EXOSC1 cDNA ORF clone, Homo sapiens(human)
Gene Symbol | EXOSC1 |
Entrez Gene ID | 51013 |
Full Name | exosome component 1 |
Synonyms | CGI-108,CSL4,Csl4p,SKI4,Ski4p,p13 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2016]. |
Disorder MIM: |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
NM_001318365.1 | NP_001305294.1 | exosome complex component CSL4 isoform e |
NM_001318366.1 | NP_001305295.1 | exosome complex component CSL4 isoform e |
NM_016046.3 | NP_057130.1 | exosome complex component CSL4 |
NM_001318364.1 | NP_001305293.1 | exosome complex component CSL4 isoform d |
NM_016046.4 | NP_057130.1 | exosome complex component CSL4 isoform a |
XM_011539847.2 | XP_011538149.1 | exosome complex component CSL4 isoform X1 |
XM_017016304.1 | XP_016871793.1 | exosome complex component CSL4 isoform X2 |
NM_001318363.1 | NP_001305292.1 | exosome complex component CSL4 isoform c |
XM_024448033.1 | XP_024303801.1 | exosome complex component CSL4 isoform X3 |
NM_016046.5 | NP_057130.1 | exosome complex component CSL4 isoform a |
NM_001318362.1 | NP_001305291.1 | exosome complex component CSL4 isoform b |

Pan troglodytes (chimpanzee) | EXOSC1 | XP_507960.2 |
EXOSC1 | XP_001103710.1 | |
Rattus norvegicus (Norway rat) | Exosc1 | XP_003749167.1 |
Danio rerio (zebrafish) | exosc1 | NP_001139039.1 |
Caenorhabditis elegans (roundworm) | exos-1 | NP_499416.1 |
Eremothecium gossypii | AGOS_ABL199W | NP_982748.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_08628 | XP_003711058.1 |
Homo sapiens (human) | EXOSC1 | NP_057130.1 |
Mus musculus (house mouse) | Exosc1 | NP_079920.1 |
Schizosaccharomyces pombe (fission yeast) | csl4 | NP_588510.1 |
Canis lupus familiaris (dog) | EXOSC1 | XP_534981.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP008063 | XP_317396.3 |
Saccharomyces cerevisiae (baker's yeast) | CSL4 | NP_014167.1 |
Arabidopsis thaliana (thale cress) | AT5G38890 | NP_568559.2 |
Bos taurus (cattle) | EXOSC1 | NP_001015529.1 |
Drosophila melanogaster (fruit fly) | Csl4 | NP_609492.1 |
Kluyveromyces lactis | KLLA0D19701g | XP_453937.1 |
Neurospora crassa | NCU04155 | XP_961311.1 |
Oryza sativa (rice) | Os02g0815800 | NP_001048506.1 |
Xenopus tropicalis (tropical clawed frog) | exosc1 | NP_001123851.1 |

Related articles in PubMed
Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)
Combined p16 and p53 expression in cervical cancer of unknown primary and other prognostic parameters : A single-center analysis.
Yildirim M, M?ller von der Gr?n J, Winkelmann R, Fokas E, R?del F, Ackermann H, R?del C, Balermpas P
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]193(4)305-314(2017 Apr)
Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Yachie N, Petsalaki E, Mellor JC, Weile J, Jacob Y, Verby M, Ozturk SB, Li S, Cote AG, Mosca R, Knapp JJ, Ko M, Yu A, Gebbia M, Sahni N, Yi S, Tyagi T, Sheykhkarimli D, Roth JF, Wong C, Musa L, Snider J, Liu YC, Yu H, Braun P, Stagljar I, Hao T, Calderwood MA, Pelletier L, Aloy P, Hill DE, Vidal M, Roth FP
Molecular systems biology12(4)863(2016 Apr)
Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA.
Wasmuth EV, Januszyk K, Lima CD
Nature511(7510)435-9(2014 Jul)
Bioinformatics analysis reveals transcriptome and microRNA signatures and drug repositioning targets for IBD and other autoimmune diseases.
Clark PM, Dawany N, Dampier W, Byers SW, Pestell RG, Tozeren A
Inflammatory bowel diseases18(12)2315-33(2012 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The combined p16- and p53-expression status in cervical metastases of CUP may represent a simple method for risk stratification. Further validation of these biomarkers in large prospective trials is essential to design rational trials for CUP treatment optimization.
Title: Combined p16 and p53 expression in cervical cancer of unknown primary and other prognostic parameters : A single-center analysis.
Human exosome hCsl4p participates in RNA degradation.
Title: Yeast RNA viruses as indicators of exosome activity: human exosome hCsl4p participates in RNA degradation in Saccharomyces cerevisiae'.
Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.
Title: Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.
association of hCsl4p with the exosome is mediated by protein-protein interactions with hRrp42p and hRrp46p
Title: Protein-protein interactions of hCsl4p with other human exosome subunits.
The following EXOSC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EXOSC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OHu13359![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_016046.3 , NM_016046.4 , NM_016046.5 | |
Accession Version | NM_016046.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-03-14 | |
Organism | Homo sapiens(Human) | |
Product | exosome complex component CSL4 | |
Comment |
1 | ATGGCGCCAC CTGTGAGATA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_057130.1 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCGCCAC CTGTGAGATA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu13359![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_016046.3 , NM_016046.4 , NM_016046.5 | |
Accession Version | NM_016046.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-25 | |
Organism | Homo sapiens(human) | |
Product | exosome complex component CSL4 isoform a | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI550688.1, BC022067.2 and AF151866.1. On Jan 5, 2016 this sequence version replaced NM_016046.3. Transcript Variant: This variant (1) encodes the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.186414.1, BI550688.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGCCAC CTGTGAGATA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_057130.1 |
CDS | 33..620 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCGCCAC CTGTGAGATA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu13359![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_016046.3 , NM_016046.4 , NM_016046.5 | |
Accession Version | NM_016046.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-10 | |
Organism | Homo sapiens(human) | |
Product | exosome complex component CSL4 isoform a | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI550688.1, BC022067.2 and AF151866.1. On May 17, 2019 this sequence version replaced NM_016046.4. Transcript Variant: This variant (1) encodes the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.169300.1, SRR5189652.229193.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370902.8/ ENSP00000359939.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGCCAC CTGTGAGATA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_057130.1 |
CDS | 22..609 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCGCCAC CTGTGAGATA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu67581 | |
Clone ID Related Accession (Same CDS sequence) | NM_001318362.1 | |
Accession Version | NM_001318362.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 513bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-10 | |
Organism | Homo sapiens(human) | |
Product | exosome complex component CSL4 isoform b | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI550688.1, AW954858.1 and AF151866.1. On Jan 5, 2016 this sequence version replaced XM_011539846.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.138836.1, SRR1163655.570836.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154529, SAMN01820691 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGCCAC CTGTGAGATA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001305291.1 |
CDS | 33..545 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCGCCAC CTGTGAGATA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu67582 | |
Clone ID Related Accession (Same CDS sequence) | XM_011539847.2 | |
Accession Version | XM_011539847.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | exosome complex component CSL4 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011539847.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGAACTC AGTATCCCAT CCCAGCCCAG CTCAGCCCAG CACTTCCAGT GGTGTCTGTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011538149.1 |
CDS | 113..595 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGCGAACTC AGTATCCCAT CCCAGCCCAG CTCAGCCCAG CACTTCCAGT GGTGTCTGTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu101639 | |
Clone ID Related Accession (Same CDS sequence) | NM_001318365.1 , NM_001318366.1 , XM_024448033.1 | |
Accession Version | NM_001318365.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-10 | |
Organism | Homo sapiens(human) | |
Product | exosome complex component CSL4 isoform e | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI550688.1, BG331954.1 and AF151866.1. Transcript Variant: This variant (5) includes an additional exon and uses an alternate splice site, and it thus differs in its 5' UTR and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (e) has a distinct and shorter N-terminus, compared to isoform a. Both variants 5 and 6 encode isoform e. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG331954.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154529, SAMN01820691 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTGGGGTC CATGCCTCTT AAGAACTCTT TTCGAGGAAC TATCCGCAAG GAAGATGTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001305294.1 |
CDS | 452..781 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGTGGGGTC CATGCCTCTT AAGAACTCTT TTCGAGGAAC TATCCGCAAG GAAGATGTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu101639 | |
Clone ID Related Accession (Same CDS sequence) | NM_001318365.1 , NM_001318366.1 , XM_024448033.1 | |
Accession Version | NM_001318366.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-09 | |
Organism | Homo sapiens(human) | |
Product | exosome complex component CSL4 isoform e | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI550688.1, BM692452.1 and AF151866.1. On Jan 5, 2016 this sequence version replaced XR_246092.2. Transcript Variant: This variant (6) uses an alternate splice site, and it thus differs in its 5' UTR and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (e) has a distinct and shorter N-terminus, compared to isoform a. Both variants 5 and 6 encode isoform e. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279844.5272.1, SRR1163655.160267.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTGGGGTC CATGCCTCTT AAGAACTCTT TTCGAGGAAC TATCCGCAAG GAAGATGTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001305295.1 |
CDS | 298..627 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGTGGGGTC CATGCCTCTT AAGAACTCTT TTCGAGGAAC TATCCGCAAG GAAGATGTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu101737 | |
Clone ID Related Accession (Same CDS sequence) | NM_001318363.1 | |
Accession Version | NM_001318363.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-10 | |
Organism | Homo sapiens(human) | |
Product | exosome complex component CSL4 isoform c | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI550688.1, N34159.1, BC022067.2 and AF151866.1. Transcript Variant: This variant (3) uses an alternate splice site and lacks two alternate in-frame exons in the 3' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: N34159.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGCCAC CTGTGAGATA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001305292.1 |
CDS | 33..491 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCGCCAC CTGTGAGATA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu101869 | |
Clone ID Related Accession (Same CDS sequence) | NM_001318364.1 | |
Accession Version | NM_001318364.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 390bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-09 | |
Organism | Homo sapiens(human) | |
Product | exosome complex component CSL4 isoform d | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI550688.1, W39427.1 and AF151866.1. Transcript Variant: This variant (4) lacks three alternate exons, resulting in the loss of an in-frame segment in the central coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: W39427.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGCCAC CTGTGAGATA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001305293.1 |
CDS | 33..422 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCGCCAC CTGTGAGATA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu101639 | |
Clone ID Related Accession (Same CDS sequence) | NM_001318365.1 , NM_001318366.1 , XM_024448033.1 | |
Accession Version | XM_024448033.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | exosome complex component CSL4 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTGGGGTC CATGCCTCTT AAGAACTCTT TTCGAGGAAC TATCCGCAAG GAAGATGTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_024303801.1 |
CDS | 2696..3025 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGTGGGGTC CATGCCTCTT AAGAACTCTT TTCGAGGAAC TATCCGCAAG GAAGATGTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu91453 | |
Clone ID Related Accession (Same CDS sequence) | XM_017016304.1 | |
Accession Version | XM_017016304.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | exosome complex component CSL4 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGCGGT CTCTAGCATC AATTCACGCT TTGCCAAAGT ACACATCCTG TATGTGGGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016871793.1 |
CDS | 148..528 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCGCGGT CTCTAGCATC AATTCACGCT TTGCCAAAGT ACACATCCTG TATGTGGGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
Architecture of the human interactome defines protein communities and disease networks. |
![]() |
Combined p16 and p53 expression in cervical cancer of unknown primary and other prognostic parameters : A single-center analysis. |
![]() |
Pooled-matrix protein interaction screens using Barcode Fusion Genetics. |
![]() |
Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA. |
![]() |
Bioinformatics analysis reveals transcriptome and microRNA signatures and drug repositioning targets for IBD and other autoimmune diseases. |