NSMCE3 cDNA ORF clone, Homo sapiens(human)
Gene Symbol | NSMCE3 |
Entrez Gene ID | 56160 |
Full Name | NSE3 homolog, SMC5-SMC6 complex component |
Synonyms | HCA4,LICS,MAGEG1,MAGEL3,NDNL2,NSE3 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superfamily. This is an intronless gene. [provided by RefSeq, May 2011]. COMPLETENESS: complete on the 3' end. |
Disorder MIM: | |
Disorder Html: | Lung disease, immunodeficiency, and chromosome breakage syndrome, 617241 (3) |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
NM_138704.3 | NP_619649.1 | non-structural maintenance of chromosomes element 3 homolog |
NM_138704.4 | NP_619649.1 | non-structural maintenance of chromosomes element 3 homolog |

Homo sapiens (human) | NDNL2 | NP_619649.1 |
Pan troglodytes (chimpanzee) | NDNL2 | XP_001163393.1 |
Bos taurus (cattle) | NDNL2 | NP_001071548.1 |
Rattus norvegicus (Norway rat) | Ndnl2 | NP_001166998.1 |
Xenopus tropicalis (tropical clawed frog) | ndnl2 | NP_001016930.1 |
NDNL2 | XP_001109764.1 | |
Canis lupus familiaris (dog) | NDNL2 | XP_005618335.1 |
Gallus gallus (chicken) | NDNL2 | NP_001098534.1 |
Mus musculus (house mouse) | Ndnl2 | NP_075728.1 |

Related articles in PubMed
Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)
Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease.
van der Crabben SN, Hennus MP, McGregor GA, Ritter DI, Nagamani SC, Wells OS, Harakalova M, Chinn IK, Alt A, Vondrova L, Hochstenbach R, van Montfrans JM, Terheggen-Lagro SW, van Lieshout S, van Roosmalen MJ, Renkens I, Duran K, Nijman IJ, Kloosterman WP, Hennekam E, Orange JS, van Hasselt PM, Wheeler DA, Palecek JJ, Lehmann AR, Oliver AW, Pearl LH, Plon SE, Murray JM, van Haaften G
The Journal of clinical investigation126(8)2881-92(2016 Aug)
Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID Families.
Hudson JJ, Bednarova K, Kozakova L, Liao C, Guerineau M, Colnaghi R, Vidot S, Marek J, Bathula SR, Lehmann AR, Palecek J
PloS one6(2)e17270(2011 Feb)
MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.
Doyle JM, Gao J, Wang J, Yang M, Potts PR
Molecular cell39(6)963-74(2010 Sep)
Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex.
Taylor EM, Copsey AC, Hudson JJ, Vidot S, Lehmann AR
Molecular and cellular biology28(4)1197-206(2008 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
NSMCE3 (also known as NDNL2) gene encodes a subunit of the SMC5/6 complex that is essential for DNA damage response and chromosome segregation
Title: Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease.
The four non-SMC components of the human complex were identified and characterized and it was demonstrated that the MAGEG1 protein is part of this complex.
Title: Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex.
gene expression, imprinting, and chromosome mapping of NDNL2
Title: A necdin/MAGE-like gene in the chromosome 15 autism susceptibility region: expression, imprinting, and mapping of the human and mouse orthologues.
The following NSMCE3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NSMCE3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OHu55633![]() |
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Clone ID Related Accession (Same CDS sequence) | NM_138704.3 , NM_138704.4 | |
Accession Version | NM_138704.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP |
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Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-22 | |
Organism | Homo sapiens(human) | |
Product | non-structural maintenance of chromosomes element 3 homolog | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU310582.1 and BC053999.1. This sequence is a reference standard in the RefSeqGene project. On May 4, 2011 this sequence version replaced NM_138704.2. COMPLETENESS: complete on the 3' end. |
1 | ATGTTGCAAA AACCGAGGAA CCGGGGCCGC TCTGGCGGCC AGGCCGAGAG GGACAGAGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_619649.1 |
CDS | 112..1026 |
Translation |

Target ORF information:
Target ORF information:
|
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ORF Insert Sequence:
1 | ATGTTGCAAA AACCGAGGAA CCGGGGCCGC TCTGGCGGCC AGGCCGAGAG GGACAGAGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu55633![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_138704.3 , NM_138704.4 | |
Accession Version | NM_138704.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-31 | |
Organism | Homo sapiens(human) | |
Product | non-structural maintenance of chromosomes element 3 homolog | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC061965.16, AU310582.1 and BC053999.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_138704.3. ##Evidence-Data-START## Transcript is intronless :: SRR1660805.354412.1, DRR138512.517665.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000332303.6/ ENSP00000330694.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTTGCAAA AACCGAGGAA CCGGGGCCGC TCTGGCGGCC AGGCCGAGAG GGACAGAGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_619649.1 |
CDS | 118..1032 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGTTGCAAA AACCGAGGAA CCGGGGCCGC TCTGGCGGCC AGGCCGAGAG GGACAGAGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
Architecture of the human interactome defines protein communities and disease networks. |
![]() |
Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease. |
![]() |
Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID Families. |
![]() |
MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. |
![]() |
Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. |