BPI cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BPI
Entrez Gene ID	671
Full Name	bactericidal/permeability-increasing protein
Synonyms	BPIFD1,rBPI
General protein information	Preferred Names bactericidal/permeability-increasing protein Names bactericidal permeability-increasing protein BPI fold containing family D, member 1 CAP 57 recombinant BPI holoprotein, rBPI
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q11.23
Summary	This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014].
Disorder MIM:	109195

mRNA and Protein(s)

mRNA	Protein	Name
NM_001725.2	NP_001716.2	bactericidal permeability-increasing protein precursor
XM_024451972.1	XP_024307740.1	bactericidal permeability-increasing protein isoform X1
NM_001725.3	NP_001716.3	bactericidal permeability-increasing protein precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	BPI	XP_534417.2
Danio rerio (zebrafish)	bpifcl	XP_001342762.2
Gallus gallus (chicken)	BPI	XP_417465.4
Rattus norvegicus (Norway rat)	Bpi	NP_001004079.1
Homo sapiens (human)	BPI	NP_001716.2
Pan troglodytes (chimpanzee)	BPI	XP_514637.4
	LOC706221	XP_001094576.1
Mus musculus (house mouse)	Bpi	NP_808518.1
Bos taurus (cattle)	BPI	NP_776320.1

Gene Ontology
Bibliography

Related articles in PubMed

Bactericidal/permeability increasing protein gene polymorphism and inflammatory bowel diseases: meta-analysis of five case-control studies.
Fan L, Fu G, Ding Y, Lv P, Li H
International journal of colorectal disease32(3)433-435(2017 Mar)

Bactericidal permeability increasing protein gene polymorphism is associated with inflammatory bowel diseases in the Turkish population.
Can G, Ak?n H, ?zdemir FT, Can H, Y?lmaz B, Eren F, Atu? ?, ?nsal B, Hamzao?lu HO
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association21(4)239-44(2015 Jul-Aug)

[Comparative analysis of the role of CD4(+) and CD8(+) T cells in severe asthma development].
Wang X, Wang J, Xing CY, Zang R, Pu YY, Yin ZX
Molekuliarnaia biologiia49(3)482-90(2015 May-Jun)

Decreased pattern recognition receptor signaling, interferon-signature, and bactericidal/permeability-increasing protein gene expression in cord blood of term low birth weight human newborns.
Singh VV, Chauhan SK, Rai R, Kumar A, Singh SM, Rai G
PloS one8(4)e62845(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

BPI G645A polymorphism was associated with a decreased risk of ulcerative colitis; the BPI G645A polymorphism was not associated with the risk of crohn's disease.
Title: Bactericidal/permeability increasing protein gene polymorphism and inflammatory bowel diseases: meta-analysis of five case-control studies.

Bactericidal permeability increasing protein Lys216Glu polymorphism is associated with both Crohn's disease and ulcerative colitis.
Title: Bactericidal permeability increasing protein gene polymorphism is associated with inflammatory bowel diseases in the Turkish population.

MPO and BPI in CD4(+)T-lymphocytes, and PDHA1 and MRPL42 in CD8(+) T-lymphocytes might be used as specific biomarkers of severe asthma progression.
Title: [Comparative analysis of the role of CD4(+) and CD8(+) T cells in severe asthma development].

Diminished PRRs, IFN-signature, and BPI gene expression raises the possibility that impairments in these pathways contribute to the susceptibility of LBW term infants to infection.
Title: Decreased pattern recognition receptor signaling, interferon-signature, and bactericidal/permeability-increasing protein gene expression in cord blood of term low birth weight human newborns.

Lung function and IgA-BPI-ANCA, but not Leeds criteria, were significantly associated with adverse outcome.
Title: BPI-ANCA and long-term prognosis among 46 adult CF patients: a prospective 10-year follow-up study.

The following BPI gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BPI cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03681	NM_001725.2 Latest version!	Homo sapiens bactericidal permeability increasing protein (BPI), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu108872	NM_001725.3 Latest version!	Homo sapiens bactericidal permeability increasing protein (BPI), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu105155	XM_024451972.1 Latest version!	Homo sapiens bactericidal permeability increasing protein (BPI), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BPI ( NM_001725.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001716.2 Homo sapiens bactericidal permeability increasing protein (BPI), mRNA.

Price & Availability↑

CloneID	OHu03681
Clone ID Related Accession (Same CDS sequence)	NM_001725.2
Accession Version	NM_001725.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1464bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	bactericidal permeability-increasing protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP306215.1, AF322588.1, DQ414688.1, AI436120.1 and BC032230.1. This sequence is a reference standard in the RefSeqGene project. On Sep 14, 2007 this sequence version replaced NM_001725.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC040955.1, AK315328.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2146236 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 17678885 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGAGAGA ACATGGCCAG GGGCCCTTGC AACGCGCCGA GATGGGCGTC CCTGATGGTG 
CTGGTCGCCA TAGGCACCGC CGTGACAGCG GCCGTCAACC CTGGCGTCGT GGTCAGGATC 
TCCCAGAAGG GCCTGGACTA CGCCAGCCAG CAGGGGACGG CCGCTCTGCA GAAGGAGCTG 
AAGAGGATCA AGATTCCTGA CTACTCAGAC AGCTTTAAGA TCAAGCATCT TGGGAAGGGG 
CATTATAGCT TCTACAGCAT GGACATCCGT GAATTCCAGC TTCCCAGTTC CCAGATAAGC 
ATGGTGCCCA ATGTGGGCCT TAAGTTCTCC ATCAGCAACG CCAATATCAA GATCAGCGGG 
AAATGGAAGG CACAAAAGAG ATTCTTAAAA ATGAGCGGCA ATTTTGACCT GAGCATAGAA 
GGCATGTCCA TTTCGGCTGA TCTGAAGCTG GGCAGTAACC CCACGTCAGG CAAGCCCACC 
ATCACCTGCT CCAGCTGCAG CAGCCACATC AACAGTGTCC ACGTGCACAT CTCAAAGAGC 
AAAGTGGGGT GGCTGATCCA ACTCTTCCAC AAAAAAATTG AGTCTGCGCT TCGAAACAAG 
ATGAACAGCC AGGTCTGCGA GAAAGTGACC AATTCTGTAT CCTCCGAGCT GCAACCTTAT 
TTCCAGACTC TGCCAGTAAT GACCAAAATA GATTCTGTGG CTGGAATCAA CTATGGTCTG 
GTGGCACCTC CAGCAACCAC GGCTGAGACC CTGGATGTAC AGATGAAGGG GGAGTTTTAC 
AGTGAGAACC ACCACAATCC ACCTCCCTTT GCTCCACCAG TGATGGAGTT TCCCGCTGCC 
CATGACCGCA TGGTATACCT GGGCCTCTCA GACTACTTCT TCAACACAGC CGGGCTTGTA 
TACCAAGAGG CTGGGGTCTT GAAGATGACC CTTAGAGATG ACATGATTCC AAAGGAGTCC 
AAATTTCGAC TGACAACCAA GTTCTTTGGA ACCTTCCTAC CTGAGGTGGC CAAGAAGTTT 
CCCAACATGA AGATACAGAT CCATGTCTCA GCCTCCACCC CGCCACACCT GTCTGTGCAG 
CCCACCGGCC TTACCTTCTA CCCTGCCGTG GATGTCCAGG CCTTTGCCGT CCTCCCCAAC 
TCCTCCCTGG CTTCCCTCTT CCTGATTGGC ATGCACACAA CTGGTTCCAT GGAGGTCAGC 
GCCGAGTCCA ACAGGCTTGT TGGAGAGCTC AAGCTGGATA GGCTGCTCCT GGAACTGAAG 
CACTCAAATA TTGGCCCCTT CCCGGTTGAA TTGCTGCAGG ATATCATGAA CTACATTGTA 
CCCATTCTTG TGCTGCCCAG GGTTAACGAG AAACTACAGA AAGGCTTCCC TCTCCCGACG 
CCGGCCAGAG TCCAGCTCTA CAACGTAGTG CTTCAGCCTC ACCAGAACTT CCTGCTGTTC 
GGTGCAGACG TTGTCTATAA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001716.2
CDS	63..1526
Translation	MRENMARGPCNAPRWASLMVLVAIGTAVTAAVNPGVVVRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGHYSFYSMDIREFQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLKLGSNPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKVTNSVSSELQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPPFAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFFGTFLPEVAKKFPNMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSSLASLFLIGMHTTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRVNEKLQKGFPLPTPARVQLYNVVLQPHQNFLLFGADVVYK

Target ORF information:

RefSeq Version	NM_001725.2
Organism	Homo sapiens(human)
Definition	Homo sapiens bactericidal permeability increasing protein (BPI), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001725.2

ORF Insert Sequence:

ATGAGAGAGA ACATGGCCAG GGGCCCTTGC AACGCGCCGA GATGGGCGTC CCTGATGGTG 
CTGGTCGCCA TAGGCACCGC CGTGACAGCG GCCGTCAACC CTGGCGTCGT GGTCAGGATC 
TCCCAGAAGG GCCTGGACTA CGCCAGCCAG CAGGGGACGG CCGCTCTGCA GAAGGAGCTG 
AAGAGGATCA AGATTCCTGA CTACTCAGAC AGCTTTAAGA TCAAGCATCT TGGGAAGGGG 
CATTATAGCT TCTACAGCAT GGACATCCGT GAATTCCAGC TTCCCAGTTC CCAGATAAGC 
ATGGTGCCCA ATGTGGGCCT TAAGTTCTCC ATCAGCAACG CCAATATCAA GATCAGCGGG 
AAATGGAAGG CACAAAAGAG ATTCTTAAAA ATGAGCGGCA ATTTTGACCT GAGCATAGAA 
GGCATGTCCA TTTCGGCTGA TCTGAAGCTG GGCAGTAACC CCACGTCAGG CAAGCCCACC 
ATCACCTGCT CCAGCTGCAG CAGCCACATC AACAGTGTCC ACGTGCACAT CTCAAAGAGC 
AAAGTGGGGT GGCTGATCCA ACTCTTCCAC AAAAAAATTG AGTCTGCGCT TCGAAACAAG 
ATGAACAGCC AGGTCTGCGA GAAAGTGACC AATTCTGTAT CCTCCGAGCT GCAACCTTAT 
TTCCAGACTC TGCCAGTAAT GACCAAAATA GATTCTGTGG CTGGAATCAA CTATGGTCTG 
GTGGCACCTC CAGCAACCAC GGCTGAGACC CTGGATGTAC AGATGAAGGG GGAGTTTTAC 
AGTGAGAACC ACCACAATCC ACCTCCCTTT GCTCCACCAG TGATGGAGTT TCCCGCTGCC 
CATGACCGCA TGGTATACCT GGGCCTCTCA GACTACTTCT TCAACACAGC CGGGCTTGTA 
TACCAAGAGG CTGGGGTCTT GAAGATGACC CTTAGAGATG ACATGATTCC AAAGGAGTCC 
AAATTTCGAC TGACAACCAA GTTCTTTGGA ACCTTCCTAC CTGAGGTGGC CAAGAAGTTT 
CCCAACATGA AGATACAGAT CCATGTCTCA GCCTCCACCC CGCCACACCT GTCTGTGCAG 
CCCACCGGCC TTACCTTCTA CCCTGCCGTG GATGTCCAGG CCTTTGCCGT CCTCCCCAAC 
TCCTCCCTGG CTTCCCTCTT CCTGATTGGC ATGCACACAA CTGGTTCCAT GGAGGTCAGC 
GCCGAGTCCA ACAGGCTTGT TGGAGAGCTC AAGCTGGATA GGCTGCTCCT GGAACTGAAG 
CACTCAAATA TTGGCCCCTT CCCGGTTGAA TTGCTGCAGG ATATCATGAA CTACATTGTA 
CCCATTCTTG TGCTGCCCAG GGTTAACGAG AAACTACAGA AAGGCTTCCC TCTCCCGACG 
CCGGCCAGAG TCCAGCTCTA CAACGTAGTG CTTCAGCCTC ACCAGAACTT CCTGCTGTTC 
GGTGCAGACG TTGTCTATAA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BPI ( NM_001725.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001716.3 Homo sapiens bactericidal permeability increasing protein (BPI), mRNA.

Price & Availability↑

CloneID	OHu108872
Clone ID Related Accession (Same CDS sequence)	NM_001725.3
Accession Version	NM_001725.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1452bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	bactericidal permeability-increasing protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL359555.9, AL499625.4 and AL391095.6. This sequence is a reference standard in the RefSeqGene project. On Jul 19, 2019 this sequence version replaced NM_001725.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC040955.1, J04739.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved Protein has antimicrobial activity :: PMID: 17678885 RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCAGGG GCCCTTGCAA CGCGCCGAGA TGGGCGTCCC TGATGGTGCT GGTCGCCATA 
GGCACCGCCG TGACAGCGGC CGTCAACCCT GGCGTCGTGG TCAGGATCTC CCAGAAGGGC 
CTGGACTACG CCAGCCAGCA GGGGACGGCC GCTCTGCAGA AGGAGCTGAA GAGGATCAAG 
ATTCCTGACT ACTCAGACAG CTTTAAGATC AAGCATCTTG GGAAGGGGCA TTATAGCTTC 
TACAGCATGG ACATCCGTGA ATTCCAGCTT CCCAGTTCCC AGATAAGCAT GGTGCCCAAT 
GTGGGCCTTA AGTTCTCCAT CAGCAACGCC AATATCAAGA TCAGCGGGAA ATGGAAGGCA 
CAAAAGAGAT TCTTAAAAAT GAGCGGCAAT TTTGACCTGA GCATAGAAGG CATGTCCATT 
TCGGCTGATC TGAAGCTGGG CAGTAACCCC ACGTCAGGCA AGCCCACCAT CACCTGCTCC 
AGCTGCAGCA GCCACATCAA CAGTGTCCAC GTGCACATCT CAAAGAGCAA AGTGGGGTGG 
CTGATCCAAC TCTTCCACAA AAAAATTGAG TCTGCGCTTC GAAACAAGAT GAACAGCCAG 
GTCTGCGAGA AAGTGACCAA TTCTGTATCC TCCGAGCTGC AACCTTATTT CCAGACTCTG 
CCAGTAATGA CCAAAATAGA TTCTGTGGCT GGAATCAACT ATGGTCTGGT GGCACCTCCA 
GCAACCACGG CTGAGACCCT GGATGTACAG ATGAAGGGGG AGTTTTACAG TGAGAACCAC 
CACAATCCAC CTCCCTTTGC TCCACCAGTG ATGGAGTTTC CCGCTGCCCA TGACCGCATG 
GTATACCTGG GCCTCTCAGA CTACTTCTTC AACACAGCCG GGCTTGTATA CCAAGAGGCT 
GGGGTCTTGA AGATGACCCT TAGAGATGAC ATGATTCCAA AGGAGTCCAA ATTTCGACTG 
ACAACCAAGT TCTTTGGAAC CTTCCTACCT GAGGTGGCCA AGAAGTTTCC CAACATGAAG 
ATACAGATCC ATGTCTCAGC CTCCACCCCG CCACACCTGT CTGTGCAGCC CACCGGCCTT 
ACCTTCTACC CTGCCGTGGA TGTCCAGGCC TTTGCCGTCC TCCCCAACTC CTCCCTGGCT 
TCCCTCTTCC TGATTGGCAT GCACACAACT GGTTCCATGG AGGTCAGCGC CGAGTCCAAC 
AGGCTTGTTG GAGAGCTCAA GCTGGATAGG CTGCTCCTGG AACTGAAGCA CTCAAATATT 
GGCCCCTTCC CGGTTGAATT GCTGCAGGAT ATCATGAACT ACATTGTACC CATTCTTGTG 
CTGCCCAGGG TTAACGAGAA ACTACAGAAA GGCTTCCCTC TCCCGACGCC GGCCAGAGTC 
CAGCTCTACA ACGTAGTGCT TCAGCCTCAC CAGAACTTCC TGCTGTTCGG TGCAGACGTT 
GTCTATAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001716.3
CDS	69..1520
Translation	MARGPCNAPRWASLMVLVAIGTAVTAAVNPGVVVRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGHYSFYSMDIREFQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLKLGSNPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKVTNSVSSELQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPPFAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFFGTFLPEVAKKFPNMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSSLASLFLIGMHTTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRVNEKLQKGFPLPTPARVQLYNVVLQPHQNFLLFGADVVYK

Target ORF information:

RefSeq Version	NM_001725.3
Organism	Homo sapiens(human)
Definition	Homo sapiens bactericidal permeability increasing protein (BPI), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001725.3

ORF Insert Sequence:

ATGGCCAGGG GCCCTTGCAA CGCGCCGAGA TGGGCGTCCC TGATGGTGCT GGTCGCCATA 
GGCACCGCCG TGACAGCGGC CGTCAACCCT GGCGTCGTGG TCAGGATCTC CCAGAAGGGC 
CTGGACTACG CCAGCCAGCA GGGGACGGCC GCTCTGCAGA AGGAGCTGAA GAGGATCAAG 
ATTCCTGACT ACTCAGACAG CTTTAAGATC AAGCATCTTG GGAAGGGGCA TTATAGCTTC 
TACAGCATGG ACATCCGTGA ATTCCAGCTT CCCAGTTCCC AGATAAGCAT GGTGCCCAAT 
GTGGGCCTTA AGTTCTCCAT CAGCAACGCC AATATCAAGA TCAGCGGGAA ATGGAAGGCA 
CAAAAGAGAT TCTTAAAAAT GAGCGGCAAT TTTGACCTGA GCATAGAAGG CATGTCCATT 
TCGGCTGATC TGAAGCTGGG CAGTAACCCC ACGTCAGGCA AGCCCACCAT CACCTGCTCC 
AGCTGCAGCA GCCACATCAA CAGTGTCCAC GTGCACATCT CAAAGAGCAA AGTGGGGTGG 
CTGATCCAAC TCTTCCACAA AAAAATTGAG TCTGCGCTTC GAAACAAGAT GAACAGCCAG 
GTCTGCGAGA AAGTGACCAA TTCTGTATCC TCCGAGCTGC AACCTTATTT CCAGACTCTG 
CCAGTAATGA CCAAAATAGA TTCTGTGGCT GGAATCAACT ATGGTCTGGT GGCACCTCCA 
GCAACCACGG CTGAGACCCT GGATGTACAG ATGAAGGGGG AGTTTTACAG TGAGAACCAC 
CACAATCCAC CTCCCTTTGC TCCACCAGTG ATGGAGTTTC CCGCTGCCCA TGACCGCATG 
GTATACCTGG GCCTCTCAGA CTACTTCTTC AACACAGCCG GGCTTGTATA CCAAGAGGCT 
GGGGTCTTGA AGATGACCCT TAGAGATGAC ATGATTCCAA AGGAGTCCAA ATTTCGACTG 
ACAACCAAGT TCTTTGGAAC CTTCCTACCT GAGGTGGCCA AGAAGTTTCC CAACATGAAG 
ATACAGATCC ATGTCTCAGC CTCCACCCCG CCACACCTGT CTGTGCAGCC CACCGGCCTT 
ACCTTCTACC CTGCCGTGGA TGTCCAGGCC TTTGCCGTCC TCCCCAACTC CTCCCTGGCT 
TCCCTCTTCC TGATTGGCAT GCACACAACT GGTTCCATGG AGGTCAGCGC CGAGTCCAAC 
AGGCTTGTTG GAGAGCTCAA GCTGGATAGG CTGCTCCTGG AACTGAAGCA CTCAAATATT 
GGCCCCTTCC CGGTTGAATT GCTGCAGGAT ATCATGAACT ACATTGTACC CATTCTTGTG 
CTGCCCAGGG TTAACGAGAA ACTACAGAAA GGCTTCCCTC TCCCGACGCC GGCCAGAGTC 
CAGCTCTACA ACGTAGTGCT TCAGCCTCAC CAGAACTTCC TGCTGTTCGG TGCAGACGTT 
GTCTATAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BPI ( XM_024451972.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024307740.1 Homo sapiens bactericidal permeability increasing protein (BPI), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu105155
Clone ID Related Accession (Same CDS sequence)	XM_024451972.1
Accession Version	XM_024451972.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 759bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	bactericidal permeability-increasing protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCCCAG AAGCCCAGGT CTGCGAGAAA GTGACCAATT CTGTATCCTC CGAGCTGCAA 
CCTTATTTCC AGACTCTGCC AGTAATGACC AAAATAGATT CTGTGGCTGG AATCAACTAT 
GGTCTGGTGG CACCTCCAGC AACCACGGCT GAGACCCTGG ATGTACAGAT GAAGGGGGAG 
TTTTACAGTG AGAACCACCA CAATCCACCT CCCTTTGCTC CACCAGTGAT GGAGTTTCCC 
GCTGCCCATG ACCGCATGGT ATACCTGGGC CTCTCAGACT ACTTCTTCAA CACAGCCGGG 
CTTGTATACC AAGAGGCTGG GGTCTTGAAG ATGACCCTTA GAGATGACAT GATTCCAAAG 
GAGTCCAAAT TTCGACTGAC AACCAAGTTC TTTGGAACCT TCCTACCTGA GGTGGCCAAG 
AAGTTTCCCA ACATGAAGAT ACAGATCCAT GTCTCAGCCT CCACCCCGCC ACACCTGTCT 
GTGCAGCCCA CCGGCCTTAC CTTCTACCCT GCCGTGGATG TCCAGGCCTT TGCCGTCCTC 
CCCAACTCCT CCCTGGCTTC CCTCTTCCTG ATTGGCATGG TTGAATTGCT GCAGGATATC 
ATGAACTACA TTGTACCCAT TCTTGTGCTG CCCAGGGTTA ACGAGAAACT ACAGAAAGGC 
TTCCCTCTCC CGACGCCGGC CAGAGTCCAG CTCTACAACG TAGTGCTTCA GCCTCACCAG 
AACTTCCTGC TGTTCGGTGC AGACGTTGTC TATAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024307740.1
CDS	48..806
Translation	MLPEAQVCEKVTNSVSSELQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPPFAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFFGTFLPEVAKKFPNMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSSLASLFLIGMVELLQDIMNYIVPILVLPRVNEKLQKGFPLPTPARVQLYNVVLQPHQNFLLFGADVVYK

Target ORF information:

RefSeq Version	XM_024451972.1
Organism	Homo sapiens(human)
Definition	Homo sapiens bactericidal permeability increasing protein (BPI), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024451972.1

ORF Insert Sequence:

ATGCTCCCAG AAGCCCAGGT CTGCGAGAAA GTGACCAATT CTGTATCCTC CGAGCTGCAA 
CCTTATTTCC AGACTCTGCC AGTAATGACC AAAATAGATT CTGTGGCTGG AATCAACTAT 
GGTCTGGTGG CACCTCCAGC AACCACGGCT GAGACCCTGG ATGTACAGAT GAAGGGGGAG 
TTTTACAGTG AGAACCACCA CAATCCACCT CCCTTTGCTC CACCAGTGAT GGAGTTTCCC 
GCTGCCCATG ACCGCATGGT ATACCTGGGC CTCTCAGACT ACTTCTTCAA CACAGCCGGG 
CTTGTATACC AAGAGGCTGG GGTCTTGAAG ATGACCCTTA GAGATGACAT GATTCCAAAG 
GAGTCCAAAT TTCGACTGAC AACCAAGTTC TTTGGAACCT TCCTACCTGA GGTGGCCAAG 
AAGTTTCCCA ACATGAAGAT ACAGATCCAT GTCTCAGCCT CCACCCCGCC ACACCTGTCT 
GTGCAGCCCA CCGGCCTTAC CTTCTACCCT GCCGTGGATG TCCAGGCCTT TGCCGTCCTC 
CCCAACTCCT CCCTGGCTTC CCTCTTCCTG ATTGGCATGG TTGAATTGCT GCAGGATATC 
ATGAACTACA TTGTACCCAT TCTTGTGCTG CCCAGGGTTA ACGAGAAACT ACAGAAAGGC 
TTCCCTCTCC CGACGCCGGC CAGAGTCCAG CTCTACAACG TAGTGCTTCA GCCTCACCAG 
AACTTCCTGC TGTTCGGTGC AGACGTTGTC TATAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Bactericidal/permeability increasing protein gene polymorphism and inflammatory bowel diseases: meta-analysis of five case-control studies.
International journal of colorectal disease32(3)433-435(2017 Mar)
Fan L,Fu G,Ding Y,Lv P,Li H

Bactericidal permeability increasing protein gene polymorphism is associated with inflammatory bowel diseases in the Turkish population.
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association21(4)239-44(2015 Jul-Aug)
Can G,Ak?n H,?zdemir FT,Can H,Y?lmaz B,Eren F,Atu? ?,?nsal B,Hamzao?lu HO

[Comparative analysis of the role of CD4(+) and CD8(+) T cells in severe asthma development].
Molekuliarnaia biologiia49(3)482-90(2015 May-Jun)
Wang X,Wang J,Xing CY,Zang R,Pu YY,Yin ZX

Decreased pattern recognition receptor signaling, interferon-signature, and bactericidal/permeability-increasing protein gene expression in cord blood of term low birth weight human newborns.
PloS one8(4)e62845(2013)
Singh VV,Chauhan SK,Rai R,Kumar A,Singh SM,Rai G