MYBPH cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Gene Symbol	MYBPH
Entrez Gene ID	4608
Full Name	myosin binding protein H
General protein information	Preferred Names myosin binding protein H Names myosin-binding protein H H-protein myBP-H
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q32.1
Disorder MIM:	160795

mRNA and Protein(s)

mRNA Protein Name

XM_005245196.3 XP_005245253.1 myosin-binding protein H isoform X1

NM_004997.3 NP_004988.2 myosin-binding protein H

NM_004997.2 NP_004988.2 myosin-binding protein H
Pathways from BioSystems

mRNA	Protein	Name
XM_005245196.3	XP_005245253.1	myosin-binding protein H isoform X1
NM_004997.3	NP_004988.2	myosin-binding protein H
NM_004997.2	NP_004988.2	myosin-binding protein H

Homologies

Homo sapiens (human)	MYBPH	NP_004988.2
Canis lupus familiaris (dog)	MYBPH	XP_005622215.1
Mus musculus (house mouse)	Mybph	NP_058029.2
Rattus norvegicus (Norway rat)	Mybph	NP_114001.1
	MYBPH	XP_001103823.1
Pan troglodytes (chimpanzee)	MYBPH	XP_514110.2
Gallus gallus (chicken)	MYBPH	NP_001026199.1
Xenopus tropicalis (tropical clawed frog)	mybph	NP_001039258.1
Bos taurus (cattle)	MYBPH	NP_001068903.1
Danio rerio (zebrafish)	mybpha	NP_956852.1
Danio rerio (zebrafish)	mybphb	NP_001093607.1

Gene Ontology
Bibliography

Related articles in PubMed

MYBPH acts as modifier of cardiac hypertrophy in hypertrophic cardiomyopathy (HCM) patients.
Mouton JM, van der Merwe L, Goosen A, Revera M, Brink PA, Moolman-Smook JC, Kinnear C
Human genetics135(5)477-83(2016 May)

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
Goldstein JI, Jarskog LF, Hilliard C, Alfirevic A, Duncan L, Fourches D, Huang H, Lek M, Neale BM, Ripke S, Shianna K, Szatkiewicz JP, Tropsha A, van den Oord EJ, Cascorbi I, Dettling M, Gazit E, Goff DC, Holden AL, Kelly DL, Malhotra AK, Nielsen J, Pirmohamed M, Rujescu D, Werge T, Levy DL, Josiassen RC, Kennedy JL, Lieberman JA, Daly MJ, Sullivan PF
Nature communications54757(2014 Sep)

Increased expression of Myosin binding protein H in the skeletal muscle of amyotrophic lateral sclerosis patients.
Conti A, Riva N, Pesca M, Iannaccone S, Cannistraci CV, Corbo M, Previtali SC, Quattrini A, Alessio M
Biochimica et biophysica acta1842(1)99-106(2014 Jan)

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
Blandin G, Marchand S, Charton K, Dani?le N, Gicquel E, Boucheteil JB, Bentaib A, Barrault L, Stockholm D, Bartoli M, Richard I
Skeletal muscle3(1)3(2013 Feb)

MYBPH inhibits NM IIA assembly via direct interaction with NMHC IIA and reduces cell motility.
Hosono Y, Usukura J, Yamaguchi T, Yanagisawa K, Suzuki M, Takahashi T
Biochemical and biophysical research communications428(1)173-8(2012 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

variation in MYBPH can modulate the severity of hypertrophy in hypertrophic cardiomyopathy patients.
Title: MYBPH acts as modifier of cardiac hypertrophy in hypertrophic cardiomyopathy (HCM) patients.

MyBP-H expression signals the onset of dysregulation in actin-myosin interaction; this in turn might contribute to the pathogenesis of amyotrophic lateral sclerosis.
Title: Increased expression of Myosin binding protein H in the skeletal muscle of amyotrophic lateral sclerosis patients.

These results suggest that MYBPH inhibits RLC and NMHC IIA, independent components of NM IIA, and negatively regulates actomyosin organization at 2 distinct steps, resulting in firm inhibition of NM IIA assembly.
Title: MYBPH inhibits NM IIA assembly via direct interaction with NMHC IIA and reduces cell motility.

MYBPH inhibited assembly competence-conferring phosphorylation of the myosin regulatory light chain (RLC) as well as activating phosphorylation of LIM domain kinase, unexpectedly through its direct physical interaction with Rho kinase 1
Title: MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis.

Observational study of gene-disease association. (HuGE Navigator)
Title: Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.

The following MYBPH gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MYBPH cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14091	NM_004997.3 Latest version!	Homo sapiens myosin binding protein H (MYBPH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu14091	XM_005245196.3 Latest version!	Homo sapiens myosin binding protein H (MYBPH), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu14091	NM_004997.2	Homo sapiens myosin binding protein H (MYBPH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MYBPH ( NM_004997.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004988.2 Homo sapiens myosin binding protein H (MYBPH), mRNA.

Price & Availability↑

CloneID	OHu14091
Clone ID Related Accession (Same CDS sequence)	XM_005245196.3 , NM_004997.3 , NM_004997.2
Accession Version	NM_004997.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1434bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	myosin-binding protein H
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC105940.2, BC044226.1 and L05606.1. On Nov 22, 2018 this sequence version replaced NM_004997.2. ##Evidence-Data-START## Transcript exon combination :: BC044226.1, ERR279855.2663.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000255416.9/ ENSP00000255416.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATGGAAA AAAACACCTC CGAGGGCCCT GCCTGCAGTC CAGAGGAGAC CGCATCTGAA 
TCTGCCAAGG TGCCCACAGC AGAGCCTCCC GGAGAAGTGG CAGTATCAGA GTCCACCAGA 
GAAGAGCAGG TGCCCAAGCC GCAGGCCCCT GCCCCACAGG CCCCTACAGC CTCCACAGCC 
ACTAAGCCTG CACCCCCAAG TGAAGATGTC CCCAGTGCCC CACTGCTGCT GACCCTGGAT 
GATGTGAGCA GCAGCTCTGT GACTGTGAGC TGGGAGCCCC CAGAGAGGCT GGGGAGGCTG 
GGCCTCCAGG GCTATGTGCT GGAGCTCTGC AGAGAGGGAG CCTCGGAGTG GGTGCCTGTG 
AGTGCCCGGC CCATGATGGT GACCCAGCAG ACTGTGCGGA ACCTGGCTCT GGGAGACAAG 
TTCCTCCTGC GCGTGTCTGC AGTGAGTTCT GCAGGGGCTG GCCCGCCGGC CATGCTGGAC 
CAGCCCATCC ACATCCGAGA GAACATTGAG GCCCCCAAGA TCCGTGTCCC CCGCCACCTC 
CGTCAGACCT ACATCCGCCA GGTGGGAGAG ACGGTCAACC TGCAAATCCC CTTCCAGGGG 
AAGCCTAAGC CTCAGGCCAC ATGGACCCAC AACGGCCATG CCCTGGACAG CCAGCGGGTG 
AGCATGCGCA CCGGGGACCA GGACTCCATC CTCTTCATTC GCTCGGCCCA GCGCTCCGAC 
TCTGGCCGCT ACGAGCTCAC TGTGCGCGTG GAAGACCTGG AGGCCAAGGC AGTCATTGAC 
ATCCTGGTGA TTGAGAAACC TGGACCCCCC AGCAGCATCA GGCTCCTGGA CGTCTGGGGC 
TGCAATGCTG CTCTTCAGTG GACGCCACCC CAGGACACAG GCAACACAGA GCTCCTGGGC 
TACATGGTGC AGAAGGCAGA CAAAAAGACA GGGCAATGGT TCACAGTGCT GGAGCGCTAC 
CACCCAACCA CCTGCACCAT CTCTGACCTC ATCATCGGCA ACTCGTACTC CTTCCGGGTC 
TTCTCAGAAA ACCTGTGTGG ACTCAGCACC TCGGCCACCG TCACCAAGGA GCTCGCCCAC 
ATCCAGAAGG CAGATATTGC TGCCAAACCT AAAGGGTTTA TTGAGCGAGA CTTCTCAGAA 
GCCCCCTCAT TCACCCAGCC CCTGGCTGAC CACACCTCCA CCCCTGGCTA CAGCACCCAG 
TTGTTCTGCA GTGTCCGAGC TTCACCCAAG CCCAAGATCA TCTGGATGAA AAACAAGATG 
GAGATCCAGG GCAACCCCAA ATACCGCGCC CTCTCTGAGC AAGGCGTCTG CACCCTAGAG 
ATCCGGAAAC CCAGCCCCTT TGATTCTGGG GTCTACACCT GCAAGGCCAT AAATGTGCTG 
GGGGAGGCAT CTGTGGACTG CCGGCTGGAG GTCAAAGCCT CAGCCGCACA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004988.2
CDS	72..1505
Translation	MMEKNTSEGPACSPEETASESAKVPTAEPPGEVAVSESTREEQVPKPQAPAPQAPTASTATKPAPPSEDVPSAPLLLTLDDVSSSSVTVSWEPPERLGRLGLQGYVLELCREGASEWVPVSARPMMVTQQTVRNLALGDKFLLRVSAVSSAGAGPPAMLDQPIHIRENIEAPKIRVPRHLRQTYIRQVGETVNLQIPFQGKPKPQATWTHNGHALDSQRVSMRTGDQDSILFIRSAQRSDSGRYELTVRVEDLEAKAVIDILVIEKPGPPSSIRLLDVWGCNAALQWTPPQDTGNTELLGYMVQKADKKTGQWFTVLERYHPTTCTISDLIIGNSYSFRVFSENLCGLSTSATVTKELAHIQKADIAAKPKGFIERDFSEAPSFTQPLADHTSTPGYSTQLFCSVRASPKPKIIWMKNKMEIQGNPKYRALSEQGVCTLEIRKPSPFDSGVYTCKAINVLGEASVDCRLEVKASAAH

Target ORF information:

RefSeq Version	NM_004997.3
Organism	Homo sapiens(human)
Definition	Homo sapiens myosin binding protein H (MYBPH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004997.3

ORF Insert Sequence:

ATGATGGAAA AAAACACCTC CGAGGGCCCT GCCTGCAGTC CAGAGGAGAC CGCATCTGAA 
TCTGCCAAGG TGCCCACAGC AGAGCCTCCC GGAGAAGTGG CAGTATCAGA GTCCACCAGA 
GAAGAGCAGG TGCCCAAGCC GCAGGCCCCT GCCCCACAGG CCCCTACAGC CTCCACAGCC 
ACTAAGCCTG CACCCCCAAG TGAAGATGTC CCCAGTGCCC CACTGCTGCT GACCCTGGAT 
GATGTGAGCA GCAGCTCTGT GACTGTGAGC TGGGAGCCCC CAGAGAGGCT GGGGAGGCTG 
GGCCTCCAGG GCTATGTGCT GGAGCTCTGC AGAGAGGGAG CCTCGGAGTG GGTGCCTGTG 
AGTGCCCGGC CCATGATGGT GACCCAGCAG ACTGTGCGGA ACCTGGCTCT GGGAGACAAG 
TTCCTCCTGC GCGTGTCTGC AGTGAGTTCT GCAGGGGCTG GCCCGCCGGC CATGCTGGAC 
CAGCCCATCC ACATCCGAGA GAACATTGAG GCCCCCAAGA TCCGTGTCCC CCGCCACCTC 
CGTCAGACCT ACATCCGCCA GGTGGGAGAG ACGGTCAACC TGCAAATCCC CTTCCAGGGG 
AAGCCTAAGC CTCAGGCCAC ATGGACCCAC AACGGCCATG CCCTGGACAG CCAGCGGGTG 
AGCATGCGCA CCGGGGACCA GGACTCCATC CTCTTCATTC GCTCGGCCCA GCGCTCCGAC 
TCTGGCCGCT ACGAGCTCAC TGTGCGCGTG GAAGACCTGG AGGCCAAGGC AGTCATTGAC 
ATCCTGGTGA TTGAGAAACC TGGACCCCCC AGCAGCATCA GGCTCCTGGA CGTCTGGGGC 
TGCAATGCTG CTCTTCAGTG GACGCCACCC CAGGACACAG GCAACACAGA GCTCCTGGGC 
TACATGGTGC AGAAGGCAGA CAAAAAGACA GGGCAATGGT TCACAGTGCT GGAGCGCTAC 
CACCCAACCA CCTGCACCAT CTCTGACCTC ATCATCGGCA ACTCGTACTC CTTCCGGGTC 
TTCTCAGAAA ACCTGTGTGG ACTCAGCACC TCGGCCACCG TCACCAAGGA GCTCGCCCAC 
ATCCAGAAGG CAGATATTGC TGCCAAACCT AAAGGGTTTA TTGAGCGAGA CTTCTCAGAA 
GCCCCCTCAT TCACCCAGCC CCTGGCTGAC CACACCTCCA CCCCTGGCTA CAGCACCCAG 
TTGTTCTGCA GTGTCCGAGC TTCACCCAAG CCCAAGATCA TCTGGATGAA AAACAAGATG 
GAGATCCAGG GCAACCCCAA ATACCGCGCC CTCTCTGAGC AAGGCGTCTG CACCCTAGAG 
ATCCGGAAAC CCAGCCCCTT TGATTCTGGG GTCTACACCT GCAAGGCCAT AAATGTGCTG 
GGGGAGGCAT CTGTGGACTG CCGGCTGGAG GTCAAAGCCT CAGCCGCACA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MYBPH ( NM_004997.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004988.2 Homo sapiens myosin binding protein H (MYBPH), mRNA.

Price & Availability↑

CloneID	OHu14091
Clone ID Related Accession (Same CDS sequence)	XM_005245196.3 , NM_004997.3 , NM_004997.2
Accession Version	NM_004997.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1434bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	myosin-binding protein H
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC044226.1 and L05606.1. On Nov 22, 2004 this sequence version replaced NM_004997.1. ##Evidence-Data-START## Transcript exon combination :: BC044226.1, ERR279855.2663.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGGAAA AAAACACCTC CGAGGGCCCT GCCTGCAGTC CAGAGGAGAC CGCATCTGAA 
TCTGCCAAGG TGCCCACAGC AGAGCCTCCC GGAGAAGTGG CAGTATCAGA GTCCACCAGA 
GAAGAGCAGG TGCCCAAGCC GCAGGCCCCT GCCCCACAGG CCCCTACAGC CTCCACAGCC 
ACTAAGCCTG CACCCCCAAG TGAAGATGTC CCCAGTGCCC CACTGCTGCT GACCCTGGAT 
GATGTGAGCA GCAGCTCTGT GACTGTGAGC TGGGAGCCCC CAGAGAGGCT GGGGAGGCTG 
GGCCTCCAGG GCTATGTGCT GGAGCTCTGC AGAGAGGGAG CCTCGGAGTG GGTGCCTGTG 
AGTGCCCGGC CCATGATGGT GACCCAGCAG ACTGTGCGGA ACCTGGCTCT GGGAGACAAG 
TTCCTCCTGC GCGTGTCTGC AGTGAGTTCT GCAGGGGCTG GCCCGCCGGC CATGCTGGAC 
CAGCCCATCC ACATCCGAGA GAACATTGAG GCCCCCAAGA TCCGTGTCCC CCGCCACCTC 
CGTCAGACCT ACATCCGCCA GGTGGGAGAG ACGGTCAACC TGCAAATCCC CTTCCAGGGG 
AAGCCTAAGC CTCAGGCCAC ATGGACCCAC AACGGCCATG CCCTGGACAG CCAGCGGGTG 
AGCATGCGCA CCGGGGACCA GGACTCCATC CTCTTCATTC GCTCGGCCCA GCGCTCCGAC 
TCTGGCCGCT ACGAGCTCAC TGTGCGCGTG GAAGACCTGG AGGCCAAGGC AGTCATTGAC 
ATCCTGGTGA TTGAGAAACC TGGACCCCCC AGCAGCATCA GGCTCCTGGA CGTCTGGGGC 
TGCAATGCTG CTCTTCAGTG GACGCCACCC CAGGACACAG GCAACACAGA GCTCCTGGGC 
TACATGGTGC AGAAGGCAGA CAAAAAGACA GGGCAATGGT TCACAGTGCT GGAGCGCTAC 
CACCCAACCA CCTGCACCAT CTCTGACCTC ATCATCGGCA ACTCGTACTC CTTCCGGGTC 
TTCTCAGAAA ACCTGTGTGG ACTCAGCACC TCGGCCACCG TCACCAAGGA GCTCGCCCAC 
ATCCAGAAGG CAGATATTGC TGCCAAACCT AAAGGGTTTA TTGAGCGAGA CTTCTCAGAA 
GCCCCCTCAT TCACCCAGCC CCTGGCTGAC CACACCTCCA CCCCTGGCTA CAGCACCCAG 
TTGTTCTGCA GTGTCCGAGC TTCACCCAAG CCCAAGATCA TCTGGATGAA AAACAAGATG 
GAGATCCAGG GCAACCCCAA ATACCGCGCC CTCTCTGAGC AAGGCGTCTG CACCCTAGAG 
ATCCGGAAAC CCAGCCCCTT TGATTCTGGG GTCTACACCT GCAAGGCCAT AAATGTGCTG 
GGGGAGGCAT CTGTGGACTG CCGGCTGGAG GTCAAAGCCT CAGCCGCACA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004988.2
CDS	60..1493
Translation	MMEKNTSEGPACSPEETASESAKVPTAEPPGEVAVSESTREEQVPKPQAPAPQAPTASTATKPAPPSEDVPSAPLLLTLDDVSSSSVTVSWEPPERLGRLGLQGYVLELCREGASEWVPVSARPMMVTQQTVRNLALGDKFLLRVSAVSSAGAGPPAMLDQPIHIRENIEAPKIRVPRHLRQTYIRQVGETVNLQIPFQGKPKPQATWTHNGHALDSQRVSMRTGDQDSILFIRSAQRSDSGRYELTVRVEDLEAKAVIDILVIEKPGPPSSIRLLDVWGCNAALQWTPPQDTGNTELLGYMVQKADKKTGQWFTVLERYHPTTCTISDLIIGNSYSFRVFSENLCGLSTSATVTKELAHIQKADIAAKPKGFIERDFSEAPSFTQPLADHTSTPGYSTQLFCSVRASPKPKIIWMKNKMEIQGNPKYRALSEQGVCTLEIRKPSPFDSGVYTCKAINVLGEASVDCRLEVKASAAH

Target ORF information:

RefSeq Version	NM_004997.2
Organism	Homo sapiens(human)
Definition	Homo sapiens myosin binding protein H (MYBPH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004997.2

ORF Insert Sequence:

ATGATGGAAA AAAACACCTC CGAGGGCCCT GCCTGCAGTC CAGAGGAGAC CGCATCTGAA 
TCTGCCAAGG TGCCCACAGC AGAGCCTCCC GGAGAAGTGG CAGTATCAGA GTCCACCAGA 
GAAGAGCAGG TGCCCAAGCC GCAGGCCCCT GCCCCACAGG CCCCTACAGC CTCCACAGCC 
ACTAAGCCTG CACCCCCAAG TGAAGATGTC CCCAGTGCCC CACTGCTGCT GACCCTGGAT 
GATGTGAGCA GCAGCTCTGT GACTGTGAGC TGGGAGCCCC CAGAGAGGCT GGGGAGGCTG 
GGCCTCCAGG GCTATGTGCT GGAGCTCTGC AGAGAGGGAG CCTCGGAGTG GGTGCCTGTG 
AGTGCCCGGC CCATGATGGT GACCCAGCAG ACTGTGCGGA ACCTGGCTCT GGGAGACAAG 
TTCCTCCTGC GCGTGTCTGC AGTGAGTTCT GCAGGGGCTG GCCCGCCGGC CATGCTGGAC 
CAGCCCATCC ACATCCGAGA GAACATTGAG GCCCCCAAGA TCCGTGTCCC CCGCCACCTC 
CGTCAGACCT ACATCCGCCA GGTGGGAGAG ACGGTCAACC TGCAAATCCC CTTCCAGGGG 
AAGCCTAAGC CTCAGGCCAC ATGGACCCAC AACGGCCATG CCCTGGACAG CCAGCGGGTG 
AGCATGCGCA CCGGGGACCA GGACTCCATC CTCTTCATTC GCTCGGCCCA GCGCTCCGAC 
TCTGGCCGCT ACGAGCTCAC TGTGCGCGTG GAAGACCTGG AGGCCAAGGC AGTCATTGAC 
ATCCTGGTGA TTGAGAAACC TGGACCCCCC AGCAGCATCA GGCTCCTGGA CGTCTGGGGC 
TGCAATGCTG CTCTTCAGTG GACGCCACCC CAGGACACAG GCAACACAGA GCTCCTGGGC 
TACATGGTGC AGAAGGCAGA CAAAAAGACA GGGCAATGGT TCACAGTGCT GGAGCGCTAC 
CACCCAACCA CCTGCACCAT CTCTGACCTC ATCATCGGCA ACTCGTACTC CTTCCGGGTC 
TTCTCAGAAA ACCTGTGTGG ACTCAGCACC TCGGCCACCG TCACCAAGGA GCTCGCCCAC 
ATCCAGAAGG CAGATATTGC TGCCAAACCT AAAGGGTTTA TTGAGCGAGA CTTCTCAGAA 
GCCCCCTCAT TCACCCAGCC CCTGGCTGAC CACACCTCCA CCCCTGGCTA CAGCACCCAG 
TTGTTCTGCA GTGTCCGAGC TTCACCCAAG CCCAAGATCA TCTGGATGAA AAACAAGATG 
GAGATCCAGG GCAACCCCAA ATACCGCGCC CTCTCTGAGC AAGGCGTCTG CACCCTAGAG 
ATCCGGAAAC CCAGCCCCTT TGATTCTGGG GTCTACACCT GCAAGGCCAT AAATGTGCTG 
GGGGAGGCAT CTGTGGACTG CCGGCTGGAG GTCAAAGCCT CAGCCGCACA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MYBPH ( XM_005245196.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005245253.1 Homo sapiens myosin binding protein H (MYBPH), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu14091
Clone ID Related Accession (Same CDS sequence)	XM_005245196.3 , NM_004997.3 , NM_004997.2
Accession Version	XM_005245196.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1434bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	myosin-binding protein H isoform X1
Comment

ATGATGGAAA AAAACACCTC CGAGGGCCCT GCCTGCAGTC CAGAGGAGAC CGCATCTGAA 
TCTGCCAAGG TGCCCACAGC AGAGCCTCCC GGAGAAGTGG CAGTATCAGA GTCCACCAGA 
GAAGAGCAGG TGCCCAAGCC GCAGGCCCCT GCCCCACAGG CCCCTACAGC CTCCACAGCC 
ACTAAGCCTG CACCCCCAAG TGAAGATGTC CCCAGTGCCC CACTGCTGCT GACCCTGGAT 
GATGTGAGCA GCAGCTCTGT GACTGTGAGC TGGGAGCCCC CAGAGAGGCT GGGGAGGCTG 
GGCCTCCAGG GCTATGTGCT GGAGCTCTGC AGAGAGGGAG CCTCGGAGTG GGTGCCTGTG 
AGTGCCCGGC CCATGATGGT GACCCAGCAG ACTGTGCGGA ACCTGGCTCT GGGAGACAAG 
TTCCTCCTGC GCGTGTCTGC AGTGAGTTCT GCAGGGGCTG GCCCGCCGGC CATGCTGGAC 
CAGCCCATCC ACATCCGAGA GAACATTGAG GCCCCCAAGA TCCGTGTCCC CCGCCACCTC 
CGTCAGACCT ACATCCGCCA GGTGGGAGAG ACGGTCAACC TGCAAATCCC CTTCCAGGGG 
AAGCCTAAGC CTCAGGCCAC ATGGACCCAC AACGGCCATG CCCTGGACAG CCAGCGGGTG 
AGCATGCGCA CCGGGGACCA GGACTCCATC CTCTTCATTC GCTCGGCCCA GCGCTCCGAC 
TCTGGCCGCT ACGAGCTCAC TGTGCGCGTG GAAGACCTGG AGGCCAAGGC AGTCATTGAC 
ATCCTGGTGA TTGAGAAACC TGGACCCCCC AGCAGCATCA GGCTCCTGGA CGTCTGGGGC 
TGCAATGCTG CTCTTCAGTG GACGCCACCC CAGGACACAG GCAACACAGA GCTCCTGGGC 
TACATGGTGC AGAAGGCAGA CAAAAAGACA GGGCAATGGT TCACAGTGCT GGAGCGCTAC 
CACCCAACCA CCTGCACCAT CTCTGACCTC ATCATCGGCA ACTCGTACTC CTTCCGGGTC 
TTCTCAGAAA ACCTGTGTGG ACTCAGCACC TCGGCCACCG TCACCAAGGA GCTCGCCCAC 
ATCCAGAAGG CAGATATTGC TGCCAAACCT AAAGGGTTTA TTGAGCGAGA CTTCTCAGAA 
GCCCCCTCAT TCACCCAGCC CCTGGCTGAC CACACCTCCA CCCCTGGCTA CAGCACCCAG 
TTGTTCTGCA GTGTCCGAGC TTCACCCAAG CCCAAGATCA TCTGGATGAA AAACAAGATG 
GAGATCCAGG GCAACCCCAA ATACCGCGCC CTCTCTGAGC AAGGCGTCTG CACCCTAGAG 
ATCCGGAAAC CCAGCCCCTT TGATTCTGGG GTCTACACCT GCAAGGCCAT AAATGTGCTG 
GGGGAGGCAT CTGTGGACTG CCGGCTGGAG GTCAAAGCCT CAGCCGCACA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_005245253.1

Translation

MMEKNTSEGPACSPEETASESAKVPTAEPPGEVAVSESTREEQVPKPQAPAPQAPTASTATKPAPPSEDVPSAPLLLTLDDVSSSSVTVSWEPPERLGRLGLQGYVLELCREGASEWVPVSARPMMVTQQTVRNLALGDKFLLRVSAVSSAGAGPPAMLDQPIHIRENIEAPKIRVPRHLRQTYIRQVGETVNLQIPFQGKPKPQATWTHNGHALDSQRVSMRTGDQDSILFIRSAQRSDSGRYELTVRVEDLEAKAVIDILVIEKPGPPSSIRLLDVWGCNAALQWTPPQDTGNTELLGYMVQKADKKTGQWFTVLERYHPTTCTISDLIIGNSYSFRVFSENLCGLSTSATVTKELAHIQKADIAAKPKGFIERDFSEAPSFTQPLADHTSTPGYSTQLFCSVRASPKPKIIWMKNKMEIQGNPKYRALSEQGVCTLEIRKPSPFDSGVYTCKAINVLGEASVDCRLEVKASAAH

Target ORF information:

RefSeq Version	XM_005245196.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens myosin binding protein H (MYBPH), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005245196.3

ORF Insert Sequence:

ATGATGGAAA AAAACACCTC CGAGGGCCCT GCCTGCAGTC CAGAGGAGAC CGCATCTGAA 
TCTGCCAAGG TGCCCACAGC AGAGCCTCCC GGAGAAGTGG CAGTATCAGA GTCCACCAGA 
GAAGAGCAGG TGCCCAAGCC GCAGGCCCCT GCCCCACAGG CCCCTACAGC CTCCACAGCC 
ACTAAGCCTG CACCCCCAAG TGAAGATGTC CCCAGTGCCC CACTGCTGCT GACCCTGGAT 
GATGTGAGCA GCAGCTCTGT GACTGTGAGC TGGGAGCCCC CAGAGAGGCT GGGGAGGCTG 
GGCCTCCAGG GCTATGTGCT GGAGCTCTGC AGAGAGGGAG CCTCGGAGTG GGTGCCTGTG 
AGTGCCCGGC CCATGATGGT GACCCAGCAG ACTGTGCGGA ACCTGGCTCT GGGAGACAAG 
TTCCTCCTGC GCGTGTCTGC AGTGAGTTCT GCAGGGGCTG GCCCGCCGGC CATGCTGGAC 
CAGCCCATCC ACATCCGAGA GAACATTGAG GCCCCCAAGA TCCGTGTCCC CCGCCACCTC 
CGTCAGACCT ACATCCGCCA GGTGGGAGAG ACGGTCAACC TGCAAATCCC CTTCCAGGGG 
AAGCCTAAGC CTCAGGCCAC ATGGACCCAC AACGGCCATG CCCTGGACAG CCAGCGGGTG 
AGCATGCGCA CCGGGGACCA GGACTCCATC CTCTTCATTC GCTCGGCCCA GCGCTCCGAC 
TCTGGCCGCT ACGAGCTCAC TGTGCGCGTG GAAGACCTGG AGGCCAAGGC AGTCATTGAC 
ATCCTGGTGA TTGAGAAACC TGGACCCCCC AGCAGCATCA GGCTCCTGGA CGTCTGGGGC 
TGCAATGCTG CTCTTCAGTG GACGCCACCC CAGGACACAG GCAACACAGA GCTCCTGGGC 
TACATGGTGC AGAAGGCAGA CAAAAAGACA GGGCAATGGT TCACAGTGCT GGAGCGCTAC 
CACCCAACCA CCTGCACCAT CTCTGACCTC ATCATCGGCA ACTCGTACTC CTTCCGGGTC 
TTCTCAGAAA ACCTGTGTGG ACTCAGCACC TCGGCCACCG TCACCAAGGA GCTCGCCCAC 
ATCCAGAAGG CAGATATTGC TGCCAAACCT AAAGGGTTTA TTGAGCGAGA CTTCTCAGAA 
GCCCCCTCAT TCACCCAGCC CCTGGCTGAC CACACCTCCA CCCCTGGCTA CAGCACCCAG 
TTGTTCTGCA GTGTCCGAGC TTCACCCAAG CCCAAGATCA TCTGGATGAA AAACAAGATG 
GAGATCCAGG GCAACCCCAA ATACCGCGCC CTCTCTGAGC AAGGCGTCTG CACCCTAGAG 
ATCCGGAAAC CCAGCCCCTT TGATTCTGGG GTCTACACCT GCAAGGCCAT AAATGTGCTG 
GGGGAGGCAT CTGTGGACTG CCGGCTGGAG GTCAAAGCCT CAGCCGCACA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MYBPH acts as modifier of cardiac hypertrophy in hypertrophic cardiomyopathy (HCM) patients.
Human genetics135(5)477-83(2016 May)
Mouton JM,van der Merwe L,Goosen A,Revera M,Brink PA,Moolman-Smook JC,Kinnear C

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
Nature communications54757(2014 Sep)
Goldstein JI,Jarskog LF,Hilliard C,Alfirevic A,Duncan L,Fourches D,Huang H,Lek M,Neale BM,Ripke S,Shianna K,Szatkiewicz JP,Tropsha A,van den Oord EJ,Cascorbi I,Dettling M,Gazit E,Goff DC,Holden AL,Kelly DL,Malhotra AK,Nielsen J,Pirmohamed M,Rujescu D,Werge T,Levy DL,Josiassen RC,Kennedy JL,Lieberman JA,Daly MJ,Sullivan PF

Increased expression of Myosin binding protein H in the skeletal muscle of amyotrophic lateral sclerosis patients.
Biochimica et biophysica acta1842(1)99-106(2014 Jan)
Conti A,Riva N,Pesca M,Iannaccone S,Cannistraci CV,Corbo M,Previtali SC,Quattrini A,Alessio M

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
Skeletal muscle3(1)3(2013 Feb)
Blandin G,Marchand S,Charton K,Dani?le N,Gicquel E,Boucheteil JB,Bentaib A,Barrault L,Stockholm D,Bartoli M,Richard I

MYBPH inhibits NM IIA assembly via direct interaction with NMHC IIA and reduces cell motility.
Biochemical and biophysical research communications428(1)173-8(2012 Nov)
Hosono Y,Usukura J,Yamaguchi T,Yanagisawa K,Suzuki M,Takahashi T

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MYBPH cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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