BET1L cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BET1L
Entrez Gene ID	51272
Full Name	Bet1 golgi vesicular membrane trafficking protein like
Synonyms	BET1L1,GOLIM3,GS15,HSPC197
General protein information	Preferred Names Bet1 golgi vesicular membrane trafficking protein like Names BET1-like protein GOS-15 blocked early in transport 1 homolog-like golgi SNARE 15 kDa protein golgi SNARE with a size of 15 kDa golgi integral membrane protein 3 vesicle transport protein GOS15
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.5
Disorder MIM:	615417

mRNA and Protein(s)

mRNA	Protein	Name
NM_016526.4	NP_057610.2	BET1-like protein isoform 2
NM_001098787.1	NP_001092257.1	BET1-like protein isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	BET1L	NP_001092257.1
Mus musculus (house mouse)	Bet1l	NP_061212.3
Gallus gallus (chicken)	BET1L	NP_001026344.2
Canis lupus familiaris (dog)	BET1L	XP_540512.2
Bos taurus (cattle)	BET1L	NP_001029534.1
Danio rerio (zebrafish)	bet1l	NP_001003998.1
Xenopus tropicalis (tropical clawed frog)	bet1l	XP_002937686.1
	BET1L	XP_001082878.1
Pan troglodytes (chimpanzee)	BET1L	XP_508184.1
Rattus norvegicus (Norway rat)	Bet1l	NP_062241.2

Gene Ontology
Bibliography

Related articles in PubMed

COG lobe B sub-complex engages v-SNARE GS15 and functions via regulated interaction with lobe A sub-complex.
Willett R, Blackburn JB, Climer L, Pokrovskaya I, Kudlyk T, Wang W, Lupashin V
Scientific reports629139(2016 Jul)

A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.
Shameer K, Denny JC, Ding K, Jouni H, Crosslin DR, de Andrade M, Chute CG, Peissig P, Pacheco JA, Li R, Bastarache L, Kho AN, Ritchie MD, Masys DR, Chisholm RL, Larson EB, McCarty CA, Roden DM, Jarvik GP, Kullo IJ
Human genetics133(1)95-109(2014 Jan)

Variants in BET1L and TNRC6B associate with increasing fibroid volume and fibroid type among European Americans.
Edwards TL, Hartmann KE, Velez Edwards DR
Human genetics132(12)1361-9(2013 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Meta-analysis showed a strong association at blocked early in transport 1 homolog (BET1L) rs2280543 for intramural uterine fibroid type in european americans.
Title: Variants in BET1L and TNRC6B associate with increasing fibroid volume and fibroid type among European Americans.

single nucleotide polymorphisms in the BET1L gene is associated with uterine fibroid.
Title: BET1L and TNRC6B associate with uterine fibroid risk among European Americans.

Data suggest that GS15 exists in a distinct SNARE complex that contains syntaxin5, GS28, and Ykt6, and may be involved in both ER-to-Golgi and intra-Golgi transport.
Title: GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus.

The following BET1L gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BET1L cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu13876	NM_001098787.1 Latest version!	Homo sapiens Bet1 golgi vesicular membrane trafficking protein like (BET1L), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu13828	NM_016526.4 Latest version!	Homo sapiens Bet1 golgi vesicular membrane trafficking protein like (BET1L), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BET1L ( NM_001098787.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001092257.1 Homo sapiens Bet1 golgi vesicular membrane trafficking protein like (BET1L), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13876
Clone ID Related Accession (Same CDS sequence)	NM_001098787.1
Accession Version	NM_001098787.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 336bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Homo sapiens(human)
Product	BET1-like protein isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA875317.1, BC008971.1, DA880679.1 and BX648752.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: The sequence BX648752.1 is from a chimeric clone. Only the blocked early in transport 1 homolog (S. cerevisiae) like sequence region was propagated into this RefSeq record. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.139647.1, SRR1660805.176950.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGACT GGGCTCGGGC TCAGAGCCCG GGCGCTGTGG AAGAGATTCT AGACCGGGAG 
AACAAGCGAA TGGCTGACAG CCTGGCCTCC AAAGTCACCA GGCTCAAATC GCTCGCCCTG 
GACATCGATA GGGATGCAGA GGATCAGAAC CGGTACCTGG ATGGCATGGA CTCGGATTTC 
ACAAGCATGA CCAGCCTGCT TACAGGGAGC GTGAAGCGCT TTTCCACAAT GGCAAGGTCC 
GGACAAGACA ACCGGAAGCT TCTATGTGGC ATGGCCGTGG GTCTAATTGT GGCCTTCTTC 
ATCCTCTCCT ACTTCTTGTC CAGGGCAAGG ACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001092257.1
CDS	102..437
Translation	MADWARAQSPGAVEEILDRENKRMADSLASKVTRLKSLALDIDRDAEDQNRYLDGMDSDFTSMTSLLTGSVKRFSTMARSGQDNRKLLCGMAVGLIVAFFILSYFLSRART

Target ORF information:

RefSeq Version	NM_001098787.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Bet1 golgi vesicular membrane trafficking protein like (BET1L), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001098787.1

ORF Insert Sequence:

ATGGCGGACT GGGCTCGGGC TCAGAGCCCG GGCGCTGTGG AAGAGATTCT AGACCGGGAG 
AACAAGCGAA TGGCTGACAG CCTGGCCTCC AAAGTCACCA GGCTCAAATC GCTCGCCCTG 
GACATCGATA GGGATGCAGA GGATCAGAAC CGGTACCTGG ATGGCATGGA CTCGGATTTC 
ACAAGCATGA CCAGCCTGCT TACAGGGAGC GTGAAGCGCT TTTCCACAAT GGCAAGGTCC 
GGACAAGACA ACCGGAAGCT TCTATGTGGC ATGGCCGTGG GTCTAATTGT GGCCTTCTTC 
ATCCTCTCCT ACTTCTTGTC CAGGGCAAGG ACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BET1L ( NM_016526.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057610.2 Homo sapiens Bet1 golgi vesicular membrane trafficking protein like (BET1L), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13828
Clone ID Related Accession (Same CDS sequence)	NM_016526.4
Accession Version	NM_016526.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	BET1-like protein isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA875317.1, BC032779.2, DA880679.1 and BX648752.1. On Jun 20, 2007 this sequence version replaced NM_016526.3. Transcript Variant: This variant (2) lacks the 3' splice junction, which results in a different 3' coding sequence, compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. Sequence Note: The sequence BX648752.1 is from a chimeric clone. Only the blocked early in transport 1 homolog (S. cerevisiae) like sequence region was propagated into this RefSeq record. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC032779.2, SRR1803615.215294.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2146236, SAMEA2146411 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGACT GGGCTCGGGC TCAGAGCCCG GGCGCTGTGG AAGAGATTCT AGACCGGGAG 
AACAAGCGAA TGGCTGACAG CCTGGCCTCC AAAGTCACCA GGCTCAAATC GCTCGCCCTG 
GACATCGATA GGGATGCAGA GGATCAGAAC CGGTACCTGG ATGGCATGGT AAGGGCCCAC 
GGTGTGCGTG TATCAGTGCC CTGCCCTAGC ACTACCTGCT GCAGAGCCTG CAGTGTCTCC 
TTCAGCACTG GTGCGGGTGG GTGGTCAAAT CACCACTTCT GTGTGATCTT GCTGGGATTC 
CTCCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057610.2
CDS	102..410
Translation	MADWARAQSPGAVEEILDRENKRMADSLASKVTRLKSLALDIDRDAEDQNRYLDGMVRAHGVRVSVPCPSTTCCRACSVSFSTGAGGWSNHHFCVILLGFLP

Target ORF information:

RefSeq Version	NM_016526.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Bet1 golgi vesicular membrane trafficking protein like (BET1L), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016526.4

ORF Insert Sequence:

ATGGCGGACT GGGCTCGGGC TCAGAGCCCG GGCGCTGTGG AAGAGATTCT AGACCGGGAG 
AACAAGCGAA TGGCTGACAG CCTGGCCTCC AAAGTCACCA GGCTCAAATC GCTCGCCCTG 
GACATCGATA GGGATGCAGA GGATCAGAAC CGGTACCTGG ATGGCATGGT AAGGGCCCAC 
GGTGTGCGTG TATCAGTGCC CTGCCCTAGC ACTACCTGCT GCAGAGCCTG CAGTGTCTCC 
TTCAGCACTG GTGCGGGTGG GTGGTCAAAT CACCACTTCT GTGTGATCTT GCTGGGATTC 
CTCCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

COG lobe B sub-complex engages v-SNARE GS15 and functions via regulated interaction with lobe A sub-complex.
Scientific reports629139(2016 Jul)
Willett R,Blackburn JB,Climer L,Pokrovskaya I,Kudlyk T,Wang W,Lupashin V

A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.
Human genetics133(1)95-109(2014 Jan)
Shameer K,Denny JC,Ding K,Jouni H,Crosslin DR,de Andrade M,Chute CG,Peissig P,Pacheco JA,Li R,Bastarache L,Kho AN,Ritchie MD,Masys DR,Chisholm RL,Larson EB,McCarty CA,Roden DM,Jarvik GP,Kullo IJ

Variants in BET1L and TNRC6B associate with increasing fibroid volume and fibroid type among European Americans.
Human genetics132(12)1361-9(2013 Dec)
Edwards TL,Hartmann KE,Velez Edwards DR

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BET1L cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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