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PPM1G cDNA ORF clone, Homo sapiens (human)

Gene Symbol PPM1G
Entrez Gene ID 5496
Full Name protein phosphatase, Mg2+/Mn2+ dependent, 1G
Synonyms PP2CG, PP2CGAMMA, PPP2CG
General protein information
Preferred Names
protein phosphatase 1G
Names
protein phosphatase 1G
PP2C-gamma
PP2C, gamma
protein phosphatase 1C
protein phosphatase 2C gamma isoform
protein phosphatase 2C isoform gamma
protein phosphatase magnesium-dependent 1 gamma
protein phosphatase 2, catalytic subunit, gamma isoform
protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform
NP_817092.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2p23.3

Summary The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]. lac of sum
Disorder MIM:

605119


mRNA and Protein(s)

mRNA Protein Name
NM_177983 NP_817092 protein phosphatase 1G



Homo sapiens (human) PPM1G NP_817092.1
Pan troglodytes (chimpanzee) PPM1G NP_001233384.1
Macaca mulatta (Rhesus monkey) PPM1G XP_001096179.1
Canis lupus familiaris (dog) PPM1G XP_532910.2
Bos taurus (cattle) PPM1G NP_777226.2
Mus musculus (house mouse) Ppm1g NP_032040.1
Rattus norvegicus (Norway rat) Ppm1g NP_671742.1
Gallus gallus (chicken) PPM1G XP_003641098.1
Danio rerio (zebrafish) ppm1g NP_958896.1
Drosophila melanogaster (fruit fly) CG10417 NP_610169.1
Xenopus (Silurana) tropicalis (western clawed frog) ppm1g NP_001015840.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PPM1G gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PPM1G cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu27573
NM_177983 Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent, 1G (PPM1G), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu27573
Clone ID Related Accession (Same CDS sequence) NM_177983
Accession Version NM_177983.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1641bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product protein phosphatase 1G
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA520893.1 and BC000057.2. On May 10, 2012 this sequence version replaced gi:29826281. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000057.2, Y13936.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGGGTGCCT ACCTCTCCCA GCCCAACACG GTGAAGTGCT CCGGGGACGG GGTCGGCGCC 
CCGCGCCTGC CGCTGCCCTA CGGCTTCTCC GCCATGCAAG GCTGGCGCGT CTCCATGGAG
GATGCTCACA ACTGTATTCC TGAGCTGGAC AGTGAGACAG CCATGTTTTC TGTCTACGAT
GGACATGGAG GGGAGGAAGT TGCCTTGTAC TGTGCCAAAT ATCTTCCTGA TATCATCAAA
GATCAGAAGG CCTACAAGGA AGGCAAGCTA CAGAAGGCTT TAGAAGATGC CTTCTTGGCT
ATTGACGCCA AATTGACCAC TGAAGAAGTC ATTAAAGAGC TGGCACAGAT TGCAGGGCGA
CCCACTGAGG ATGAAGATGA AAAAGAAAAA GTAGCTGATG AAGATGATGT GGACAATGAG
GAGGCTGCAC TGCTGCATGA AGAGGCTACC ATGACTATTG AAGAGCTGCT GACACGCTAC
GGGCAGAACT GTCACAAGGG CCCTCCCCAC AGCAAATCTG GAGGTGGGAC AGGCGAGGAA
CCAGGGTCCC AGGGCCTCAA TGGGGAGGCA GGACCTGAGG ACTCAACTAG GGAAACTCCT
TCACAAGAAA ATGGCCCCAC AGCCAAGGCC TACACAGGCT TTTCCTCCAA CTCGGAACGT
GGGACTGAGG CAGGCCAAGT TGGTGAGCCT GGCATTCCCA CTGGTGAGGC TGGGCCTTCC
TGCTCTTCAG CCTCTGACAA GCTGCCTCGA GTTGCTAAGT CCAAGTTCTT TGAGGACAGT
GAGGATGAGT CAGATGAGGC GGAGGAAGAA GAGGAAGACA GTGAGGAATG CAGCGAGGAA
GAGGATGGCT ACAGCAGTGA GGAGGCAGAG AATGAGGAAG ATGAGGATGA CACCGAGGAG
GCTGAAGAGG ACGATGAAGA AGAAGAAGAA GAGATGATGG TGCCAGGGAT GGAAGGCAAA
GAGGAGCCTG GCTCTGACAG TGGTACAACA GCGGTGGTGG CCCTGATACG AGGGAAGCAG
TTGATTGTAG CCAACGCAGG AGACTCTCGC TGTGTGGTAT CTGAGGCTGG CAAAGCTTTA
GACATGTCCT ATGATCACAA ACCAGAGGAT GAAGTAGAAC TAGCACGCAT CAAGAATGCT
GGTGGCAAGG TCACCATGGA TGGGCGAGTC AACGGGGGCC TCAACCTCTC CAGAGCCATT
GGGGACCACT TCTATAAGAG AAACAAGAAC CTGCCACCTG AGGAACAGAT GATTTCAGCC
CTTCCTGACA TCAAGGTGCT GACTCTCACT GACGACCATG AATTCATGGT CATTGCCTGT
GATGGCATCT GGAATGTGAT GAGCAGCCAG GAAGTTGTAG ATTTCATTCA ATCAAAGATC
AGCCAGCGTG ATGAAAATGG GGAGCTTCGG TTATTGTCAT CCATTGTGGA AGAGCTGCTG
GATCAGTGCC TGGCACCAGA CACTTCTGGG GATGGTACAG GGTGTGACAA CATGACCTGC
ATCATCATTT GCTTCAAGCC CCGAAACACA GCAGAGCTCC AGCCAGAGAG TGGCAAGCGA
AAACTAGAGG AGGTGCTCTC TACTGAGGGG GCTGAAGAAA ATGGCAACAG CGACAAGAAG
AAGAAGGCCA AGCGAGACTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_817092.1
CDS262..1902
Misc Feature(1)238..240(+)
Misc Feature(2)340..>618(+)
Misc Feature(3)367..447(+)
Misc Feature(4)808..810(+)
Misc Feature(5)808..810(+)
Misc Feature(6)1231..1776(+)
Misc Feature(7)1408..1410(+)
Misc Feature(8)1840..1842(+)
Exon (1)1..381
Gene:PPM1G
Gene Synonym:
Exon (2)382..451
Gene:PPM1G
Gene Synonym:
Exon (3)452..537
Gene:PPM1G
Gene Synonym:
Exon (4)538..670
Gene:PPM1G
Gene Synonym:
Exon (5)671..1086
Gene:PPM1G
Gene Synonym:
Exon (6)1087..1227
Gene:PPM1G
Gene Synonym:
Exon (7)1228..1462
Gene:PPM1G
Gene Synonym:
Exon (8)1463..1592
Gene:PPM1G
Gene Synonym:
Exon (9)1593..1695
Gene:PPM1G
Gene Synonym:
Exon (10)1696..2302
Gene:PPM1G
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_177983
Organism Homo sapiens (human)
Definition Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent, 1G (PPM1G), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_177983

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGGGTGCCT ACCTCTCCCA GCCCAACACG GTGAAGTGCT CCGGGGACGG GGTCGGCGCC 
CCGCGCCTGC CGCTGCCCTA CGGCTTCTCC GCCATGCAAG GCTGGCGCGT CTCCATGGAG
GATGCTCACA ACTGTATTCC TGAGCTGGAC AGTGAGACAG CCATGTTTTC TGTCTACGAT
GGACATGGAG GGGAGGAAGT TGCCTTGTAC TGTGCCAAAT ATCTTCCTGA TATCATCAAA
GATCAGAAGG CCTACAAGGA AGGCAAGCTA CAGAAGGCTT TAGAAGATGC CTTCTTGGCT
ATTGACGCCA AATTGACCAC TGAAGAAGTC ATTAAAGAGC TGGCACAGAT TGCAGGGCGA
CCCACTGAGG ATGAAGATGA AAAAGAAAAA GTAGCTGATG AAGATGATGT GGACAATGAG
GAGGCTGCAC TGCTGCATGA AGAGGCTACC ATGACTATTG AAGAGCTGCT GACACGCTAC
GGGCAGAACT GTCACAAGGG CCCTCCCCAC AGCAAATCTG GAGGTGGGAC AGGCGAGGAA
CCAGGGTCCC AGGGCCTCAA TGGGGAGGCA GGACCTGAGG ACTCAACTAG GGAAACTCCT
TCACAAGAAA ATGGCCCCAC AGCCAAGGCC TACACAGGCT TTTCCTCCAA CTCGGAACGT
GGGACTGAGG CAGGCCAAGT TGGTGAGCCT GGCATTCCCA CTGGTGAGGC TGGGCCTTCC
TGCTCTTCAG CCTCTGACAA GCTGCCTCGA GTTGCTAAGT CCAAGTTCTT TGAGGACAGT
GAGGATGAGT CAGATGAGGC GGAGGAAGAA GAGGAAGACA GTGAGGAATG CAGCGAGGAA
GAGGATGGCT ACAGCAGTGA GGAGGCAGAG AATGAGGAAG ATGAGGATGA CACCGAGGAG
GCTGAAGAGG ACGATGAAGA AGAAGAAGAA GAGATGATGG TGCCAGGGAT GGAAGGCAAA
GAGGAGCCTG GCTCTGACAG TGGTACAACA GCGGTGGTGG CCCTGATACG AGGGAAGCAG
TTGATTGTAG CCAACGCAGG AGACTCTCGC TGTGTGGTAT CTGAGGCTGG CAAAGCTTTA
GACATGTCCT ATGATCACAA ACCAGAGGAT GAAGTAGAAC TAGCACGCAT CAAGAATGCT
GGTGGCAAGG TCACCATGGA TGGGCGAGTC AACGGGGGCC TCAACCTCTC CAGAGCCATT
GGGGACCACT TCTATAAGAG AAACAAGAAC CTGCCACCTG AGGAACAGAT GATTTCAGCC
CTTCCTGACA TCAAGGTGCT GACTCTCACT GACGACCATG AATTCATGGT CATTGCCTGT
GATGGCATCT GGAATGTGAT GAGCAGCCAG GAAGTTGTAG ATTTCATTCA ATCAAAGATC
AGCCAGCGTG ATGAAAATGG GGAGCTTCGG TTATTGTCAT CCATTGTGGA AGAGCTGCTG
GATCAGTGCC TGGCACCAGA CACTTCTGGG GATGGTACAG GGTGTGACAA CATGACCTGC
ATCATCATTT GCTTCAAGCC CCGAAACACA GCAGAGCTCC AGCCAGAGAG TGGCAAGCGA
AAACTAGAGG AGGTGCTCTC TACTGAGGGG GCTGAAGAAA ATGGCAACAG CGACAAGAAG
AAGAAGGCCA AGCGAGACTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Protein phosphatase PPM1G regulates protein translation and cell growth by dephosphorylating 4E binding protein 1 (4E-BP1)
J. Biol. Chem. 288 (32), 23225-23233 (2013)
Liu J, Stevens PD, Eshleman NE and Gao T.


book

Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci
J. Med. Genet. 50 (5), 298-308 (2013)
Weissglas-Volkov D, Aguilar-Salinas CA, Nikkola E, Deere KA, Cruz-Bautista I, Arellano-Campos O, Munoz-Hernandez LL, Gomez-Munguia L, Ordonez-Sanchez ML, Reddy PM, Lusis AJ, Matikainen N, Taskinen MR, Riba L, Cantor RM, Sinsheimer JS, Tusie-Luna T and Pajukanta P.


book

ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage
Mol. Cell 45 (6), 801-813 (2012)
Khoronenkova SV, Dianova II, Ternette N, Kessler BM, Parsons JL and Dianov GL.


book

Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts
Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (6), 1179-1188 (2010)
Dick DM, Meyers J, Aliev F, Nurnberger J Jr, Kramer J, Kuperman S, Porjesz B, Tischfield J, Edenberg HJ, Foroud T, Schuckit M, Goate A, Hesselbrock V and Bierut L.


book

Protein phosphatase 2Cgamma regulates the level of p21Cip1/WAF1 by Akt signaling
Biochem. Biophys. Res. Commun. 386 (3), 467-470 (2009)
Suh EJ, Kim YJ and Kim SH.


book

PP2Cgamma-mediated S-phase accumulation induced by the proteasome-dependent degradation of p21(WAF1/CIP1)
FEBS Lett. 580 (26), 6100-6104 (2006)
Suh EJ, Kim TY and Kim SH.


book

Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3
Proc. Natl. Acad. Sci. U.S.A. 100 (26), 16006-16011 (2003)
Flajolet M, Rakhilin S, Wang H, Starkova N, Nuangchamnong N, Nairn AC and Greengard P.


book

The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factor
Genes Dev. 13 (1), 87-97 (1999)
Murray MV, Kobayashi R and Krainer AR.


book

FIN13, a novel growth factor-inducible serine-threonine phosphatase which can inhibit cell cycle progression
Mol. Cell. Biol. 17 (9), 5485-5498 (1997)
Guthridge MA, Bellosta P, Tavoloni N and Basilico C.


book

PP2C gamma: a human protein phosphatase with a unique acidic domain
FEBS Lett. 412 (3), 415-419 (1997)
Travis SM and Welsh MJ.


 
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