NDP cDNA ORF clone, Homo sapiens(human)
Gene Symbol | NDP |
Entrez Gene ID | 4693 |
Full Name | NDP, norrin cystine knot growth factor |
Synonyms | EVR2,FEVR,ND |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a secreted protein with a cystein-knot motif that activates the Wnt/beta-catenin pathway. The protein forms disulfide-linked oligomers in the extracellular matrix. Mutations in this gene result in Norrie disease and X-linked exudative vitreoretinopathy. [provided by RefSeq, Feb 2009]. |
Disorder MIM: | |
Disorder Html: | Norrie disease, 310600 (3); Exudative vitreoretinopathy 2, X-linked, 305390 (3) |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
NM_000266.4 | NP_000257.1 | norrin precursor |
NM_000266.3 | NP_000257.1 | norrin precursor |

Pan troglodytes (chimpanzee) | NDP | XP_001139783.1 |
Bos taurus (cattle) | NDP | NP_001039555.1 |
NDP | XP_002806251.1 | |
Canis lupus familiaris (dog) | NDP | XP_855261.1 |
Gallus gallus (chicken) | NDP | NP_001265015.1 |
Danio rerio (zebrafish) | LOC100003793 | XP_001338820.2 |
Homo sapiens (human) | NDP | NP_000257.1 |
Mus musculus (house mouse) | Ndp | NP_035013.1 |
Xenopus tropicalis (tropical clawed frog) | ndp | XP_002932837.1 |

Related articles in PubMed
Next-generation sequencing reveals a novel NDP gene mutation in a Chinese family with Norrie disease.
Huang X, Tian M, Li J, Cui L, Li M, Zhang J
Indian journal of ophthalmology65(11)1161-1165(2017 Nov)
Mutation Spectrum of the LRP5, NDP, and TSPAN12 Genes in Chinese Patients With Familial Exudative Vitreoretinopathy.
Tang M, Sun L, Hu A, Yuan M, Yang Y, Peng X, Ding X
Investigative ophthalmology & visual science58(13)5949-5957(2017 Nov)
Mutations in LRP5,FZD4, TSPAN12, NDP, ZNF408, or KIF11 Genes Account for 38.7% of Chinese Patients With Familial Exudative Vitreoretinopathy.
Rao FQ, Cai XB, Cheng FF, Cheng W, Fang XL, Li N, Huang XF, Li LH, Jin ZB
Investigative ophthalmology & visual science58(5)2623-2629(2017 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
c.314C>A mutation of NDP gene is a novel mutation and broadens the genetic spectrum of Norrie disease.
Title: Next-generation sequencing reveals a novel NDP gene mutation in a Chinese family with Norrie disease.
Probands with LRP5 or NDP mutations were mainly categorized into group III and IV, TSPAN12 mutations were mainly observed in probands with group IV and V FEVR.
Title: Mutation Spectrum of the LRP5, NDP, and TSPAN12 Genes in Chinese Patients With Familial Exudative Vitreoretinopathy.
Among the detected mutations, LRP5 accounted for the largest proportion with a mean mutation rate of 16.1% (5/31, 16.1%), followed by NDP (3/31, 9.7%), FZD4 (2/31, 6.5%), TSPAN12 (1/31, 3.2%), and KIF11 (1/31, 3.2%). All the novel changes were predicted to be pathogenic by a series of bioinformatics analyses.
Title: Mutations in LRP5,FZD4, TSPAN12, NDP, ZNF408, or KIF11 Genes Account for 38.7% of Chinese Patients With Familial Exudative Vitreoretinopathy.
The mutation c.310A>C (p.Lys104Gln) in exon 3 of NDP is associated with familial exudative vitreoretinopathy in the studied family
Title: A novel missense mutation of NDP in a Chinese family with X-linked familial exudative vitreoretinopathy.
First study to demonstrate the involvement of NDP among patients with Indian familial exudative vitreoretinopathy (FEVR) that further expands its mutation spectrum.
Title: Mutation spectrum of the Norrie disease pseudoglioma (NDP) gene in Indian patients with FEVR.
The following NDP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NDP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OHu26248![]() |
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Clone ID Related Accession (Same CDS sequence) | NM_000266.4 , NM_000266.3 | |
Accession Version | NM_000266.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 402bp) Protein sequence SNP |
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Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-22 | |
Organism | Homo sapiens(human) | |
Product | norrin precursor | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X65882.1 and BC029901.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_000266.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1017256.1, SRR3476690.582694.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153427, SAMEA2155371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000642620.1/ ENSP00000495972.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGAGAAAAC ATGTACTAGC TGCATCCTTT TCTATGCTCT CCCTGCTGGT GATAATGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_000257.1 |
CDS | 295..696 |
Translation |

Target ORF information:
Target ORF information:
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ORF Insert Sequence:
1 | ATGAGAAAAC ATGTACTAGC TGCATCCTTT TCTATGCTCT CCCTGCTGGT GATAATGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu26248![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_000266.4 , NM_000266.3 | |
Accession Version | NM_000266.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 402bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-12-28 | |
Organism | Homo sapiens(human) | |
Product | norrin precursor | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA714180.1, X65882.1 and BC029901.1. This sequence is a reference standard in the RefSeqGene project. On Feb 18, 2009 this sequence version replaced NM_000266.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X65724.1, SRR1660809.89329.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153427, SAMEA2155371 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAGAAAAC ATGTACTAGC TGCATCCTTT TCTATGCTCT CCCTGCTGGT GATAATGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_000257.1 |
CDS | 580..981 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGAGAAAAC ATGTACTAGC TGCATCCTTT TCTATGCTCT CCCTGCTGGT GATAATGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
Next-generation sequencing reveals a novel NDP gene mutation in a Chinese family with Norrie disease. |
![]() |
Mutation Spectrum of the LRP5, NDP, and TSPAN12 Genes in Chinese Patients With Familial Exudative Vitreoretinopathy. |
![]() |
Mutations in LRP5,FZD4, TSPAN12, NDP, ZNF408, or KIF11 Genes Account for 38.7% of Chinese Patients With Familial Exudative Vitreoretinopathy. |