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EXOSC1 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol EXOSC1
Entrez Gene ID 51013
Full Name exosome component 1
Synonyms CGI-108,CSL4,Csl4p,SKI4,Ski4p,p13
General protein information
Preferred Names

exosome component 1

Names

exosome complex component CSL4
3'-5' exoribonuclease CSL4 homolog
exosomal core protein CSL4
homolog of yeast exosomal core protein CSL4
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

10

10q24.1
Summary This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2016].
Disorder MIM:

606493


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_001318365.1 NP_001305294.1 exosome complex component CSL4 isoform e
NM_001318366.1 NP_001305295.1 exosome complex component CSL4 isoform e
NM_016046.3 NP_057130.1 exosome complex component CSL4
NM_001318364.1 NP_001305293.1 exosome complex component CSL4 isoform d
NM_016046.4 NP_057130.1 exosome complex component CSL4 isoform a
XM_011539847.2 XP_011538149.1 exosome complex component CSL4 isoform X1
XM_017016304.1 XP_016871793.1 exosome complex component CSL4 isoform X2
NM_001318363.1 NP_001305292.1 exosome complex component CSL4 isoform c
XM_024448033.1 XP_024303801.1 exosome complex component CSL4 isoform X3
NM_016046.5 NP_057130.1 exosome complex component CSL4 isoform a
NM_001318362.1 NP_001305291.1 exosome complex component CSL4 isoform b

Pathways from BioSystems


Homologies


Pan troglodytes (chimpanzee) EXOSC1 XP_507960.2
EXOSC1 XP_001103710.1
Rattus norvegicus (Norway rat) Exosc1 XP_003749167.1
Danio rerio (zebrafish) exosc1 NP_001139039.1
Caenorhabditis elegans (roundworm) exos-1 NP_499416.1
Eremothecium gossypii AGOS_ABL199W NP_982748.1
Magnaporthe oryzae (rice blast fungus) MGG_08628 XP_003711058.1
Homo sapiens (human) EXOSC1 NP_057130.1
Mus musculus (house mouse) Exosc1 NP_079920.1
Schizosaccharomyces pombe (fission yeast) csl4 NP_588510.1
Canis lupus familiaris (dog) EXOSC1 XP_534981.1
Anopheles gambiae (African malaria mosquito) AgaP_AGAP008063 XP_317396.3
Saccharomyces cerevisiae (baker's yeast) CSL4 NP_014167.1
Arabidopsis thaliana (thale cress) AT5G38890 NP_568559.2
Bos taurus (cattle) EXOSC1 NP_001015529.1
Drosophila melanogaster (fruit fly) Csl4 NP_609492.1
Kluyveromyces lactis KLLA0D19701g XP_453937.1
Neurospora crassa NCU04155 XP_961311.1
Oryza sativa (rice) Os02g0815800 NP_001048506.1
Xenopus tropicalis (tropical clawed frog) exosc1 NP_001123851.1

Gene Ontology


Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Combined p16 and p53 expression in cervical cancer of unknown primary and other prognostic parameters : A single-center analysis.
Yildirim M, M?ller von der Gr?n J, Winkelmann R, Fokas E, R?del F, Ackermann H, R?del C, Balermpas P
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]193(4)305-314(2017 Apr)

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Yachie N, Petsalaki E, Mellor JC, Weile J, Jacob Y, Verby M, Ozturk SB, Li S, Cote AG, Mosca R, Knapp JJ, Ko M, Yu A, Gebbia M, Sahni N, Yi S, Tyagi T, Sheykhkarimli D, Roth JF, Wong C, Musa L, Snider J, Liu YC, Yu H, Braun P, Stagljar I, Hao T, Calderwood MA, Pelletier L, Aloy P, Hill DE, Vidal M, Roth FP
Molecular systems biology12(4)863(2016 Apr)

Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA.
Wasmuth EV, Januszyk K, Lima CD
Nature511(7510)435-9(2014 Jul)

Bioinformatics analysis reveals transcriptome and microRNA signatures and drug repositioning targets for IBD and other autoimmune diseases.
Clark PM, Dawany N, Dampier W, Byers SW, Pestell RG, Tozeren A
Inflammatory bowel diseases18(12)2315-33(2012 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The combined p16- and p53-expression status in cervical metastases of CUP may represent a simple method for risk stratification. Further validation of these biomarkers in large prospective trials is essential to design rational trials for CUP treatment optimization.
Title: Combined p16 and p53 expression in cervical cancer of unknown primary and other prognostic parameters : A single-center analysis.

Human exosome hCsl4p participates in RNA degradation.
Title: Yeast RNA viruses as indicators of exosome activity: human exosome hCsl4p participates in RNA degradation in Saccharomyces cerevisiae'.

Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.
Title: Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.

association of hCsl4p with the exosome is mediated by protein-protein interactions with hRrp42p and hRrp46p
Title: Protein-protein interactions of hCsl4p with other human exosome subunits.

The following EXOSC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EXOSC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu13359 NM_016046.5
Latest version!		 Homo sapiens exosome component 1 (EXOSC1), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu67581 NM_001318362.1
Latest version!		 Homo sapiens exosome component 1 (EXOSC1), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu67582 XM_011539847.2
Latest version!		 Homo sapiens exosome component 1 (EXOSC1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu101639 NM_001318366.1
Latest version!		 Homo sapiens exosome component 1 (EXOSC1), transcript variant 6, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $69.30
$99.00
OHu101639 NM_001318365.1
Latest version!		 Homo sapiens exosome component 1 (EXOSC1), transcript variant 5, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $69.30
$99.00
OHu101737 NM_001318363.1
Latest version!		 Homo sapiens exosome component 1 (EXOSC1), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $69.30
$99.00
OHu101869 NM_001318364.1
Latest version!		 Homo sapiens exosome component 1 (EXOSC1), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $69.30
$99.00
OHu101639 XM_024448033.1
Latest version!		 Homo sapiens exosome component 1 (EXOSC1), transcript variant X3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $69.30
$99.00
OHu91453 XM_017016304.1
Latest version!		 Homo sapiens exosome component 1 (EXOSC1), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $69.30
$99.00
View Old Accession Versions >>
OHu13359 NM_016046.3 Homo sapiens exosome component 1 (EXOSC1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu13359 NM_016046.4 Homo sapiens exosome component 1 (EXOSC1), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu13359
Clone ID Related Accession (Same CDS sequence) NM_016046.3 , NM_016046.4 , NM_016046.5
Accession Version NM_016046.3 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 588bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2015-03-14
Organism Homo sapiens(Human)
Product exosome complex component CSL4
Comment 

1
61
121
181
241
301
361
421
481
541
ATGGCGCCAC CTGTGAGATA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAGGGC 
AGCCCGGGCA GCGGCACCTA CACCCGCCAC GGCTACATCT TTTCGTCGCT TGCCGGCTGT 
CTGATGAAGA GCAGCGAGAA TGGCGCGCTT CCAGTGGTGT CTGTAGTGAG AGAAACAGAG 
TCCCAGTTAC TGCCAGATGT GGGAGCTATT GTAACCTGTA AGGTCTCTAG CATCAATTCA 
CGCTTTGCCA AAGTACACAT CCTGTATGTG GGGTCCATGC CTCTTAAGAA CTCTTTTCGA 
GGAACTATCC GCAAGGAAGA TGTCCGAGCA ACTGAAAAAG ACAAGGTTGA AATTTATAAG 
AGTTTCCGCC CAGGTGACAT TGTCTTGGCC AAAGTGATCT CCTTAGGTGA TGCACAGTCC 
AACTACCTGC TAACCACCGC CGAGAACGAG CTGGGAGTGG TGGTAGCCCA CAGTGAGTCA 
GGTATCCAGA TGGTTCCCAT CAGCTGGTGT GAGATGCAGT GCCCTAAGAC CCACACTAAA 
GAATTCCGGA AAGTAGCCCG AGTACAACCC GAATTCTTGC AGACCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_057130.1
Translation

Target ORF information:

RefSeq Version NM_016046.3
Organism Homo sapiens(Human)
Definition Homo sapiens exosome component 1 (EXOSC1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_016046.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGCGCCAC CTGTGAGATA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAGGGC 
AGCCCGGGCA GCGGCACCTA CACCCGCCAC GGCTACATCT TTTCGTCGCT TGCCGGCTGT 
CTGATGAAGA GCAGCGAGAA TGGCGCGCTT CCAGTGGTGT CTGTAGTGAG AGAAACAGAG 
TCCCAGTTAC TGCCAGATGT GGGAGCTATT GTAACCTGTA AGGTCTCTAG CATCAATTCA 
CGCTTTGCCA AAGTACACAT CCTGTATGTG GGGTCCATGC CTCTTAAGAA CTCTTTTCGA 
GGAACTATCC GCAAGGAAGA TGTCCGAGCA ACTGAAAAAG ACAAGGTTGA AATTTATAAG 
AGTTTCCGCC CAGGTGACAT TGTCTTGGCC AAAGTGATCT CCTTAGGTGA TGCACAGTCC 
AACTACCTGC TAACCACCGC CGAGAACGAG CTGGGAGTGG TGGTAGCCCA CAGTGAGTCA 
GGTATCCAGA TGGTTCCCAT CAGCTGGTGT GAGATGCAGT GCCCTAAGAC CCACACTAAA 
GAATTCCGGA AAGTAGCCCG AGTACAACCC GAATTCTTGC AGACCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu13359
Clone ID Related Accession (Same CDS sequence) NM_016046.3 , NM_016046.4 , NM_016046.5
Accession Version NM_016046.4 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 588bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-02-25
Organism Homo sapiens(human)
Product exosome complex component CSL4 isoform a
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI550688.1, BC022067.2 and AF151866.1. On Jan 5, 2016 this sequence version replaced NM_016046.3. Transcript Variant: This variant (1) encodes the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.186414.1, BI550688.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
ATGGCGCCAC CTGTGAGATA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAGGGC 
AGCCCGGGCA GCGGCACCTA CACCCGCCAC GGCTACATCT TTTCGTCGCT TGCCGGCTGT 
CTGATGAAGA GCAGCGAGAA TGGCGCGCTT CCAGTGGTGT CTGTAGTGAG AGAAACAGAG 
TCCCAGTTAC TGCCAGATGT GGGAGCTATT GTAACCTGTA AGGTCTCTAG CATCAATTCA 
CGCTTTGCCA AAGTACACAT CCTGTATGTG GGGTCCATGC CTCTTAAGAA CTCTTTTCGA 
GGAACTATCC GCAAGGAAGA TGTCCGAGCA ACTGAAAAAG ACAAGGTTGA AATTTATAAG 
AGTTTCCGCC CAGGTGACAT TGTCTTGGCC AAAGTGATCT CCTTAGGTGA TGCACAGTCC 
AACTACCTGC TAACCACCGC CGAGAACGAG CTGGGAGTGG TGGTAGCCCA CAGTGAGTCA 
GGTATCCAGA TGGTTCCCAT CAGCTGGTGT GAGATGCAGT GCCCTAAGAC CCACACTAAA 
GAATTCCGGA AAGTAGCCCG AGTACAACCC GAATTCTTGC AGACCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_057130.1
CDS33..620
Translation

Target ORF information:

RefSeq Version NM_016046.4
Organism Homo sapiens(human)
Definition Homo sapiens exosome component 1 (EXOSC1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_016046.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGCGCCAC CTGTGAGATA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAGGGC 
AGCCCGGGCA GCGGCACCTA CACCCGCCAC GGCTACATCT TTTCGTCGCT TGCCGGCTGT 
CTGATGAAGA GCAGCGAGAA TGGCGCGCTT CCAGTGGTGT CTGTAGTGAG AGAAACAGAG 
TCCCAGTTAC TGCCAGATGT GGGAGCTATT GTAACCTGTA AGGTCTCTAG CATCAATTCA 
CGCTTTGCCA AAGTACACAT CCTGTATGTG GGGTCCATGC CTCTTAAGAA CTCTTTTCGA 
GGAACTATCC GCAAGGAAGA TGTCCGAGCA ACTGAAAAAG ACAAGGTTGA AATTTATAAG 
AGTTTCCGCC CAGGTGACAT TGTCTTGGCC AAAGTGATCT CCTTAGGTGA TGCACAGTCC 
AACTACCTGC TAACCACCGC CGAGAACGAG CTGGGAGTGG TGGTAGCCCA CAGTGAGTCA 
GGTATCCAGA TGGTTCCCAT CAGCTGGTGT GAGATGCAGT GCCCTAAGAC CCACACTAAA 
GAATTCCGGA AAGTAGCCCG AGTACAACCC GAATTCTTGC AGACCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu13359
Clone ID Related Accession (Same CDS sequence) NM_016046.3 , NM_016046.4 , NM_016046.5
Accession Version NM_016046.5 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 588bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-10-10
Organism Homo sapiens(human)
Product exosome complex component CSL4 isoform a
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI550688.1, BC022067.2 and AF151866.1. On May 17, 2019 this sequence version replaced NM_016046.4. Transcript Variant: This variant (1) encodes the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.169300.1, SRR5189652.229193.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370902.8/ ENSP00000359939.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
ATGGCGCCAC CTGTGAGATA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAGGGC 
AGCCCGGGCA GCGGCACCTA CACCCGCCAC GGCTACATCT TTTCGTCGCT TGCCGGCTGT 
CTGATGAAGA GCAGCGAGAA TGGCGCGCTT CCAGTGGTGT CTGTAGTGAG AGAAACAGAG 
TCCCAGTTAC TGCCAGATGT GGGAGCTATT GTAACCTGTA AGGTCTCTAG CATCAATTCA 
CGCTTTGCCA AAGTACACAT CCTGTATGTG GGGTCCATGC CTCTTAAGAA CTCTTTTCGA 
GGAACTATCC GCAAGGAAGA TGTCCGAGCA ACTGAAAAAG ACAAGGTTGA AATTTATAAG 
AGTTTCCGCC CAGGTGACAT TGTCTTGGCC AAAGTGATCT CCTTAGGTGA TGCACAGTCC 
AACTACCTGC TAACCACCGC CGAGAACGAG CTGGGAGTGG TGGTAGCCCA CAGTGAGTCA 
GGTATCCAGA TGGTTCCCAT CAGCTGGTGT GAGATGCAGT GCCCTAAGAC CCACACTAAA 
GAATTCCGGA AAGTAGCCCG AGTACAACCC GAATTCTTGC AGACCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_057130.1
CDS22..609
Translation

Target ORF information:

RefSeq Version NM_016046.5
Organism Homo sapiens(human)
Definition Homo sapiens exosome component 1 (EXOSC1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_016046.5

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGCGCCAC CTGTGAGATA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAGGGC 
AGCCCGGGCA GCGGCACCTA CACCCGCCAC GGCTACATCT TTTCGTCGCT TGCCGGCTGT 
CTGATGAAGA GCAGCGAGAA TGGCGCGCTT CCAGTGGTGT CTGTAGTGAG AGAAACAGAG 
TCCCAGTTAC TGCCAGATGT GGGAGCTATT GTAACCTGTA AGGTCTCTAG CATCAATTCA 
CGCTTTGCCA AAGTACACAT CCTGTATGTG GGGTCCATGC CTCTTAAGAA CTCTTTTCGA 
GGAACTATCC GCAAGGAAGA TGTCCGAGCA ACTGAAAAAG ACAAGGTTGA AATTTATAAG 
AGTTTCCGCC CAGGTGACAT TGTCTTGGCC AAAGTGATCT CCTTAGGTGA TGCACAGTCC 
AACTACCTGC TAACCACCGC CGAGAACGAG CTGGGAGTGG TGGTAGCCCA CAGTGAGTCA 
GGTATCCAGA TGGTTCCCAT CAGCTGGTGT GAGATGCAGT GCCCTAAGAC CCACACTAAA 
GAATTCCGGA AAGTAGCCCG AGTACAACCC GAATTCTTGC AGACCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu67581
Clone ID Related Accession (Same CDS sequence) NM_001318362.1
Accession Version NM_001318362.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 513bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-10-10
Organism Homo sapiens(human)
Product exosome complex component CSL4 isoform b
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI550688.1, AW954858.1 and AF151866.1. On Jan 5, 2016 this sequence version replaced XM_011539846.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.138836.1, SRR1163655.570836.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154529, SAMN01820691 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
ATGGCGCCAC CTGTGAGATA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAGGGC 
AGCCCGGGCA GCGGCACCTA CACCCGCCAC GGCTACATCT TTTCGTCGCT TGCCGGCTGT 
CTGATGAAGA GCAGCGAGAA TGGCGCGGTC TCTAGCATCA ATTCACGCTT TGCCAAAGTA 
CACATCCTGT ATGTGGGGTC CATGCCTCTT AAGAACTCTT TTCGAGGAAC TATCCGCAAG 
GAAGATGTCC GAGCAACTGA AAAAGACAAG GTTGAAATTT ATAAGAGTTT CCGCCCAGGT 
GACATTGTCT TGGCCAAAGT GATCTCCTTA GGTGATGCAC AGTCCAACTA CCTGCTAACC 
ACCGCCGAGA ACGAGCTGGG AGTGGTGGTA GCCCACAGTG AGTCAGGTAT CCAGATGGTT 
CCCATCAGCT GGTGTGAGAT GCAGTGCCCT AAGACCCACA CTAAAGAATT CCGGAAAGTA 
GCCCGAGTAC AACCCGAATT CTTGCAGACC TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001305291.1
CDS33..545
Translation

Target ORF information:

RefSeq Version NM_001318362.1
Organism Homo sapiens(human)
Definition Homo sapiens exosome component 1 (EXOSC1), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001318362.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGCGCCAC CTGTGAGATA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAGGGC 
AGCCCGGGCA GCGGCACCTA CACCCGCCAC GGCTACATCT TTTCGTCGCT TGCCGGCTGT 
CTGATGAAGA GCAGCGAGAA TGGCGCGGTC TCTAGCATCA ATTCACGCTT TGCCAAAGTA 
CACATCCTGT ATGTGGGGTC CATGCCTCTT AAGAACTCTT TTCGAGGAAC TATCCGCAAG 
GAAGATGTCC GAGCAACTGA AAAAGACAAG GTTGAAATTT ATAAGAGTTT CCGCCCAGGT 
GACATTGTCT TGGCCAAAGT GATCTCCTTA GGTGATGCAC AGTCCAACTA CCTGCTAACC 
ACCGCCGAGA ACGAGCTGGG AGTGGTGGTA GCCCACAGTG AGTCAGGTAT CCAGATGGTT 
CCCATCAGCT GGTGTGAGAT GCAGTGCCCT AAGACCCACA CTAAAGAATT CCGGAAAGTA 
GCCCGAGTAC AACCCGAATT CTTGCAGACC TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu67582
Clone ID Related Accession (Same CDS sequence) XM_011539847.2
Accession Version XM_011539847.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 483bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product exosome complex component CSL4 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011539847.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
ATGCGAACTC AGTATCCCAT CCCAGCCCAG CTCAGCCCAG CACTTCCAGT GGTGTCTGTA 
GTGAGAGAAA CAGAGTCCCA GTTACTGCCA GATGTGGGAG CTATTGTAAC CTGTAAGGTC 
TCTAGCATCA ATTCACGCTT TGCCAAAGTA CACATCCTGT ATGTGGGGTC CATGCCTCTT 
AAGAACTCTT TTCGAGGAAC TATCCGCAAG GAAGATGTCC GAGCAACTGA AAAAGACAAG 
GTTGAAATTT ATAAGAGTTT CCGCCCAGGT GACATTGTCT TGGCCAAAGT GATCTCCTTA 
GGTGATGCAC AGTCCAACTA CCTGCTAACC ACCGCCGAGA ACGAGCTGGG AGTGGTGGTA 
GCCCACAGTG AGTCAGGTAT CCAGATGGTT CCCATCAGCT GGTGTGAGAT GCAGTGCCCT 
AAGACCCACA CTAAAGAATT CCGGAAAGTA GCCCGAGTAC AACCCGAATT CTTGCAGACC 
TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011538149.1
CDS113..595
Translation

Target ORF information:

RefSeq Version XM_011539847.2
Organism Homo sapiens(human)
Definition Homo sapiens exosome component 1 (EXOSC1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_011539847.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGCGAACTC AGTATCCCAT CCCAGCCCAG CTCAGCCCAG CACTTCCAGT GGTGTCTGTA 
GTGAGAGAAA CAGAGTCCCA GTTACTGCCA GATGTGGGAG CTATTGTAAC CTGTAAGGTC 
TCTAGCATCA ATTCACGCTT TGCCAAAGTA CACATCCTGT ATGTGGGGTC CATGCCTCTT 
AAGAACTCTT TTCGAGGAAC TATCCGCAAG GAAGATGTCC GAGCAACTGA AAAAGACAAG 
GTTGAAATTT ATAAGAGTTT CCGCCCAGGT GACATTGTCT TGGCCAAAGT GATCTCCTTA 
GGTGATGCAC AGTCCAACTA CCTGCTAACC ACCGCCGAGA ACGAGCTGGG AGTGGTGGTA 
GCCCACAGTG AGTCAGGTAT CCAGATGGTT CCCATCAGCT GGTGTGAGAT GCAGTGCCCT 
AAGACCCACA CTAAAGAATT CCGGAAAGTA GCCCGAGTAC AACCCGAATT CTTGCAGACC 
TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu101639
Clone ID Related Accession (Same CDS sequence) NM_001318365.1 , NM_001318366.1 , XM_024448033.1
Accession Version NM_001318365.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 330bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-10-10
Organism Homo sapiens(human)
Product exosome complex component CSL4 isoform e
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI550688.1, BG331954.1 and AF151866.1. Transcript Variant: This variant (5) includes an additional exon and uses an alternate splice site, and it thus differs in its 5' UTR and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (e) has a distinct and shorter N-terminus, compared to isoform a. Both variants 5 and 6 encode isoform e. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG331954.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154529, SAMN01820691 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
ATGTGGGGTC CATGCCTCTT AAGAACTCTT TTCGAGGAAC TATCCGCAAG GAAGATGTCC 
GAGCAACTGA AAAAGACAAG GTTGTTGGTT GAAATTTATA AGAGTTTCCG CCCAGGTGAC 
ATTGTCTTGG CCAAAGTGAT CTCCTTAGGT GATGCACAGT CCAACTACCT GCTAACCACC 
GCCGAGAACG AGCTGGGAGT GGTGGTAGCC CACAGTGAGT CAGGTATCCA GATGGTTCCC 
ATCAGCTGGT GTGAGATGCA GTGCCCTAAG ACCCACACTA AAGAATTCCG GAAAGTAGCC 
CGAGTACAAC CCGAATTCTT GCAGACCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001305294.1
CDS452..781
Translation

Target ORF information:

RefSeq Version NM_001318365.1
Organism Homo sapiens(human)
Definition Homo sapiens exosome component 1 (EXOSC1), transcript variant 5, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001318365.1

ORF Insert Sequence:

1
61
121
181
241
301
ATGTGGGGTC CATGCCTCTT AAGAACTCTT TTCGAGGAAC TATCCGCAAG GAAGATGTCC 
GAGCAACTGA AAAAGACAAG GTTGTTGGTT GAAATTTATA AGAGTTTCCG CCCAGGTGAC 
ATTGTCTTGG CCAAAGTGAT CTCCTTAGGT GATGCACAGT CCAACTACCT GCTAACCACC 
GCCGAGAACG AGCTGGGAGT GGTGGTAGCC CACAGTGAGT CAGGTATCCA GATGGTTCCC 
ATCAGCTGGT GTGAGATGCA GTGCCCTAAG ACCCACACTA AAGAATTCCG GAAAGTAGCC 
CGAGTACAAC CCGAATTCTT GCAGACCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu101639
Clone ID Related Accession (Same CDS sequence) NM_001318365.1 , NM_001318366.1 , XM_024448033.1
Accession Version NM_001318366.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 330bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-10-09
Organism Homo sapiens(human)
Product exosome complex component CSL4 isoform e
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI550688.1, BM692452.1 and AF151866.1. On Jan 5, 2016 this sequence version replaced XR_246092.2. Transcript Variant: This variant (6) uses an alternate splice site, and it thus differs in its 5' UTR and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (e) has a distinct and shorter N-terminus, compared to isoform a. Both variants 5 and 6 encode isoform e. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279844.5272.1, SRR1163655.160267.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
ATGTGGGGTC CATGCCTCTT AAGAACTCTT TTCGAGGAAC TATCCGCAAG GAAGATGTCC 
GAGCAACTGA AAAAGACAAG GTTGTTGGTT GAAATTTATA AGAGTTTCCG CCCAGGTGAC 
ATTGTCTTGG CCAAAGTGAT CTCCTTAGGT GATGCACAGT CCAACTACCT GCTAACCACC 
GCCGAGAACG AGCTGGGAGT GGTGGTAGCC CACAGTGAGT CAGGTATCCA GATGGTTCCC 
ATCAGCTGGT GTGAGATGCA GTGCCCTAAG ACCCACACTA AAGAATTCCG GAAAGTAGCC 
CGAGTACAAC CCGAATTCTT GCAGACCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001305295.1
CDS298..627
Translation

Target ORF information:

RefSeq Version NM_001318366.1
Organism Homo sapiens(human)
Definition Homo sapiens exosome component 1 (EXOSC1), transcript variant 6, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001318366.1

ORF Insert Sequence:

1
61
121
181
241
301
ATGTGGGGTC CATGCCTCTT AAGAACTCTT TTCGAGGAAC TATCCGCAAG GAAGATGTCC 
GAGCAACTGA AAAAGACAAG GTTGTTGGTT GAAATTTATA AGAGTTTCCG CCCAGGTGAC 
ATTGTCTTGG CCAAAGTGAT CTCCTTAGGT GATGCACAGT CCAACTACCT GCTAACCACC 
GCCGAGAACG AGCTGGGAGT GGTGGTAGCC CACAGTGAGT CAGGTATCCA GATGGTTCCC 
ATCAGCTGGT GTGAGATGCA GTGCCCTAAG ACCCACACTA AAGAATTCCG GAAAGTAGCC 
CGAGTACAAC CCGAATTCTT GCAGACCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu101737
Clone ID Related Accession (Same CDS sequence) NM_001318363.1
Accession Version NM_001318363.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 459bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-10-10
Organism Homo sapiens(human)
Product exosome complex component CSL4 isoform c
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI550688.1, N34159.1, BC022067.2 and AF151866.1. Transcript Variant: This variant (3) uses an alternate splice site and lacks two alternate in-frame exons in the 3' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: N34159.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
ATGGCGCCAC CTGTGAGATA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAGGGC 
AGCCCGGGCA GCGGCACCTA CACCCGCCAC GGCTACATCT TTTCGTCGCT TGCCGGCTGT 
CTGATGAAGA GCAGCGAGAA TGGCGCGCTT CCAGTGGTGT CTGTAGTGAG AGAAACAGAG 
TCCCAGTTAC TGCCAGATGT GGGAGCTATT GTAACCTGTA AGGTCTCTAG CATCAATTCA 
CGCTTTGCCA AAGTACACAT CCTGTATGTG GGGTCCATGC CTCTTAAGAA CTCTTTTCGA 
GGAACTATCC GCAAGGAAGA TGTCCGAGCA ACTGAAAAAG ACAAGGTTGT TGGTATCCAG 
ATGGTTCCCA TCAGCTGGTG TGAGATGCAG TGCCCTAAGA CCCACACTAA AGAATTCCGG 
AAAGTAGCCC GAGTACAACC CGAATTCTTG CAGACCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001305292.1
CDS33..491
Translation

Target ORF information:

RefSeq Version NM_001318363.1
Organism Homo sapiens(human)
Definition Homo sapiens exosome component 1 (EXOSC1), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001318363.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGCGCCAC CTGTGAGATA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAGGGC 
AGCCCGGGCA GCGGCACCTA CACCCGCCAC GGCTACATCT TTTCGTCGCT TGCCGGCTGT 
CTGATGAAGA GCAGCGAGAA TGGCGCGCTT CCAGTGGTGT CTGTAGTGAG AGAAACAGAG 
TCCCAGTTAC TGCCAGATGT GGGAGCTATT GTAACCTGTA AGGTCTCTAG CATCAATTCA 
CGCTTTGCCA AAGTACACAT CCTGTATGTG GGGTCCATGC CTCTTAAGAA CTCTTTTCGA 
GGAACTATCC GCAAGGAAGA TGTCCGAGCA ACTGAAAAAG ACAAGGTTGT TGGTATCCAG 
ATGGTTCCCA TCAGCTGGTG TGAGATGCAG TGCCCTAAGA CCCACACTAA AGAATTCCGG 
AAAGTAGCCC GAGTACAACC CGAATTCTTG CAGACCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu101869
Clone ID Related Accession (Same CDS sequence) NM_001318364.1
Accession Version NM_001318364.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 390bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-10-09
Organism Homo sapiens(human)
Product exosome complex component CSL4 isoform d
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI550688.1, W39427.1 and AF151866.1. Transcript Variant: This variant (4) lacks three alternate exons, resulting in the loss of an in-frame segment in the central coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: W39427.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
ATGGCGCCAC CTGTGAGATA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAGGGC 
AGCCCGGGCA GCGGCACCTA CACCCGCCAC GGCTACATCT TTTCGTCGCT TGCCGGCTGT 
CTGATGAAGA GCAGCGAGAA TGGCGCGGTT GAAATTTATA AGAGTTTCCG CCCAGGTGAC 
ATTGTCTTGG CCAAAGTGAT CTCCTTAGGT GATGCACAGT CCAACTACCT GCTAACCACC 
GCCGAGAACG AGCTGGGAGT GGTGGTAGCC CACAGTGAGT CAGGTATCCA GATGGTTCCC 
ATCAGCTGGT GTGAGATGCA GTGCCCTAAG ACCCACACTA AAGAATTCCG GAAAGTAGCC 
CGAGTACAAC CCGAATTCTT GCAGACCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001305293.1
CDS33..422
Translation

Target ORF information:

RefSeq Version NM_001318364.1
Organism Homo sapiens(human)
Definition Homo sapiens exosome component 1 (EXOSC1), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001318364.1

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGGCGCCAC CTGTGAGATA CTGCATCCCC GGCGAACGTC TGTGTAACTT GGAGGAGGGC 
AGCCCGGGCA GCGGCACCTA CACCCGCCAC GGCTACATCT TTTCGTCGCT TGCCGGCTGT 
CTGATGAAGA GCAGCGAGAA TGGCGCGGTT GAAATTTATA AGAGTTTCCG CCCAGGTGAC 
ATTGTCTTGG CCAAAGTGAT CTCCTTAGGT GATGCACAGT CCAACTACCT GCTAACCACC 
GCCGAGAACG AGCTGGGAGT GGTGGTAGCC CACAGTGAGT CAGGTATCCA GATGGTTCCC 
ATCAGCTGGT GTGAGATGCA GTGCCCTAAG ACCCACACTA AAGAATTCCG GAAAGTAGCC 
CGAGTACAAC CCGAATTCTT GCAGACCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu101639
Clone ID Related Accession (Same CDS sequence) NM_001318365.1 , NM_001318366.1 , XM_024448033.1
Accession Version XM_024448033.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 330bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product exosome complex component CSL4 isoform X3
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
ATGTGGGGTC CATGCCTCTT AAGAACTCTT TTCGAGGAAC TATCCGCAAG GAAGATGTCC 
GAGCAACTGA AAAAGACAAG GTTGTTGGTT GAAATTTATA AGAGTTTCCG CCCAGGTGAC 
ATTGTCTTGG CCAAAGTGAT CTCCTTAGGT GATGCACAGT CCAACTACCT GCTAACCACC 
GCCGAGAACG AGCTGGGAGT GGTGGTAGCC CACAGTGAGT CAGGTATCCA GATGGTTCCC 
ATCAGCTGGT GTGAGATGCA GTGCCCTAAG ACCCACACTA AAGAATTCCG GAAAGTAGCC 
CGAGTACAAC CCGAATTCTT GCAGACCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_024303801.1
CDS2696..3025
Translation

Target ORF information:

RefSeq Version XM_024448033.1
Organism Homo sapiens(human)
Definition Homo sapiens exosome component 1 (EXOSC1), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_024448033.1

ORF Insert Sequence:

1
61
121
181
241
301
ATGTGGGGTC CATGCCTCTT AAGAACTCTT TTCGAGGAAC TATCCGCAAG GAAGATGTCC 
GAGCAACTGA AAAAGACAAG GTTGTTGGTT GAAATTTATA AGAGTTTCCG CCCAGGTGAC 
ATTGTCTTGG CCAAAGTGAT CTCCTTAGGT GATGCACAGT CCAACTACCT GCTAACCACC 
GCCGAGAACG AGCTGGGAGT GGTGGTAGCC CACAGTGAGT CAGGTATCCA GATGGTTCCC 
ATCAGCTGGT GTGAGATGCA GTGCCCTAAG ACCCACACTA AAGAATTCCG GAAAGTAGCC 
CGAGTACAAC CCGAATTCTT GCAGACCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu91453
Clone ID Related Accession (Same CDS sequence) XM_017016304.1
Accession Version XM_017016304.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 381bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product exosome complex component CSL4 isoform X2
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
ATGGCGCGGT CTCTAGCATC AATTCACGCT TTGCCAAAGT ACACATCCTG TATGTGGGGT 
CCATGCCTCT TAAGAACTCT TTTCGAGGAA CTATCCGCAA GGAAGATGTC CGAGCAACTG 
AAAAAGACAA GGTTGTTGGT TGAAATTTAT AAGAGTTTCC GCCCAGGTGA CATTGTCTTG 
GCCAAAGTGA TCTCCTTAGG TGATGCACAG TCCAACTACC TGCTAACCAC CGCCGAGAAC 
GAGCTGGGAG TGGTGGTAGC CCACAGTGAG TCAGGTATCC AGATGGTTCC CATCAGCTGG 
TGTGAGATGC AGTGCCCTAA GACCCACACT AAAGAATTCC GGAAAGTAGC CCGAGTACAA 
CCCGAATTCT TGCAGACCTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016871793.1
CDS148..528
Translation

Target ORF information:

RefSeq Version XM_017016304.1
Organism Homo sapiens(human)
Definition Homo sapiens exosome component 1 (EXOSC1), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017016304.1

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGGCGCGGT CTCTAGCATC AATTCACGCT TTGCCAAAGT ACACATCCTG TATGTGGGGT 
CCATGCCTCT TAAGAACTCT TTTCGAGGAA CTATCCGCAA GGAAGATGTC CGAGCAACTG 
AAAAAGACAA GGTTGTTGGT TGAAATTTAT AAGAGTTTCC GCCCAGGTGA CATTGTCTTG 
GCCAAAGTGA TCTCCTTAGG TGATGCACAG TCCAACTACC TGCTAACCAC CGCCGAGAAC 
GAGCTGGGAG TGGTGGTAGC CCACAGTGAG TCAGGTATCC AGATGGTTCC CATCAGCTGG 
TGTGAGATGC AGTGCCCTAA GACCCACACT AAAGAATTCC GGAAAGTAGC CCGAGTACAA 
CCCGAATTCT TGCAGACCTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW


book

Combined p16 and p53 expression in cervical cancer of unknown primary and other prognostic parameters : A single-center analysis.
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]193(4)305-314(2017 Apr)
Yildirim M,M?ller von der Gr?n J,Winkelmann R,Fokas E,R?del F,Ackermann H,R?del C,Balermpas P


book

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Molecular systems biology12(4)863(2016 Apr)
Yachie N,Petsalaki E,Mellor JC,Weile J,Jacob Y,Verby M,Ozturk SB,Li S,Cote AG,Mosca R,Knapp JJ,Ko M,Yu A,Gebbia M,Sahni N,Yi S,Tyagi T,Sheykhkarimli D,Roth JF,Wong C,Musa L,Snider J,Liu YC,Yu H,Braun P,Stagljar I,Hao T,Calderwood MA,Pelletier L,Aloy P,Hill DE,Vidal M,Roth FP


book

Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA.
Nature511(7510)435-9(2014 Jul)
Wasmuth EV,Januszyk K,Lima CD


book

Bioinformatics analysis reveals transcriptome and microRNA signatures and drug repositioning targets for IBD and other autoimmune diseases.
Inflammatory bowel diseases18(12)2315-33(2012 Dec)
Clark PM,Dawany N,Dampier W,Byers SW,Pestell RG,Tozeren A