Gene Symbol | ADTRP |
Entrez Gene ID | 84830 |
Full Name | androgen dependent TFPI regulating protein |
Synonyms | AIG1L,C6orf105,dJ413H6.1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » ADTRP cDNA ORF clone
gRNAs
Gene Symbol | ADTRP |
Entrez Gene ID | 84830 |
Full Name | androgen dependent TFPI regulating protein |
Synonyms | AIG1L,C6orf105,dJ413H6.1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
XM_017011377.1 | XP_016866866.1 | androgen-dependent TFPI-regulating protein isoform X5 |
NM_032744.3 | NP_116133.1 | androgen-dependent TFPI-regulating protein isoform 2 |
XM_005249454.2 | XP_005249511.1 | androgen-dependent TFPI-regulating protein isoform X1 |
NM_001143948.1 | NP_001137420.1 | androgen-dependent TFPI-regulating protein isoform 1 |
XM_011514959.1 | XP_011513261.1 | androgen-dependent TFPI-regulating protein isoform X4 |
XM_011514958.2 | XP_011513260.1 | androgen-dependent TFPI-regulating protein isoform X3 |
XM_011514956.1 | XP_011513258.1 | androgen-dependent TFPI-regulating protein isoform X1 |
XM_005249454.3 | XP_005249511.1 | androgen-dependent TFPI-regulating protein isoform X2 |
Gallus gallus (chicken) | C2H6ORF105 | XP_001234747.1 |
Canis lupus familiaris (dog) | ADTRP | XP_535887.3 |
Bos taurus (cattle) | ADTRP | NP_001032710.1 |
Danio rerio (zebrafish) | LOC100537455 | XP_005169590.1 |
Xenopus tropicalis (tropical clawed frog) | adtrp | XP_004915357.1 |
Pan troglodytes (chimpanzee) | ADTRP | NP_001238825.1 |
Rattus norvegicus (Norway rat) | Adtrp | NP_001014166.1 |
Homo sapiens (human) | ADTRP | NP_116133.1 |
Mus musculus (house mouse) | Adtrp | NP_780626.1 |
Androgen inhibits key atherosclerotic processes by directly activating ADTRP transcription.
Luo C, Pook E, Tang B, Zhang W, Li S, Leineweber K, Cheung SH, Chen Q, Bechem M, Hu JS, Laux V, Wang QK
Biochimica et biophysica acta1863(9)2319-2332(2017 Sep)
Identification of a molecular signaling gene-gene regulatory network between GWAS susceptibility genes ADTRP and MIA3/TANGO1 for coronary artery disease.
Luo C, Wang F, Ren X, Ke T, Xu C, Tang B, Qin S, Yao Y, Chen Q, Wang QK
Biochimica et biophysica acta1863(6)1640-1653(2017 Jun)
Coronary artery disease susceptibility gene ADTRP regulates cell cycle progression, proliferation, and apoptosis by global gene expression regulation.
Luo C, Wang F, Qin S, Chen Q, Wang QK
Physiological genomics48(8)554-64(2016 Aug)
AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs.
Parsons WH, Kolar MJ, Kamat SS, Cognetta AB 3rd, Hulce JJ, Saez E, Kahn BB, Saghatelian A, Cravatt BF
Nature chemical biology12(5)367-372(2016 May)
Common Variants in Promoter of ADTRP Associate with Early-Onset Coronary Artery Disease in a Southern Han Chinese Population.
Huang EW, Peng LY, Zheng JX, Wang D, Xu QY, Huang L, Wu QP, Tang SB, Luo B, Liu SP, Liu XS, Li ZH, Quan L, Li Y, Shi H, Lv GL, Zhao J, Cheng JD, Liu C
PloS one10(9)e0137547(2015)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These results indicate that AIG1 and ADTRP are founding members of an evolutionarily conserved class of transmembrane threonine hydrolases involved in bioactive lipid metabolism.
Title: AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs.
SNP rs6903956 associated with asymptomatic hyperuricemia susceptibility in Han Chinese
Title: A coronary artery disease-associated SNP rs6903956 contributed to asymptomatic hyperuricemia susceptibility in Han Chinese.
Activation of PPARG increases the expression of C6ORF105 in human macrophages and atherosclerotic lesions.
Title: The coronary artery disease-associated gene C6ORF105 is expressed in human macrophages under the transcriptional control of PPAR?.
association of ADTRP with the pathogenesis of early-onset CAD
Title: Common Variants in Promoter of ADTRP Associate with Early-Onset Coronary Artery Disease in a Southern Han Chinese Population.
ADTRP polymorphism is associated with the development of coronary atherosclerosis.
Title: Associations between the CDKN2A/B, ADTRP and PDGFD polymorphisms and the development of coronary atherosclerosis in Japanese patients.
The following ADTRP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADTRP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu13645![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_032744.3 , XM_005249454.2 , XM_005249454.3 | |
Accession Version | NM_032744.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 693bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Homo sapiens(human) | |
Product | androgen-dependent TFPI-regulating protein isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC388625.1, BP330027.1, BC007011.1, AJ420520.1, AI147084.1 and AI336841.1. On Jan 22, 2009 this sequence version replaced NM_032744.2. Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ420520.1, BC007011.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGACGAAGA CTTCTACATG CATATACCAC TTCCTTGTTC TGAGCTGGTA TACTTTCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_116133.1 |
CDS | 289..981 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGACGAAGA CTTCTACATG CATATACCAC TTCCTTGTTC TGAGCTGGTA TACTTTCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu13645![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_032744.3 , XM_005249454.2 , XM_005249454.3 | |
Accession Version | XM_005249454.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 693bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-03-11 | |
Organism | Homo sapiens(Human) | |
Product | androgen-dependent TFPI-regulating protein isoform X1 | |
Comment |
1 | ATGACGAAGA CTTCTACATG CATATACCAC TTCCTTGTTC TGAGCTGGTA TACTTTCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005249511.1 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGACGAAGA CTTCTACATG CATATACCAC TTCCTTGTTC TGAGCTGGTA TACTTTCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu13645![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_032744.3 , XM_005249454.2 , XM_005249454.3 | |
Accession Version | XM_005249454.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 693bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | androgen-dependent TFPI-regulating protein isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005249454.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACGAAGA CTTCTACATG CATATACCAC TTCCTTGTTC TGAGCTGGTA TACTTTCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005249511.1 |
CDS | 314..1006 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGACGAAGA CTTCTACATG CATATACCAC TTCCTTGTTC TGAGCTGGTA TACTTTCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu73772 | |
Clone ID Related Accession (Same CDS sequence) | XM_011514956.1 | |
Accession Version | XM_011514956.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 768bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | androgen-dependent TFPI-regulating protein isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACGAAGA CTTCTACATG CATATACCAC TTCCTTGTTC TGAGCTGGTA TACTTTCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011513258.1 |
CDS | 314..1081 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGACGAAGA CTTCTACATG CATATACCAC TTCCTTGTTC TGAGCTGGTA TACTTTCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu13691 | |
Clone ID Related Accession (Same CDS sequence) | NM_001143948.1 | |
Accession Version | NM_001143948.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 747bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-10 | |
Organism | Homo sapiens(human) | |
Product | androgen-dependent TFPI-regulating protein isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC388625.1, BP330027.1, BC007011.1, AK300919.1, AJ420520.1, AI147084.1 and AI336841.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK300919.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGACGAAGA CTTCTACATG CATATACCAC TTCCTTGTTC TGAGCTGGTA TACTTTCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001137420.1 |
CDS | 289..1035 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGACGAAGA CTTCTACATG CATATACCAC TTCCTTGTTC TGAGCTGGTA TACTTTCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu73773 | |
Clone ID Related Accession (Same CDS sequence) | XM_011514958.2 | |
Accession Version | XM_011514958.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 513bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | androgen-dependent TFPI-regulating protein isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011514958.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACGAAGA CTTCTACATG CATATACCAC TTCCTTGTTC TGAGCTGGTA TACTTTCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011513260.1 |
CDS | 314..826 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGACGAAGA CTTCTACATG CATATACCAC TTCCTTGTTC TGAGCTGGTA TACTTTCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu73774 | |
Clone ID Related Accession (Same CDS sequence) | XM_011514959.1 | |
Accession Version | XM_011514959.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 510bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | androgen-dependent TFPI-regulating protein isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACGAAGA CTTCTACATG CATATACCAC TTCCTTGTTC TGAGCTGGTA TACTTTCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011513261.1 |
CDS | 314..823 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGACGAAGA CTTCTACATG CATATACCAC TTCCTTGTTC TGAGCTGGTA TACTTTCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu96846 | |
Clone ID Related Accession (Same CDS sequence) | XM_017011377.1 | |
Accession Version | XM_017011377.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | androgen-dependent TFPI-regulating protein isoform X5 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCACACTT TCATATTCCC CATCACATTG GCTGAAGTCG TCCTCAGGCC TCACTCCTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016866866.1 |
CDS | 294..674 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCACACTT TCATATTCCC CATCACATTG GCTGAAGTCG TCCTCAGGCC TCACTCCTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Androgen inhibits key atherosclerotic processes by directly activating ADTRP transcription. |
Identification of a molecular signaling gene-gene regulatory network between GWAS susceptibility genes ADTRP and MIA3/TANGO1 for coronary artery disease. |
Coronary artery disease susceptibility gene ADTRP regulates cell cycle progression, proliferation, and apoptosis by global gene expression regulation. |
AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. |
Common Variants in Promoter of ADTRP Associate with Early-Onset Coronary Artery Disease in a Southern Han Chinese Population. |