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POU1F1 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol POU1F1
Entrez Gene ID 5449
Full Name POU class 1 homeobox 1
Synonyms CPHD1,GHF-1,PIT1,POU1F1a,Pit-1
General protein information
Preferred Names

POU class 1 homeobox 1

Names

pituitary-specific positive transcription factor 1
POU domain, class 1, transcription factor 1
growth hormone factor 1

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

3

3p11.2

Disorder MIM:

173110

Disorder Html: Pituitary hormone deficiency, combined, 1, 613038 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_000306.3 NP_000297.1 pituitary-specific positive transcription factor 1 isoform alpha
NM_001122757.2 NP_001116229.1 pituitary-specific positive transcription factor 1 isoform beta



Homo sapiens (human) POU1F1 NP_001116229.1
Canis lupus familiaris (dog) POU1F1 NP_001006950.1
Xenopus tropicalis (tropical clawed frog) pou1f1 XP_002931806.1
Pan troglodytes (chimpanzee) POU1F1 XP_003318250.1
Danio rerio (zebrafish) pou1f1 NP_998016.1
Macaca mulatta (rhesus monkey) POU1F1 NP_001036325.1
Mus musculus (house mouse) Pou1f1 NP_032875.1
Gallus gallus (chicken) POU1F1 NP_989650.1
Bos taurus (cattle) POU1F1 NP_777004.1
Rattus norvegicus (Norway rat) Pou1f1 NP_037140.2


Related articles in PubMed

Functional characterization of a human POU1F1 mutation associated with isolated growth hormone deficiency: a novel etiology for IGHD.
Sobrier ML, Tsai YC, Pérez C, Leheup B, Bouceba T, Duquesnoy P, Copin B, Sizova D, Penzo A, Stanger BZ, Cooke NE, Liebhaber SA, Amselem S
Human molecular genetics25(3)472-83(2016 Feb)

Molecular analysis of PROP1, POU1F1, LHX3, and HESX1 in Turkish patients with combined pituitary hormone deficiency: a multicenter study.
Baş F, Uyguner ZO, Darendeliler F, Aycan Z, Çetinkaya E, Berberoğlu M, Şiklar Z, Öcal G, Darcan Ş, Gökşen D, Topaloğlu AK, Yüksel B, Özbek MN, Ercan O, Evliyaoğlu O, Çetinkaya S, Şen Y, Atabek E, Toksoy G, Aydin BK, Bundak R
Endocrine49(2)479-91(2015 Jun)

Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD.
Yu D, Mathews CA, Scharf JM, Neale BM, Davis LK, Gamazon ER, Derks EM, Evans P, Edlund CK, Crane J, Fagerness JA, Osiecki L, Gallagher P, Gerber G, Haddad S, Illmann C, McGrath LM, Mayerfeld C, Arepalli S, Barlassina C, Barr CL, Bellodi L, Benarroch F, Berrió GB, Bienvenu OJ, Black DW, Bloch MH, Brentani H, Bruun RD, Budman CL, Camarena B, Campbell DD, Cappi C, Silgado JC, Cavallini MC, Chavira DA, Chouinard S, Cook EH, Cookson MR, Coric V, Cullen B, Cusi D, Delorme R, Denys D, Dion Y, Eapen V, Egberts K, Falkai P, Fernandez T, Fournier E, Garrido H, Geller D, Gilbert DL, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Hardy J, Heiman GA, Hemmings SM, Herrera LD, Hezel DM, Hoekstra PJ, Jankovic J, Kennedy JL, King RA, Konkashbaev AI, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Lupoli S, Macciardi F, Maier W, Manunta P, Marconi M, McCracken JT, Mesa Restrepo SC, Moessner R, Moorjani P, Morgan J, Muller H, Murphy DL, Naarden AL, Nurmi E, Ochoa WC, Ophoff RA, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner T, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosário MC, Rosenberg D, Ruhrmann S, Sabatti C, Salvi E, Sampaio AS, Samuels J, Sandor P, Service SK, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Turiel M, Valencia Duarte AV, Vallada H, Veenstra-VanderWeele J, Walitza S, Wang Y, Weale M, Weiss R, Wendland JR, Westenberg HG, Shugart YY, Hounie AG, Miguel EC, Nicolini H, Wagner M, Ruiz-Linares A, Cath DC, McMahon W, Posthuma D, Oostra BA, Nestadt G, Rouleau GA, Purcell S, Jenike MA, Heutink P, Hanna GL, Conti DV, Arnold PD, Freimer NB, Stewart SE, Knowles JA, Cox NJ, Pauls DL
The American journal of psychiatry172(1)82-93(2015 Jan)

Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of metalloproteinase (MMP)-13.
Sendon-Lago J, Seoane S, Eiro N, Bermudez MA, Macia M, Garcia-Caballero T, Vizoso FJ, Perez-Fernandez R
Breast cancer research : BCR16(6)505(2014 Dec)

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
Perry JR, Day F, Elks CE, Sulem P, Thompson DJ, Ferreira T, He C, Chasman DI, Esko T, Thorleifsson G, Albrecht E, Ang WQ, Corre T, Cousminer DL, Feenstra B, Franceschini N, Ganna A, Johnson AD, Kjellqvist S, Lunetta KL, McMahon G, Nolte IM, Paternoster L, Porcu E, Smith AV, Stolk L, Teumer A, Tšernikova N, Tikkanen E, Ulivi S, Wagner EK, Amin N, Bierut LJ, Byrne EM, Hottenga JJ, Koller DL, Mangino M, Pers TH, Yerges-Armstrong LM, Zhao JH, Andrulis IL, Anton-Culver H, Atsma F, Bandinelli S, Beckmann MW, Benitez J, Blomqvist C, Bojesen SE, Bolla MK, Bonanni B, Brauch H, Brenner H, Buring JE, Chang-Claude J, Chanock S, Chen J, Chenevix-Trench G, Collée JM, Couch FJ, Couper D, Coveillo AD, Cox A, Czene K, D'adamo AP, Smith GD, De Vivo I, Demerath EW, Dennis J, Devilee P, Dieffenbach AK, Dunning AM, Eiriksdottir G, Eriksson JG, Fasching PA, Ferrucci L, Flesch-Janys D, Flyger H, Foroud T, Franke L, Garcia ME, García-Closas M, Geller F, de Geus EE, Giles GG, Gudbjartsson DF, Gudnason V, Guénel P, Guo S, Hall P, Hamann U, Haring R, Hartman CA, Heath AC, Hofman A, Hooning MJ, Hopper JL, Hu FB, Hunter DJ, Karasik D, Kiel DP, Knight JA, Kosma VM, Kutalik Z, Lai S, Lambrechts D, Lindblom A, Mägi R, Magnusson PK, Mannermaa A, Martin NG, Masson G, McArdle PF, McArdle WL, Melbye M, Michailidou K, Mihailov E, Milani L, Milne RL, Nevanlinna H, Neven P, Nohr EA, Oldehinkel AJ, Oostra BA, Palotie A, Peacock M, Pedersen NL, Peterlongo P, Peto J, Pharoah PD, Postma DS, Pouta A, Pylkäs K, Radice P, Ring S, Rivadeneira F, Robino A, Rose LM, Rudolph A, Salomaa V, Sanna S, Schlessinger D, Schmidt MK, Southey MC, Sovio U, Stampfer MJ, Stöckl D, Storniolo AM, Timpson NJ, Tyrer J, Visser JA, Vollenweider P, Völzke H, Waeber G, Waldenberger M, Wallaschofski H, Wang Q, Willemsen G, Winqvist R, Wolffenbuttel BH, Wright MJ, , , , , , , Boomsma DI, Econs MJ, Khaw KT, Loos RJ, McCarthy MI, Montgomery GW, Rice JP, Streeten EA, Thorsteinsdottir U, van Duijn CM, Alizadeh BZ, Bergmann S, Boerwinkle E, Boyd HA, Crisponi L, Gasparini P, Gieger C, Harris TB, Ingelsson E, Järvelin MR, Kraft P, Lawlor D, Metspalu A, Pennell CE, Ridker PM, Snieder H, Sørensen TI, Spector TD, Strachan DP, Uitterlinden AG, Wareham NJ, Widen E, Zygmunt M, Murray A, Easton DF, Stefansson K, Murabito JM, Ong KK
Nature514(7520)92-97(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that the first screening step diagnosis for pituitary adenoma was determined based upon immunohistochemical (IHC) scores for Pit-1, SF-1, and ACTH.
Title: Steroidogenic Factor 1, Pit-1, and Adrenocorticotropic Hormone: A Rational Starting Place for the Immunohistochemical Characterization of Pituitary Adenoma.

The present study reports on screening of POU1F1, PROP1, and HESX1 in combined pituitary hormone deficiency patients and the novel variations identified.
Title: Identification of Novel PROP1 and POU1F1 Mutations in Patients with Combined Pituitary Hormone Deficiency.

High expression level of Pit-1 was significantly associated with poor overall survival of the patients (P=0.001) and Cox regression analysis indicated that Pit-1 might be a prognostic factor for breast cancer prognosis (HR=1.955, 95% CI=1.295-3.035, P=0.003).
Title: Over-Expression of POU Class 1 Homeobox 1 Transcription Factor (Pit-1) Predicts Poor Prognosis for Breast Cancer Patients.

Data identify silent subtype 3 adenomas as aggressive monomorphous plurihormonal adenomas of Pit-1 lineage that may be associated with hyperthyroidism, acromegaly or galactorrhea and amenorrhea.
Title: Silent subtype 3 pituitary adenomas are not always silent and represent poorly differentiated monomorphous plurihormonal Pit-1 lineage adenomas.

A missense POU1F1 mutation is associated with isolated growth hormone deficiency.
Title: Functional characterization of a human POU1F1 mutation associated with isolated growth hormone deficiency: a novel etiology for IGHD.

The following POU1F1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the POU1F1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu23455 NM_001122757.2
Latest version!
Homo sapiens POU class 1 homeobox 1 (POU1F1), transcript variant beta, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $216.30
$309.00
OHu23957 NM_000306.3
Latest version!
Homo sapiens POU class 1 homeobox 1 (POU1F1), transcript variant alpha, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $216.30
$309.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu23455
Clone ID Related Accession (Same CDS sequence) NM_001122757.2
Accession Version NM_001122757.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 954bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-10-08
Organism Homo sapiens(Human)
Product pituitary-specific positive transcription factor 1 isoform beta
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC130885.3 and KF457648.1. This sequence is a reference standard in the RefSeqGene project. On Jan 17, 2014 this sequence version replaced NM_001122757.1. Transcript Variant: This variant (beta), also known as GHF-2 or PIT-2, represents the longer transcript and encodes the longer isoform (beta). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA2158188, SAMEA2162895 [ECO:0000350] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGAGTTGCC AAGCTTTTAC TTCGGCTGAT ACCTTTATAC CTCTGAATTC TGACGCCTCT 
GCAACTCTGC CTCTGATAAT GCATCACAGT GCTGCCGAGT GTCTACCAGT CTCCAACCAT
GCCACCAATG TGATGTCTAC AGTCCCATCT ATTTTGTCTT TGATCCAAAC TCCTAAATGT
TTGTGCACAC ATTTCTCGGT GACAACGTTG GGAAACACAG CAACAGGACT TCATTATTCT
GTTCCTTCCT GTCATTATGG AAACCAGCCA TCAACCTATG GAGTGATGGC AGGTAGTTTA
ACCCCTTGTC TTTATAAATT TCCTGACCAC ACCTTGAGTC ATGGATTTCC TCCTATACAC
CAGCCTCTTC TGGCAGAGGA CCCCACAGCT GCTGATTTCA AGCAGGAACT CAGGCGGAAA
AGTAAATTGG TGGAAGAGCC AATAGACATG GATTCTCCAG AAATCAGAGA ACTTGAAAAG
TTTGCCAATG AATTTAAAGT GAGACGAATT AAATTAGGAT ACACCCAGAC AAATGTTGGG
GAGGCCCTGG CAGCTGTGCA TGGCTCTGAA TTCAGTCAAA CAACAATCTG CCGATTTGAA
AATCTGCAGC TCAGCTTTAA AAATGCATGC AAACTGAAAG CAATATTATC CAAATGGCTG
GAGGAAGCTG AGCAAGTAGG AGCTTTGTAC AATGAAAAAG TGGGAGCAAA TGAAAGGAAA
AGAAAACGAA GAACAACTAT AAGCATTGCT GCTAAAGATG CTCTGGAGAG ACACTTTGGA
GAACAGAATA AACCTTCTTC TCAAGAGATC ATGAGGATGG CTGAAGAACT GAATCTGGAG
AAAGAAGTAG TAAGAGTTTG GTTTTGCAAC CGGAGGCAGA GAGAAAAACG GGTGAAAACA
AGTCTGAATC AGAGTTTATT TTCTATTTCT AAGGAACATC TTGAGTGCAG ATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001116229.1
CDS126..1079
Misc Feature(1)78..80
Misc Feature(2)573..797
Misc Feature(3)order(846..860,864..866,915..917,933..935,972..974,978..983,990..995,999..1007,1011..1016)
Misc Feature(4)852..1013
Misc Feature(5)order(852..854,861..863,981..983,990..995,1002..1004)
Exon (1)1..267
Exon (2)268..417
Exon (3)418..642
Exon (4)643..807
Exon (5)808..868
Exon (6)869..1340
Translation

Target ORF information:

RefSeq Version NM_001122757.2
Organism Homo sapiens(Human)
Definition Homo sapiens POU class 1 homeobox 1 (POU1F1), transcript variant beta, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001122757.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGAGTTGCC AAGCTTTTAC TTCGGCTGAT ACCTTTATAC CTCTGAATTC TGACGCCTCT 
GCAACTCTGC CTCTGATAAT GCATCACAGT GCTGCCGAGT GTCTACCAGT CTCCAACCAT
GCCACCAATG TGATGTCTAC AGTCCCATCT ATTTTGTCTT TGATCCAAAC TCCTAAATGT
TTGTGCACAC ATTTCTCGGT GACAACGTTG GGAAACACAG CAACAGGACT TCATTATTCT
GTTCCTTCCT GTCATTATGG AAACCAGCCA TCAACCTATG GAGTGATGGC AGGTAGTTTA
ACCCCTTGTC TTTATAAATT TCCTGACCAC ACCTTGAGTC ATGGATTTCC TCCTATACAC
CAGCCTCTTC TGGCAGAGGA CCCCACAGCT GCTGATTTCA AGCAGGAACT CAGGCGGAAA
AGTAAATTGG TGGAAGAGCC AATAGACATG GATTCTCCAG AAATCAGAGA ACTTGAAAAG
TTTGCCAATG AATTTAAAGT GAGACGAATT AAATTAGGAT ACACCCAGAC AAATGTTGGG
GAGGCCCTGG CAGCTGTGCA TGGCTCTGAA TTCAGTCAAA CAACAATCTG CCGATTTGAA
AATCTGCAGC TCAGCTTTAA AAATGCATGC AAACTGAAAG CAATATTATC CAAATGGCTG
GAGGAAGCTG AGCAAGTAGG AGCTTTGTAC AATGAAAAAG TGGGAGCAAA TGAAAGGAAA
AGAAAACGAA GAACAACTAT AAGCATTGCT GCTAAAGATG CTCTGGAGAG ACACTTTGGA
GAACAGAATA AACCTTCTTC TCAAGAGATC ATGAGGATGG CTGAAGAACT GAATCTGGAG
AAAGAAGTAG TAAGAGTTTG GTTTTGCAAC CGGAGGCAGA GAGAAAAACG GGTGAAAACA
AGTCTGAATC AGAGTTTATT TTCTATTTCT AAGGAACATC TTGAGTGCAG ATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23957
Clone ID Related Accession (Same CDS sequence) NM_000306.3
Accession Version NM_000306.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 876bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-10-08
Organism Homo sapiens(Human)
Product pituitary-specific positive transcription factor 1 isoform alpha
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from D10216.1 and KF457648.1. On Jan 17, 2014 this sequence version replaced NM_000306.2. Transcript Variant: This variant (alpha) uses an alternate in-frame splice site in the 5' coding region, compared to variant beta, resulting in a shorter protein (isoform alpha). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D10216.1, X62429.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2158188, SAMEA2162895 [ECO:0000350] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGAGTTGCC AAGCTTTTAC TTCGGCTGAT ACCTTTATAC CTCTGAATTC TGACGCCTCT 
GCAACTCTGC CTCTGATAAT GCATCACAGT GCTGCCGAGT GTCTACCAGT CTCCAACCAT
GCCACCAATG TGATGTCTAC AGCAACAGGA CTTCATTATT CTGTTCCTTC CTGTCATTAT
GGAAACCAGC CATCAACCTA TGGAGTGATG GCAGGTAGTT TAACCCCTTG TCTTTATAAA
TTTCCTGACC ACACCTTGAG TCATGGATTT CCTCCTATAC ACCAGCCTCT TCTGGCAGAG
GACCCCACAG CTGCTGATTT CAAGCAGGAA CTCAGGCGGA AAAGTAAATT GGTGGAAGAG
CCAATAGACA TGGATTCTCC AGAAATCAGA GAACTTGAAA AGTTTGCCAA TGAATTTAAA
GTGAGACGAA TTAAATTAGG ATACACCCAG ACAAATGTTG GGGAGGCCCT GGCAGCTGTG
CATGGCTCTG AATTCAGTCA AACAACAATC TGCCGATTTG AAAATCTGCA GCTCAGCTTT
AAAAATGCAT GCAAACTGAA AGCAATATTA TCCAAATGGC TGGAGGAAGC TGAGCAAGTA
GGAGCTTTGT ACAATGAAAA AGTGGGAGCA AATGAAAGGA AAAGAAAACG AAGAACAACT
ATAAGCATTG CTGCTAAAGA TGCTCTGGAG AGACACTTTG GAGAACAGAA TAAACCTTCT
TCTCAAGAGA TCATGAGGAT GGCTGAAGAA CTGAATCTGG AGAAAGAAGT AGTAAGAGTT
TGGTTTTGCA ACCGGAGGCA GAGAGAAAAA CGGGTGAAAA CAAGTCTGAA TCAGAGTTTA
TTTTCTATTT CTAAGGAACA TCTTGAGTGC AGATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000297.1
CDS126..1001
Misc Feature(1)78..80
Misc Feature(2)495..719
Misc Feature(3)order(768..782,786..788,837..839,855..857,894..896,900..905,912..917,921..929,933..938)
Misc Feature(4)774..935
Misc Feature(5)order(774..776,783..785,903..905,912..917,924..926)
Exon (1)1..267
Exon (2)268..339
Exon (3)340..564
Exon (4)565..729
Exon (5)730..790
Exon (6)791..1262
Translation

Target ORF information:

RefSeq Version NM_000306.3
Organism Homo sapiens(Human)
Definition Homo sapiens POU class 1 homeobox 1 (POU1F1), transcript variant alpha, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000306.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGAGTTGCC AAGCTTTTAC TTCGGCTGAT ACCTTTATAC CTCTGAATTC TGACGCCTCT 
GCAACTCTGC CTCTGATAAT GCATCACAGT GCTGCCGAGT GTCTACCAGT CTCCAACCAT
GCCACCAATG TGATGTCTAC AGCAACAGGA CTTCATTATT CTGTTCCTTC CTGTCATTAT
GGAAACCAGC CATCAACCTA TGGAGTGATG GCAGGTAGTT TAACCCCTTG TCTTTATAAA
TTTCCTGACC ACACCTTGAG TCATGGATTT CCTCCTATAC ACCAGCCTCT TCTGGCAGAG
GACCCCACAG CTGCTGATTT CAAGCAGGAA CTCAGGCGGA AAAGTAAATT GGTGGAAGAG
CCAATAGACA TGGATTCTCC AGAAATCAGA GAACTTGAAA AGTTTGCCAA TGAATTTAAA
GTGAGACGAA TTAAATTAGG ATACACCCAG ACAAATGTTG GGGAGGCCCT GGCAGCTGTG
CATGGCTCTG AATTCAGTCA AACAACAATC TGCCGATTTG AAAATCTGCA GCTCAGCTTT
AAAAATGCAT GCAAACTGAA AGCAATATTA TCCAAATGGC TGGAGGAAGC TGAGCAAGTA
GGAGCTTTGT ACAATGAAAA AGTGGGAGCA AATGAAAGGA AAAGAAAACG AAGAACAACT
ATAAGCATTG CTGCTAAAGA TGCTCTGGAG AGACACTTTG GAGAACAGAA TAAACCTTCT
TCTCAAGAGA TCATGAGGAT GGCTGAAGAA CTGAATCTGG AGAAAGAAGT AGTAAGAGTT
TGGTTTTGCA ACCGGAGGCA GAGAGAAAAA CGGGTGAAAA CAAGTCTGAA TCAGAGTTTA
TTTTCTATTT CTAAGGAACA TCTTGAGTGC AGATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Functional characterization of a human POU1F1 mutation associated with isolated growth hormone deficiency: a novel etiology for IGHD.
Human molecular genetics25(3)472-83(2016 Feb)
Sobrier ML,Tsai YC,Pérez C,Leheup B,Bouceba T,Duquesnoy P,Copin B,Sizova D,Penzo A,Stanger BZ,Cooke NE,Liebhaber SA,Amselem S


book

Molecular analysis of PROP1, POU1F1, LHX3, and HESX1 in Turkish patients with combined pituitary hormone deficiency: a multicenter study.
Endocrine49(2)479-91(2015 Jun)
Baş F,Uyguner ZO,Darendeliler F,Aycan Z,Çetinkaya E,Berberoğlu M,Şiklar Z,Öcal G,Darcan Ş,Gökşen D,Topaloğlu AK,Yüksel B,Özbek MN,Ercan O,Evliyaoğlu O,Çetinkaya S,Şen Y,Atabek E,Toksoy G,Aydin BK,Bundak R


book

Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD.
The American journal of psychiatry172(1)82-93(2015 Jan)
Yu D,Mathews CA,Scharf JM,Neale BM,Davis LK,Gamazon ER,Derks EM,Evans P,Edlund CK,Crane J,Fagerness JA,Osiecki L,Gallagher P,Gerber G,Haddad S,Illmann C,McGrath LM,Mayerfeld C,Arepalli S,Barlassina C,Barr CL,Bellodi L,Benarroch F,Berrió GB,Bienvenu OJ,Black DW,Bloch MH,Brentani H,Bruun RD,Budman CL,Camarena B,Campbell DD,Cappi C,Silgado JC,Cavallini MC,Chavira DA,Chouinard S,Cook EH,Cookson MR,Coric V,Cullen B,Cusi D,Delorme R,Denys D,Dion Y,Eapen V,Egberts K,Falkai P,Fernandez T,Fournier E,Garrido H,Geller D,Gilbert DL,Girard SL,Grabe HJ,Grados MA,Greenberg BD,Gross-Tsur V,Grünblatt E,Hardy J,Heiman GA,Hemmings SM,Herrera LD,Hezel DM,Hoekstra PJ,Jankovic J,Kennedy JL,King RA,Konkashbaev AI,Kremeyer B,Kurlan R,Lanzagorta N,Leboyer M,Leckman JF,Lennertz L,Liu C,Lochner C,Lowe TL,Lupoli S,Macciardi F,Maier W,Manunta P,Marconi M,McCracken JT,Mesa Restrepo SC,Moessner R,Moorjani P,Morgan J,Muller H,Murphy DL,Naarden AL,Nurmi E,Ochoa WC,Ophoff RA,Pakstis AJ,Pato MT,Pato CN,Piacentini J,Pittenger C,Pollak Y,Rauch SL,Renner T,Reus VI,Richter MA,Riddle MA,Robertson MM,Romero R,Rosário MC,Rosenberg D,Ruhrmann S,Sabatti C,Salvi E,Sampaio AS,Samuels J,Sandor P,Service SK,Sheppard B,Singer HS,Smit JH,Stein DJ,Strengman E,Tischfield JA,Turiel M,Valencia Duarte AV,Vallada H,Veenstra-VanderWeele J,Walitza S,Wang Y,Weale M,Weiss R,Wendland JR,Westenberg HG,Shugart YY,Hounie AG,Miguel EC,Nicolini H,Wagner M,Ruiz-Linares A,Cath DC,McMahon W,Posthuma D,Oostra BA,Nestadt G,Rouleau GA,Purcell S,Jenike MA,Heutink P,Hanna GL,Conti DV,Arnold PD,Freimer NB,Stewart SE,Knowles JA,Cox NJ,Pauls DL


book

Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of metalloproteinase (MMP)-13.
Breast cancer research : BCR16(6)505(2014 Dec)
Sendon-Lago J,Seoane S,Eiro N,Bermudez MA,Macia M,Garcia-Caballero T,Vizoso FJ,Perez-Fernandez R


book

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
Nature514(7520)92-97(2014 Oct)
Perry JR,Day F,Elks CE,Sulem P,Thompson DJ,Ferreira T,He C,Chasman DI,Esko T,Thorleifsson G,Albrecht E,Ang WQ,Corre T,Cousminer DL,Feenstra B,Franceschini N,Ganna A,Johnson AD,Kjellqvist S,Lunetta KL,McMahon G,Nolte IM,Paternoster L,Porcu E,Smith AV,Stolk L,Teumer A,Tšernikova N,Tikkanen E,Ulivi S,Wagner EK,Amin N,Bierut LJ,Byrne EM,Hottenga JJ,Koller DL,Mangino M,Pers TH,Yerges-Armstrong LM,Zhao JH,Andrulis IL,Anton-Culver H,Atsma F,Bandinelli S,Beckmann MW,Benitez J,Blomqvist C,Bojesen SE,Bolla MK,Bonanni B,Brauch H,Brenner H,Buring JE,Chang-Claude J,Chanock S,Chen J,Chenevix-Trench G,Collée JM,Couch FJ,Couper D,Coveillo AD,Cox A,Czene K,D'adamo AP,Smith GD,De Vivo I,Demerath EW,Dennis J,Devilee P,Dieffenbach AK,Dunning AM,Eiriksdottir G,Eriksson JG,Fasching PA,Ferrucci L,Flesch-Janys D,Flyger H,Foroud T,Franke L,Garcia ME,García-Closas M,Geller F,de Geus EE,Giles GG,Gudbjartsson DF,Gudnason V,Guénel P,Guo S,Hall P,Hamann U,Haring R,Hartman CA,Heath AC,Hofman A,Hooning MJ,Hopper JL,Hu FB,Hunter DJ,Karasik D,Kiel DP,Knight JA,Kosma VM,Kutalik Z,Lai S,Lambrechts D,Lindblom A,Mägi R,Magnusson PK,Mannermaa A,Martin NG,Masson G,McArdle PF,McArdle WL,Melbye M,Michailidou K,Mihailov E,Milani L,Milne RL,Nevanlinna H,Neven P,Nohr EA,Oldehinkel AJ,Oostra BA,Palotie A,Peacock M,Pedersen NL,Peterlongo P,Peto J,Pharoah PD,Postma DS,Pouta A,Pylkäs K,Radice P,Ring S,Rivadeneira F,Robino A,Rose LM,Rudolph A,Salomaa V,Sanna S,Schlessinger D,Schmidt MK,Southey MC,Sovio U,Stampfer MJ,Stöckl D,Storniolo AM,Timpson NJ,Tyrer J,Visser JA,Vollenweider P,Völzke H,Waeber G,Waldenberger M,Wallaschofski H,Wang Q,Willemsen G,Winqvist R,Wolffenbuttel BH,Wright MJ,,,,,,,Boomsma DI,Econs MJ,Khaw KT,Loos RJ,McCarthy MI,Montgomery GW,Rice JP,Streeten EA,Thorsteinsdottir U,van Duijn CM,Alizadeh BZ,Bergmann S,Boerwinkle E,Boyd HA,Crisponi L,Gasparini P,Gieger C,Harris TB,Ingelsson E,Järvelin MR,Kraft P,Lawlor D,Metspalu A,Pennell CE,Ridker PM,Snieder H,Sørensen TI,Spector TD,Strachan DP,Uitterlinden AG,Wareham NJ,Widen E,Zygmunt M,Murray A,Easton DF,Stefansson K,Murabito JM,Ong KK


 
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