DNAJC14 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DNAJC14
Entrez Gene ID	85406
Full Name	DnaJ heat shock protein family (Hsp40) member C14
Synonyms	DNAJ,DRIP78,HDJ3,LIP6
General protein information	Preferred Names DnaJ heat shock protein family (Hsp40) member C14 Names dnaJ homolog subfamily C member 14 DnaJ (Hsp40) homolog, subfamily C, member 14 LYST-interacting protein LIP6 dnaJ protein homolog 3 dopamine receptor interacting protein dopamine receptor-interacting protein of 78 kDa hDj-3 human DnaJ protein 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.2
Disorder MIM:	606092

mRNA and Protein(s)

mRNA	Protein	Name
NM_032364.5	NP_115740.5	dnaJ homolog subfamily C member 14

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DNAJC14	XP_003313663.1
Rattus norvegicus (Norway rat)	Dnajc14	NP_446142.2
Danio rerio (zebrafish)	LOC555824	XP_683557.3
Xenopus tropicalis (tropical clawed frog)	dnajc14	XP_004911947.1
Gallus gallus (chicken)	LOC426418	XP_004950802.1
Bos taurus (cattle)	DNAJC14	NP_776699.1
Mus musculus (house mouse)	Dnajc14	NP_083149.3
Homo sapiens (human)	DNAJC14	NP_115740.5
	DNAJC14	XP_001111427.2
Canis lupus familiaris (dog)	DNAJC14	XP_003431497.2

Gene Ontology
Bibliography

Related articles in PubMed

The HSP70 co-chaperone DNAJC14 targets misfolded pendrin for unconventional protein secretion.
Jung J, Kim J, Roh SH, Jun I, Sampson RD, Gee HY, Choi JY, Lee MG
Nature communications711386(2016 Apr)

Chaperone-Assisted Protein Folding Is Critical for Yellow Fever Virus NS3/4A Cleavage and Replication.
Bozzacco L, Yi Z, Andreo U, Conklin CR, Li MM, Rice CM, MacDonald MR
Journal of virology90(6)3212-28(2016 Jan)

Flavivirus replication complex assembly revealed by DNAJC14 functional mapping.
Yi Z, Yuan Z, Rice CM, MacDonald MR
Journal of virology86(21)11815-32(2012 Nov)

Dopamine receptor-interacting protein 78 acts as a molecular chaperone for CCR5 chemokine receptor signaling complex organization.
Kuang YQ, Charette N, Frazer J, Holland PJ, Attwood KM, Dellaire G, Dupr? DJ
PloS one7(7)e40522(2012)

Identification and characterization of the host protein DNAJC14 as a broadly active flavivirus replication modulator.
Yi Z, Sperzel L, N?rnberger C, Bredenbeek PJ, Lubick KJ, Best SM, Stoyanov CT, Law LM, Yuan Z, Rice CM, MacDonald MR
PLoS pathogens7(1)e1001255(2011 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This suggests that DNAJC14's folding activity normally modulates yellow fever virus NS3/4A/2K cleavage events to liberate appropriate levels of NS3 and NS4A and promote replication complex formation.
Title: Chaperone-Assisted Protein Folding Is Critical for Yellow Fever Virus NS3/4A Cleavage and Replication.

These findings support a novel model of DNAJC14 action that includes specific membrane targeting of both DNAJC14 and yellow fever virus replication proteins.
Title: Flavivirus replication complex assembly revealed by DNAJC14 functional mapping.

a molecular chaperone, DRiP78, that interacts with both CXCR4 and CCR5, but not the heterodimer formed by these receptors
Title: Dopamine receptor-interacting protein 78 acts as a molecular chaperone for CCR5 chemokine receptor signaling complex organization.

DNAJC14 is required for yellow fever virus replication.
Title: Identification and characterization of the host protein DNAJC14 as a broadly active flavivirus replication modulator.

The following DNAJC14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DNAJC14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu04985	NM_032364.5 Latest version!	Homo sapiens DnaJ heat shock protein family (Hsp40) member C14 (DNAJC14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DNAJC14 ( NM_032364.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_115740.5 Homo sapiens DnaJ heat shock protein family (Hsp40) member C14 (DNAJC14), mRNA.

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CloneID	OHu04985
Clone ID Related Accession (Same CDS sequence)	NM_032364.5
Accession Version	NM_032364.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2109bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	dnaJ homolog subfamily C member 14
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA127901.1, AY188447.1 and BC080655.1. On Dec 25, 2006 this sequence version replaced NM_032364.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY188447.1, SRR1803617.227182.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCCCAGA AGCACCCCGG AGAAAGAGGG TTGTATGGAG CCCACCACAG TGGTGGTGCC 
TCCCTCAGGA CTTTAGGACC CTCCGTGGAC CCTGAAATAC CTTCATTCTC AGGACTCAGG 
GACTCAGCAG GGACTGCTCC TAATGGTACC CGCTGCCTCA CAGAGCACTC TGGTCCTAAG 
CACACACAGC ACCCAAACCC AGCCCATTGG TTGGACCCAA GCCATGGCCC CCCAGGGGGT 
CCAGGACCAC CTAGAGATGC AGAGGACCCT GATCAGAGTG AGACGTCTTC AGAAGAAGAA 
TCAGGAGTGG ACCAGGAACT CTCAAAAGAA AACGAGACTG GGAACCAGAA GGATGGGAAC 
TCTTTTCTTT CCATTCCATC TGCTTGCAAC TGCCAGGGAA CACCTGGAAT TCCAGAAGGG 
CCTTACTCTG AGGGAGGAAA TGGTTCTTCT AGCAACTTTT GCCACCACTG TACCTCTCCA 
GCTTTGGGGG AAGATGAGTT GGAAGAGGAA TATGATGATG AAGAATCTCT CAAGTTCCCC 
AGTGATTTTT CACGTGTGTC CAGCGGAAAG AAACCCCCAT CCCGGAGACA GCGGCACCGC 
TTTCCAACGA AGGAGGATAC TCGGGAGGGT GGACGTAGGG ATCCCAGGTC CCCTGGTCGA 
CATCGGCTGG GTCGGAAACG AAGTCAGGCA GATAAGCGCA AAGGCCTGGG ATTGTGGGGA 
GCCGAGGAAC TATGTCAACT TGGACAGGCA GGCTTTTGGT GGCTGATTGA ACTGCTGGTA 
TTGGTGGGAG AGTACGTAGA AACTTGTGGC CATCTCATCT ATGCCTGCAG GCAACTGAAA 
AGCAGTGATT TGGACCTTTT TCGAGTTTGG ATGGGAGTGT GGACAGGGCG GTTAGGGGGC 
TGGGCCCAGG TCATGTTTCA GTTTCTAAGC CAGGGGTTTT ACTGTGGAGT AGGACTGTTT 
ACTCGTTTTC TTAAGCTGCT GGGTGCTTTG CTGCTCCTGG CTCTGGCCCT CTTTTTGGGC 
TTTCTACAGT TGGGATGGCG GTTTCTGGTG GGACTAGGTG ACCGGTTAGG CTGGAGGGAT 
AAGGCTACCT GGCTCTTCTC TTGGCTGGAT TCTCCAGCCT TGCAGCGTTG CTTGACTCTG 
CTGAGAGATA GCAGGCCATG GCAGCGGCTG GTAAGAATAG TTCAGTGGGG CTGGCTGGAG 
TTGCCTTGGG TCAAGCAGAA TATTAATAGG CAGGGGAATG CACCTGTAGC TAGTGGGCGC 
TACTGCCAGC CTGAAGAGGA AGTGGCTCGA CTCTTGACCA TGGCTGGGGT TCCTGAGGAT 
GAGCTAAACC CTTTCCATGT ACTGGGGGTT GAGGCCACAG CATCAGATGT TGAACTGAAG 
AAGGCCTATA GACAGCTGGC AGTGATGGTT CATCCTGACA AAAATCATCA TCCCCGGGCT 
GAGGAGGCCT TCAAGGTTTT GCGAGCAGCT TGGGACATTG TCAGCAATGC TGAAAAGCGA 
AAGGAGTATG AGATGAAACG AATGGCAGAG AATGAGCTGA GCCGGTCAGT AAATGAGTTT 
CTGTCCAAGC TGCAAGATGA CCTCAAGGAG GCAATGAATA CTATGATGTG TAGCCGATGC 
CAAGGAAAGC ATAGGAGGTT TGAAATGGAC CGGGAACCTA AGAGTGCCAG ATACTGTGCT 
GAGTGTAATA GGCTGCATCC TGCTGAGGAA GGAGACTTTT GGGCAGAGTC AAGCATGTTG 
GGCCTCAAGA TCACCTACTT TGCACTGATG GATGGAAAGG TGTATGACAT CACAGAGTGG 
GCTGGATGCC AGCGTGTAGG TATCTCCCCA GATACCCACA GAGTCCCCTA TCACATCTCA 
TTTGGTTCTC GGATTCCAGG CACCAGAGGG CGGCAGAGAG CCACCCCAGA TGCCCCTCCT 
GCTGATCTTC AGGATTTCTT GAGTCGGATC TTTCAAGTAC CCCCAGGGCA GATGCCCAAT 
GGGAACTTCT TTGCAGCTCC TCAGCCTGCC CCTGGAGCCG CTGCAGCCTC TAAGCCCAAC 
AGCACAGTAC CCAAGGGAGA AGCCAAACCT AAGCGGCGGA AGAAAGTGAG GAGGCCCTTC 
CAACGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115740.5
CDS	205..2313
Translation	MAQKHPGERGLYGAHHSGGASLRTLGPSVDPEIPSFSGLRDSAGTAPNGTRCLTEHSGPKHTQHPNPAHWLDPSHGPPGGPGPPRDAEDPDQSETSSEEESGVDQELSKENETGNQKDGNSFLSIPSACNCQGTPGIPEGPYSEGGNGSSSNFCHHCTSPALGEDELEEEYDDEESLKFPSDFSRVSSGKKPPSRRQRHRFPTKEDTREGGRRDPRSPGRHRLGRKRSQADKRKGLGLWGAEELCQLGQAGFWWLIELLVLVGEYVETCGHLIYACRQLKSSDLDLFRVWMGVWTGRLGGWAQVMFQFLSQGFYCGVGLFTRFLKLLGALLLLALALFLGFLQLGWRFLVGLGDRLGWRDKATWLFSWLDSPALQRCLTLLRDSRPWQRLVRIVQWGWLELPWVKQNINRQGNAPVASGRYCQPEEEVARLLTMAGVPEDELNPFHVLGVEATASDVELKKAYRQLAVMVHPDKNHHPRAEEAFKVLRAAWDIVSNAEKRKEYEMKRMAENELSRSVNEFLSKLQDDLKEAMNTMMCSRCQGKHRRFEMDREPKSARYCAECNRLHPAEEGDFWAESSMLGLKITYFALMDGKVYDITEWAGCQRVGISPDTHRVPYHISFGSRIPGTRGRQRATPDAPPADLQDFLSRIFQVPPGQMPNGNFFAAPQPAPGAAAASKPNSTVPKGEAKPKRRKKVRRPFQR

Target ORF information:

RefSeq Version	NM_032364.5
Organism	Homo sapiens(human)
Definition	Homo sapiens DnaJ heat shock protein family (Hsp40) member C14 (DNAJC14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032364.5

ORF Insert Sequence:

ATGGCCCAGA AGCACCCCGG AGAAAGAGGG TTGTATGGAG CCCACCACAG TGGTGGTGCC 
TCCCTCAGGA CTTTAGGACC CTCCGTGGAC CCTGAAATAC CTTCATTCTC AGGACTCAGG 
GACTCAGCAG GGACTGCTCC TAATGGTACC CGCTGCCTCA CAGAGCACTC TGGTCCTAAG 
CACACACAGC ACCCAAACCC AGCCCATTGG TTGGACCCAA GCCATGGCCC CCCAGGGGGT 
CCAGGACCAC CTAGAGATGC AGAGGACCCT GATCAGAGTG AGACGTCTTC AGAAGAAGAA 
TCAGGAGTGG ACCAGGAACT CTCAAAAGAA AACGAGACTG GGAACCAGAA GGATGGGAAC 
TCTTTTCTTT CCATTCCATC TGCTTGCAAC TGCCAGGGAA CACCTGGAAT TCCAGAAGGG 
CCTTACTCTG AGGGAGGAAA TGGTTCTTCT AGCAACTTTT GCCACCACTG TACCTCTCCA 
GCTTTGGGGG AAGATGAGTT GGAAGAGGAA TATGATGATG AAGAATCTCT CAAGTTCCCC 
AGTGATTTTT CACGTGTGTC CAGCGGAAAG AAACCCCCAT CCCGGAGACA GCGGCACCGC 
TTTCCAACGA AGGAGGATAC TCGGGAGGGT GGACGTAGGG ATCCCAGGTC CCCTGGTCGA 
CATCGGCTGG GTCGGAAACG AAGTCAGGCA GATAAGCGCA AAGGCCTGGG ATTGTGGGGA 
GCCGAGGAAC TATGTCAACT TGGACAGGCA GGCTTTTGGT GGCTGATTGA ACTGCTGGTA 
TTGGTGGGAG AGTACGTAGA AACTTGTGGC CATCTCATCT ATGCCTGCAG GCAACTGAAA 
AGCAGTGATT TGGACCTTTT TCGAGTTTGG ATGGGAGTGT GGACAGGGCG GTTAGGGGGC 
TGGGCCCAGG TCATGTTTCA GTTTCTAAGC CAGGGGTTTT ACTGTGGAGT AGGACTGTTT 
ACTCGTTTTC TTAAGCTGCT GGGTGCTTTG CTGCTCCTGG CTCTGGCCCT CTTTTTGGGC 
TTTCTACAGT TGGGATGGCG GTTTCTGGTG GGACTAGGTG ACCGGTTAGG CTGGAGGGAT 
AAGGCTACCT GGCTCTTCTC TTGGCTGGAT TCTCCAGCCT TGCAGCGTTG CTTGACTCTG 
CTGAGAGATA GCAGGCCATG GCAGCGGCTG GTAAGAATAG TTCAGTGGGG CTGGCTGGAG 
TTGCCTTGGG TCAAGCAGAA TATTAATAGG CAGGGGAATG CACCTGTAGC TAGTGGGCGC 
TACTGCCAGC CTGAAGAGGA AGTGGCTCGA CTCTTGACCA TGGCTGGGGT TCCTGAGGAT 
GAGCTAAACC CTTTCCATGT ACTGGGGGTT GAGGCCACAG CATCAGATGT TGAACTGAAG 
AAGGCCTATA GACAGCTGGC AGTGATGGTT CATCCTGACA AAAATCATCA TCCCCGGGCT 
GAGGAGGCCT TCAAGGTTTT GCGAGCAGCT TGGGACATTG TCAGCAATGC TGAAAAGCGA 
AAGGAGTATG AGATGAAACG AATGGCAGAG AATGAGCTGA GCCGGTCAGT AAATGAGTTT 
CTGTCCAAGC TGCAAGATGA CCTCAAGGAG GCAATGAATA CTATGATGTG TAGCCGATGC 
CAAGGAAAGC ATAGGAGGTT TGAAATGGAC CGGGAACCTA AGAGTGCCAG ATACTGTGCT 
GAGTGTAATA GGCTGCATCC TGCTGAGGAA GGAGACTTTT GGGCAGAGTC AAGCATGTTG 
GGCCTCAAGA TCACCTACTT TGCACTGATG GATGGAAAGG TGTATGACAT CACAGAGTGG 
GCTGGATGCC AGCGTGTAGG TATCTCCCCA GATACCCACA GAGTCCCCTA TCACATCTCA 
TTTGGTTCTC GGATTCCAGG CACCAGAGGG CGGCAGAGAG CCACCCCAGA TGCCCCTCCT 
GCTGATCTTC AGGATTTCTT GAGTCGGATC TTTCAAGTAC CCCCAGGGCA GATGCCCAAT 
GGGAACTTCT TTGCAGCTCC TCAGCCTGCC CCTGGAGCCG CTGCAGCCTC TAAGCCCAAC 
AGCACAGTAC CCAAGGGAGA AGCCAAACCT AAGCGGCGGA AGAAAGTGAG GAGGCCCTTC 
CAACGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The HSP70 co-chaperone DNAJC14 targets misfolded pendrin for unconventional protein secretion.
Nature communications711386(2016 Apr)
Jung J,Kim J,Roh SH,Jun I,Sampson RD,Gee HY,Choi JY,Lee MG

Chaperone-Assisted Protein Folding Is Critical for Yellow Fever Virus NS3/4A Cleavage and Replication.
Journal of virology90(6)3212-28(2016 Jan)
Bozzacco L,Yi Z,Andreo U,Conklin CR,Li MM,Rice CM,MacDonald MR

Flavivirus replication complex assembly revealed by DNAJC14 functional mapping.
Journal of virology86(21)11815-32(2012 Nov)
Yi Z,Yuan Z,Rice CM,MacDonald MR

Dopamine receptor-interacting protein 78 acts as a molecular chaperone for CCR5 chemokine receptor signaling complex organization.
PloS one7(7)e40522(2012)
Kuang YQ,Charette N,Frazer J,Holland PJ,Attwood KM,Dellaire G,Dupr? DJ

Identification and characterization of the host protein DNAJC14 as a broadly active flavivirus replication modulator.
PLoS pathogens7(1)e1001255(2011 Jan)
Yi Z,Sperzel L,N?rnberger C,Bredenbeek PJ,Lubick KJ,Best SM,Stoyanov CT,Law LM,Yuan Z,Rice CM,MacDonald MR

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DNAJC14 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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