The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010].
The following NR1H2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NR1H2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA053472.1, BC047750.2 and AI252503.1. On Feb 15, 2012 this sequence version replaced NM_007121.4.
Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1803611.210809.1, SRR1660805.224356.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA053472.1, AK297978.1, BC047750.2 and AI252503.1.
Transcript Variant: This variant (2) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1660805.41166.1, AK297978.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2142586 [ECO:0000348]
##Evidence-Data-END##
Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA053472.1, AK297978.1, BC047750.2 and AI252503.1. On Sep 15, 2018 this sequence version replaced NM_001256647.1.
Transcript Variant: This variant (2) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
CCDS Note: The coding region was updated to make it identical to the current human reference genome sequence.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1660805.41166.1, SRR3476690.346851.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1970526 [ECO:0000348]
##Evidence-Data-END##
Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA053472.1, BC047750.2 and AI252503.1. On Sep 16, 2018 this sequence version replaced NM_007121.5.
Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
CCDS Note: The coding region was updated to make it identical to the current human reference genome sequence.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1803616.249390.1, SRR1660805.224356.1 [ECO:0000332]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA053472.1, BC047750.2, AI252503.1 and AC008655.7. On May 17, 2019 this sequence version replaced NM_007121.6.
Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
CCDS Note: The coding region was updated to make it identical to the current human reference genome sequence.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1803616.249390.1, SRR1803611.102460.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000253727.10/ ENSP00000253727.4
RefSeq Select criteria :: based on conservation, expression, longest protein
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.