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NDP cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol NDP
Entrez Gene ID 4693
Full Name NDP, norrin cystine knot growth factor
Synonyms EVR2,FEVR,ND
General protein information
Preferred Names

NDP, norrin cystine knot growth factor

Names

norrin
Norrie disease (pseudoglioma)
X-linked exudative vitreoretinopathy 2 protein
norrie disease protein
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

X

Xp11.3
Summary This gene encodes a secreted protein with a cystein-knot motif that activates the Wnt/beta-catenin pathway. The protein forms disulfide-linked oligomers in the extracellular matrix. Mutations in this gene result in Norrie disease and X-linked exudative vitreoretinopathy. [provided by RefSeq, Feb 2009].
Disorder MIM:

300658

Disorder Html: Norrie disease, 310600 (3); Exudative vitreoretinopathy 2, X-linked, 305390 (3)

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_000266.4 NP_000257.1 norrin precursor
NM_000266.3 NP_000257.1 norrin precursor

Pathways from BioSystems


Homologies


Pan troglodytes (chimpanzee) NDP XP_001139783.1
Bos taurus (cattle) NDP NP_001039555.1
NDP XP_002806251.1
Canis lupus familiaris (dog) NDP XP_855261.1
Gallus gallus (chicken) NDP NP_001265015.1
Danio rerio (zebrafish) LOC100003793 XP_001338820.2
Homo sapiens (human) NDP NP_000257.1
Mus musculus (house mouse) Ndp NP_035013.1
Xenopus tropicalis (tropical clawed frog) ndp XP_002932837.1

Gene Ontology


Bibliography

Related articles in PubMed

Next-generation sequencing reveals a novel NDP gene mutation in a Chinese family with Norrie disease.
Huang X, Tian M, Li J, Cui L, Li M, Zhang J
Indian journal of ophthalmology65(11)1161-1165(2017 Nov)

Mutation Spectrum of the LRP5, NDP, and TSPAN12 Genes in Chinese Patients With Familial Exudative Vitreoretinopathy.
Tang M, Sun L, Hu A, Yuan M, Yang Y, Peng X, Ding X
Investigative ophthalmology & visual science58(13)5949-5957(2017 Nov)

Mutations in LRP5,FZD4, TSPAN12, NDP, ZNF408, or KIF11 Genes Account for 38.7% of Chinese Patients With Familial Exudative Vitreoretinopathy.
Rao FQ, Cai XB, Cheng FF, Cheng W, Fang XL, Li N, Huang XF, Li LH, Jin ZB
Investigative ophthalmology & visual science58(5)2623-2629(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

c.314C>A mutation of NDP gene is a novel mutation and broadens the genetic spectrum of Norrie disease.
Title: Next-generation sequencing reveals a novel NDP gene mutation in a Chinese family with Norrie disease.

Probands with LRP5 or NDP mutations were mainly categorized into group III and IV, TSPAN12 mutations were mainly observed in probands with group IV and V FEVR.
Title: Mutation Spectrum of the LRP5, NDP, and TSPAN12 Genes in Chinese Patients With Familial Exudative Vitreoretinopathy.

Among the detected mutations, LRP5 accounted for the largest proportion with a mean mutation rate of 16.1% (5/31, 16.1%), followed by NDP (3/31, 9.7%), FZD4 (2/31, 6.5%), TSPAN12 (1/31, 3.2%), and KIF11 (1/31, 3.2%). All the novel changes were predicted to be pathogenic by a series of bioinformatics analyses.
Title: Mutations in LRP5,FZD4, TSPAN12, NDP, ZNF408, or KIF11 Genes Account for 38.7% of Chinese Patients With Familial Exudative Vitreoretinopathy.

The mutation c.310A>C (p.Lys104Gln) in exon 3 of NDP is associated with familial exudative vitreoretinopathy in the studied family
Title: A novel missense mutation of NDP in a Chinese family with X-linked familial exudative vitreoretinopathy.

First study to demonstrate the involvement of NDP among patients with Indian familial exudative vitreoretinopathy (FEVR) that further expands its mutation spectrum.
Title: Mutation spectrum of the Norrie disease pseudoglioma (NDP) gene in Indian patients with FEVR.

The following NDP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NDP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu26248 NM_000266.4
Latest version!		 Homo sapiens norrin cystine knot growth factor NDP (NDP), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
View Old Accession Versions >>
OHu26248 NM_000266.3 Homo sapiens NDP, norrin cystine knot growth factor (NDP), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu26248
Clone ID Related Accession (Same CDS sequence) NM_000266.4 , NM_000266.3
Accession Version NM_000266.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 402bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-22
Organism Homo sapiens(human)
Product norrin precursor
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X65882.1 and BC029901.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_000266.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1017256.1, SRR3476690.582694.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153427, SAMEA2155371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000642620.1/ ENSP00000495972.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
ATGAGAAAAC ATGTACTAGC TGCATCCTTT TCTATGCTCT CCCTGCTGGT GATAATGGGA 
GATACAGACA GTAAAACGGA CAGCTCATTC ATAATGGACT CGGACCCTCG ACGCTGCATG 
AGGCACCACT ATGTGGATTC TATCAGTCAC CCATTGTACA AGTGTAGCTC AAAGATGGTG 
CTCCTGGCCA GGTGCGAGGG GCACTGCAGC CAGGCGTCAC GCTCCGAGCC TTTGGTGTCG 
TTCAGCACTG TCCTCAAGCA ACCCTTCCGT TCCTCCTGTC ACTGCTGCCG GCCCCAGACT 
TCCAAGCTGA AGGCACTGCG GCTGCGATGC TCAGGGGGCA TGCGACTCAC TGCCACCTAC 
CGGTACATCC TCTCCTGTCA CTGCGAGGAA TGCAATTCCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000257.1
CDS295..696
Translation

Target ORF information:

RefSeq Version NM_000266.4
Organism Homo sapiens(human)
Definition Homo sapiens norrin cystine knot growth factor NDP (NDP), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_000266.4

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGAGAAAAC ATGTACTAGC TGCATCCTTT TCTATGCTCT CCCTGCTGGT GATAATGGGA 
GATACAGACA GTAAAACGGA CAGCTCATTC ATAATGGACT CGGACCCTCG ACGCTGCATG 
AGGCACCACT ATGTGGATTC TATCAGTCAC CCATTGTACA AGTGTAGCTC AAAGATGGTG 
CTCCTGGCCA GGTGCGAGGG GCACTGCAGC CAGGCGTCAC GCTCCGAGCC TTTGGTGTCG 
TTCAGCACTG TCCTCAAGCA ACCCTTCCGT TCCTCCTGTC ACTGCTGCCG GCCCCAGACT 
TCCAAGCTGA AGGCACTGCG GCTGCGATGC TCAGGGGGCA TGCGACTCAC TGCCACCTAC 
CGGTACATCC TCTCCTGTCA CTGCGAGGAA TGCAATTCCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26248
Clone ID Related Accession (Same CDS sequence) NM_000266.4 , NM_000266.3
Accession Version NM_000266.3 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 402bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-12-28
Organism Homo sapiens(human)
Product norrin precursor
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA714180.1, X65882.1 and BC029901.1. This sequence is a reference standard in the RefSeqGene project. On Feb 18, 2009 this sequence version replaced NM_000266.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X65724.1, SRR1660809.89329.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153427, SAMEA2155371 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
ATGAGAAAAC ATGTACTAGC TGCATCCTTT TCTATGCTCT CCCTGCTGGT GATAATGGGA 
GATACAGACA GTAAAACGGA CAGCTCATTC ATAATGGACT CGGACCCTCG ACGCTGCATG 
AGGCACCACT ATGTGGATTC TATCAGTCAC CCATTGTACA AGTGTAGCTC AAAGATGGTG 
CTCCTGGCCA GGTGCGAGGG GCACTGCAGC CAGGCGTCAC GCTCCGAGCC TTTGGTGTCG 
TTCAGCACTG TCCTCAAGCA ACCCTTCCGT TCCTCCTGTC ACTGCTGCCG GCCCCAGACT 
TCCAAGCTGA AGGCACTGCG GCTGCGATGC TCAGGGGGCA TGCGACTCAC TGCCACCTAC 
CGGTACATCC TCTCCTGTCA CTGCGAGGAA TGCAATTCCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000257.1
CDS580..981
Translation

Target ORF information:

RefSeq Version NM_000266.3
Organism Homo sapiens(human)
Definition Homo sapiens NDP, norrin cystine knot growth factor (NDP), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_000266.3

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGAGAAAAC ATGTACTAGC TGCATCCTTT TCTATGCTCT CCCTGCTGGT GATAATGGGA 
GATACAGACA GTAAAACGGA CAGCTCATTC ATAATGGACT CGGACCCTCG ACGCTGCATG 
AGGCACCACT ATGTGGATTC TATCAGTCAC CCATTGTACA AGTGTAGCTC AAAGATGGTG 
CTCCTGGCCA GGTGCGAGGG GCACTGCAGC CAGGCGTCAC GCTCCGAGCC TTTGGTGTCG 
TTCAGCACTG TCCTCAAGCA ACCCTTCCGT TCCTCCTGTC ACTGCTGCCG GCCCCAGACT 
TCCAAGCTGA AGGCACTGCG GCTGCGATGC TCAGGGGGCA TGCGACTCAC TGCCACCTAC 
CGGTACATCC TCTCCTGTCA CTGCGAGGAA TGCAATTCCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Next-generation sequencing reveals a novel NDP gene mutation in a Chinese family with Norrie disease.
Indian journal of ophthalmology65(11)1161-1165(2017 Nov)
Huang X,Tian M,Li J,Cui L,Li M,Zhang J


book

Mutation Spectrum of the LRP5, NDP, and TSPAN12 Genes in Chinese Patients With Familial Exudative Vitreoretinopathy.
Investigative ophthalmology & visual science58(13)5949-5957(2017 Nov)
Tang M,Sun L,Hu A,Yuan M,Yang Y,Peng X,Ding X


book

Mutations in LRP5,FZD4, TSPAN12, NDP, ZNF408, or KIF11 Genes Account for 38.7% of Chinese Patients With Familial Exudative Vitreoretinopathy.
Investigative ophthalmology & visual science58(5)2623-2629(2017 May)
Rao FQ,Cai XB,Cheng FF,Cheng W,Fang XL,Li N,Huang XF,Li LH,Jin ZB