TNFSF12-TNFSF13 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TNFSF12-TNFSF13
Entrez Gene ID	407977
Full Name	TNFSF12-TNFSF13 readthrough
Synonyms	TWE-PRIL
General protein information	Preferred Names TNFSF12-TNFSF13 readthrough Names TNFSF12-TNFSF13 protein tumor necrosis factor (ligand) superfamily, member 12-member 13
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p13.1
Summary	This gene encodes a member of the tumor necrosis factor superfamily. It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of family member 12 fused to the C-terminal domain of family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of family member 13 at the cell surface. It stimulates cycling in T- and B-lymphoma cell lines. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_172089.3	NP_742086.1	TNFSF12-TNFSF13 protein
NM_172089.4	NP_742086.1	TNFSF12-TNFSF13 protein

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	tnfsf13	NP_001161936.1
	LOC715750	XP_001109101.1
Mus musculus (house mouse)	Tnfsf12Tnfsf13	NP_001029269.1
Homo sapiens (human)	TNFSF12-TNFSF13	NP_742086.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome-wide association study identifies TNFSF13 as a susceptibility gene for IgA in a South Chinese population in smokers.
Yang C, Jie W, Yanlong Y, Xuefeng G, Aihua T, Yong G, Zheng L, Youjie Z, Haiying Z, Xue Q, Min Q, Linjian M, Xiaobo Y, Yanling H, Zengnan M
Immunogenetics64(10)747-53(2012 Oct)

Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese.
Osman W, Okada Y, Kamatani Y, Kubo M, Matsuda K, Nakamura Y
PloS one7(4)e32683(2012)

Genome-wide scan identifies variant in TNFSF13 associated with serum IgM in a healthy Chinese male population.
Yang M, Wu Y, Lu Y, Liu C, Sun J, Liao M, Qin M, Mo L, Gao Y, Lu Z, Wu C, Zhang Y, Zhang H, Qin X, Hu Y, Zhang S, Li J, Dong M, Zheng SL, Xu J, Yang X, Tan A, Mo Z
PloS one7(10)e47990(2012)

A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy.
Yu XQ, Li M, Zhang H, Low HQ, Wei X, Wang JQ, Sun LD, Sim KS, Li Y, Foo JN, Wang W, Li ZJ, Yin XY, Tang XQ, Fan L, Chen J, Li RS, Wan JX, Liu ZS, Lou TQ, Zhu L, Huang XJ, Zhang XJ, Liu ZH, Liu JJ
Nature genetics44(2)178-82(2011 Dec)

Expression of conjoined genes: another mechanism for gene regulation in eukaryotes.
Prakash T, Sharma VK, Adati N, Ozawa R, Kumar N, Nishida Y, Fujikake T, Takeda T, Taylor TD
PloS one5(10)e13284(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

The following TNFSF12-TNFSF13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TNFSF12-TNFSF13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27811	NM_172089.4 Latest version!	Homo sapiens TNFSF12-TNFSF13 readthrough (TNFSF12-TNFSF13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu27811	NM_172089.3	Homo sapiens TNFSF12-TNFSF13 readthrough (TNFSF12-TNFSF13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TNFSF12-TNFSF13 ( NM_172089.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_742086.1 Homo sapiens TNFSF12-TNFSF13 readthrough (TNFSF12-TNFSF13), mRNA.

Price & Availability↑

CloneID	OHu27811
Clone ID Related Accession (Same CDS sequence)	NM_172089.3 , NM_172089.4
Accession Version	NM_172089.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	TNFSF12-TNFSF13 protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC016876.10, AY081051.1 and BQ016244.1. On Oct 29, 2010 this sequence version replaced NM_172089.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY081051.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## readthrough transcript :: includes exons from GeneID 8741, 8742 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCCC GTCGGAGCCA GAGGCGGAGG GGGCGCCGGG GGGAGCCGGG CACCGCCCTG 
CTGGTCCCGC TCGCGCTGGG CCTGGGCCTG GCGCTGGCCT GCCTCGGCCT CCTGCTGGCC 
GTGGTCAGTT TGGGGAGCCG GGCATCGCTG TCCGCCCAGG AGCCTGCCCA GGAGGAGCTG 
GTGGCAGAGG AGGACCAGGA CCCGTCGGAA CTGAATCCCC AGACAGAAGA AAGCCAGGAT 
CCTGCGCCTT TCCTGAACCG ACTAGTTCGG CCTCGCAGAA GTGCACCTAA AGGCCGGAAA 
ACACGGGCTC GAAGAGCGAT CGCAGCCCAT TATGAAGTTC ATCCACGACC TGGACAGGAC 
GGAGCGCAGG CAGGTGTGGA CGGGACAGTG AGTGGCTGGG AGGAAGCCAG AATCAACAGC 
TCCAGCCCTC TGCGCTACAA CCGCCAGATC GGGGAGTTTA TAGTCACCCG GGCTGGGCTC 
TACTACCTGT ACTGTCAGAG TTCCGATGCC CTGGAAGCCT GGGAGAATGG GGAGAGATCC 
CGGAAAAGGA GAGCAGTGCT CACCCAAAAA CAGAAGAAGC AGCACTCTGT CCTGCACCTG 
GTTCCCATTA ACGCCACCTC CAAGGATGAC TCCGATGTGA CAGAGGTGAT GTGGCAACCA 
GCTCTTAGGC GTGGGAGAGG CCTACAGGCC CAAGGATATG GTGTCCGAAT CCAGGATGCT 
GGAGTTTATC TGCTGTATAG CCAGGTCCTG TTTCAAGACG TGACTTTCAC CATGGGTCAG 
GTGGTGTCTC GAGAAGGCCA AGGAAGGCAG GAGACTCTAT TCCGATGTAT AAGAAGTATG 
CCCTCCCACC CGGACCGGGC CTACAACAGC TGCTATAGCG CAGGTGTCTT CCATTTACAC 
CAAGGGGATA TTCTGAGTGT CATAATTCCC CGGGCAAGGG CGAAACTTAA CCTCTCTCCA 
CATGGAACCT TCCTGGGGTT TGTGAAACTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_742086.1
CDS	97..1089
Translation	MAARRSQRRRGRRGEPGTALLVPLALGLGLALACLGLLLAVVSLGSRASLSAQEPAQEELVAEEDQDPSELNPQTEESQDPAPFLNRLVRPRRSAPKGRKTRARRAIAAHYEVHPRPGQDGAQAGVDGTVSGWEEARINSSSPLRYNRQIGEFIVTRAGLYYLYCQSSDALEAWENGERSRKRRAVLTQKQKKQHSVLHLVPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGTFLGFVKL

Target ORF information:

RefSeq Version	NM_172089.3
Organism	Homo sapiens(human)
Definition	Homo sapiens TNFSF12-TNFSF13 readthrough (TNFSF12-TNFSF13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172089.3

ORF Insert Sequence:

ATGGCCGCCC GTCGGAGCCA GAGGCGGAGG GGGCGCCGGG GGGAGCCGGG CACCGCCCTG 
CTGGTCCCGC TCGCGCTGGG CCTGGGCCTG GCGCTGGCCT GCCTCGGCCT CCTGCTGGCC 
GTGGTCAGTT TGGGGAGCCG GGCATCGCTG TCCGCCCAGG AGCCTGCCCA GGAGGAGCTG 
GTGGCAGAGG AGGACCAGGA CCCGTCGGAA CTGAATCCCC AGACAGAAGA AAGCCAGGAT 
CCTGCGCCTT TCCTGAACCG ACTAGTTCGG CCTCGCAGAA GTGCACCTAA AGGCCGGAAA 
ACACGGGCTC GAAGAGCGAT CGCAGCCCAT TATGAAGTTC ATCCACGACC TGGACAGGAC 
GGAGCGCAGG CAGGTGTGGA CGGGACAGTG AGTGGCTGGG AGGAAGCCAG AATCAACAGC 
TCCAGCCCTC TGCGCTACAA CCGCCAGATC GGGGAGTTTA TAGTCACCCG GGCTGGGCTC 
TACTACCTGT ACTGTCAGAG TTCCGATGCC CTGGAAGCCT GGGAGAATGG GGAGAGATCC 
CGGAAAAGGA GAGCAGTGCT CACCCAAAAA CAGAAGAAGC AGCACTCTGT CCTGCACCTG 
GTTCCCATTA ACGCCACCTC CAAGGATGAC TCCGATGTGA CAGAGGTGAT GTGGCAACCA 
GCTCTTAGGC GTGGGAGAGG CCTACAGGCC CAAGGATATG GTGTCCGAAT CCAGGATGCT 
GGAGTTTATC TGCTGTATAG CCAGGTCCTG TTTCAAGACG TGACTTTCAC CATGGGTCAG 
GTGGTGTCTC GAGAAGGCCA AGGAAGGCAG GAGACTCTAT TCCGATGTAT AAGAAGTATG 
CCCTCCCACC CGGACCGGGC CTACAACAGC TGCTATAGCG CAGGTGTCTT CCATTTACAC 
CAAGGGGATA TTCTGAGTGT CATAATTCCC CGGGCAAGGG CGAAACTTAA CCTCTCTCCA 
CATGGAACCT TCCTGGGGTT TGTGAAACTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TNFSF12-TNFSF13 ( NM_172089.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_742086.1 Homo sapiens TNFSF12-TNFSF13 readthrough (TNFSF12-TNFSF13), mRNA.

Price & Availability↑

CloneID	OHu27811
Clone ID Related Accession (Same CDS sequence)	NM_172089.3 , NM_172089.4
Accession Version	NM_172089.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-01
Organism	Homo sapiens(human)
Product	TNFSF12-TNFSF13 protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC016876.10 and AY081051.1. On Jun 2, 2019 this sequence version replaced NM_172089.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY081051.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## readthrough transcript :: includes exons from GeneID 8741, 8742 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCCC GTCGGAGCCA GAGGCGGAGG GGGCGCCGGG GGGAGCCGGG CACCGCCCTG 
CTGGTCCCGC TCGCGCTGGG CCTGGGCCTG GCGCTGGCCT GCCTCGGCCT CCTGCTGGCC 
GTGGTCAGTT TGGGGAGCCG GGCATCGCTG TCCGCCCAGG AGCCTGCCCA GGAGGAGCTG 
GTGGCAGAGG AGGACCAGGA CCCGTCGGAA CTGAATCCCC AGACAGAAGA AAGCCAGGAT 
CCTGCGCCTT TCCTGAACCG ACTAGTTCGG CCTCGCAGAA GTGCACCTAA AGGCCGGAAA 
ACACGGGCTC GAAGAGCGAT CGCAGCCCAT TATGAAGTTC ATCCACGACC TGGACAGGAC 
GGAGCGCAGG CAGGTGTGGA CGGGACAGTG AGTGGCTGGG AGGAAGCCAG AATCAACAGC 
TCCAGCCCTC TGCGCTACAA CCGCCAGATC GGGGAGTTTA TAGTCACCCG GGCTGGGCTC 
TACTACCTGT ACTGTCAGAG TTCCGATGCC CTGGAAGCCT GGGAGAATGG GGAGAGATCC 
CGGAAAAGGA GAGCAGTGCT CACCCAAAAA CAGAAGAAGC AGCACTCTGT CCTGCACCTG 
GTTCCCATTA ACGCCACCTC CAAGGATGAC TCCGATGTGA CAGAGGTGAT GTGGCAACCA 
GCTCTTAGGC GTGGGAGAGG CCTACAGGCC CAAGGATATG GTGTCCGAAT CCAGGATGCT 
GGAGTTTATC TGCTGTATAG CCAGGTCCTG TTTCAAGACG TGACTTTCAC CATGGGTCAG 
GTGGTGTCTC GAGAAGGCCA AGGAAGGCAG GAGACTCTAT TCCGATGTAT AAGAAGTATG 
CCCTCCCACC CGGACCGGGC CTACAACAGC TGCTATAGCG CAGGTGTCTT CCATTTACAC 
CAAGGGGATA TTCTGAGTGT CATAATTCCC CGGGCAAGGG CGAAACTTAA CCTCTCTCCA 
CATGGAACCT TCCTGGGGTT TGTGAAACTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_742086.1
CDS	97..1089
Translation	MAARRSQRRRGRRGEPGTALLVPLALGLGLALACLGLLLAVVSLGSRASLSAQEPAQEELVAEEDQDPSELNPQTEESQDPAPFLNRLVRPRRSAPKGRKTRARRAIAAHYEVHPRPGQDGAQAGVDGTVSGWEEARINSSSPLRYNRQIGEFIVTRAGLYYLYCQSSDALEAWENGERSRKRRAVLTQKQKKQHSVLHLVPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGTFLGFVKL

Target ORF information:

RefSeq Version	NM_172089.4
Organism	Homo sapiens(human)
Definition	Homo sapiens TNFSF12-TNFSF13 readthrough (TNFSF12-TNFSF13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172089.4

ORF Insert Sequence:

ATGGCCGCCC GTCGGAGCCA GAGGCGGAGG GGGCGCCGGG GGGAGCCGGG CACCGCCCTG 
CTGGTCCCGC TCGCGCTGGG CCTGGGCCTG GCGCTGGCCT GCCTCGGCCT CCTGCTGGCC 
GTGGTCAGTT TGGGGAGCCG GGCATCGCTG TCCGCCCAGG AGCCTGCCCA GGAGGAGCTG 
GTGGCAGAGG AGGACCAGGA CCCGTCGGAA CTGAATCCCC AGACAGAAGA AAGCCAGGAT 
CCTGCGCCTT TCCTGAACCG ACTAGTTCGG CCTCGCAGAA GTGCACCTAA AGGCCGGAAA 
ACACGGGCTC GAAGAGCGAT CGCAGCCCAT TATGAAGTTC ATCCACGACC TGGACAGGAC 
GGAGCGCAGG CAGGTGTGGA CGGGACAGTG AGTGGCTGGG AGGAAGCCAG AATCAACAGC 
TCCAGCCCTC TGCGCTACAA CCGCCAGATC GGGGAGTTTA TAGTCACCCG GGCTGGGCTC 
TACTACCTGT ACTGTCAGAG TTCCGATGCC CTGGAAGCCT GGGAGAATGG GGAGAGATCC 
CGGAAAAGGA GAGCAGTGCT CACCCAAAAA CAGAAGAAGC AGCACTCTGT CCTGCACCTG 
GTTCCCATTA ACGCCACCTC CAAGGATGAC TCCGATGTGA CAGAGGTGAT GTGGCAACCA 
GCTCTTAGGC GTGGGAGAGG CCTACAGGCC CAAGGATATG GTGTCCGAAT CCAGGATGCT 
GGAGTTTATC TGCTGTATAG CCAGGTCCTG TTTCAAGACG TGACTTTCAC CATGGGTCAG 
GTGGTGTCTC GAGAAGGCCA AGGAAGGCAG GAGACTCTAT TCCGATGTAT AAGAAGTATG 
CCCTCCCACC CGGACCGGGC CTACAACAGC TGCTATAGCG CAGGTGTCTT CCATTTACAC 
CAAGGGGATA TTCTGAGTGT CATAATTCCC CGGGCAAGGG CGAAACTTAA CCTCTCTCCA 
CATGGAACCT TCCTGGGGTT TGTGAAACTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-wide association study identifies TNFSF13 as a susceptibility gene for IgA in a South Chinese population in smokers.
Immunogenetics64(10)747-53(2012 Oct)
Yang C,Jie W,Yanlong Y,Xuefeng G,Aihua T,Yong G,Zheng L,Youjie Z,Haiying Z,Xue Q,Min Q,Linjian M,Xiaobo Y,Yanling H,Zengnan M

Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese.
PloS one7(4)e32683(2012)
Osman W,Okada Y,Kamatani Y,Kubo M,Matsuda K,Nakamura Y

Genome-wide scan identifies variant in TNFSF13 associated with serum IgM in a healthy Chinese male population.
PloS one7(10)e47990(2012)
Yang M,Wu Y,Lu Y,Liu C,Sun J,Liao M,Qin M,Mo L,Gao Y,Lu Z,Wu C,Zhang Y,Zhang H,Qin X,Hu Y,Zhang S,Li J,Dong M,Zheng SL,Xu J,Yang X,Tan A,Mo Z

A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy.
Nature genetics44(2)178-82(2011 Dec)
Yu XQ,Li M,Zhang H,Low HQ,Wei X,Wang JQ,Sun LD,Sim KS,Li Y,Foo JN,Wang W,Li ZJ,Yin XY,Tang XQ,Fan L,Chen J,Li RS,Wan JX,Liu ZS,Lou TQ,Zhu L,Huang XJ,Zhang XJ,Liu ZH,Liu JJ

Expression of conjoined genes: another mechanism for gene regulation in eukaryotes.
PloS one5(10)e13284(2010 Oct)
Prakash T,Sharma VK,Adati N,Ozawa R,Kumar N,Nishida Y,Fujikake T,Takeda T,Taylor TD

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TNFSF12-TNFSF13 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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