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IL5 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol IL5
Entrez Gene ID 3567
Full Name interleukin 5
Synonyms EDF,IL-5,TRF
General protein information
Preferred Names

interleukin 5

Names

interleukin-5
B-cell differentiation factor I
T-cell replacing factor
colony-stimulating factor, eosinophil
eosinophil differentiation factor
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

5

5q31.1
Summary This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013].
Disorder MIM:

147850


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_011543373.2 XP_011541675.1 interleukin-5 isoform X2
XM_011543373.1 XP_011541675.1 interleukin-5 isoform X1
NM_000879.2 NP_000870.1 interleukin-5 precursor
XM_011543373.3 XP_011541675.1 interleukin-5 isoform X2
XM_005271988.3 XP_005272045.1 interleukin-5 isoform X1
NM_000879.3 NP_000870.1 interleukin-5 precursor
XM_005271988.4 XP_005272045.1 interleukin-5 isoform X1
XM_011543374.2 XP_011541676.1 interleukin-5 isoform X2
XM_011543374.1 XP_011541676.1 interleukin-5 isoform X1
XM_011543374.3 XP_011541676.1 interleukin-5 isoform X2

Pathways from BioSystems


Homologies


Homo sapiens (human) IL5 NP_000870.1
Mus musculus (house mouse) Il5 NP_034688.1
Rattus norvegicus (Norway rat) Il5 NP_068606.1
Canis lupus familiaris (dog) IL5 NP_001006951.1
Pan troglodytes (chimpanzee) IL5 XP_001163452.1
IL5 NP_001040598.1
Bos taurus (cattle) IL5 NP_776347.1

Gene Ontology


Bibliography

Related articles in PubMed

Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and?GM-CSF.
Quail DF, Olson OC, Bhardwaj P, Walsh LA, Akkari L, Quick ML, Chen IC, Wendel N, Ben-Chetrit N, Walker J, Holt PR, Dannenberg AJ, Joyce JA
Nature cell biology19(8)974-987(2017 Aug)

Longitudinal co-variations between inflammatory cytokines, lung function and patient reported outcomes in patients with asthma.
Lodin K, Lekander M, Syk J, Alving K, Petrovic P, Andreasson A
PloS one12(9)e0185019(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Obesity alters the lung neutrophil infiltration to enhance breast cancer metastasis through IL5 and GM-CSF.
Title: Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and?GM-CSF.

Longitudinal co-variations between inflammatory cytokines, lung function and patient reported outcomes in patients with asthma
Title: Longitudinal co-variations between inflammatory cytokines, lung function and patient reported outcomes in patients with asthma.

Serum IL-5 and IL-13 are reliable biomarkers for the blood eosinophilia asthma phenotype.
Title: Serum IL-5 and IL-13 consistently serve as the best predictors for the blood eosinophilia phenotype in adult asthmatics.

Interleukin-5/-targeted treatments offer promises to patients with eosinophilic respiratory disorders; review
Title: Interleukin-5 pathway inhibition in the treatment of eosinophilic respiratory disorders: evidence and unmet needs.

simvastatin was demonstrated to inhibit IL-5-induced CCR3 expression and chemotaxis of eosinophils mediated via the mevalonate pathway.
Title: Simvastatin Inhibits IL-5-Induced Chemotaxis and CCR3 Expression of HL-60-Derived and Human Primary Eosinophils.

The following IL5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu26848 NM_000879.3
Latest version!		 Homo sapiens interleukin 5 (IL5), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu26848 XM_011543373.3
Latest version!		 Homo sapiens interleukin 5 (IL5), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu26848 XM_011543374.3
Latest version!		 Homo sapiens interleukin 5 (IL5), transcript variant X3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu39562 XM_005271988.4
Latest version!		 Homo sapiens interleukin 5 (IL5), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
View Old Accession Versions >>
OHu26848 XM_011543373.1 Homo sapiens interleukin 5 (IL5), transcript variant X3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu26848 XM_011543373.2 Homo sapiens interleukin 5 (IL5), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu26848 NM_000879.2 Homo sapiens interleukin 5 (IL5), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu39562 XM_005271988.3 Homo sapiens interleukin 5 (IL5), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu26848 XM_011543374.1 Homo sapiens interleukin 5 (IL5), transcript variant X4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu26848 XM_011543374.2 Homo sapiens interleukin 5 (IL5), transcript variant X3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu26848
Clone ID Related Accession (Same CDS sequence) XM_011543373.2 , XM_011543373.1 , NM_000879.2 , XM_011543373.3 , NM_000879.3 , XM_011543374.2 , XM_011543374.1 , XM_011543374.3
Accession Version NM_000879.2 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 405bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-12-26
Organism Homo sapiens(human)
Product interleukin-5 precursor
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X04688.1. This sequence is a reference standard in the RefSeqGene project. On Feb 25, 2003 this sequence version replaced NM_000879.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X04688.1, X12705.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length. 

1
61
121
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ATGAGGATGC TTCTGCATTT GAGTTTGCTA GCTCTTGGAG CTGCCTACGT GTATGCCATC 
CCCACAGAAA TTCCCACAAG TGCATTGGTG AAAGAGACCT TGGCACTGCT TTCTACTCAT 
CGAACTCTGC TGATAGCCAA TGAGACTCTG AGGATTCCTG TTCCTGTACA TAAAAATCAC 
CAACTGTGCA CTGAAGAAAT CTTTCAGGGA ATAGGCACAC TGGAGAGTCA AACTGTGCAA 
GGGGGTACTG TGGAAAGACT ATTCAAAAAC TTGTCCTTAA TAAAGAAATA CATTGACGGC 
CAAAAAAAAA AGTGTGGAGA AGAAAGACGG AGAGTAAACC AATTCCTAGA CTACCTGCAA 
GAGTTTCTTG GTGTAATGAA CACCGAGTGG ATAATAGAAA GTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000870.1
CDS45..449
Translation

Target ORF information:

RefSeq Version NM_000879.2
Organism Homo sapiens(human)
Definition Homo sapiens interleukin 5 (IL5), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_000879.2

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGAGGATGC TTCTGCATTT GAGTTTGCTA GCTCTTGGAG CTGCCTACGT GTATGCCATC 
CCCACAGAAA TTCCCACAAG TGCATTGGTG AAAGAGACCT TGGCACTGCT TTCTACTCAT 
CGAACTCTGC TGATAGCCAA TGAGACTCTG AGGATTCCTG TTCCTGTACA TAAAAATCAC 
CAACTGTGCA CTGAAGAAAT CTTTCAGGGA ATAGGCACAC TGGAGAGTCA AACTGTGCAA 
GGGGGTACTG TGGAAAGACT ATTCAAAAAC TTGTCCTTAA TAAAGAAATA CATTGACGGC 
CAAAAAAAAA AGTGTGGAGA AGAAAGACGG AGAGTAAACC AATTCCTAGA CTACCTGCAA 
GAGTTTCTTG GTGTAATGAA CACCGAGTGG ATAATAGAAA GTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26848
Clone ID Related Accession (Same CDS sequence) XM_011543373.2 , XM_011543373.1 , NM_000879.2 , XM_011543373.3 , NM_000879.3 , XM_011543374.2 , XM_011543374.1 , XM_011543374.3
Accession Version NM_000879.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 405bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2020-01-01
Organism Homo sapiens(human)
Product interleukin-5 precursor
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC116366.2. This sequence is a reference standard in the RefSeqGene project. On Nov 25, 2018 this sequence version replaced NM_000879.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X04688.1, X12705.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000231454.6/ ENSP00000231454.1 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
ATGAGGATGC TTCTGCATTT GAGTTTGCTA GCTCTTGGAG CTGCCTACGT GTATGCCATC 
CCCACAGAAA TTCCCACAAG TGCATTGGTG AAAGAGACCT TGGCACTGCT TTCTACTCAT 
CGAACTCTGC TGATAGCCAA TGAGACTCTG AGGATTCCTG TTCCTGTACA TAAAAATCAC 
CAACTGTGCA CTGAAGAAAT CTTTCAGGGA ATAGGCACAC TGGAGAGTCA AACTGTGCAA 
GGGGGTACTG TGGAAAGACT ATTCAAAAAC TTGTCCTTAA TAAAGAAATA CATTGACGGC 
CAAAAAAAAA AGTGTGGAGA AGAAAGACGG AGAGTAAACC AATTCCTAGA CTACCTGCAA 
GAGTTTCTTG GTGTAATGAA CACCGAGTGG ATAATAGAAA GTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000870.1
CDS45..449
Translation

Target ORF information:

RefSeq Version NM_000879.3
Organism Homo sapiens(human)
Definition Homo sapiens interleukin 5 (IL5), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_000879.3

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGAGGATGC TTCTGCATTT GAGTTTGCTA GCTCTTGGAG CTGCCTACGT GTATGCCATC 
CCCACAGAAA TTCCCACAAG TGCATTGGTG AAAGAGACCT TGGCACTGCT TTCTACTCAT 
CGAACTCTGC TGATAGCCAA TGAGACTCTG AGGATTCCTG TTCCTGTACA TAAAAATCAC 
CAACTGTGCA CTGAAGAAAT CTTTCAGGGA ATAGGCACAC TGGAGAGTCA AACTGTGCAA 
GGGGGTACTG TGGAAAGACT ATTCAAAAAC TTGTCCTTAA TAAAGAAATA CATTGACGGC 
CAAAAAAAAA AGTGTGGAGA AGAAAGACGG AGAGTAAACC AATTCCTAGA CTACCTGCAA 
GAGTTTCTTG GTGTAATGAA CACCGAGTGG ATAATAGAAA GTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26848
Clone ID Related Accession (Same CDS sequence) XM_011543373.2 , XM_011543373.1 , NM_000879.2 , XM_011543373.3 , NM_000879.3 , XM_011543374.2 , XM_011543374.1 , XM_011543374.3
Accession Version XM_011543373.2 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 405bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-05
Organism Homo sapiens(human)
Product interleukin-5 isoform X2
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011543373.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
ATGAGGATGC TTCTGCATTT GAGTTTGCTA GCTCTTGGAG CTGCCTACGT GTATGCCATC 
CCCACAGAAA TTCCCACAAG TGCATTGGTG AAAGAGACCT TGGCACTGCT TTCTACTCAT 
CGAACTCTGC TGATAGCCAA TGAGACTCTG AGGATTCCTG TTCCTGTACA TAAAAATCAC 
CAACTGTGCA CTGAAGAAAT CTTTCAGGGA ATAGGCACAC TGGAGAGTCA AACTGTGCAA 
GGGGGTACTG TGGAAAGACT ATTCAAAAAC TTGTCCTTAA TAAAGAAATA CATTGACGGC 
CAAAAAAAAA AGTGTGGAGA AGAAAGACGG AGAGTAAACC AATTCCTAGA CTACCTGCAA 
GAGTTTCTTG GTGTAATGAA CACCGAGTGG ATAATAGAAA GTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011541675.1
CDS281..685
Translation

Target ORF information:

RefSeq Version XM_011543373.2
Organism Homo sapiens(human)
Definition Homo sapiens interleukin 5 (IL5), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_011543373.2

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGAGGATGC TTCTGCATTT GAGTTTGCTA GCTCTTGGAG CTGCCTACGT GTATGCCATC 
CCCACAGAAA TTCCCACAAG TGCATTGGTG AAAGAGACCT TGGCACTGCT TTCTACTCAT 
CGAACTCTGC TGATAGCCAA TGAGACTCTG AGGATTCCTG TTCCTGTACA TAAAAATCAC 
CAACTGTGCA CTGAAGAAAT CTTTCAGGGA ATAGGCACAC TGGAGAGTCA AACTGTGCAA 
GGGGGTACTG TGGAAAGACT ATTCAAAAAC TTGTCCTTAA TAAAGAAATA CATTGACGGC 
CAAAAAAAAA AGTGTGGAGA AGAAAGACGG AGAGTAAACC AATTCCTAGA CTACCTGCAA 
GAGTTTCTTG GTGTAATGAA CACCGAGTGG ATAATAGAAA GTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26848
Clone ID Related Accession (Same CDS sequence) XM_011543373.2 , XM_011543373.1 , NM_000879.2 , XM_011543373.3 , NM_000879.3 , XM_011543374.2 , XM_011543374.1 , XM_011543374.3
Accession Version XM_011543373.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 405bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2015-03-11
Organism Homo sapiens(Human)
Product interleukin-5 isoform X1
Comment 

1
61
121
181
241
301
361
ATGAGGATGC TTCTGCATTT GAGTTTGCTA GCTCTTGGAG CTGCCTACGT GTATGCCATC 
CCCACAGAAA TTCCCACAAG TGCATTGGTG AAAGAGACCT TGGCACTGCT TTCTACTCAT 
CGAACTCTGC TGATAGCCAA TGAGACTCTG AGGATTCCTG TTCCTGTACA TAAAAATCAC 
CAACTGTGCA CTGAAGAAAT CTTTCAGGGA ATAGGCACAC TGGAGAGTCA AACTGTGCAA 
GGGGGTACTG TGGAAAGACT ATTCAAAAAC TTGTCCTTAA TAAAGAAATA CATTGACGGC 
CAAAAAAAAA AGTGTGGAGA AGAAAGACGG AGAGTAAACC AATTCCTAGA CTACCTGCAA 
GAGTTTCTTG GTGTAATGAA CACCGAGTGG ATAATAGAAA GTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011541675.1
Translation

Target ORF information:

RefSeq Version XM_011543373.1
Organism Homo sapiens(Human)
Definition Homo sapiens interleukin 5 (IL5), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_011543373.1

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGAGGATGC TTCTGCATTT GAGTTTGCTA GCTCTTGGAG CTGCCTACGT GTATGCCATC 
CCCACAGAAA TTCCCACAAG TGCATTGGTG AAAGAGACCT TGGCACTGCT TTCTACTCAT 
CGAACTCTGC TGATAGCCAA TGAGACTCTG AGGATTCCTG TTCCTGTACA TAAAAATCAC 
CAACTGTGCA CTGAAGAAAT CTTTCAGGGA ATAGGCACAC TGGAGAGTCA AACTGTGCAA 
GGGGGTACTG TGGAAAGACT ATTCAAAAAC TTGTCCTTAA TAAAGAAATA CATTGACGGC 
CAAAAAAAAA AGTGTGGAGA AGAAAGACGG AGAGTAAACC AATTCCTAGA CTACCTGCAA 
GAGTTTCTTG GTGTAATGAA CACCGAGTGG ATAATAGAAA GTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26848
Clone ID Related Accession (Same CDS sequence) XM_011543373.2 , XM_011543373.1 , NM_000879.2 , XM_011543373.3 , NM_000879.3 , XM_011543374.2 , XM_011543374.1 , XM_011543374.3
Accession Version XM_011543373.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 405bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product interleukin-5 isoform X2
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011543373.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
ATGAGGATGC TTCTGCATTT GAGTTTGCTA GCTCTTGGAG CTGCCTACGT GTATGCCATC 
CCCACAGAAA TTCCCACAAG TGCATTGGTG AAAGAGACCT TGGCACTGCT TTCTACTCAT 
CGAACTCTGC TGATAGCCAA TGAGACTCTG AGGATTCCTG TTCCTGTACA TAAAAATCAC 
CAACTGTGCA CTGAAGAAAT CTTTCAGGGA ATAGGCACAC TGGAGAGTCA AACTGTGCAA 
GGGGGTACTG TGGAAAGACT ATTCAAAAAC TTGTCCTTAA TAAAGAAATA CATTGACGGC 
CAAAAAAAAA AGTGTGGAGA AGAAAGACGG AGAGTAAACC AATTCCTAGA CTACCTGCAA 
GAGTTTCTTG GTGTAATGAA CACCGAGTGG ATAATAGAAA GTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011541675.1
CDS318..722
Translation

Target ORF information:

RefSeq Version XM_011543373.3
Organism Homo sapiens(human)
Definition Homo sapiens interleukin 5 (IL5), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_011543373.3

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGAGGATGC TTCTGCATTT GAGTTTGCTA GCTCTTGGAG CTGCCTACGT GTATGCCATC 
CCCACAGAAA TTCCCACAAG TGCATTGGTG AAAGAGACCT TGGCACTGCT TTCTACTCAT 
CGAACTCTGC TGATAGCCAA TGAGACTCTG AGGATTCCTG TTCCTGTACA TAAAAATCAC 
CAACTGTGCA CTGAAGAAAT CTTTCAGGGA ATAGGCACAC TGGAGAGTCA AACTGTGCAA 
GGGGGTACTG TGGAAAGACT ATTCAAAAAC TTGTCCTTAA TAAAGAAATA CATTGACGGC 
CAAAAAAAAA AGTGTGGAGA AGAAAGACGG AGAGTAAACC AATTCCTAGA CTACCTGCAA 
GAGTTTCTTG GTGTAATGAA CACCGAGTGG ATAATAGAAA GTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26848
Clone ID Related Accession (Same CDS sequence) XM_011543373.2 , XM_011543373.1 , NM_000879.2 , XM_011543373.3 , NM_000879.3 , XM_011543374.2 , XM_011543374.1 , XM_011543374.3
Accession Version XM_011543374.2 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 405bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-05
Organism Homo sapiens(human)
Product interleukin-5 isoform X2
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011543374.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
ATGAGGATGC TTCTGCATTT GAGTTTGCTA GCTCTTGGAG CTGCCTACGT GTATGCCATC 
CCCACAGAAA TTCCCACAAG TGCATTGGTG AAAGAGACCT TGGCACTGCT TTCTACTCAT 
CGAACTCTGC TGATAGCCAA TGAGACTCTG AGGATTCCTG TTCCTGTACA TAAAAATCAC 
CAACTGTGCA CTGAAGAAAT CTTTCAGGGA ATAGGCACAC TGGAGAGTCA AACTGTGCAA 
GGGGGTACTG TGGAAAGACT ATTCAAAAAC TTGTCCTTAA TAAAGAAATA CATTGACGGC 
CAAAAAAAAA AGTGTGGAGA AGAAAGACGG AGAGTAAACC AATTCCTAGA CTACCTGCAA 
GAGTTTCTTG GTGTAATGAA CACCGAGTGG ATAATAGAAA GTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011541676.1
CDS232..636
Translation

Target ORF information:

RefSeq Version XM_011543374.2
Organism Homo sapiens(human)
Definition Homo sapiens interleukin 5 (IL5), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_011543374.2

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGAGGATGC TTCTGCATTT GAGTTTGCTA GCTCTTGGAG CTGCCTACGT GTATGCCATC 
CCCACAGAAA TTCCCACAAG TGCATTGGTG AAAGAGACCT TGGCACTGCT TTCTACTCAT 
CGAACTCTGC TGATAGCCAA TGAGACTCTG AGGATTCCTG TTCCTGTACA TAAAAATCAC 
CAACTGTGCA CTGAAGAAAT CTTTCAGGGA ATAGGCACAC TGGAGAGTCA AACTGTGCAA 
GGGGGTACTG TGGAAAGACT ATTCAAAAAC TTGTCCTTAA TAAAGAAATA CATTGACGGC 
CAAAAAAAAA AGTGTGGAGA AGAAAGACGG AGAGTAAACC AATTCCTAGA CTACCTGCAA 
GAGTTTCTTG GTGTAATGAA CACCGAGTGG ATAATAGAAA GTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26848
Clone ID Related Accession (Same CDS sequence) XM_011543373.2 , XM_011543373.1 , NM_000879.2 , XM_011543373.3 , NM_000879.3 , XM_011543374.2 , XM_011543374.1 , XM_011543374.3
Accession Version XM_011543374.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 405bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2015-03-11
Organism Homo sapiens(Human)
Product interleukin-5 isoform X1
Comment 

1
61
121
181
241
301
361
ATGAGGATGC TTCTGCATTT GAGTTTGCTA GCTCTTGGAG CTGCCTACGT GTATGCCATC 
CCCACAGAAA TTCCCACAAG TGCATTGGTG AAAGAGACCT TGGCACTGCT TTCTACTCAT 
CGAACTCTGC TGATAGCCAA TGAGACTCTG AGGATTCCTG TTCCTGTACA TAAAAATCAC 
CAACTGTGCA CTGAAGAAAT CTTTCAGGGA ATAGGCACAC TGGAGAGTCA AACTGTGCAA 
GGGGGTACTG TGGAAAGACT ATTCAAAAAC TTGTCCTTAA TAAAGAAATA CATTGACGGC 
CAAAAAAAAA AGTGTGGAGA AGAAAGACGG AGAGTAAACC AATTCCTAGA CTACCTGCAA 
GAGTTTCTTG GTGTAATGAA CACCGAGTGG ATAATAGAAA GTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011541676.1
Translation

Target ORF information:

RefSeq Version XM_011543374.1
Organism Homo sapiens(Human)
Definition Homo sapiens interleukin 5 (IL5), transcript variant X4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_011543374.1

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGAGGATGC TTCTGCATTT GAGTTTGCTA GCTCTTGGAG CTGCCTACGT GTATGCCATC 
CCCACAGAAA TTCCCACAAG TGCATTGGTG AAAGAGACCT TGGCACTGCT TTCTACTCAT 
CGAACTCTGC TGATAGCCAA TGAGACTCTG AGGATTCCTG TTCCTGTACA TAAAAATCAC 
CAACTGTGCA CTGAAGAAAT CTTTCAGGGA ATAGGCACAC TGGAGAGTCA AACTGTGCAA 
GGGGGTACTG TGGAAAGACT ATTCAAAAAC TTGTCCTTAA TAAAGAAATA CATTGACGGC 
CAAAAAAAAA AGTGTGGAGA AGAAAGACGG AGAGTAAACC AATTCCTAGA CTACCTGCAA 
GAGTTTCTTG GTGTAATGAA CACCGAGTGG ATAATAGAAA GTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26848
Clone ID Related Accession (Same CDS sequence) XM_011543373.2 , XM_011543373.1 , NM_000879.2 , XM_011543373.3 , NM_000879.3 , XM_011543374.2 , XM_011543374.1 , XM_011543374.3
Accession Version XM_011543374.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 405bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product interleukin-5 isoform X2
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011543374.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
ATGAGGATGC TTCTGCATTT GAGTTTGCTA GCTCTTGGAG CTGCCTACGT GTATGCCATC 
CCCACAGAAA TTCCCACAAG TGCATTGGTG AAAGAGACCT TGGCACTGCT TTCTACTCAT 
CGAACTCTGC TGATAGCCAA TGAGACTCTG AGGATTCCTG TTCCTGTACA TAAAAATCAC 
CAACTGTGCA CTGAAGAAAT CTTTCAGGGA ATAGGCACAC TGGAGAGTCA AACTGTGCAA 
GGGGGTACTG TGGAAAGACT ATTCAAAAAC TTGTCCTTAA TAAAGAAATA CATTGACGGC 
CAAAAAAAAA AGTGTGGAGA AGAAAGACGG AGAGTAAACC AATTCCTAGA CTACCTGCAA 
GAGTTTCTTG GTGTAATGAA CACCGAGTGG ATAATAGAAA GTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011541676.1
CDS269..673
Translation

Target ORF information:

RefSeq Version XM_011543374.3
Organism Homo sapiens(human)
Definition Homo sapiens interleukin 5 (IL5), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_011543374.3

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGAGGATGC TTCTGCATTT GAGTTTGCTA GCTCTTGGAG CTGCCTACGT GTATGCCATC 
CCCACAGAAA TTCCCACAAG TGCATTGGTG AAAGAGACCT TGGCACTGCT TTCTACTCAT 
CGAACTCTGC TGATAGCCAA TGAGACTCTG AGGATTCCTG TTCCTGTACA TAAAAATCAC 
CAACTGTGCA CTGAAGAAAT CTTTCAGGGA ATAGGCACAC TGGAGAGTCA AACTGTGCAA 
GGGGGTACTG TGGAAAGACT ATTCAAAAAC TTGTCCTTAA TAAAGAAATA CATTGACGGC 
CAAAAAAAAA AGTGTGGAGA AGAAAGACGG AGAGTAAACC AATTCCTAGA CTACCTGCAA 
GAGTTTCTTG GTGTAATGAA CACCGAGTGG ATAATAGAAA GTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu39562
Clone ID Related Accession (Same CDS sequence) XM_005271988.3 , XM_005271988.4
Accession Version XM_005271988.3 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 471bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-05
Organism Homo sapiens(human)
Product interleukin-5 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005271988.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
ATGGGGGTAG TGGTGGGGTG GATTGGAGAC CCAGGAAGCG GGGCAAACGC AGAACGTTTC 
AGAGCCATGA GGATGCTTCT GCATTTGAGT TTGCTAGCTC TTGGAGCTGC CTACGTGTAT 
GCCATCCCCA CAGAAATTCC CACAAGTGCA TTGGTGAAAG AGACCTTGGC ACTGCTTTCT 
ACTCATCGAA CTCTGCTGAT AGCCAATGAG ACTCTGAGGA TTCCTGTTCC TGTACATAAA 
AATCACCAAC TGTGCACTGA AGAAATCTTT CAGGGAATAG GCACACTGGA GAGTCAAACT 
GTGCAAGGGG GTACTGTGGA AAGACTATTC AAAAACTTGT CCTTAATAAA GAAATACATT 
GACGGCCAAA AAAAAAAGTG TGGAGAAGAA AGACGGAGAG TAAACCAATT CCTAGACTAC 
CTGCAAGAGT TTCTTGGTGT AATGAACACC GAGTGGATAA TAGAAAGTTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005272045.1
CDS113..583
Translation

Target ORF information:

RefSeq Version XM_005271988.3
Organism Homo sapiens(human)
Definition Homo sapiens interleukin 5 (IL5), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_005271988.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGGGGTAG TGGTGGGGTG GATTGGAGAC CCAGGAAGCG GGGCAAACGC AGAACGTTTC 
AGAGCCATGA GGATGCTTCT GCATTTGAGT TTGCTAGCTC TTGGAGCTGC CTACGTGTAT 
GCCATCCCCA CAGAAATTCC CACAAGTGCA TTGGTGAAAG AGACCTTGGC ACTGCTTTCT 
ACTCATCGAA CTCTGCTGAT AGCCAATGAG ACTCTGAGGA TTCCTGTTCC TGTACATAAA 
AATCACCAAC TGTGCACTGA AGAAATCTTT CAGGGAATAG GCACACTGGA GAGTCAAACT 
GTGCAAGGGG GTACTGTGGA AAGACTATTC AAAAACTTGT CCTTAATAAA GAAATACATT 
GACGGCCAAA AAAAAAAGTG TGGAGAAGAA AGACGGAGAG TAAACCAATT CCTAGACTAC 
CTGCAAGAGT TTCTTGGTGT AATGAACACC GAGTGGATAA TAGAAAGTTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu39562
Clone ID Related Accession (Same CDS sequence) XM_005271988.3 , XM_005271988.4
Accession Version XM_005271988.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 471bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product interleukin-5 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005271988.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
ATGGGGGTAG TGGTGGGGTG GATTGGAGAC CCAGGAAGCG GGGCAAACGC AGAACGTTTC 
AGAGCCATGA GGATGCTTCT GCATTTGAGT TTGCTAGCTC TTGGAGCTGC CTACGTGTAT 
GCCATCCCCA CAGAAATTCC CACAAGTGCA TTGGTGAAAG AGACCTTGGC ACTGCTTTCT 
ACTCATCGAA CTCTGCTGAT AGCCAATGAG ACTCTGAGGA TTCCTGTTCC TGTACATAAA 
AATCACCAAC TGTGCACTGA AGAAATCTTT CAGGGAATAG GCACACTGGA GAGTCAAACT 
GTGCAAGGGG GTACTGTGGA AAGACTATTC AAAAACTTGT CCTTAATAAA GAAATACATT 
GACGGCCAAA AAAAAAAGTG TGGAGAAGAA AGACGGAGAG TAAACCAATT CCTAGACTAC 
CTGCAAGAGT TTCTTGGTGT AATGAACACC GAGTGGATAA TAGAAAGTTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005272045.1
CDS150..620
Translation

Target ORF information:

RefSeq Version XM_005271988.4
Organism Homo sapiens(human)
Definition Homo sapiens interleukin 5 (IL5), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_005271988.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGGGGTAG TGGTGGGGTG GATTGGAGAC CCAGGAAGCG GGGCAAACGC AGAACGTTTC 
AGAGCCATGA GGATGCTTCT GCATTTGAGT TTGCTAGCTC TTGGAGCTGC CTACGTGTAT 
GCCATCCCCA CAGAAATTCC CACAAGTGCA TTGGTGAAAG AGACCTTGGC ACTGCTTTCT 
ACTCATCGAA CTCTGCTGAT AGCCAATGAG ACTCTGAGGA TTCCTGTTCC TGTACATAAA 
AATCACCAAC TGTGCACTGA AGAAATCTTT CAGGGAATAG GCACACTGGA GAGTCAAACT 
GTGCAAGGGG GTACTGTGGA AAGACTATTC AAAAACTTGT CCTTAATAAA GAAATACATT 
GACGGCCAAA AAAAAAAGTG TGGAGAAGAA AGACGGAGAG TAAACCAATT CCTAGACTAC 
CTGCAAGAGT TTCTTGGTGT AATGAACACC GAGTGGATAA TAGAAAGTTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and?GM-CSF.
Nature cell biology19(8)974-987(2017 Aug)
Quail DF,Olson OC,Bhardwaj P,Walsh LA,Akkari L,Quick ML,Chen IC,Wendel N,Ben-Chetrit N,Walker J,Holt PR,Dannenberg AJ,Joyce JA


book

Longitudinal co-variations between inflammatory cytokines, lung function and patient reported outcomes in patients with asthma.
PloS one12(9)e0185019(2017)
Lodin K,Lekander M,Syk J,Alving K,Petrovic P,Andreasson A