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PINK1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol PINK1
Entrez Gene ID 65018
Full Name PTEN induced putative kinase 1
Synonyms BRPK, PARK6
General protein information
Preferred Names
serine/threonine-protein kinase PINK1, mitochondrial
Names
serine/threonine-protein kinase PINK1, mitochondrial
protein kinase BRPK
PTEN-induced putative kinase protein 1
NP_115785.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p36

Summary This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

608309

Disorder Html: Parkinson disease 6, early onset, 605909 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_032409 NP_115785 serine/threonine-protein kinase PINK1, mitochondrial precursor



Homo sapiens (human) PINK1 NP_115785.1
Pan troglodytes (chimpanzee) PINK1 XP_001164912.2
Macaca mulatta (Rhesus monkey) LOC698013 XP_001086306.1
Macaca mulatta (Rhesus monkey) PINK1 XP_001096957.1
Canis lupus familiaris (dog) PINK1 XP_005617989.1
Bos taurus (cattle) PINK1 NP_001093171.1
Mus musculus (house mouse) Pink1 NP_081156.2
Rattus norvegicus (Norway rat) Pink1 NP_001100164.1
Gallus gallus (chicken) PINK1 XP_423139.3
Danio rerio (zebrafish) pink1 NP_001008628.1
Caenorhabditis elegans pink-1 NP_495017.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PINK1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PINK1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu25380 NM_032409 Homo sapiens PTEN induced putative kinase 1 (PINK1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $307.30
$439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu25380
Clone ID Related Accession (Same CDS sequence) NM_032409
Accession Version NM_032409.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1746bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product serine/threonine-protein kinase PINK1, mitochondrial precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB053323.1 and AL391357.20. This sequence is a reference standard in the RefSeqGene project. On Aug 16, 2006 this sequence version replaced gi:14165271. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: AB053323.1, AF316873.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGGCGGTGC GACAGGCGCT GGGCCGCGGC CTGCAGCTGG GTCGAGCGCT GCTGCTGCGC 
TTCACGGGCA AGCCCGGCCG GGCCTACGGC TTGGGGCGGC CGGGCCCGGC GGCGGGCTGT
GTCCGCGGGG AGCGTCCAGG CTGGGCCGCA GGACCGGGCG CGGAGCCTCG CAGGGTCGGG
CTCGGGCTCC CTAACCGTCT CCGCTTCTTC CGCCAGTCGG TGGCCGGGCT GGCGGCGCGG
TTGCAGCGGC AGTTCGTGGT GCGGGCCTGG GGCTGCGCGG GCCCTTGCGG CCGGGCAGTC
TTTCTGGCCT TCGGGCTAGG GCTGGGCCTC ATCGAGGAAA AACAGGCGGA GAGCCGGCGG
GCGGTCTCGG CCTGTCAGGA GATCCAGGCA ATTTTTACCC AGAAAAGCAA GCCGGGGCCT
GACCCGTTGG ACACGAGACG CTTGCAGGGC TTTCGGCTGG AGGAGTATCT GATAGGGCAG
TCCATTGGTA AGGGCTGCAG TGCTGCTGTG TATGAAGCCA CCATGCCTAC ATTGCCCCAG
AACCTGGAGG TGACAAAGAG CACCGGGTTG CTTCCAGGGA GAGGCCCAGG TACCAGTGCA
CCAGGAGAAG GGCAGGAGCG AGCTCCGGGG GCCCCTGCCT TCCCCTTGGC CATCAAGATG
ATGTGGAACA TCTCGGCAGG TTCCTCCAGC GAAGCCATCT TGAACACAAT GAGCCAGGAG
CTGGTCCCAG CGAGCCGAGT GGCCTTGGCT GGGGAGTATG GAGCAGTCAC TTACAGAAAA
TCCAAGAGAG GTCCCAAGCA ACTAGCCCCT CACCCCAACA TCATCCGGGT TCTCCGCGCC
TTCACCTCTT CCGTGCCGCT GCTGCCAGGG GCCCTGGTCG ACTACCCTGA TGTGCTGCCC
TCACGCCTCC ACCCTGAAGG CCTGGGCCAT GGCCGGACGC TGTTCCTCGT TATGAAGAAC
TATCCCTGTA CCCTGCGCCA GTACCTTTGT GTGAACACAC CCAGCCCCCG CCTCGCCGCC
ATGATGCTGC TGCAGCTGCT GGAAGGCGTG GACCATCTGG TTCAACAGGG CATCGCGCAC
AGAGACCTGA AATCCGACAA CATCCTTGTG GAGCTGGACC CAGACGGCTG CCCCTGGCTG
GTGATCGCAG ATTTTGGCTG CTGCCTGGCT GATGAGAGCA TCGGCCTGCA GTTGCCCTTC
AGCAGCTGGT ACGTGGATCG GGGCGGAAAC GGCTGTCTGA TGGCCCCAGA GGTGTCCACG
GCCCGTCCTG GCCCCAGGGC AGTGATTGAC TACAGCAAGG CTGATGCCTG GGCAGTGGGA
GCCATCGCCT ATGAAATCTT CGGGCTTGTC AATCCCTTCT ACGGCCAGGG CAAGGCCCAC
CTTGAAAGCC GCAGCTACCA AGAGGCTCAG CTACCTGCAC TGCCCGAGTC AGTGCCTCCA
GACGTGAGAC AGTTGGTGAG GGCACTGCTC CAGCGAGAGG CCAGCAAGAG ACCATCTGCC
CGAGTAGCCG CAAATGTGCT TCATCTAAGC CTCTGGGGTG AACATATTCT AGCCCTGAAG
AATCTGAAGT TAGACAAGAT GGTTGGCTGG CTCCTCCAAC AATCGGCCGC CACTTTGTTG
GCCAACAGGC TCACAGAGAA GTGTTGTGTG GAAACAAAAA TGAAGATGCT CTTTCTGGCT
AACCTGGAGT GTGAAACGCT CTGCCAGGCA GCCCTCCTCC TCTGCTCATG GAGGGCAGCC
CTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_115785.1
CDS95..1840
Misc Feature(1)374..424(+)
Misc Feature(2)578..1630(+)
Misc Feature(3)578..1330(+)
Misc Feature(4)578..1246(+)
Misc Feature(5)590..1330(+)
Misc Feature(6)776..778(+)
Misc Feature(7)1241..1330(+)
Misc Feature(8)1298..1300(+)
Exon (1)1..481
Gene:PINK1
Gene Synonym:
Exon (2)482..769
Gene:PINK1
Gene Synonym:
Exon (3)770..870
Gene:PINK1
Gene Synonym:
Exon (4)871..1053
Gene:PINK1
Gene Synonym:
Exon (5)1054..1217
Gene:PINK1
Gene Synonym:
Exon (6)1218..1345
Gene:PINK1
Gene Synonym:
Exon (7)1346..1582
Gene:PINK1
Gene Synonym:
Exon (8)1583..2660
Gene:PINK1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_032409
Organism Homo sapiens (human)
Definition Homo sapiens PTEN induced putative kinase 1 (PINK1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_032409

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGGCGGTGC GACAGGCGCT GGGCCGCGGC CTGCAGCTGG GTCGAGCGCT GCTGCTGCGC 
TTCACGGGCA AGCCCGGCCG GGCCTACGGC TTGGGGCGGC CGGGCCCGGC GGCGGGCTGT
GTCCGCGGGG AGCGTCCAGG CTGGGCCGCA GGACCGGGCG CGGAGCCTCG CAGGGTCGGG
CTCGGGCTCC CTAACCGTCT CCGCTTCTTC CGCCAGTCGG TGGCCGGGCT GGCGGCGCGG
TTGCAGCGGC AGTTCGTGGT GCGGGCCTGG GGCTGCGCGG GCCCTTGCGG CCGGGCAGTC
TTTCTGGCCT TCGGGCTAGG GCTGGGCCTC ATCGAGGAAA AACAGGCGGA GAGCCGGCGG
GCGGTCTCGG CCTGTCAGGA GATCCAGGCA ATTTTTACCC AGAAAAGCAA GCCGGGGCCT
GACCCGTTGG ACACGAGACG CTTGCAGGGC TTTCGGCTGG AGGAGTATCT GATAGGGCAG
TCCATTGGTA AGGGCTGCAG TGCTGCTGTG TATGAAGCCA CCATGCCTAC ATTGCCCCAG
AACCTGGAGG TGACAAAGAG CACCGGGTTG CTTCCAGGGA GAGGCCCAGG TACCAGTGCA
CCAGGAGAAG GGCAGGAGCG AGCTCCGGGG GCCCCTGCCT TCCCCTTGGC CATCAAGATG
ATGTGGAACA TCTCGGCAGG TTCCTCCAGC GAAGCCATCT TGAACACAAT GAGCCAGGAG
CTGGTCCCAG CGAGCCGAGT GGCCTTGGCT GGGGAGTATG GAGCAGTCAC TTACAGAAAA
TCCAAGAGAG GTCCCAAGCA ACTAGCCCCT CACCCCAACA TCATCCGGGT TCTCCGCGCC
TTCACCTCTT CCGTGCCGCT GCTGCCAGGG GCCCTGGTCG ACTACCCTGA TGTGCTGCCC
TCACGCCTCC ACCCTGAAGG CCTGGGCCAT GGCCGGACGC TGTTCCTCGT TATGAAGAAC
TATCCCTGTA CCCTGCGCCA GTACCTTTGT GTGAACACAC CCAGCCCCCG CCTCGCCGCC
ATGATGCTGC TGCAGCTGCT GGAAGGCGTG GACCATCTGG TTCAACAGGG CATCGCGCAC
AGAGACCTGA AATCCGACAA CATCCTTGTG GAGCTGGACC CAGACGGCTG CCCCTGGCTG
GTGATCGCAG ATTTTGGCTG CTGCCTGGCT GATGAGAGCA TCGGCCTGCA GTTGCCCTTC
AGCAGCTGGT ACGTGGATCG GGGCGGAAAC GGCTGTCTGA TGGCCCCAGA GGTGTCCACG
GCCCGTCCTG GCCCCAGGGC AGTGATTGAC TACAGCAAGG CTGATGCCTG GGCAGTGGGA
GCCATCGCCT ATGAAATCTT CGGGCTTGTC AATCCCTTCT ACGGCCAGGG CAAGGCCCAC
CTTGAAAGCC GCAGCTACCA AGAGGCTCAG CTACCTGCAC TGCCCGAGTC AGTGCCTCCA
GACGTGAGAC AGTTGGTGAG GGCACTGCTC CAGCGAGAGG CCAGCAAGAG ACCATCTGCC
CGAGTAGCCG CAAATGTGCT TCATCTAAGC CTCTGGGGTG AACATATTCT AGCCCTGAAG
AATCTGAAGT TAGACAAGAT GGTTGGCTGG CTCCTCCAAC AATCGGCCGC CACTTTGTTG
GCCAACAGGC TCACAGAGAA GTGTTGTGTG GAAACAAAAA TGAAGATGCT CTTTCTGGCT
AACCTGGAGT GTGAAACGCT CTGCCAGGCA GCCCTCCTCC TCTGCTCATG GAGGGCAGCC
CTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through protein kinase A
J. Neurochem. 128 (6), 864-877 (2014)
Dagda RK, Pien I, Wang R, Zhu J, Wang KZ, Callio J, Banerjee TD, Dagda RY and Chu CT.


book

Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control
EMBO J. 33 (4), 282-295 (2014)
McLelland GL, Soubannier V, Chen CX, McBride HM and Fon EA.


book

A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment
J. Biol. Chem. 288 (51), 36372-36384 (2013)
Okatsu K, Uno M, Koyano F, Go E, Kimura M, Oka T, Tanaka K and Matsuda N.


book

The BAG2 protein stabilises PINK1 by decreasing its ubiquitination
Biochem. Biophys. Res. Commun. 441 (2), 488-492 (2013)
Che,X., Tang,B., Wang,X., Chen,D., Yan,X., Jiang,H., Shen,L., Xu,Q., Wang,G. and Guo,J.


book

Clinical and subclinical dopaminergic dysfunction in PARK6-linked parkinsonism: an 18F-dopa PET study
Ann. Neurol. 52 (6), 849-853 (2002)
Khan NL, Valente EM, Bentivoglio AR, Wood NW, Albanese A, Brooks DJ and Piccini P.


book

Autosomal recessive early onset parkinsonism is linked to three loci: PARK2, PARK6, and PARK7
Neurol. Sci. 23 (SUPPL 2), S59-S60 (2002)
Bonifati V, Dekker MC, Vanacore N, Fabbrini G, Squitieri F, Marconi R, Antonini A, Brustenghi P, Dalla Libera A, De Mari M, Stocchi F, Montagna P, Gallai V, Rizzu P, van Swieten JC, Oostra B, van Duijn CM, Meco G and Heutink P.


book

Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway
Oncogene 20 (33), 4457-4465 (2001)
Unoki M and Nakamura Y.


book

Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36
Am. J. Hum. Genet. 68 (4), 895-900 (2001)
Valente EM, Bentivoglio AR, Dixon PH, Ferraris A, Ialongo T, Frontali M, Albanese A and Wood NW.


book

PINK1 Type of Young-Onset Parkinson Disease
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Schneider,S.A. and Klein,C.


book

Parkinson Disease Overview
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Farlow,J., Pankratz,N.D., Wojcieszek,J. and Foroud,T.


 
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