HSPA1B cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | HSPA1B |
| Entrez Gene ID | 3304 |
| Full Name | heat shock protein family A (Hsp70) member 1B |
| Synonyms | HSP70-1B,HSP70-2,HSP70.2 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_005346.4 | NP_005337.2 | heat shock 70 kDa protein 1B |
| NM_005346.5 | NP_005337.2 | heat shock 70 kDa protein 1B |
| Homo sapiens (human) | HSPA1B | NP_005337.2 |
| Bos taurus (cattle) | HSPA1A | NP_976067.2 |
| Mus musculus (house mouse) | Hspa1a | NP_034609.2 |
| Rattus norvegicus (Norway rat) | Hspa1a | NP_114177.2 |
| Drosophila melanogaster (fruit fly) | Hsp70Bbb | NP_788663.1 |
| Arabidopsis thaliana (thale cress) | AT5G02490 | NP_195869.1 |
| HSPA1B | XP_001115060.2 | |
| Danio rerio (zebrafish) | hsc70 | NP_956908.1 |
| Drosophila melanogaster (fruit fly) | Hsc70-2 | NP_524339.1 |
| Saccharomyces cerevisiae (baker's yeast) | SSA4 | NP_011029.3 |
| Saccharomyces cerevisiae (baker's yeast) | SSA3 | NP_009478.1 |
| Xenopus tropicalis (tropical clawed frog) | hspa1l | NP_001072429.1 |
| Homo sapiens (human) | HSPA1A | NP_005336.3 |
| Drosophila melanogaster (fruit fly) | Hsp70Ba | NP_731716.1 |
| Drosophila melanogaster (fruit fly) | Hsp70Bc | NP_650209.1 |
| Kluyveromyces lactis | KLLA0E20527g | XP_454878.1 |
| Pan troglodytes (chimpanzee) | HSPA1A | XP_003311223.1 |
| Canis lupus familiaris (dog) | LOC102155697 | XP_005627221.1 |
| Rattus norvegicus (Norway rat) | Hspa1b | NP_997669.1 |
| Drosophila melanogaster (fruit fly) | Hsp70Ab | NP_524798.2 |
| Drosophila melanogaster (fruit fly) | Hsp68 | NP_524474.1 |
| Drosophila melanogaster (fruit fly) | Hsp70Aa | NP_731651.1 |
| Drosophila melanogaster (fruit fly) | Hsp70Bb | NP_524927.2 |
| Eremothecium gossypii | AGOS_AER187W | NP_985044.2 |
| Xenopus tropicalis (tropical clawed frog) | LOC100485441 | XP_002937685.1 |
| Xenopus tropicalis (tropical clawed frog) | hsp70 | NP_001106370.1 |
Related articles in PubMed
Downregulation of Heat Shock Protein 70 Impairs Osteogenic and Chondrogenic Differentiation in Human Mesenchymal Stem Cells.
Li C, Sunderic K, Nicoll SB, Wang S
Scientific reports8(1)553(2018 Jan)
Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
Sokolina K, Kittanakom S, Snider J, Kotlyar M, Maurice P, Gand?a J, Benleulmi-Chaachoua A, Tadagaki K, Oishi A, Wong V, Malty RH, Deineko V, Aoki H, Amin S, Yao Z, Morat? X, Otasek D, Kobayashi H, Menendez J, Auerbach D, Angers S, Pr?ulj N, Bouvier M, Babu M, Ciruela F, Jockers R, Jurisica I, Stagljar I
Molecular systems biology13(3)918(2017 03)
[The GG genotype of the HSPA1B gene is associated with increased risk of glaucoma in northern ].
Salehi Z, Gholaminia M, Gholaminia Z, Panjtanpanah M, Qazvini MG
Molekuliarnaia biologiia51(1)31-36(2017 Jan-Feb)
Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study.
Li Y, Yu S, Gu G, Chen G, Zheng Y, Jiao J, Zhou W, Wu H, Zhang Z, Zhang H, He L, Yang Q, Xu X
PloS one12(2)e0171722(2017)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The rs2763979 locus of the HSP70 genes may be associated with susceptibility to noise-induced hearing loss (NIHL) in Chinese individuals, and other HSP70 genes may also be susceptibility genes for NIHL, but the results must be further replicated in additional independent sample sets.
Title: Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study.
The 1267HSP70-2 polymorphism is associated with obesity in an ian population, supporting a possible potential genetic link between obesity and cardiovascular diseases.
Title: Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity.
Heat shock protein 70-2 (HSP70-2) expression was detected in 78 % of colorectal cancer (CRC) patients.
Title: Heat shock protein 70-2 (HSP70-2) is a novel therapeutic target for colorectal cancer and is associated with tumor growth.
HSPA1B was down-regulated in atrial fibrillation subjects who suffered a stroke.
Title: Hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis without increased bleeding risk.
Polymorphism of HSP70 A1B gene is associated with the development of esophageal Carcinoma.
Title: Polymorphisms in Heat Shock Proteins A1B and A1L (HOM) as Risk Factors for Oesophageal Carcinoma in Northeast India.
The following HSPA1B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HSPA1B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu26976 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_005346.4 , NM_005346.5 | |
| Accession Version | NM_005346.4 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1926bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-10-29 | |
| Organism | Homo sapiens(human) | |
| Product | heat shock 70 kDa protein 1B | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB015158.1, BC063507.1 and AL671762.10. On Feb 8, 2008 this sequence version replaced NM_005346.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC063507.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGCCAAAG CCGCGGCGAT CGGCATCGAC CTGGGCACCA CCTACTCCTG CGTGGGGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_005337.2 |
| CDS | 217..2142 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_005346.4 |
ORF Insert Sequence:
1 | ATGGCCAAAG CCGCGGCGAT CGGCATCGAC CTGGGCACCA CCTACTCCTG CGTGGGGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu26976 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_005346.4 , NM_005346.5 | |
| Accession Version | NM_005346.5 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1926bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-05-20 | |
| Organism | Homo sapiens(human) | |
| Product | heat shock 70 kDa protein 1B | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB015158.1, BC063507.1 and AL671762.10. On Nov 22, 2018 this sequence version replaced NM_005346.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC063507.1, SRR7346977.1152369.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGGCCAAAG CCGCGGCGAT CGGCATCGAC CTGGGCACCA CCTACTCCTG CGTGGGGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_005337.2 |
| CDS | 214..2139 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_005346.5 |
ORF Insert Sequence:
1 | ATGGCCAAAG CCGCGGCGAT CGGCATCGAC CTGGGCACCA CCTACTCCTG CGTGGGGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Downregulation of Heat Shock Protein 70 Impairs Osteogenic and Chondrogenic Differentiation in Human Mesenchymal Stem Cells. |
|
Systematic protein-protein interaction mapping for clinically relevant human GPCRs. |
|
[The GG genotype of the HSPA1B gene is associated with increased risk of glaucoma in northern Iran]. |
|
Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study. |