GEMIN6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GEMIN6
Entrez Gene ID	79833
Full Name	gem nuclear organelle associated protein 6
General protein information	Preferred Names gem nuclear organelle associated protein 6 Names gem-associated protein 6 SIP2 gemin-6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p22.1
Summary	GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM, Jul 2002].
Disorder MIM:	607006

mRNA and Protein(s)

mRNA	Protein	Name
NM_024775.9	NP_079051.9	gem-associated protein 6
NM_024775.10	NP_079051.9	gem-associated protein 6

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	GEMIN6	NP_001264651.1
Canis lupus familiaris (dog)	GEMIN6	XP_005630425.1
Bos taurus (cattle)	GEMIN6	NP_001039743.1
Mus musculus (house mouse)	Gemin6	NP_080329.1
Xenopus tropicalis (tropical clawed frog)	gemin6	NP_001016037.1
Homo sapiens (human)	GEMIN6	NP_079051.9
Pan troglodytes (chimpanzee)	GEMIN6	XP_515422.1
	GEMIN6	XP_001110016.1
Mus musculus (house mouse)	Gm6253	XP_891195.1
Rattus norvegicus (Norway rat)	Gemin6	NP_001009466.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

Global landscape of HIV-human protein complexes.
J?ger S, Cimermancic P, Gulbahce N, Johnson JR, McGovern KE, Clarke SC, Shales M, Mercenne G, Pache L, Li K, Hernandez H, Jang GM, Roth SL, Akiva E, Marlett J, Stephens M, D'Orso I, Fernandes J, Fahey M, Mahon C, O'Donoghue AJ, Todorovic A, Morris JH, Maltby DA, Alber T, Cagney G, Bushman FD, Young JA, Chanda SK, Sundquist WI, Kortemme T, Hernandez RD, Craik CS, Burlingame A, Sali A, Frankel AD, Krogan NJ
Nature481(7381)365-70(2011 Dec)

Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis.
Yong J, Kasim M, Bachorik JL, Wan L, Dreyfuss G
Molecular cell38(4)551-62(2010 May)

An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.
Chari A, Golas MM, Klingenh?ger M, Neuenkirchen N, Sander B, Englbrecht C, Sickmann A, Stark H, Fischer U
Cell135(3)497-509(2008 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Gemin8 has an essential role in the proper structural organization of the SMN complex and the involvement of the heteromeric subunit containing Gemin6, Gemin7, Gemin8, and Unrip in the recruitment of Sm proteins to the snRNP assembly pathway
Title: Gemin8 is required for the architecture and function of the survival motor neuron complex.

Gemin6 is a component of the SMN complex that localizes to gems and interacts with several Sm proteins of the spliceosomal snRNPs.
Title: Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component.

The following GEMIN6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GEMIN6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29350	NM_024775.10 Latest version!	Homo sapiens gem nuclear organelle associated protein 6 (GEMIN6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	Quote Price
View Old Accession Versions >>
OHu29350	NM_024775.9	Homo sapiens gem nuclear organelle associated protein 6 (GEMIN6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	Quote Price
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GEMIN6 ( NM_024775.9 ) cDNA ORF clone, Homo sapiens(human) -> NP_079051.9 Homo sapiens gem nuclear organelle associated protein 6 (GEMIN6), mRNA.

Price & Availability↑

CloneID	OHu29350
Clone ID Related Accession (Same CDS sequence)	NM_024775.9 , NM_024775.10
Accession Version	NM_024775.9	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	gem-associated protein 6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC029584.1 and BM471707.1. On Jan 30, 2004 this sequence version replaced NM_024775.8. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD512238.1, BU533922.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGAGTGAAT GGATGAAGAA AGGCCCCTTA GAATGGCAAG ATTACATTTA CAAAGAGGTC 
CGAGTGACAG CCAGTGAGAA GAATGAGTAT AAAGGATGGG TTTTAACTAC AGACCCAGTC 
TCTGCCAATA TTGTCCTTGT GAACTTCCTT GAAGATGGCA GCATGTCTGT GACCGGAATT 
ATGGGACATG CTGTGCAGAC TGTTGAAACT ATGAATGAAG GGGACCATAG AGTGAGGGAG 
AAGCTGATGC ATTTGTTCAC GTCTGGAGAC TGCAAAGCAT ACAGCCCAGA GGATCTGGAA 
GAGAGAAAGA ACAGCCTAAA GAAATGGCTT GAGAAGAACC ACATCCCCAT CACTGAACAG 
GGAGACGCTC CAAGGACTCT CTGTGTGGCT GGGGTCCTGA CTATAGACCC ACCATATGGT 
CCAGAAAATT GCAGCAGCTC TAATGAGATT ATTCTGTCGC GTGTTCAGGA TCTTATTGAA 
GGACATCTTA CAGCTTCCCA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079051.9
CDS	117..620
Translation	MSEWMKKGPLEWQDYIYKEVRVTASEKNEYKGWVLTTDPVSANIVLVNFLEDGSMSVTGIMGHAVQTVETMNEGDHRVREKLMHLFTSGDCKAYSPEDLEERKNSLKKWLEKNHIPITEQGDAPRTLCVAGVLTIDPPYGPENCSSSNEIILSRVQDLIEGHLTASQ

Target ORF information:

RefSeq Version	NM_024775.9
Organism	Homo sapiens(human)
Definition	Homo sapiens gem nuclear organelle associated protein 6 (GEMIN6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024775.9

ORF Insert Sequence:

ATGAGTGAAT GGATGAAGAA AGGCCCCTTA GAATGGCAAG ATTACATTTA CAAAGAGGTC 
CGAGTGACAG CCAGTGAGAA GAATGAGTAT AAAGGATGGG TTTTAACTAC AGACCCAGTC 
TCTGCCAATA TTGTCCTTGT GAACTTCCTT GAAGATGGCA GCATGTCTGT GACCGGAATT 
ATGGGACATG CTGTGCAGAC TGTTGAAACT ATGAATGAAG GGGACCATAG AGTGAGGGAG 
AAGCTGATGC ATTTGTTCAC GTCTGGAGAC TGCAAAGCAT ACAGCCCAGA GGATCTGGAA 
GAGAGAAAGA ACAGCCTAAA GAAATGGCTT GAGAAGAACC ACATCCCCAT CACTGAACAG 
GGAGACGCTC CAAGGACTCT CTGTGTGGCT GGGGTCCTGA CTATAGACCC ACCATATGGT 
CCAGAAAATT GCAGCAGCTC TAATGAGATT ATTCTGTCGC GTGTTCAGGA TCTTATTGAA 
GGACATCTTA CAGCTTCCCA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GEMIN6 ( NM_024775.10 ) cDNA ORF clone, Homo sapiens(human) -> NP_079051.9 Homo sapiens gem nuclear organelle associated protein 6 (GEMIN6), mRNA.

Price & Availability↑

CloneID	OHu29350
Clone ID Related Accession (Same CDS sequence)	NM_024775.9 , NM_024775.10
Accession Version	NM_024775.10 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	gem-associated protein 6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC029584.1, BM471707.1 and AC018693.8. On Nov 22, 2018 this sequence version replaced NM_024775.9. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM782269.1, SRR1660803.10553.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000281950.8/ ENSP00000281950.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGTGAAT GGATGAAGAA AGGCCCCTTA GAATGGCAAG ATTACATTTA CAAAGAGGTC 
CGAGTGACAG CCAGTGAGAA GAATGAGTAT AAAGGATGGG TTTTAACTAC AGACCCAGTC 
TCTGCCAATA TTGTCCTTGT GAACTTCCTT GAAGATGGCA GCATGTCTGT GACCGGAATT 
ATGGGACATG CTGTGCAGAC TGTTGAAACT ATGAATGAAG GGGACCATAG AGTGAGGGAG 
AAGCTGATGC ATTTGTTCAC GTCTGGAGAC TGCAAAGCAT ACAGCCCAGA GGATCTGGAA 
GAGAGAAAGA ACAGCCTAAA GAAATGGCTT GAGAAGAACC ACATCCCCAT CACTGAACAG 
GGAGACGCTC CAAGGACTCT CTGTGTGGCT GGGGTCCTGA CTATAGACCC ACCATATGGT 
CCAGAAAATT GCAGCAGCTC TAATGAGATT ATTCTGTCGC GTGTTCAGGA TCTTATTGAA 
GGACATCTTA CAGCTTCCCA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079051.9
CDS	92..595
Translation	MSEWMKKGPLEWQDYIYKEVRVTASEKNEYKGWVLTTDPVSANIVLVNFLEDGSMSVTGIMGHAVQTVETMNEGDHRVREKLMHLFTSGDCKAYSPEDLEERKNSLKKWLEKNHIPITEQGDAPRTLCVAGVLTIDPPYGPENCSSSNEIILSRVQDLIEGHLTASQ

Target ORF information:

RefSeq Version	NM_024775.10
Organism	Homo sapiens(human)
Definition	Homo sapiens gem nuclear organelle associated protein 6 (GEMIN6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024775.10

ORF Insert Sequence:

ATGAGTGAAT GGATGAAGAA AGGCCCCTTA GAATGGCAAG ATTACATTTA CAAAGAGGTC 
CGAGTGACAG CCAGTGAGAA GAATGAGTAT AAAGGATGGG TTTTAACTAC AGACCCAGTC 
TCTGCCAATA TTGTCCTTGT GAACTTCCTT GAAGATGGCA GCATGTCTGT GACCGGAATT 
ATGGGACATG CTGTGCAGAC TGTTGAAACT ATGAATGAAG GGGACCATAG AGTGAGGGAG 
AAGCTGATGC ATTTGTTCAC GTCTGGAGAC TGCAAAGCAT ACAGCCCAGA GGATCTGGAA 
GAGAGAAAGA ACAGCCTAAA GAAATGGCTT GAGAAGAACC ACATCCCCAT CACTGAACAG 
GGAGACGCTC CAAGGACTCT CTGTGTGGCT GGGGTCCTGA CTATAGACCC ACCATATGGT 
CCAGAAAATT GCAGCAGCTC TAATGAGATT ATTCTGTCGC GTGTTCAGGA TCTTATTGAA 
GGACATCTTA CAGCTTCCCA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

Global landscape of HIV-human protein complexes.
Nature481(7381)365-70(2011 Dec)
J?ger S,Cimermancic P,Gulbahce N,Johnson JR,McGovern KE,Clarke SC,Shales M,Mercenne G,Pache L,Li K,Hernandez H,Jang GM,Roth SL,Akiva E,Marlett J,Stephens M,D'Orso I,Fernandes J,Fahey M,Mahon C,O'Donoghue AJ,Todorovic A,Morris JH,Maltby DA,Alber T,Cagney G,Bushman FD,Young JA,Chanda SK,Sundquist WI,Kortemme T,Hernandez RD,Craik CS,Burlingame A,Sali A,Frankel AD,Krogan NJ

Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis.
Molecular cell38(4)551-62(2010 May)
Yong J,Kasim M,Bachorik JL,Wan L,Dreyfuss G

An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.
Cell135(3)497-509(2008 Oct)
Chari A,Golas MM,Klingenh?ger M,Neuenkirchen N,Sander B,Englbrecht C,Sickmann A,Stark H,Fischer U

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GEMIN6 cDNA ORF clone, Homo sapiens(human)

Gene

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Related articles in PubMed

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Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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