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PF4 cDNA ORF clone, Homo sapiens (human)

Gene Symbol PF4
Entrez Gene ID 5196
Full Name platelet factor 4
Synonyms CXCL4, PF-4, SCYB4
General protein information
Preferred Names
platelet factor 4
Names
platelet factor 4
iroplact
oncostatin-A
C-X-C motif chemokine 4
chemokine (C-X-C motif) ligand 4
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q12-q21

Summary This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014]. lac of sum
Disorder MIM:

173460


mRNA and Protein(s)

mRNA Protein Name
XM_005265696 XP_005265753 platelet factor 4 isoform X1
NM_002619 NP_002610 platelet factor 4 precursor



Homo sapiens (human) PF4 NP_002610.1
Pan troglodytes (chimpanzee) PF4 XP_001155980.1
Macaca mulatta (Rhesus monkey) PF4 XP_001102788.1
Bos taurus (cattle) PF4 NP_001094532.1
Mus musculus (house mouse) Pf4 NP_064316.1
Rattus norvegicus (Norway rat) Pf4 NP_001007730.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PF4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PF4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu38968 XM_005265696 PREDICTED: Homo sapiens platelet factor 4 (PF4), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu21626
NM_002619 Homo sapiens platelet factor 4 (PF4), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu38968
Clone ID Related Accession (Same CDS sequence) XM_005265696
Accession Version XM_005265696.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 333bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product platelet factor 4 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_016354.20) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:530376992. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
ATGATCACAG CCACACTTAA CGGAGAGCCT GCTGAGTGTC TGGCCACAGT GCCAGGCGCT 
GCACCTGCAC CTCCCACCTG GTTAGAACAA CTTCTGTCTG GGGGAGGTGT GATTTATGCT
GAAGCTGAAG AAGATGGGGA CCTGCAGTGC CTGTGTGTGA AGACCACCTC CCAGGTCCGT
CCCAGGCACA TCACCAGCCT GGAGGTGATC AAGGCCGGAC CCCACTGCCC CACTGCCCAA
CTGATAGCCA CGCTGAAGAA TGGAAGGAAA ATTTGCTTGG ACCTGCAAGC CCCGCTGTAC
AAGAAAATAA TTAAGAAACT TTTGGAGAGT TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005265753.1
CDS61..393
Misc Feature(1)199..387(+)
Misc Feature(2)199..366(+)
Misc Feature(3)199..207(+)
Misc Feature(4)202..384(+)
Misc Feature(5)202..330(+)
Misc Feature(6)205..216(+)
Misc Feature(7)211..252(+)
Misc Feature(8)217..333(+)
Misc Feature(9)238..387(+)
Misc Feature(10)244..330(+)
Misc Feature(11)250..384(+)
Misc Feature(12)277..285(+)
Misc Feature(13)277..285(+)
Misc Feature(14)316..324(+)
Translation

Target ORF information:

RefSeq Version XM_005265696
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens platelet factor 4 (PF4), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005265696

ORF Insert Sequence:

1
61
121
181
241
301
ATGATCACAG CCACACTTAA CGGAGAGCCT GCTGAGTGTC TGGCCACAGT GCCAGGCGCT 
GCACCTGCAC CTCCCACCTG GTTAGAACAA CTTCTGTCTG GGGGAGGTGT GATTTATGCT
GAAGCTGAAG AAGATGGGGA CCTGCAGTGC CTGTGTGTGA AGACCACCTC CCAGGTCCGT
CCCAGGCACA TCACCAGCCT GGAGGTGATC AAGGCCGGAC CCCACTGCCC CACTGCCCAA
CTGATAGCCA CGCTGAAGAA TGGAAGGAAA ATTTGCTTGG ACCTGCAAGC CCCGCTGTAC
AAGAAAATAA TTAAGAAACT TTTGGAGAGT TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu21626
Clone ID Related Accession (Same CDS sequence) NM_002619
Accession Version NM_002619.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 306bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product platelet factor 4 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC097709.3, M25897.1 and GD143506.1. This sequence is a reference standard in the RefSeqGene project. On Mar 14, 2012 this sequence version replaced gi:194097423. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 23245326 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: H82497.1, AJ705588.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2146236, SAMEA2149004 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
ATGAGCTCCG CAGCCGGGTT CTGCGCCTCA CGCCCCGGGC TGCTGTTCCT GGGGTTGCTG 
CTCCTGCCAC TTGTGGTCGC CTTCGCCAGC GCTGAAGCTG AAGAAGATGG GGACCTGCAG
TGCCTGTGTG TGAAGACCAC CTCCCAGGTC CGTCCCAGGC ACATCACCAG CCTGGAGGTG
ATCAAGGCCG GACCCCACTG CCCCACTGCC CAACTGATAG CCACGCTGAA GAATGGAAGG
AAAATTTGCT TGGACCTGCA AGCCCCGCTG TACAAGAAAA TAATTAAGAA ACTTTTGGAG
AGTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002610.1
CDS172..477
Misc Feature(1)136..138(+)
Misc Feature(2)283..471(+)
Misc Feature(3)283..450(+)
Misc Feature(4)283..291(+)
Misc Feature(5)286..468(+)
Misc Feature(6)286..414(+)
Misc Feature(7)289..300(+)
Misc Feature(8)292..372(+)
Misc Feature(9)295..336(+)
Misc Feature(10)298..420(+)
Misc Feature(11)301..417(+)
Misc Feature(12)322..471(+)
Misc Feature(13)328..414(+)
Misc Feature(14)334..468(+)
Misc Feature(15)361..369(+)
Misc Feature(16)361..369(+)
Misc Feature(17)400..408(+)
Misc Feature(18)445..465(+)
Exon (1)1..262
Gene:PF4
Gene Synonym:
Exon (2)263..389
Gene:PF4
Gene Synonym:
Exon (3)390..856
Gene:PF4
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_002619
Organism Homo sapiens (human)
Definition Homo sapiens platelet factor 4 (PF4), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002619

ORF Insert Sequence:

1
61
121
181
241
301
ATGAGCTCCG CAGCCGGGTT CTGCGCCTCA CGCCCCGGGC TGCTGTTCCT GGGGTTGCTG 
CTCCTGCCAC TTGTGGTCGC CTTCGCCAGC GCTGAAGCTG AAGAAGATGG GGACCTGCAG
TGCCTGTGTG TGAAGACCAC CTCCCAGGTC CGTCCCAGGC ACATCACCAG CCTGGAGGTG
ATCAAGGCCG GACCCCACTG CCCCACTGCC CAACTGATAG CCACGCTGAA GAATGGAAGG
AAAATTTGCT TGGACCTGCA AGCCCCGCTG TACAAGAAAA TAATTAAGAA ACTTTTGGAG
AGTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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