NR1H2 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | NR1H2 |
| Entrez Gene ID | 7376 |
| Full Name | nuclear receptor subfamily 1 group H member 2 |
| Synonyms | LXR-b,LXRB,NER,NER-I,RIP15,UNR |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_007121.5 | NP_009052.3 | oxysterols receptor LXR-beta isoform 1 |
| NM_001256647.1 | NP_001243576.1 | oxysterols receptor LXR-beta isoform 2 |
| Homo sapiens (human) | NR1H2 | NP_009052.3 |
| Xenopus tropicalis (tropical clawed frog) | nr1h2 | NP_001072853.1 |
| Rattus norvegicus (Norway rat) | Nr1h2 | NP_113814.1 |
| Pan troglodytes (chimpanzee) | NR1H2 | XP_512838.4 |
| Canis lupus familiaris (dog) | NR1H2 | XP_851316.1 |
| Mus musculus (house mouse) | Nr1h2 | NP_001272447.1 |
| Drosophila melanogaster (fruit fly) | EcR | NP_724456.1 |
| NR1H2 | XP_001115995.2 | |
| Bos taurus (cattle) | NR1H2 | NP_001014883.1 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP012211 | XP_320323.4 |
Related articles in PubMed
Liver X Receptor (LXR)-regulated Genes of Cholesterol Trafficking and Breast Cancer Severity.
Bobin-Dubigeon C, Chauvin A, Brillaud-Meflah V, Boiffard F, Joalland MP, Bard JM
Anticancer research37(10)5495-5498(2017 10)
25-Hydroxycholesterol promotes migration and invasion of lung adenocarcinoma cells.
Chen L, Zhang L, Xian G, Lv Y, Lin Y, Wang Y
Biochemical and biophysical research communications484(4)857-863(2017 03)
Liver X receptors agonist GW3965 re-sensitizes gefitinib-resistant human non-small cell lung cancer cell to gefitinib treatment by inhibiting NF-?B in vitro.
Hu Y, Zang J, Cao H, Wu Y, Yan D, Qin X, Zhou L, Fan F, Ni J, Xu X, Sha H, Liu S, Yu S, Wang Z, Ma R, Wu J, Feng J
Oncotarget8(9)15802-15814(2017 Feb)
Interactions among polymorphisms of NER genes prompt the risk of transplantation rejection.
Wang BG, Lv Z, Xu Q, Liu YF
Yi chuan = Hereditas39(1)22-31(2017 01)
Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells.
Sinha RA, Singh BK, Zhou J, Xie S, Farah BL, Lesmana R, Ohba K, Tripathi M, Ghosh S, Hollenberg AN, Yen PM
Autophagy13(1)169-186(2017 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Expression of some LXR-dependent genes of cholesterol trafficking is related to breast tumor characteristics, but not time to recurrence.
Title: Liver X Receptor (LXR)-regulated Genes of Cholesterol Trafficking and Breast Cancer Severity.
These results suggested that 25-HC promoted ADC cell migration and invasion in an LXR-dependent manner in the monoculture system but that in the coculture system, the 25-HC-induced IL-1beta secretion enhanced the effect of 25-HC in an LXR-independent manner.
Title: 25-Hydroxycholesterol promotes migration and invasion of lung adenocarcinoma cells.
GW3965 significantly increases the expression of liver X nuclear receptor beta (LXRbeta) mRNA, while the liver X nuclear receptor alpha (LXRalpha( mRNA expression did not change a lot, and sensitizes gefitinib by inhibiting NF-kappa B (NF-kappaB) activation.
Title: Liver X receptors agonist GW3965 re-sensitizes gefitinib-resistant human non-small cell lung cancer cell to gefitinib treatment by inhibiting NF-?B in vitro.
Interactions among SNPs in nucleotide excision repair (NER) genes.
Title: Interactions among polymorphisms of NER genes prompt the risk of transplantation rejection.
ULK1 has a role in RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells
Title: Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells.
The following NR1H2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NR1H2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu20228 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_007121.5 | |
| Accession Version | NM_007121.5 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1386bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | COA |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-12-27 | |
| Organism | Homo sapiens(human) | |
| Product | oxysterols receptor LXR-beta isoform 1 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA053472.1, BC047750.2 and AI252503.1. On Feb 15, 2012 this sequence version replaced NM_007121.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.210809.1, SRR1660805.224356.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGTCCTCTC CTACCACGAG TTCCCTGGAT ACCCCCCTGC CTGGAAATGG CCCCCCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_009052.3 |
| CDS | 282..1667 |
| Misc Feature(1) | 213..215 |
| Misc Feature(2) | 282..536 |
| Misc Feature(3) | 480..770 |
| Misc Feature(4) | order(540..542,549..551,591..593,600..602,654..656,672..674,702..704,711..713) |
| Misc Feature(5) | order(570..578,594..599,603..605,609..611,618..620,627..629,693..698,705..707,714..716,747..749,756..758) |
| Misc Feature(6) | 939..1664 |
| Misc Feature(7) | 951..1658 |
| Misc Feature(8) | order(1083..1085,1092..1097,1101..1106,1206..1208,1215..1220,1227..1229,1260..1262,1326..1328,1338..1340,1584..1586,1593..1598,1605..1607,1626..1628,1638..1640,1650..1652) |
| Misc Feature(9) | order(1119..1121,1128..1130,1140..1142,1170..1175,1179..1184,1194..1196,1632..1637,1644..1646) |
| Misc Feature(10) | order(1425..1427,1458..1460,1470..1472,1482..1484,1491..1493,1503..1505,1527..1529,1533..1541,1545..1550,1554..1562,1566..1571,1578..1580) |
| Exon (1) | 1..154 |
| Exon (2) | 155..262 |
| Exon (3) | 263..324 |
| Exon (4) | 325..462 |
| Exon (5) | 463..753 |
| Exon (6) | 754..1031 |
| Exon (7) | 1032..1211 |
| Exon (8) | 1212..1311 |
| Exon (9) | 1312..1520 |
| Exon (10) | 1521..2093 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_007121.5 |
ORF Insert Sequence:
1 | ATGTCCTCTC CTACCACGAG TTCCCTGGAT ACCCCCCTGC CTGGAAATGG CCCCCCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu20332 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_001256647.1 | |
| Accession Version | NM_001256647.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1095bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | COA |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-12-11 | |
| Organism | Homo sapiens(human) | |
| Product | oxysterols receptor LXR-beta isoform 2 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA053472.1, AK297978.1, BC047750.2 and AI252503.1. Transcript Variant: This variant (2) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.41166.1, AK297978.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGTCCTCTC CTACCACGAG TTCCCTGGAT ACCCCCCTGC CTGGAAATGG CCCCCCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001243576.1 |
| CDS | 282..1376 |
| Misc Feature(1) | 213..215 |
| Misc Feature(2) | 660..1367 |
| Misc Feature(3) | order(792..794,801..806,810..815,915..917,924..929,936..938,969..971,1035..1037,1047..1049,1293..1295,1302..1307,1314..1316,1335..1337,1347..1349,1359..1361) |
| Misc Feature(4) | order(828..830,837..839,849..851,879..884,888..893,903..905,1341..1346,1353..1355) |
| Misc Feature(5) | order(1134..1136,1167..1169,1179..1181,1191..1193,1200..1202,1212..1214,1236..1238,1242..1250,1254..1259,1263..1271,1275..1280,1287..1289) |
| Exon (1) | 1..154 |
| Exon (2) | 155..262 |
| Exon (3) | 263..324 |
| Exon (4) | 325..462 |
| Exon (5) | 463..740 |
| Exon (6) | 741..920 |
| Exon (7) | 921..1020 |
| Exon (8) | 1021..1229 |
| Exon (9) | 1230..1802 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001256647.1 |
ORF Insert Sequence:
1 | ATGTCCTCTC CTACCACGAG TTCCCTGGAT ACCCCCCTGC CTGGAAATGG CCCCCCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Liver X Receptor (LXR)-regulated Genes of Cholesterol Trafficking and Breast Cancer Severity. |
|
25-Hydroxycholesterol promotes migration and invasion of lung adenocarcinoma cells. |
|
Liver X receptors agonist GW3965 re-sensitizes gefitinib-resistant human non-small cell lung cancer cell to gefitinib treatment by inhibiting NF-?B in vitro. |
|
Interactions among polymorphisms of NER genes prompt the risk of transplantation rejection. |
|
Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells. |