Gene Symbol | HMGCS1 |
Entrez Gene ID | 3157 |
Full Name | 3-hydroxy-3-methylglutaryl-CoA synthase 1 |
Synonyms | HMGCS |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » HMGCS1 cDNA ORF clone
gRNAs
Gene Symbol | HMGCS1 |
Entrez Gene ID | 3157 |
Full Name | 3-hydroxy-3-methylglutaryl-CoA synthase 1 |
Synonyms | HMGCS |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_001324220.1 | NP_001311149.1 | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 |
NM_001324222.2 | NP_001311151.1 | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 2 |
NM_001330663.2 | NP_001317592.1 | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 |
XM_011514036.3 | XP_011512338.1 | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1 |
NM_001324224.1 | NP_001311153.1 | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 2 |
NM_002130.7 | NP_002121.4 | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 |
NM_001324222.1 | NP_001311151.1 | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 2 |
NM_001098272.3 | NP_001091742.1 | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 |
NM_001324223.2 | NP_001311152.1 | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 2 |
NM_001330663.1 | NP_001317592.1 | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 |
NM_001324219.2 | NP_001311148.1 | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 |
NM_001324224.2 | NP_001311153.1 | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 2 |
NM_001364188.2 | NP_001351117.1 | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 |
XM_024446038.1 | XP_024301806.1 | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1 |
NM_001324223.1 | NP_001311152.1 | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 2 |
NM_001324219.1 | NP_001311148.1 | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 |
NM_001364188.1 | NP_001351117.1 | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 |
NM_001098272.2 | NP_001091742.1 | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 |
XM_011514036.2 | XP_011512338.1 | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X2 |
NM_002130.8 | NP_002121.4 | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 |
NM_001324220.2 | NP_001311149.1 | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 |
Mus musculus (house mouse) | Hmgcs1 | NP_666054.2 |
Kluyveromyces lactis | KLLA0D10505g | XP_453529.2 |
Eremothecium gossypii | AGOS_ADL356C | NP_983739.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_01026 | XP_003717917.1 |
Neurospora crassa | NCU03922 | XP_957561.1 |
Oryza sativa (rice) | Os08g0544900 | NP_001062410.1 |
Canis lupus familiaris (dog) | HMGCS1 | XP_005619400.1 |
Bos taurus (cattle) | HMGCS1 | NP_001193507.1 |
Danio rerio (zebrafish) | hmgcs1 | NP_957379.1 |
Arabidopsis thaliana (thale cress) | MVA1 | NP_192919.1 |
Oryza sativa (rice) | Os03g0118800 | NP_001048774.1 |
Oryza sativa (rice) | Os09g0521400 | NP_001063706.1 |
HMGCS1 | XP_002804403.1 | |
Saccharomyces cerevisiae (baker's yeast) | ERG13 | NP_013580.1 |
Xenopus tropicalis (tropical clawed frog) | hmgcs1 | NP_001120172.1 |
Homo sapiens (human) | HMGCS1 | NP_001091742.1 |
Rattus norvegicus (Norway rat) | Hmgcs1 | NP_058964.1 |
Pan troglodytes (chimpanzee) | HMGCS1 | XP_003310783.1 |
Gallus gallus (chicken) | HMGCS1 | NP_990742.1 |
Drosophila melanogaster (fruit fly) | Hmgs | NP_725570.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP005847 | XP_315872.3 |
Schizosaccharomyces pombe (fission yeast) | hcs1 | NP_593859.1 |
HMG-CoA synthase 1 is a synthetic lethal partner of BRAF
Zhao L, Fan J, Xia S, Pan Y, Liu S, Qian G, Qian Z, Kang HB, Arbiser JL, Pollack BP, Kudchadkar RR, Lawson DH, Rossi M, Abdel-Wahab O, Merghoub T, Khoury HJ, Khuri FR, Boise LH, Lonial S, Chen F, Chen J, Lin R
The Journal of biological chemistry292(24)10142-10152(2017 06)
Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.
Shafqat N, Turnbull A, Zschocke J, Oppermann U, Yue WW
Journal of molecular biology398(4)497-506(2010 May)
Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Doll? ME, Imholz S, van 't Slot R, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM
Journal of lipid research49(12)2582-9(2008 Dec)
Transcriptional regulation of HMG-CoA synthase and HMG-CoA reductase genes by human ACBP.
Vock C, D?ring F, Nitz I
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology22(5-6)515-24(2008)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data suggest that HMGCS1 (HMG-CoA synthase 1) signals through ketogenesis/acetoacetate to promote cell proliferation and BRAF(V600E)-dependent MEK1 activation in BRAF(V600E)-positive melanoma and colon cancer cells; HMGCS1 co-localizes with HMGCL (HMG-CoA lyase) and BRAF(V600E) in cytosol of melanoma and colon cancer cells. (BRAF = proto-oncogene protein B-raf)
Title: HMG-CoA synthase 1 is a synthetic lethal partner of BRAF
The authors report high-resolution crystal structures of the human cytosolic (hHMGCS1) and mitochondrial (hHMGCS2) isoforms in binary product complexes.
Title: Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.
Observational study of gene-disease association. (HuGE Navigator)
Title: Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Observational study of gene-disease association. (HuGE Navigator)
Title: Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.
ACBP is a transcriptional regulator of the HMGCS1 and HMGCR genes encoding rate-limiting enzymes of cholesterol synthesis pathway.
Title: Transcriptional regulation of HMG-CoA synthase and HMG-CoA reductase genes by human ACBP.
The following HMGCS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HMGCS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu01309![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001324220.1 , NM_001330663.2 , NM_002130.7 , NM_001098272.3 , NM_001330663.1 , NM_001324219.2 , NM_001364188.2 , NM_001324219.1 , NM_001364188.1 , NM_001098272.2 , NM_002130.8 , NM_001324220.2 | |
Accession Version | NM_001324220.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1563bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-24 | |
Organism | Homo sapiens(human) | |
Product | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB074885.1, BJ995153.1, AK315593.1 and AC114947.2. On Apr 28, 2016 this sequence version replaced XM_011514034.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.61106.1, SRR1803611.194174.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001311149.1 |
CDS | 247..1809 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu01309![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001324220.1 , NM_001330663.2 , NM_002130.7 , NM_001098272.3 , NM_001330663.1 , NM_001324219.2 , NM_001364188.2 , NM_001324219.1 , NM_001364188.1 , NM_001098272.2 , NM_002130.8 , NM_001324220.2 | |
Accession Version | NM_001330663.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1563bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-27 | |
Organism | Homo sapiens(human) | |
Product | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC114947.2. On May 31, 2019 this sequence version replaced NM_001330663.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.96054.1, SRR1660807.126299.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001317592.1 |
CDS | 230..1792 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu01309![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001324220.1 , NM_001330663.2 , NM_002130.7 , NM_001098272.3 , NM_001330663.1 , NM_001324219.2 , NM_001364188.2 , NM_001324219.1 , NM_001364188.1 , NM_001098272.2 , NM_002130.8 , NM_001324220.2 | |
Accession Version | NM_002130.7 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1563bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-22 | |
Organism | Homo sapiens(human) | |
Product | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC114947.2. On May 17, 2012 this sequence version replaced NM_002130.6. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.158150.1, SRR1803613.257271.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267761 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_002121.4 |
CDS | 168..1730 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu01309![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001324220.1 , NM_001330663.2 , NM_002130.7 , NM_001098272.3 , NM_001330663.1 , NM_001324219.2 , NM_001364188.2 , NM_001324219.1 , NM_001364188.1 , NM_001098272.2 , NM_002130.8 , NM_001324220.2 | |
Accession Version | NM_001098272.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1563bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-25 | |
Organism | Homo sapiens(human) | |
Product | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK315593.1 and AC114947.2. On Nov 22, 2018 this sequence version replaced NM_001098272.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.216745.1, SRR1803615.11048.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000325110.11/ ENSP00000322706.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001091742.1 |
CDS | 127..1689 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu01309![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001324220.1 , NM_001330663.2 , NM_002130.7 , NM_001098272.3 , NM_001330663.1 , NM_001324219.2 , NM_001364188.2 , NM_001324219.1 , NM_001364188.1 , NM_001098272.2 , NM_002130.8 , NM_001324220.2 | |
Accession Version | NM_001330663.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1563bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-25 | |
Organism | Homo sapiens(human) | |
Product | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC114947.2. On Sep 1, 2016 this sequence version replaced XM_017009412.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.96054.1, SRR1660807.126299.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001317592.1 |
CDS | 346..1908 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu01309![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001324220.1 , NM_001330663.2 , NM_002130.7 , NM_001098272.3 , NM_001330663.1 , NM_001324219.2 , NM_001364188.2 , NM_001324219.1 , NM_001364188.1 , NM_001098272.2 , NM_002130.8 , NM_001324220.2 | |
Accession Version | NM_001324219.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1563bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-27 | |
Organism | Homo sapiens(human) | |
Product | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA801434.1, AK315593.1 and AC114947.2. On May 31, 2019 this sequence version replaced NM_001324219.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.2816.1, SRR1803616.112840.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267755, SAMN03267761 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001311148.1 |
CDS | 171..1733 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu01309![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001324220.1 , NM_001330663.2 , NM_002130.7 , NM_001098272.3 , NM_001330663.1 , NM_001324219.2 , NM_001364188.2 , NM_001324219.1 , NM_001364188.1 , NM_001098272.2 , NM_002130.8 , NM_001324220.2 | |
Accession Version | NM_001364188.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1563bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-27 | |
Organism | Homo sapiens(human) | |
Product | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC114947.2. On May 31, 2019 this sequence version replaced NM_001364188.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.42317.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001351117.1 |
CDS | 250..1812 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu01309![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001324220.1 , NM_001330663.2 , NM_002130.7 , NM_001098272.3 , NM_001330663.1 , NM_001324219.2 , NM_001364188.2 , NM_001324219.1 , NM_001364188.1 , NM_001098272.2 , NM_002130.8 , NM_001324220.2 | |
Accession Version | NM_001324219.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1563bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-25 | |
Organism | Homo sapiens(human) | |
Product | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA801434.1, AK315593.1 and AC114947.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.252369.1, SRR1803616.2816.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267755, SAMN03267761 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001311148.1 |
CDS | 214..1776 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu01309![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001324220.1 , NM_001330663.2 , NM_002130.7 , NM_001098272.3 , NM_001330663.1 , NM_001324219.2 , NM_001364188.2 , NM_001324219.1 , NM_001364188.1 , NM_001098272.2 , NM_002130.8 , NM_001324220.2 | |
Accession Version | NM_001364188.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1563bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-27 | |
Organism | Homo sapiens(human) | |
Product | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC114947.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.42317.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001351117.1 |
CDS | 250..1812 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu01309![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001324220.1 , NM_001330663.2 , NM_002130.7 , NM_001098272.3 , NM_001330663.1 , NM_001324219.2 , NM_001364188.2 , NM_001324219.1 , NM_001364188.1 , NM_001098272.2 , NM_002130.8 , NM_001324220.2 | |
Accession Version | NM_001098272.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1563bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-02 | |
Organism | Homo sapiens(human) | |
Product | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB074885.1, AK315593.1 and AC114947.2. On May 16, 2012 this sequence version replaced NM_001098272.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.11048.1, SRR1660809.42847.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001091742.1 |
CDS | 227..1789 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu01309![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001324220.1 , NM_001330663.2 , NM_002130.7 , NM_001098272.3 , NM_001330663.1 , NM_001324219.2 , NM_001364188.2 , NM_001324219.1 , NM_001364188.1 , NM_001098272.2 , NM_002130.8 , NM_001324220.2 | |
Accession Version | NM_002130.8 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1563bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-27 | |
Organism | Homo sapiens(human) | |
Product | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC114947.2. On May 31, 2019 this sequence version replaced NM_002130.7. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.92027.1, SRR1660807.236422.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267761 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_002121.4 |
CDS | 68..1630 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu01309![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001324220.1 , NM_001330663.2 , NM_002130.7 , NM_001098272.3 , NM_001330663.1 , NM_001324219.2 , NM_001364188.2 , NM_001324219.1 , NM_001364188.1 , NM_001098272.2 , NM_002130.8 , NM_001324220.2 | |
Accession Version | NM_001324220.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1563bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-28 | |
Organism | Homo sapiens(human) | |
Product | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BJ995153.1, AK315593.1 and AC114947.2. On Jun 1, 2019 this sequence version replaced NM_001324220.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.163703.1, SRR1660803.231163.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001311149.1 |
CDS | 147..1709 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu39317 | |
Clone ID Related Accession (Same CDS sequence) | NM_001324222.2 , NM_001324224.1 , NM_001324222.1 , NM_001324223.2 , NM_001324224.2 , NM_001324223.1 | |
Accession Version | NM_001324222.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-27 | |
Organism | Homo sapiens(human) | |
Product | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK315593.1 and AC114947.2. On Jun 1, 2019 this sequence version replaced NM_001324222.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.84804.1, SRR1803613.16109.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001311151.1 |
CDS | 127..1563 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu39317 | |
Clone ID Related Accession (Same CDS sequence) | NM_001324222.2 , NM_001324224.1 , NM_001324222.1 , NM_001324223.2 , NM_001324224.2 , NM_001324223.1 | |
Accession Version | NM_001324224.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-24 | |
Organism | Homo sapiens(human) | |
Product | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB074885.1, BJ995153.1, AK315593.1 and AC114947.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.92218.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001311153.1 |
CDS | 247..1683 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu39317 | |
Clone ID Related Accession (Same CDS sequence) | NM_001324222.2 , NM_001324224.1 , NM_001324222.1 , NM_001324223.2 , NM_001324224.2 , NM_001324223.1 | |
Accession Version | NM_001324222.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-24 | |
Organism | Homo sapiens(human) | |
Product | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB074885.1, AK315593.1 and AC114947.2. On Apr 28, 2016 this sequence version replaced XM_011514035.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.84804.1, SRR1803613.16109.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001311151.1 |
CDS | 227..1663 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu39317 | |
Clone ID Related Accession (Same CDS sequence) | NM_001324222.2 , NM_001324224.1 , NM_001324222.1 , NM_001324223.2 , NM_001324224.2 , NM_001324223.1 | |
Accession Version | NM_001324223.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-27 | |
Organism | Homo sapiens(human) | |
Product | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB074885.1, AK315593.1 and AC114947.2. On May 31, 2019 this sequence version replaced NM_001324223.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.272420.1, SRR1660803.103675.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267761 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001311152.1 |
CDS | 68..1504 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu39317 | |
Clone ID Related Accession (Same CDS sequence) | NM_001324222.2 , NM_001324224.1 , NM_001324222.1 , NM_001324223.2 , NM_001324224.2 , NM_001324223.1 | |
Accession Version | NM_001324224.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-27 | |
Organism | Homo sapiens(human) | |
Product | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BJ995153.1, AK315593.1 and AC114947.2. On May 31, 2019 this sequence version replaced NM_001324224.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.92218.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001311153.1 |
CDS | 147..1583 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu39317 | |
Clone ID Related Accession (Same CDS sequence) | NM_001324222.2 , NM_001324224.1 , NM_001324222.1 , NM_001324223.2 , NM_001324224.2 , NM_001324223.1 | |
Accession Version | NM_001324223.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-24 | |
Organism | Homo sapiens(human) | |
Product | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB074885.1, AK315593.1 and AC114947.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.284767.1, SRR1803617.187120.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267761 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001311152.1 |
CDS | 168..1604 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCTGGAT CACTTCCTTT GAATGCAGAA GCTTGCTGGC CAAAAGATGT GGGAATTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu58268 | |
Clone ID Related Accession (Same CDS sequence) | XM_011514036.3 , XM_024446038.1 , XM_011514036.2 | |
Accession Version | XM_011514036.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011514036.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCAACATG CCTATGATTT TTACAAGCCT GATATGCTAT CTGAATATCC TATAGTAGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011512338.1 |
CDS | 1587..2558 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCAACATG CCTATGATTT TTACAAGCCT GATATGCTAT CTGAATATCC TATAGTAGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu58268 | |
Clone ID Related Accession (Same CDS sequence) | XM_011514036.3 , XM_024446038.1 , XM_011514036.2 | |
Accession Version | XM_024446038.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCAACATG CCTATGATTT TTACAAGCCT GATATGCTAT CTGAATATCC TATAGTAGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_024301806.1 |
CDS | 1636..2607 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCAACATG CCTATGATTT TTACAAGCCT GATATGCTAT CTGAATATCC TATAGTAGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu58268 | |
Clone ID Related Accession (Same CDS sequence) | XM_011514036.3 , XM_024446038.1 , XM_011514036.2 | |
Accession Version | XM_011514036.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011514036.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCAACATG CCTATGATTT TTACAAGCCT GATATGCTAT CTGAATATCC TATAGTAGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011512338.1 |
CDS | 624..1595 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCAACATG CCTATGATTT TTACAAGCCT GATATGCTAT CTGAATATCC TATAGTAGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
HMG-CoA synthase 1 is a synthetic lethal partner of BRAF |
Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design. |
Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. |
Transcriptional regulation of HMG-CoA synthase and HMG-CoA reductase genes by human ACBP. |