC 
TCAGCCTCGG GCCTCAGCTG CCTGGCCTGG AACTCCGATC TGCTCTACCA GGAGCTGCAC 
GTGGACTCCG TGGGCGCCGC GGCCCTGCTG GGCCTGGGCC CCCATGCCTA CTGCCGGAAT 
CCGGACAATG ACGAGAGGCC CTGGTGCTAC GTGGTGAAGG ACAGCGCGCT CTCCTGGGAG 
TACTGCCGCC TGGAGGCCTG CGAATCCCTC ACCAGAGTCC AACTGTCACC GGATCTCCTG 
GCGACCCTGC CTGAGCCAGC CTCCCCGGGG CGCCAGGCCT GCGGCAGGAG GCACAAGAAG 
AGGACGTTCC TGCGGCCACG TATCATCGGC GGCTCCTCCT CGCTGCCCGG CTCGCACCCC 
TGGCTGGCCG CCATCTACAT CGGGGACAGC TTCTGCGCCG GGAGCCTGGT CCACACCTGC 
TGGGTGGTGT CGGCCGCCCA CTGCTTCTCC CACAGCCCCC CCAGGGACAG CGTCTCCGTG 
GTGCTGGGCC AGCACTTCTT CAACCGCACG ACGGACGTGA CGCAGACCTT CGGCATCGAG 
AAGTACATCC CGTACACCCT GTACTCGGTG TTCAACCCCA GCGACCACGA CCTCGTCCTG 
ATCCGGCTGA AGAAGAAAGG GGACCGCTGT GCCACACGCT CGCAGTTCGT GCAGCCCATC 
TGCCTGCCCG AGCCCGGCAG CACCTTCCCC GCAGGACACA AGTGCCAGAT TGCGGGCTGG 
GGCCACTTGG ATGAGAACGT GAGCGGCTAC TCCAGCTCCC TGCGGGAGGC CCTGGTCCCC 
CTGGTCGCCG ACCACAAGTG CAGCAGCCCT GAGGTCTACG GCGCCGACAT CAGCCCCAAC 
ATGCTCTGTG CCGGCTACTT CGACTGCAAG TCCGACGCCT GCCAGGGGGA CTCAGGGGGG 
CCCCTGGCCT GCGAGAAGAA CGGCGTGGCT TACCTCTACG GCATCATCAG CTGGGGTGAC 
GGCTGCGGGC GGCTCCACAA GCCGGGGGTC TACACCCGCG TGGCCAACTA TGTGGACTGG 
ATCAACGACC GGATACGGCC TCCCAGGCGG CTTGTGGCTC CCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HGFAC ( NM_001297439.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001284368.1 Homo sapiens HGF activator (HGFAC), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu28747
Clone ID Related Accession (Same CDS sequence)	NM_001297439.2 , NM_001297439.1
Accession Version	NM_001297439.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1989bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	hepatocyte growth factor activator isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC112190.1, D14012.1 and AK314099.1. On Jun 2, 2019 this sequence version replaced NM_001297439.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK314099.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145122, SAMEA2155590 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGCGCT GGGCCTGGGT CCCCAGCCCC TGGCCCCCAC CGGGGCTGGG CCCCTTCCTC 
CTCCTCCTCC TGCTGCTGCT GCTGCTGCCA CGGGGGTTCC AGCCCCAGCC TGGCGGGAAC 
CGTACGGAGT CCCCAGAACC TAATGCCACA GCGACCCCTG CGATCCCCAC TATCCTGGTG 
ACCTCTGTGA CCTCTGAGAC CCCAGCAACA AGTGCTCCAG AGGCAGAGGG ACCCCAAAGT 
GGGGGGCTCC CGCCCCCGCC CAGGGCAGTT CCCTCGAGCA GTAGCCCCCA GGCCCAAGCA 
CTCACCGAGG ACGGGAGGCC CTGCAGGTTC CCCTTCCGCT ACGGGGGCCG CATGCTGCAT 
GCCTGCACTT CGGAGGGCAG TGCACACAGG AAGTGGTGTG CCACAACTCA CAACTACGAC 
CGGGACAGGG CCTGGGGCTA CTGTGTGGAG GCCACCCCGC CTCCAGGGGG CCCAGCTGCC 
CTGGATCCCT GTGCCTCCGG CCCCTGCCTC AATGGAGGCT CCTGCTCCAA TACCCAGGAC 
CCCCAGTCCT ATCACTGCAG CTGCCCCCGG GCCTTCACCG GCAAGGACTG CGGCACAGAG 
AAATGCTTTG ATGAGACCCG CTACGAGTAC CTGGAGGGGG GCGACCGCTG GGCCCGCGTG 
CGCCAGGGCC ACGTGGAACA GTGCGAGTGC TTCGGGGGCC GGACCTGGTG CGAAGGCACC 
CGACATACAG CTTGTCTGAG CAGCCCTTGC CTGAACGGGG GCACCTGCCA CCTGATCGTG 
GCCACCGGGA CCACCGTGTG TGCCTGCCCA CCAGGCTTCG CTGGACGGCT CTGCAACATC 
GAGCCTGATG AGCGCTGCTT CTTGGGGAAC GGCACTGGGT ACCGTGGCGT GGCCAGCACC 
TCAGCCTCGG GCCTCAGCTG CCTGGCCTGG AACTCCGATC TGCTCTACCA GGAGCTGCAC 
GTGGACTCCG TGGGCGCCGC GGCCCTGCTG GGCCTGGGCC CCCATGCCTA CTGCCGGAAT 
CCGGACAATG ACGAGAGGCC CTGGTGCTAC GTGGTGAAGG ACAGCGCGCT CTCCTGGGAG 
TACTGCCGCC TGGAGGCCTG CGATTTGGAA ACTGAGGGCA GAGAATCCCT CACCAGAGTC 
CAACTGTCAC CGGATCTCCT GGCGACCCTG CCTGAGCCAG CCTCCCCGGG GCGCCAGGCC 
TGCGGCAGGA GGCACAAGAA GAGGACGTTC CTGCGGCCAC GTATCATCGG CGGCTCCTCC 
TCGCTGCCCG GCTCGCACCC CTGGCTGGCC GCCATCTACA TCGGGGACAG CTTCTGCGCC 
GGGAGCCTGG TCCACACCTG CTGGGTGGTG TCGGCCGCCC ACTGCTTCTC CCACAGCCCC 
CCCAGGGACA GCGTCTCCGT GGTGCTGGGC CAGCACTTCT TCAACCGCAC GACGGACGTG 
ACGCAGACCT TCGGCATCGA GAAGTACATC CCGTACACCC TGTACTCGGT GTTCAACCCC 
AGCGACCACG ACCTCGTCCT GATCCGGCTG AAGAAGAAAG GGGACCGCTG TGCCACACGC 
TCGCAGTTCG TGCAGCCCAT CTGCCTGCCC GAGCCCGGCA GCACCTTCCC CGCAGGACAC 
AAGTGCCAGA TTGCGGGCTG GGGCCACTTG GATGAGAACG TGAGCGGCTA CTCCAGCTCC 
CTGCGGGAGG CCCTGGTCCC CCTGGTCGCC GACCACAAGT GCAGCAGCCC TGAGGTCTAC 
GGCGCCGACA TCAGCCCCAA CATGCTCTGT GCCGGCTACT TCGACTGCAA GTCCGACGCC 
TGCCAGGGGG ACTCAGGGGG GCCCCTGGCC TGCGAGAAGA ACGGCGTGGC TTACCTCTAC 
GGCATCATCA GCTGGGGTGA CGGCTGCGGG CGGCTCCACA AGCCGGGGGT CTACACCCGC 
GTGGCCAACT ATGTGGACTG GATCAACGAC CGGATACGGC CTCCCAGGCG GCTTGTGGCT 
CCCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001284368.1
CDS	35..2023
Translation	MGRWAWVPSPWPPPGLGPFLLLLLLLLLLPRGFQPQPGGNRTESPEPNATATPAIPTILVTSVTSETPATSAPEAEGPQSGGLPPPPRAVPSSSSPQAQALTEDGRPCRFPFRYGGRMLHACTSEGSAHRKWCATTHNYDRDRAWGYCVEATPPPGGPAALDPCASGPCLNGGSCSNTQDPQSYHCSCPRAFTGKDCGTEKCFDETRYEYLEGGDRWARVRQGHVEQCECFGGRTWCEGTRHTACLSSPCLNGGTCHLIVATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVASTSASGLSCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYVVKDSALSWEYCRLEACDLETEGRESLTRVQLSPDLLATLPEPASPGRQACGRRHKKRTFLRPRIIGGSSSLPGSHPWLAAIYIGDSFCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQTFGIEKYIPYTLYSVFNPSDHDLVLIRLKKKGDRCATRSQFVQPICLPEPGSTFPAGHKCQIAGWGHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIRPPRRLVAPS

Target ORF information:

RefSeq Version	NM_001297439.2
Organism	Homo sapiens(human)
Definition	Homo sapiens HGF activator (HGFAC), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001297439.2

ORF Insert Sequence:

ATGGGGCGCT GGGCCTGGGT CCCCAGCCCC TGGCCCCCAC CGGGGCTGGG CCCCTTCCTC 
CTCCTCCTCC TGCTGCTGCT GCTGCTGCCA CGGGGGTTCC AGCCCCAGCC TGGCGGGAAC 
CGTACGGAGT CCCCAGAACC TAATGCCACA GCGACCCCTG CGATCCCCAC TATCCTGGTG 
ACCTCTGTGA CCTCTGAGAC CCCAGCAACA AGTGCTCCAG AGGCAGAGGG ACCCCAAAGT 
GGGGGGCTCC CGCCCCCGCC CAGGGCAGTT CCCTCGAGCA GTAGCCCCCA GGCCCAAGCA 
CTCACCGAGG ACGGGAGGCC CTGCAGGTTC CCCTTCCGCT ACGGGGGCCG CATGCTGCAT 
GCCTGCACTT CGGAGGGCAG TGCACACAGG AAGTGGTGTG CCACAACTCA CAACTACGAC 
CGGGACAGGG CCTGGGGCTA CTGTGTGGAG GCCACCCCGC CTCCAGGGGG CCCAGCTGCC 
CTGGATCCCT GTGCCTCCGG CCCCTGCCTC AATGGAGGCT CCTGCTCCAA TACCCAGGAC 
CCCCAGTCCT ATCACTGCAG CTGCCCCCGG GCCTTCACCG GCAAGGACTG CGGCACAGAG 
AAATGCTTTG ATGAGACCCG CTACGAGTAC CTGGAGGGGG GCGACCGCTG GGCCCGCGTG 
CGCCAGGGCC ACGTGGAACA GTGCGAGTGC TTCGGGGGCC GGACCTGGTG CGAAGGCACC 
CGACATACAG CTTGTCTGAG CAGCCCTTGC CTGAACGGGG GCACCTGCCA CCTGATCGTG 
GCCACCGGGA CCACCGTGTG TGCCTGCCCA CCAGGCTTCG CTGGACGGCT CTGCAACATC 
GAGCCTGATG AGCGCTGCTT CTTGGGGAAC GGCACTGGGT ACCGTGGCGT GGCCAGCACC 
TCAGCCTCGG GCCTCAGCTG CCTGGCCTGG AACTCCGATC TGCTCTACCA GGAGCTGCAC 
GTGGACTCCG TGGGCGCCGC GGCCCTGCTG GGCCTGGGCC CCCATGCCTA CTGCCGGAAT 
CCGGACAATG ACGAGAGGCC CTGGTGCTAC GTGGTGAAGG ACAGCGCGCT CTCCTGGGAG 
TACTGCCGCC TGGAGGCCTG CGATTTGGAA ACTGAGGGCA GAGAATCCCT CACCAGAGTC 
CAACTGTCAC CGGATCTCCT GGCGACCCTG CCTGAGCCAG CCTCCCCGGG GCGCCAGGCC 
TGCGGCAGGA GGCACAAGAA GAGGACGTTC CTGCGGCCAC GTATCATCGG CGGCTCCTCC 
TCGCTGCCCG GCTCGCACCC CTGGCTGGCC GCCATCTACA TCGGGGACAG CTTCTGCGCC 
GGGAGCCTGG TCCACACCTG CTGGGTGGTG TCGGCCGCCC ACTGCTTCTC CCACAGCCCC 
CCCAGGGACA GCGTCTCCGT GGTGCTGGGC CAGCACTTCT TCAACCGCAC GACGGACGTG 
ACGCAGACCT TCGGCATCGA GAAGTACATC CCGTACACCC TGTACTCGGT GTTCAACCCC 
AGCGACCACG ACCTCGTCCT GATCCGGCTG AAGAAGAAAG GGGACCGCTG TGCCACACGC 
TCGCAGTTCG TGCAGCCCAT CTGCCTGCCC GAGCCCGGCA GCACCTTCCC CGCAGGACAC 
AAGTGCCAGA TTGCGGGCTG GGGCCACTTG GATGAGAACG TGAGCGGCTA CTCCAGCTCC 
CTGCGGGAGG CCCTGGTCCC CCTGGTCGCC GACCACAAGT GCAGCAGCCC TGAGGTCTAC 
GGCGCCGACA TCAGCCCCAA CATGCTCTGT GCCGGCTACT TCGACTGCAA GTCCGACGCC 
TGCCAGGGGG ACTCAGGGGG GCCCCTGGCC TGCGAGAAGA ACGGCGTGGC TTACCTCTAC 
GGCATCATCA GCTGGGGTGA CGGCTGCGGG CGGCTCCACA AGCCGGGGGT CTACACCCGC 
GTGGCCAACT ATGTGGACTG GATCAACGAC CGGATACGGC CTCCCAGGCG GCTTGTGGCT 
CCCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HGFAC ( NM_001297439.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001284368.1 Homo sapiens HGF activator (HGFAC), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu28747
Clone ID Related Accession (Same CDS sequence)	NM_001297439.2 , NM_001297439.1
Accession Version	NM_001297439.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1989bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	hepatocyte growth factor activator isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC112190.1, D14012.1 and AK314099.1. On Jul 2, 2014 this sequence version replaced XM_005247966.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK314099.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145122, SAMEA2155590 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGCGCT GGGCCTGGGT CCCCAGCCCC TGGCCCCCAC CGGGGCTGGG CCCCTTCCTC 
CTCCTCCTCC TGCTGCTGCT GCTGCTGCCA CGGGGGTTCC AGCCCCAGCC TGGCGGGAAC 
CGTACGGAGT CCCCAGAACC TAATGCCACA GCGACCCCTG CGATCCCCAC TATCCTGGTG 
ACCTCTGTGA CCTCTGAGAC CCCAGCAACA AGTGCTCCAG AGGCAGAGGG ACCCCAAAGT 
GGGGGGCTCC CGCCCCCGCC CAGGGCAGTT CCCTCGAGCA GTAGCCCCCA GGCCCAAGCA 
CTCACCGAGG ACGGGAGGCC CTGCAGGTTC CCCTTCCGCT ACGGGGGCCG CATGCTGCAT 
GCCTGCACTT CGGAGGGCAG TGCACACAGG AAGTGGTGTG CCACAACTCA CAACTACGAC 
CGGGACAGGG CCTGGGGCTA CTGTGTGGAG GCCACCCCGC CTCCAGGGGG CCCAGCTGCC 
CTGGATCCCT GTGCCTCCGG CCCCTGCCTC AATGGAGGCT CCTGCTCCAA TACCCAGGAC 
CCCCAGTCCT ATCACTGCAG CTGCCCCCGG GCCTTCACCG GCAAGGACTG CGGCACAGAG 
AAATGCTTTG ATGAGACCCG CTACGAGTAC CTGGAGGGGG GCGACCGCTG GGCCCGCGTG 
CGCCAGGGCC ACGTGGAACA GTGCGAGTGC TTCGGGGGCC GGACCTGGTG CGAAGGCACC 
CGACATACAG CTTGTCTGAG CAGCCCTTGC CTGAACGGGG GCACCTGCCA CCTGATCGTG 
GCCACCGGGA CCACCGTGTG TGCCTGCCCA CCAGGCTTCG CTGGACGGCT CTGCAACATC 
GAGCCTGATG AGCGCTGCTT CTTGGGGAAC GGCACTGGGT ACCGTGGCGT GGCCAGCACC 
TCAGCCTCGG GCCTCAGCTG CCTGGCCTGG AACTCCGATC TGCTCTACCA GGAGCTGCAC 
GTGGACTCCG TGGGCGCCGC GGCCCTGCTG GGCCTGGGCC CCCATGCCTA CTGCCGGAAT 
CCGGACAATG ACGAGAGGCC CTGGTGCTAC GTGGTGAAGG ACAGCGCGCT CTCCTGGGAG 
TACTGCCGCC TGGAGGCCTG CGATTTGGAA ACTGAGGGCA GAGAATCCCT CACCAGAGTC 
CAACTGTCAC CGGATCTCCT GGCGACCCTG CCTGAGCCAG CCTCCCCGGG GCGCCAGGCC 
TGCGGCAGGA GGCACAAGAA GAGGACGTTC CTGCGGCCAC GTATCATCGG CGGCTCCTCC 
TCGCTGCCCG GCTCGCACCC CTGGCTGGCC GCCATCTACA TCGGGGACAG CTTCTGCGCC 
GGGAGCCTGG TCCACACCTG CTGGGTGGTG TCGGCCGCCC ACTGCTTCTC CCACAGCCCC 
CCCAGGGACA GCGTCTCCGT GGTGCTGGGC CAGCACTTCT TCAACCGCAC GACGGACGTG 
ACGCAGACCT TCGGCATCGA GAAGTACATC CCGTACACCC TGTACTCGGT GTTCAACCCC 
AGCGACCACG ACCTCGTCCT GATCCGGCTG AAGAAGAAAG GGGACCGCTG TGCCACACGC 
TCGCAGTTCG TGCAGCCCAT CTGCCTGCCC GAGCCCGGCA GCACCTTCCC CGCAGGACAC 
AAGTGCCAGA TTGCGGGCTG GGGCCACTTG GATGAGAACG TGAGCGGCTA CTCCAGCTCC 
CTGCGGGAGG CCCTGGTCCC CCTGGTCGCC GACCACAAGT GCAGCAGCCC TGAGGTCTAC 
GGCGCCGACA TCAGCCCCAA CATGCTCTGT GCCGGCTACT TCGACTGCAA GTCCGACGCC 
TGCCAGGGGG ACTCAGGGGG GCCCCTGGCC TGCGAGAAGA ACGGCGTGGC TTACCTCTAC 
GGCATCATCA GCTGGGGTGA CGGCTGCGGG CGGCTCCACA AGCCGGGGGT CTACACCCGC 
GTGGCCAACT ATGTGGACTG GATCAACGAC CGGATACGGC CTCCCAGGCG GCTTGTGGCT 
CCCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001284368.1
CDS	70..2058
Translation	MGRWAWVPSPWPPPGLGPFLLLLLLLLLLPRGFQPQPGGNRTESPEPNATATPAIPTILVTSVTSETPATSAPEAEGPQSGGLPPPPRAVPSSSSPQAQALTEDGRPCRFPFRYGGRMLHACTSEGSAHRKWCATTHNYDRDRAWGYCVEATPPPGGPAALDPCASGPCLNGGSCSNTQDPQSYHCSCPRAFTGKDCGTEKCFDETRYEYLEGGDRWARVRQGHVEQCECFGGRTWCEGTRHTACLSSPCLNGGTCHLIVATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVASTSASGLSCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYVVKDSALSWEYCRLEACDLETEGRESLTRVQLSPDLLATLPEPASPGRQACGRRHKKRTFLRPRIIGGSSSLPGSHPWLAAIYIGDSFCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQTFGIEKYIPYTLYSVFNPSDHDLVLIRLKKKGDRCATRSQFVQPICLPEPGSTFPAGHKCQIAGWGHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIRPPRRLVAPS

Target ORF information:

RefSeq Version	NM_001297439.1
Organism	Homo sapiens(human)
Definition	Homo sapiens HGF activator (HGFAC), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001297439.1

ORF Insert Sequence:

ATGGGGCGCT GGGCCTGGGT CCCCAGCCCC TGGCCCCCAC CGGGGCTGGG CCCCTTCCTC 
CTCCTCCTCC TGCTGCTGCT GCTGCTGCCA CGGGGGTTCC AGCCCCAGCC TGGCGGGAAC 
CGTACGGAGT CCCCAGAACC TAATGCCACA GCGACCCCTG CGATCCCCAC TATCCTGGTG 
ACCTCTGTGA CCTCTGAGAC CCCAGCAACA AGTGCTCCAG AGGCAGAGGG ACCCCAAAGT 
GGGGGGCTCC CGCCCCCGCC CAGGGCAGTT CCCTCGAGCA GTAGCCCCCA GGCCCAAGCA 
CTCACCGAGG ACGGGAGGCC CTGCAGGTTC CCCTTCCGCT ACGGGGGCCG CATGCTGCAT 
GCCTGCACTT CGGAGGGCAG TGCACACAGG AAGTGGTGTG CCACAACTCA CAACTACGAC 
CGGGACAGGG CCTGGGGCTA CTGTGTGGAG GCCACCCCGC CTCCAGGGGG CCCAGCTGCC 
CTGGATCCCT GTGCCTCCGG CCCCTGCCTC AATGGAGGCT CCTGCTCCAA TACCCAGGAC 
CCCCAGTCCT ATCACTGCAG CTGCCCCCGG GCCTTCACCG GCAAGGACTG CGGCACAGAG 
AAATGCTTTG ATGAGACCCG CTACGAGTAC CTGGAGGGGG GCGACCGCTG GGCCCGCGTG 
CGCCAGGGCC ACGTGGAACA GTGCGAGTGC TTCGGGGGCC GGACCTGGTG CGAAGGCACC 
CGACATACAG CTTGTCTGAG CAGCCCTTGC CTGAACGGGG GCACCTGCCA CCTGATCGTG 
GCCACCGGGA CCACCGTGTG TGCCTGCCCA CCAGGCTTCG CTGGACGGCT CTGCAACATC 
GAGCCTGATG AGCGCTGCTT CTTGGGGAAC GGCACTGGGT ACCGTGGCGT GGCCAGCACC 
TCAGCCTCGG GCCTCAGCTG CCTGGCCTGG AACTCCGATC TGCTCTACCA GGAGCTGCAC 
GTGGACTCCG TGGGCGCCGC GGCCCTGCTG GGCCTGGGCC CCCATGCCTA CTGCCGGAAT 
CCGGACAATG ACGAGAGGCC CTGGTGCTAC GTGGTGAAGG ACAGCGCGCT CTCCTGGGAG 
TACTGCCGCC TGGAGGCCTG CGATTTGGAA ACTGAGGGCA GAGAATCCCT CACCAGAGTC 
CAACTGTCAC CGGATCTCCT GGCGACCCTG CCTGAGCCAG CCTCCCCGGG GCGCCAGGCC 
TGCGGCAGGA GGCACAAGAA GAGGACGTTC CTGCGGCCAC GTATCATCGG CGGCTCCTCC 
TCGCTGCCCG GCTCGCACCC CTGGCTGGCC GCCATCTACA TCGGGGACAG CTTCTGCGCC 
GGGAGCCTGG TCCACACCTG CTGGGTGGTG TCGGCCGCCC ACTGCTTCTC CCACAGCCCC 
CCCAGGGACA GCGTCTCCGT GGTGCTGGGC CAGCACTTCT TCAACCGCAC GACGGACGTG 
ACGCAGACCT TCGGCATCGA GAAGTACATC CCGTACACCC TGTACTCGGT GTTCAACCCC 
AGCGACCACG ACCTCGTCCT GATCCGGCTG AAGAAGAAAG GGGACCGCTG TGCCACACGC 
TCGCAGTTCG TGCAGCCCAT CTGCCTGCCC GAGCCCGGCA GCACCTTCCC CGCAGGACAC 
AAGTGCCAGA TTGCGGGCTG GGGCCACTTG GATGAGAACG TGAGCGGCTA CTCCAGCTCC 
CTGCGGGAGG CCCTGGTCCC CCTGGTCGCC GACCACAAGT GCAGCAGCCC TGAGGTCTAC 
GGCGCCGACA TCAGCCCCAA CATGCTCTGT GCCGGCTACT TCGACTGCAA GTCCGACGCC 
TGCCAGGGGG ACTCAGGGGG GCCCCTGGCC TGCGAGAAGA ACGGCGTGGC TTACCTCTAC 
GGCATCATCA GCTGGGGTGA CGGCTGCGGG CGGCTCCACA AGCCGGGGGT CTACACCCGC 
GTGGCCAACT ATGTGGACTG GATCAACGAC CGGATACGGC CTCCCAGGCG GCTTGTGGCT 
CCCTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Trans-ethnic meta-analysis identifies common and rare variants associated with hepatocyte growth factor levels in the Multi-Ethnic Study of Atherosclerosis (MESA).
Annals of human genetics79(4)264-74(2015 Jul)
Larson NB,Berardi C,Decker PA,Wassel CL,Kirsch PS,Pankow JS,Sale MM,de Andrade M,Sicotte H,Tang W,Hanson NQ,Tsai MY,Taylor KD,Bielinski SJ

L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
Nephron. Clinical practice115(4)c237-43(2010)
Yokoyama K,Urashima M,Ohkido I,Kono T,Yoshida T,Muramatsu M,Niu T,Hosoya T

Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein.
The FEBS journal276(13)3481-90(2009 Jul)
Kawaguchi M,Orikawa H,Baba T,Fukushima T,Kataoka H

Elevated serum concentrations of activated hepatocyte growth factor activator in patients with multiple myeloma.
European journal of haematology81(5)380-3(2008 Nov)
Wader KF,Fagerli UM,Holt RU,Stordal B,B?rset M,Sundan A,Waage A

Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer.
Cancer science99(7)1341-7(2008 Jul)
Kitajima Y,Ide T,Ohtsuka T,Miyazaki K

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HGFAC cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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