Gene Symbol
PDE5A
Entrez Gene ID
8654
Full Name
phosphodiesterase 5A
Synonyms
CGB-PDE,CN5A,PDE5
General protein information
Preferred Namesphosphodiesterase 5A
NamescGMP-specific 3',5'-cyclic phosphodiesterase cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase cGMP-specific phosphodiesterase PDE5A2 cGMP-specific phosphodiesterase type 5A phosphodiesterase 5A, cGMP-specific phosphodiesterase isozyme 5
Gene Type
protein-coding
Organism
Homo sapiens(human)
Genome
Chromosome: 4
Map Location: 4q26
Summary
This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Disorder MIM:
603310
mRNA and Protein(s)
mRNA
Protein
Name
NM_033430.3
NP_236914.2
cGMP-specific 3',5'-cyclic phosphodiesterase isoform 2
XM_017008791.2
XP_016864280.1
cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1
NM_001083.3
NP_001074.2
cGMP-specific 3',5'-cyclic phosphodiesterase isoform 1
NM_033437.3
NP_246273.2
cGMP-specific 3',5'-cyclic phosphodiesterase isoform 3
XM_017008791.1
XP_016864280.1
cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1
NM_033430.2
NP_236914.2
cGMP-specific 3',5'-cyclic phosphodiesterase isoform 2
NM_001083.4
NP_001074.2
cGMP-specific 3',5'-cyclic phosphodiesterase isoform 1
Danio rerio (zebrafish)
pde5ab
NP_001116732.1
Drosophila melanogaster (fruit fly)
Pde11
NP_001188837.1
Pan troglodytes (chimpanzee)
PDE5A
XP_001150967.2
PDE5A
XP_001099652.1
Canis lupus familiaris (dog)
PDE5A
NP_001003188.1
Bos taurus (cattle)
PDE5A
NP_776842.1
Anopheles gambiae (African malaria mosquito)
AgaP_AGAP008646
XP_314743.3
Rattus norvegicus (Norway rat)
Pde5a
NP_598268.1
Xenopus tropicalis (tropical clawed frog)
pde5a
NP_001072812.1
Homo sapiens (human)
PDE5A
NP_001074.2
Mus musculus (house mouse)
Pde5a
NP_700471.2
Gallus gallus (chicken)
PDE5A
XP_420631.3
Related articles in PubMed
Distinct phosphodiesterase 5A-containing compartments allow selective regulation of cGMP-dependent signalling in human arterial smooth muscle cells.
Wilson LS, Guo M, Umana MB, Maurice DH Cellular signalling36204-211(2017 Aug)
Inhibition of PDE5A1 guanosine cyclic monophosphate (cGMP) hydrolysing activity by sildenafil analogues that inhibit cellular cGMP efflux.
Subbotina A, Ravna AW, Lysaa RA, Abagyan R, Bugno R, Sager G The Journal of pharmacy and pharmacology69(6)675-683(2017 Jun)
Type 5 phosphodiesterase regulates glioblastoma multiforme aggressiveness and clinical outcome.
Cesarini V, Martini M, Vitiani LR, Gravina GL, Di Agostino S, Graziani G, D'Alessandris QG, Pallini R, Larocca LM, Rossi P, Jannini EA, Dolci S Oncotarget8(8)13223-13239(2017 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The following PDE5A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PDE5A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+ /C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID
OHu00024
Clone ID Related Accession (Same CDS sequence)
NM_033437.3
Accession Version
NM_033437.3 Latest version!
Documents for ORF clone product in default vector
Sequence Information
ORF Nucleotide Sequence (Length: 2472bp)
Protein sequence
SNP
Vector
pcDNA3.1+ /C-(K)DYK or customized vector
User Manual
Clone information
Clone Map
MSDS
Tag on pcDNA3.1+ /C-(K)DYK
C terminal DYKDDDDK tags
ORF Insert Method
CloneEZ™ Seamless cloning technology
Insert Structure
linear
Update Date
2019-12-03
Organism
Homo sapiens(human)
Product
cGMP-specific 3',5'-cyclic phosphodiesterase isoform 3
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF155194.1, CD511199.1, BC126233.1, AC093752.2 and BM978332.1. On Jul 28, 2010 this sequence version replaced NM_033437.2.
Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (3, also known as PDE5A3) is shorter at the N-terminus, compared to isoform 1. There are no publicly available full-length transcripts supporting this variant; it is represented based on full-length cloning by RT-PCR in PMID:10679255.
Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1803616.108416.1, SRR1803611.184255.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA2467148 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 1381 1441 1501 1561 1621 1681 1741 1801 1861 1921 1981 2041 2101 2161 2221 2281 2341 2401 2461 ATGGTCAATG CATGGTTTGC TGAGAGAGTT CACACCATCC CTGTGTGCAA GGAAGGTATC AGAGGCCACA CCGAATCTTG CTCTTGTCCC TTGCAGCAGA GTCCTCGTGC AGATAACAGT GCCCCTGGAA CACCAACCAG GAAAATCTCT GCCTCTGAAT TTGACCGGCC TCTTAGACCC ATTGTTGTCA AGGATTCTGA GGGAACTGTG AGCTTCCTCT CTGACTCAGA AAAGAAGGAA CAGATGCCTC TAACCCCTCC AAGGTTTGAT CATGATGAAG GGGACCAGTG CTCAAGACTC TTGGAATTAG TGAAGGATAT TTCTAGTCAT TTGGATGTCA CAGCCTTATG TCACAAAATT TTCTTGCATA TCCATGGACT GATATCTGCT GACCGCTATT CCCTGTTCCT TGTCTGTGAA GACAGCTCCA ATGACAAGTT TCTTATCAGC CGCCTCTTTG ATGTTGCTGA AGGTTCAACA CTGGAAGAAG TTTCAAATAA CTGTATCCGC TTAGAATGGA ACAAAGGCAT TGTGGGACAT GTGGCAGCGC TTGGTGAGCC CTTGAACATC AAAGATGCAT ATGAGGATCC TCGGTTCAAT GCAGAAGTTG ACCAAATTAC AGGCTACAAG ACACAAAGCA TTCTTTGTAT GCCAATTAAG AATCATAGGG AAGAGGTTGT TGGTGTAGCC CAGGCCATCA ACAAGAAATC AGGAAACGGT GGGACATTTA CTGAAAAAGA TGAAAAGGAC TTTGCTGCTT ATTTGGCATT TTGTGGTATT GTTCTTCATA ATGCTCAGCT CTATGAGACT TCACTGCTGG AGAACAAGAG AAATCAGGTG CTGCTTGACC TTGCTAGTTT AATTTTTGAA GAACAACAAT CATTAGAAGT AATTTTGAAG AAAATAGCTG CCACTATTAT CTCTTTCATG CAAGTGCAGA AATGCACCAT TTTCATAGTG GATGAAGATT GCTCCGATTC TTTTTCTAGT GTGTTTCACA TGGAGTGTGA GGAATTAGAA AAATCATCTG ATACATTAAC AAGGGAACAT GATGCAAACA AAATCAATTA CATGTATGCT CAGTATGTCA AAAATACTAT GGAACCACTT AATATCCCAG ATGTCAGTAA GGATAAAAGA TTTCCCTGGA CAACTGAAAA TACAGGAAAT GTAAACCAGC AGTGCATTAG AAGTTTGCTT TGTACACCTA TAAAAAATGG AAAGAAGAAT AAAGTTATAG GGGTTTGCCA ACTTGTTAAT AAGATGGAGG AGAATACTGG CAAGGTTAAG CCTTTCAACC GAAATGACGA ACAGTTTCTG GAAGCTTTTG TCATCTTTTG TGGCTTGGGG ATCCAGAACA CGCAGATGTA TGAAGCAGTG GAGAGAGCCA TGGCCAAGCA AATGGTCACA TTGGAGGTTC TGTCGTATCA TGCTTCAGCA GCAGAGGAAG AAACAAGAGA GCTACAGTCG TTAGCGGCTG CTGTGGTGCC ATCTGCCCAG ACCCTTAAAA TTACTGACTT TAGCTTCAGT GACTTTGAGC TGTCTGATCT GGAAACAGCA CTGTGTACAA TTCGGATGTT TACTGACCTC AACCTTGTGC AGAACTTCCA GATGAAACAT GAGGTTCTTT GCAGATGGAT TTTAAGTGTT AAGAAGAATT ATCGGAAGAA TGTTGCCTAT CATAATTGGA GACATGCCTT TAATACAGCT CAGTGCATGT TTGCTGCTCT AAAAGCAGGC AAAATTCAGA ACAAGCTGAC TGACCTGGAG ATACTTGCAT TGCTGATTGC TGCACTAAGC CACGATTTGG ATCACCGTGG TGTGAATAAC TCTTACATAC AGCGAAGTGA ACATCCACTT GCCCAGCTTT ACTGCCATTC AATCATGGAA CACCATCATT TTGACCAGTG CCTGATGATT CTTAATAGTC CAGGCAATCA GATTCTCAGT GGCCTCTCCA TTGAAGAATA TAAGACCACG TTGAAAATAA TCAAGCAAGC TATTTTAGCT ACAGACCTAG CACTGTACAT TAAGAGGCGA GGAGAATTTT TTGAACTTAT AAGAAAAAAT CAATTCAATT TGGAAGATCC TCATCAAAAG GAGTTGTTTT TGGCAATGCT GATGACAGCT TGTGATCTTT CTGCAATTAC AAAACCCTGG CCTATTCAAC AACGGATAGC AGAACTTGTA GCAACTGAAT TTTTTGATCA AGGAGACAGA GAGAGAAAAG AACTCAACAT AGAACCCACT GATCTAATGA ACAGGGAGAA GAAAAACAAA ATCCCAAGTA TGCAAGTTGG GTTCATAGAT GCCATCTGCT TGCAACTGTA TGAGGCCCTG ACCCACGTGT CAGAGGACTG TTTCCCTTTG CTAGATGGCT GCAGAAAGAA CAGGCAGAAA TGGCAGGCCC TTGCAGAACA GCAGGAGAAG ATGCTGATTA ATGGGGAAAG CGGCCAGGCC AAGCGGAACT GA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
RefSeq
NP_246273.2
CDS 95..2566
Translation
Target ORF information:
RefSeq Version NM_033437.3
Organism Homo sapiens(human)
Definition Homo sapiens phosphodiesterase 5A (PDE5A), transcript variant 3, mRNA.
Target ORF information:
Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+ /C-(K)DYK
NM_033437.3
ORF Insert Sequence:
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 1381 1441 1501 1561 1621 1681 1741 1801 1861 1921 1981 2041 2101 2161 2221 2281 2341 2401 2461 ATGGTCAATG CATGGTTTGC TGAGAGAGTT CACACCATCC CTGTGTGCAA GGAAGGTATC AGAGGCCACA CCGAATCTTG CTCTTGTCCC TTGCAGCAGA GTCCTCGTGC AGATAACAGT GCCCCTGGAA CACCAACCAG GAAAATCTCT GCCTCTGAAT TTGACCGGCC TCTTAGACCC ATTGTTGTCA AGGATTCTGA GGGAACTGTG AGCTTCCTCT CTGACTCAGA AAAGAAGGAA CAGATGCCTC TAACCCCTCC AAGGTTTGAT CATGATGAAG GGGACCAGTG CTCAAGACTC TTGGAATTAG TGAAGGATAT TTCTAGTCAT TTGGATGTCA CAGCCTTATG TCACAAAATT TTCTTGCATA TCCATGGACT GATATCTGCT GACCGCTATT CCCTGTTCCT TGTCTGTGAA GACAGCTCCA ATGACAAGTT TCTTATCAGC CGCCTCTTTG ATGTTGCTGA AGGTTCAACA CTGGAAGAAG TTTCAAATAA CTGTATCCGC TTAGAATGGA ACAAAGGCAT TGTGGGACAT GTGGCAGCGC TTGGTGAGCC CTTGAACATC AAAGATGCAT ATGAGGATCC TCGGTTCAAT GCAGAAGTTG ACCAAATTAC AGGCTACAAG ACACAAAGCA TTCTTTGTAT GCCAATTAAG AATCATAGGG AAGAGGTTGT TGGTGTAGCC CAGGCCATCA ACAAGAAATC AGGAAACGGT GGGACATTTA CTGAAAAAGA TGAAAAGGAC TTTGCTGCTT ATTTGGCATT TTGTGGTATT GTTCTTCATA ATGCTCAGCT CTATGAGACT TCACTGCTGG AGAACAAGAG AAATCAGGTG CTGCTTGACC TTGCTAGTTT AATTTTTGAA GAACAACAAT CATTAGAAGT AATTTTGAAG AAAATAGCTG CCACTATTAT CTCTTTCATG CAAGTGCAGA AATGCACCAT TTTCATAGTG GATGAAGATT GCTCCGATTC TTTTTCTAGT GTGTTTCACA TGGAGTGTGA GGAATTAGAA AAATCATCTG ATACATTAAC AAGGGAACAT GATGCAAACA AAATCAATTA CATGTATGCT CAGTATGTCA AAAATACTAT GGAACCACTT AATATCCCAG ATGTCAGTAA GGATAAAAGA TTTCCCTGGA CAACTGAAAA TACAGGAAAT GTAAACCAGC AGTGCATTAG AAGTTTGCTT TGTACACCTA TAAAAAATGG AAAGAAGAAT AAAGTTATAG GGGTTTGCCA ACTTGTTAAT AAGATGGAGG AGAATACTGG CAAGGTTAAG CCTTTCAACC GAAATGACGA ACAGTTTCTG GAAGCTTTTG TCATCTTTTG TGGCTTGGGG ATCCAGAACA CGCAGATGTA TGAAGCAGTG GAGAGAGCCA TGGCCAAGCA AATGGTCACA TTGGAGGTTC TGTCGTATCA TGCTTCAGCA GCAGAGGAAG AAACAAGAGA GCTACAGTCG TTAGCGGCTG CTGTGGTGCC ATCTGCCCAG ACCCTTAAAA TTACTGACTT TAGCTTCAGT GACTTTGAGC TGTCTGATCT GGAAACAGCA CTGTGTACAA TTCGGATGTT TACTGACCTC AACCTTGTGC AGAACTTCCA GATGAAACAT GAGGTTCTTT GCAGATGGAT TTTAAGTGTT AAGAAGAATT ATCGGAAGAA TGTTGCCTAT CATAATTGGA GACATGCCTT TAATACAGCT CAGTGCATGT TTGCTGCTCT AAAAGCAGGC AAAATTCAGA ACAAGCTGAC TGACCTGGAG ATACTTGCAT TGCTGATTGC TGCACTAAGC CACGATTTGG ATCACCGTGG TGTGAATAAC TCTTACATAC AGCGAAGTGA ACATCCACTT GCCCAGCTTT ACTGCCATTC AATCATGGAA CACCATCATT TTGACCAGTG CCTGATGATT CTTAATAGTC CAGGCAATCA GATTCTCAGT GGCCTCTCCA TTGAAGAATA TAAGACCACG TTGAAAATAA TCAAGCAAGC TATTTTAGCT ACAGACCTAG CACTGTACAT TAAGAGGCGA GGAGAATTTT TTGAACTTAT AAGAAAAAAT CAATTCAATT TGGAAGATCC TCATCAAAAG GAGTTGTTTT TGGCAATGCT GATGACAGCT TGTGATCTTT CTGCAATTAC AAAACCCTGG CCTATTCAAC AACGGATAGC AGAACTTGTA GCAACTGAAT TTTTTGATCA AGGAGACAGA GAGAGAAAAG AACTCAACAT AGAACCCACT GATCTAATGA ACAGGGAGAA GAAAAACAAA ATCCCAAGTA TGCAAGTTGG GTTCATAGAT GCCATCTGCT TGCAACTGTA TGAGGCCCTG ACCCACGTGT CAGAGGACTG TTTCCCTTTG CTAGATGGCT GCAGAAAGAA CAGGCAGAAA TGGCAGGCCC TTGCAGAACA GCAGGAGAAG ATGCTGATTA ATGGGGAAAG CGGCCAGGCC AAGCGGAACT GA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
CloneID
OHu02694
Clone ID Related Accession (Same CDS sequence)
NM_001083.3
, NM_001083.4
Accession Version
NM_001083.3
Documents for ORF clone product in default vector
Sequence Information
ORF Nucleotide Sequence (Length: 2628bp)
Protein sequence
SNP
Vector
pcDNA3.1+ /C-(K)DYK or customized vector
User Manual
Clone information
Clone Map
MSDS
Tag on pcDNA3.1+ /C-(K)DYK
C terminal DYKDDDDK tags
ORF Insert Method
CloneEZ™ Seamless cloning technology
Insert Structure
linear
Update Date
2017-12-26
Organism
Homo sapiens(human)
Product
cGMP-specific 3',5'-cyclic phosphodiesterase isoform 1
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM920622.1, AF043731.1, AY264918.1, AC093752.2 and BM978332.1. On or before Mar 24, 2005 this sequence version replaced NM_033431.1, NM_001083.2.
Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as PDE5A1).
Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC126233.1, SRR1803611.275562.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA2467148 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 1381 1441 1501 1561 1621 1681 1741 1801 1861 1921 1981 2041 2101 2161 2221 2281 2341 2401 2461 2521 2581 ATGGAGCGGG CCGGCCCCAG CTTCGGGCAG CAGCGACAGC AGCAGCAGCC CCAGCAGCAG AAGCAGCAGC AGAGGGATCA GGACTCGGTC GAAGCATGGC TGGACGATCA CTGGGACTTT ACCTTCTCAT ACTTTGTTAG AAAAGCCACC AGAGAAATGG TCAATGCATG GTTTGCTGAG AGAGTTCACA CCATCCCTGT GTGCAAGGAA GGTATCAGAG GCCACACCGA ATCTTGCTCT TGTCCCTTGC AGCAGAGTCC TCGTGCAGAT AACAGTGCCC CTGGAACACC AACCAGGAAA ATCTCTGCCT CTGAATTTGA CCGGCCTCTT AGACCCATTG TTGTCAAGGA TTCTGAGGGA ACTGTGAGCT TCCTCTCTGA CTCAGAAAAG AAGGAACAGA TGCCTCTAAC CCCTCCAAGG TTTGATCATG ATGAAGGGGA CCAGTGCTCA AGACTCTTGG AATTAGTGAA GGATATTTCT AGTCATTTGG ATGTCACAGC CTTATGTCAC AAAATTTTCT TGCATATCCA TGGACTGATA TCTGCTGACC GCTATTCCCT GTTCCTTGTC TGTGAAGACA GCTCCAATGA CAAGTTTCTT ATCAGCCGCC TCTTTGATGT TGCTGAAGGT TCAACACTGG AAGAAGTTTC AAATAACTGT ATCCGCTTAG AATGGAACAA AGGCATTGTG GGACATGTGG CAGCGCTTGG TGAGCCCTTG AACATCAAAG ATGCATATGA GGATCCTCGG TTCAATGCAG AAGTTGACCA AATTACAGGC TACAAGACAC AAAGCATTCT TTGTATGCCA ATTAAGAATC ATAGGGAAGA GGTTGTTGGT GTAGCCCAGG CCATCAACAA GAAATCAGGA AACGGTGGGA CATTTACTGA AAAAGATGAA AAGGACTTTG CTGCTTATTT GGCATTTTGT GGTATTGTTC TTCATAATGC TCAGCTCTAT GAGACTTCAC TGCTGGAGAA CAAGAGAAAT CAGGTGCTGC TTGACCTTGC TAGTTTAATT TTTGAAGAAC AACAATCATT AGAAGTAATT TTGAAGAAAA TAGCTGCCAC TATTATCTCT TTCATGCAAG TGCAGAAATG CACCATTTTC ATAGTGGATG AAGATTGCTC CGATTCTTTT TCTAGTGTGT TTCACATGGA GTGTGAGGAA TTAGAAAAAT CATCTGATAC ATTAACAAGG GAACATGATG CAAACAAAAT CAATTACATG TATGCTCAGT ATGTCAAAAA TACTATGGAA CCACTTAATA TCCCAGATGT CAGTAAGGAT AAAAGATTTC CCTGGACAAC TGAAAATACA GGAAATGTAA ACCAGCAGTG CATTAGAAGT TTGCTTTGTA CACCTATAAA AAATGGAAAG AAGAATAAAG TTATAGGGGT TTGCCAACTT GTTAATAAGA TGGAGGAGAA TACTGGCAAG GTTAAGCCTT TCAACCGAAA TGACGAACAG TTTCTGGAAG CTTTTGTCAT CTTTTGTGGC TTGGGGATCC AGAACACGCA GATGTATGAA GCAGTGGAGA GAGCCATGGC CAAGCAAATG GTCACATTGG AGGTTCTGTC GTATCATGCT TCAGCAGCAG AGGAAGAAAC AAGAGAGCTA CAGTCGTTAG CGGCTGCTGT GGTGCCATCT GCCCAGACCC TTAAAATTAC TGACTTTAGC TTCAGTGACT TTGAGCTGTC TGATCTGGAA ACAGCACTGT GTACAATTCG GATGTTTACT GACCTCAACC TTGTGCAGAA CTTCCAGATG AAACATGAGG TTCTTTGCAG ATGGATTTTA AGTGTTAAGA AGAATTATCG GAAGAATGTT GCCTATCATA ATTGGAGACA TGCCTTTAAT ACAGCTCAGT GCATGTTTGC TGCTCTAAAA GCAGGCAAAA TTCAGAACAA GCTGACTGAC CTGGAGATAC TTGCATTGCT GATTGCTGCA CTAAGCCACG ATTTGGATCA CCGTGGTGTG AATAACTCTT ACATACAGCG AAGTGAACAT CCACTTGCCC AGCTTTACTG CCATTCAATC ATGGAACACC ATCATTTTGA CCAGTGCCTG ATGATTCTTA ATAGTCCAGG CAATCAGATT CTCAGTGGCC TCTCCATTGA AGAATATAAG ACCACGTTGA AAATAATCAA GCAAGCTATT TTAGCTACAG ACCTAGCACT GTACATTAAG AGGCGAGGAG AATTTTTTGA ACTTATAAGA AAAAATCAAT TCAATTTGGA AGATCCTCAT CAAAAGGAGT TGTTTTTGGC AATGCTGATG ACAGCTTGTG ATCTTTCTGC AATTACAAAA CCCTGGCCTA TTCAACAACG GATAGCAGAA CTTGTAGCAA CTGAATTTTT TGATCAAGGA GACAGAGAGA GAAAAGAACT CAACATAGAA CCCACTGATC TAATGAACAG GGAGAAGAAA AACAAAATCC CAAGTATGCA AGTTGGGTTC ATAGATGCCA TCTGCTTGCA ACTGTATGAG GCCCTGACCC ACGTGTCAGA GGACTGTTTC CCTTTGCTAG ATGGCTGCAG AAAGAACAGG CAGAAATGGC AGGCCCTTGC AGAACAGCAG GAGAAGATGC TGATTAATGG GGAAAGCGGC CAGGCCAAGC GGAACTGA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
RefSeq
NP_001074.2
CDS 156..2783
Translation
Target ORF information:
RefSeq Version NM_001083.3
Organism Homo sapiens(human)
Definition Homo sapiens phosphodiesterase 5A (PDE5A), transcript variant 1, mRNA.
Target ORF information:
Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+ /C-(K)DYK
NM_001083.3
ORF Insert Sequence:
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 1381 1441 1501 1561 1621 1681 1741 1801 1861 1921 1981 2041 2101 2161 2221 2281 2341 2401 2461 2521 2581 ATGGAGCGGG CCGGCCCCAG CTTCGGGCAG CAGCGACAGC AGCAGCAGCC CCAGCAGCAG AAGCAGCAGC AGAGGGATCA GGACTCGGTC GAAGCATGGC TGGACGATCA CTGGGACTTT ACCTTCTCAT ACTTTGTTAG AAAAGCCACC AGAGAAATGG TCAATGCATG GTTTGCTGAG AGAGTTCACA CCATCCCTGT GTGCAAGGAA GGTATCAGAG GCCACACCGA ATCTTGCTCT TGTCCCTTGC AGCAGAGTCC TCGTGCAGAT AACAGTGCCC CTGGAACACC AACCAGGAAA ATCTCTGCCT CTGAATTTGA CCGGCCTCTT AGACCCATTG TTGTCAAGGA TTCTGAGGGA ACTGTGAGCT TCCTCTCTGA CTCAGAAAAG AAGGAACAGA TGCCTCTAAC CCCTCCAAGG TTTGATCATG ATGAAGGGGA CCAGTGCTCA AGACTCTTGG AATTAGTGAA GGATATTTCT AGTCATTTGG ATGTCACAGC CTTATGTCAC AAAATTTTCT TGCATATCCA TGGACTGATA TCTGCTGACC GCTATTCCCT GTTCCTTGTC TGTGAAGACA GCTCCAATGA CAAGTTTCTT ATCAGCCGCC TCTTTGATGT TGCTGAAGGT TCAACACTGG AAGAAGTTTC AAATAACTGT ATCCGCTTAG AATGGAACAA AGGCATTGTG GGACATGTGG CAGCGCTTGG TGAGCCCTTG AACATCAAAG ATGCATATGA GGATCCTCGG TTCAATGCAG AAGTTGACCA AATTACAGGC TACAAGACAC AAAGCATTCT TTGTATGCCA ATTAAGAATC ATAGGGAAGA GGTTGTTGGT GTAGCCCAGG CCATCAACAA GAAATCAGGA AACGGTGGGA CATTTACTGA AAAAGATGAA AAGGACTTTG CTGCTTATTT GGCATTTTGT GGTATTGTTC TTCATAATGC TCAGCTCTAT GAGACTTCAC TGCTGGAGAA CAAGAGAAAT CAGGTGCTGC TTGACCTTGC TAGTTTAATT TTTGAAGAAC AACAATCATT AGAAGTAATT TTGAAGAAAA TAGCTGCCAC TATTATCTCT TTCATGCAAG TGCAGAAATG CACCATTTTC ATAGTGGATG AAGATTGCTC CGATTCTTTT TCTAGTGTGT TTCACATGGA GTGTGAGGAA TTAGAAAAAT CATCTGATAC ATTAACAAGG GAACATGATG CAAACAAAAT CAATTACATG TATGCTCAGT ATGTCAAAAA TACTATGGAA CCACTTAATA TCCCAGATGT CAGTAAGGAT AAAAGATTTC CCTGGACAAC TGAAAATACA GGAAATGTAA ACCAGCAGTG CATTAGAAGT TTGCTTTGTA CACCTATAAA AAATGGAAAG AAGAATAAAG TTATAGGGGT TTGCCAACTT GTTAATAAGA TGGAGGAGAA TACTGGCAAG GTTAAGCCTT TCAACCGAAA TGACGAACAG TTTCTGGAAG CTTTTGTCAT CTTTTGTGGC TTGGGGATCC AGAACACGCA GATGTATGAA GCAGTGGAGA GAGCCATGGC CAAGCAAATG GTCACATTGG AGGTTCTGTC GTATCATGCT TCAGCAGCAG AGGAAGAAAC AAGAGAGCTA CAGTCGTTAG CGGCTGCTGT GGTGCCATCT GCCCAGACCC TTAAAATTAC TGACTTTAGC TTCAGTGACT TTGAGCTGTC TGATCTGGAA ACAGCACTGT GTACAATTCG GATGTTTACT GACCTCAACC TTGTGCAGAA CTTCCAGATG AAACATGAGG TTCTTTGCAG ATGGATTTTA AGTGTTAAGA AGAATTATCG GAAGAATGTT GCCTATCATA ATTGGAGACA TGCCTTTAAT ACAGCTCAGT GCATGTTTGC TGCTCTAAAA GCAGGCAAAA TTCAGAACAA GCTGACTGAC CTGGAGATAC TTGCATTGCT GATTGCTGCA CTAAGCCACG ATTTGGATCA CCGTGGTGTG AATAACTCTT ACATACAGCG AAGTGAACAT CCACTTGCCC AGCTTTACTG CCATTCAATC ATGGAACACC ATCATTTTGA CCAGTGCCTG ATGATTCTTA ATAGTCCAGG CAATCAGATT CTCAGTGGCC TCTCCATTGA AGAATATAAG ACCACGTTGA AAATAATCAA GCAAGCTATT TTAGCTACAG ACCTAGCACT GTACATTAAG AGGCGAGGAG AATTTTTTGA ACTTATAAGA AAAAATCAAT TCAATTTGGA AGATCCTCAT CAAAAGGAGT TGTTTTTGGC AATGCTGATG ACAGCTTGTG ATCTTTCTGC AATTACAAAA CCCTGGCCTA TTCAACAACG GATAGCAGAA CTTGTAGCAA CTGAATTTTT TGATCAAGGA GACAGAGAGA GAAAAGAACT CAACATAGAA CCCACTGATC TAATGAACAG GGAGAAGAAA AACAAAATCC CAAGTATGCA AGTTGGGTTC ATAGATGCCA TCTGCTTGCA ACTGTATGAG GCCCTGACCC ACGTGTCAGA GGACTGTTTC CCTTTGCTAG ATGGCTGCAG AAAGAACAGG CAGAAATGGC AGGCCCTTGC AGAACAGCAG GAGAAGATGC TGATTAATGG GGAAAGCGGC CAGGCCAAGC GGAACTGA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
CloneID
OHu02694
Clone ID Related Accession (Same CDS sequence)
NM_001083.3
, NM_001083.4
Accession Version
NM_001083.4 Latest version!
Documents for ORF clone product in default vector
Sequence Information
ORF Nucleotide Sequence (Length: 2628bp)
Protein sequence
SNP
Vector
pcDNA3.1+ /C-(K)DYK or customized vector
User Manual
Clone information
Clone Map
MSDS
Tag on pcDNA3.1+ /C-(K)DYK
C terminal DYKDDDDK tags
ORF Insert Method
CloneEZ™ Seamless cloning technology
Insert Structure
linear
Update Date
2019-12-03
Organism
Homo sapiens(human)
Product
cGMP-specific 3',5'-cyclic phosphodiesterase isoform 1
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF043731.1, AY264918.1, AC093752.2 and BM978332.1. On Nov 23, 2018 this sequence version replaced NM_001083.3.
Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as PDE5A1).
Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC126233.1, SRR1803611.275562.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA2467148 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000354960.8/ ENSP00000347046.3
RefSeq Select criteria :: based on conservation, expression, longest protein
##RefSeq-Attributes-END##
COMPLETENESS: full length.
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 1381 1441 1501 1561 1621 1681 1741 1801 1861 1921 1981 2041 2101 2161 2221 2281 2341 2401 2461 2521 2581 ATGGAGCGGG CCGGCCCCAG CTTCGGGCAG CAGCGACAGC AGCAGCAGCC CCAGCAGCAG AAGCAGCAGC AGAGGGATCA GGACTCGGTC GAAGCATGGC TGGACGATCA CTGGGACTTT ACCTTCTCAT ACTTTGTTAG AAAAGCCACC AGAGAAATGG TCAATGCATG GTTTGCTGAG AGAGTTCACA CCATCCCTGT GTGCAAGGAA GGTATCAGAG GCCACACCGA ATCTTGCTCT TGTCCCTTGC AGCAGAGTCC TCGTGCAGAT AACAGTGCCC CTGGAACACC AACCAGGAAA ATCTCTGCCT CTGAATTTGA CCGGCCTCTT AGACCCATTG TTGTCAAGGA TTCTGAGGGA ACTGTGAGCT TCCTCTCTGA CTCAGAAAAG AAGGAACAGA TGCCTCTAAC CCCTCCAAGG TTTGATCATG ATGAAGGGGA CCAGTGCTCA AGACTCTTGG AATTAGTGAA GGATATTTCT AGTCATTTGG ATGTCACAGC CTTATGTCAC AAAATTTTCT TGCATATCCA TGGACTGATA TCTGCTGACC GCTATTCCCT GTTCCTTGTC TGTGAAGACA GCTCCAATGA CAAGTTTCTT ATCAGCCGCC TCTTTGATGT TGCTGAAGGT TCAACACTGG AAGAAGTTTC AAATAACTGT ATCCGCTTAG AATGGAACAA AGGCATTGTG GGACATGTGG CAGCGCTTGG TGAGCCCTTG AACATCAAAG ATGCATATGA GGATCCTCGG TTCAATGCAG AAGTTGACCA AATTACAGGC TACAAGACAC AAAGCATTCT TTGTATGCCA ATTAAGAATC ATAGGGAAGA GGTTGTTGGT GTAGCCCAGG CCATCAACAA GAAATCAGGA AACGGTGGGA CATTTACTGA AAAAGATGAA AAGGACTTTG CTGCTTATTT GGCATTTTGT GGTATTGTTC TTCATAATGC TCAGCTCTAT GAGACTTCAC TGCTGGAGAA CAAGAGAAAT CAGGTGCTGC TTGACCTTGC TAGTTTAATT TTTGAAGAAC AACAATCATT AGAAGTAATT TTGAAGAAAA TAGCTGCCAC TATTATCTCT TTCATGCAAG TGCAGAAATG CACCATTTTC ATAGTGGATG AAGATTGCTC CGATTCTTTT TCTAGTGTGT TTCACATGGA GTGTGAGGAA TTAGAAAAAT CATCTGATAC ATTAACAAGG GAACATGATG CAAACAAAAT CAATTACATG TATGCTCAGT ATGTCAAAAA TACTATGGAA CCACTTAATA TCCCAGATGT CAGTAAGGAT AAAAGATTTC CCTGGACAAC TGAAAATACA GGAAATGTAA ACCAGCAGTG CATTAGAAGT TTGCTTTGTA CACCTATAAA AAATGGAAAG AAGAATAAAG TTATAGGGGT TTGCCAACTT GTTAATAAGA TGGAGGAGAA TACTGGCAAG GTTAAGCCTT TCAACCGAAA TGACGAACAG TTTCTGGAAG CTTTTGTCAT CTTTTGTGGC TTGGGGATCC AGAACACGCA GATGTATGAA GCAGTGGAGA GAGCCATGGC CAAGCAAATG GTCACATTGG AGGTTCTGTC GTATCATGCT TCAGCAGCAG AGGAAGAAAC AAGAGAGCTA CAGTCGTTAG CGGCTGCTGT GGTGCCATCT GCCCAGACCC TTAAAATTAC TGACTTTAGC TTCAGTGACT TTGAGCTGTC TGATCTGGAA ACAGCACTGT GTACAATTCG GATGTTTACT GACCTCAACC TTGTGCAGAA CTTCCAGATG AAACATGAGG TTCTTTGCAG ATGGATTTTA AGTGTTAAGA AGAATTATCG GAAGAATGTT GCCTATCATA ATTGGAGACA TGCCTTTAAT ACAGCTCAGT GCATGTTTGC TGCTCTAAAA GCAGGCAAAA TTCAGAACAA GCTGACTGAC CTGGAGATAC TTGCATTGCT GATTGCTGCA CTAAGCCACG ATTTGGATCA CCGTGGTGTG AATAACTCTT ACATACAGCG AAGTGAACAT CCACTTGCCC AGCTTTACTG CCATTCAATC ATGGAACACC ATCATTTTGA CCAGTGCCTG ATGATTCTTA ATAGTCCAGG CAATCAGATT CTCAGTGGCC TCTCCATTGA AGAATATAAG ACCACGTTGA AAATAATCAA GCAAGCTATT TTAGCTACAG ACCTAGCACT GTACATTAAG AGGCGAGGAG AATTTTTTGA ACTTATAAGA AAAAATCAAT TCAATTTGGA AGATCCTCAT CAAAAGGAGT TGTTTTTGGC AATGCTGATG ACAGCTTGTG ATCTTTCTGC AATTACAAAA CCCTGGCCTA TTCAACAACG GATAGCAGAA CTTGTAGCAA CTGAATTTTT TGATCAAGGA GACAGAGAGA GAAAAGAACT CAACATAGAA CCCACTGATC TAATGAACAG GGAGAAGAAA AACAAAATCC CAAGTATGCA AGTTGGGTTC ATAGATGCCA TCTGCTTGCA ACTGTATGAG GCCCTGACCC ACGTGTCAGA GGACTGTTTC CCTTTGCTAG ATGGCTGCAG AAAGAACAGG CAGAAATGGC AGGCCCTTGC AGAACAGCAG GAGAAGATGC TGATTAATGG GGAAAGCGGC CAGGCCAAGC GGAACTGA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
RefSeq
NP_001074.2
CDS 134..2761
Translation
Target ORF information:
RefSeq Version NM_001083.4
Organism Homo sapiens(human)
Definition Homo sapiens phosphodiesterase 5A (PDE5A), transcript variant 1, mRNA.
Target ORF information:
Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+ /C-(K)DYK
NM_001083.4
ORF Insert Sequence:
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 1381 1441 1501 1561 1621 1681 1741 1801 1861 1921 1981 2041 2101 2161 2221 2281 2341 2401 2461 2521 2581 ATGGAGCGGG CCGGCCCCAG CTTCGGGCAG CAGCGACAGC AGCAGCAGCC CCAGCAGCAG AAGCAGCAGC AGAGGGATCA GGACTCGGTC GAAGCATGGC TGGACGATCA CTGGGACTTT ACCTTCTCAT ACTTTGTTAG AAAAGCCACC AGAGAAATGG TCAATGCATG GTTTGCTGAG AGAGTTCACA CCATCCCTGT GTGCAAGGAA GGTATCAGAG GCCACACCGA ATCTTGCTCT TGTCCCTTGC AGCAGAGTCC TCGTGCAGAT AACAGTGCCC CTGGAACACC AACCAGGAAA ATCTCTGCCT CTGAATTTGA CCGGCCTCTT AGACCCATTG TTGTCAAGGA TTCTGAGGGA ACTGTGAGCT TCCTCTCTGA CTCAGAAAAG AAGGAACAGA TGCCTCTAAC CCCTCCAAGG TTTGATCATG ATGAAGGGGA CCAGTGCTCA AGACTCTTGG AATTAGTGAA GGATATTTCT AGTCATTTGG ATGTCACAGC CTTATGTCAC AAAATTTTCT TGCATATCCA TGGACTGATA TCTGCTGACC GCTATTCCCT GTTCCTTGTC TGTGAAGACA GCTCCAATGA CAAGTTTCTT ATCAGCCGCC TCTTTGATGT TGCTGAAGGT TCAACACTGG AAGAAGTTTC AAATAACTGT ATCCGCTTAG AATGGAACAA AGGCATTGTG GGACATGTGG CAGCGCTTGG TGAGCCCTTG AACATCAAAG ATGCATATGA GGATCCTCGG TTCAATGCAG AAGTTGACCA AATTACAGGC TACAAGACAC AAAGCATTCT TTGTATGCCA ATTAAGAATC ATAGGGAAGA GGTTGTTGGT GTAGCCCAGG CCATCAACAA GAAATCAGGA AACGGTGGGA CATTTACTGA AAAAGATGAA AAGGACTTTG CTGCTTATTT GGCATTTTGT GGTATTGTTC TTCATAATGC TCAGCTCTAT GAGACTTCAC TGCTGGAGAA CAAGAGAAAT CAGGTGCTGC TTGACCTTGC TAGTTTAATT TTTGAAGAAC AACAATCATT AGAAGTAATT TTGAAGAAAA TAGCTGCCAC TATTATCTCT TTCATGCAAG TGCAGAAATG CACCATTTTC ATAGTGGATG AAGATTGCTC CGATTCTTTT TCTAGTGTGT TTCACATGGA GTGTGAGGAA TTAGAAAAAT CATCTGATAC ATTAACAAGG GAACATGATG CAAACAAAAT CAATTACATG TATGCTCAGT ATGTCAAAAA TACTATGGAA CCACTTAATA TCCCAGATGT CAGTAAGGAT AAAAGATTTC CCTGGACAAC TGAAAATACA GGAAATGTAA ACCAGCAGTG CATTAGAAGT TTGCTTTGTA CACCTATAAA AAATGGAAAG AAGAATAAAG TTATAGGGGT TTGCCAACTT GTTAATAAGA TGGAGGAGAA TACTGGCAAG GTTAAGCCTT TCAACCGAAA TGACGAACAG TTTCTGGAAG CTTTTGTCAT CTTTTGTGGC TTGGGGATCC AGAACACGCA GATGTATGAA GCAGTGGAGA GAGCCATGGC CAAGCAAATG GTCACATTGG AGGTTCTGTC GTATCATGCT TCAGCAGCAG AGGAAGAAAC AAGAGAGCTA CAGTCGTTAG CGGCTGCTGT GGTGCCATCT GCCCAGACCC TTAAAATTAC TGACTTTAGC TTCAGTGACT TTGAGCTGTC TGATCTGGAA ACAGCACTGT GTACAATTCG GATGTTTACT GACCTCAACC TTGTGCAGAA CTTCCAGATG AAACATGAGG TTCTTTGCAG ATGGATTTTA AGTGTTAAGA AGAATTATCG GAAGAATGTT GCCTATCATA ATTGGAGACA TGCCTTTAAT ACAGCTCAGT GCATGTTTGC TGCTCTAAAA GCAGGCAAAA TTCAGAACAA GCTGACTGAC CTGGAGATAC TTGCATTGCT GATTGCTGCA CTAAGCCACG ATTTGGATCA CCGTGGTGTG AATAACTCTT ACATACAGCG AAGTGAACAT CCACTTGCCC AGCTTTACTG CCATTCAATC ATGGAACACC ATCATTTTGA CCAGTGCCTG ATGATTCTTA ATAGTCCAGG CAATCAGATT CTCAGTGGCC TCTCCATTGA AGAATATAAG ACCACGTTGA AAATAATCAA GCAAGCTATT TTAGCTACAG ACCTAGCACT GTACATTAAG AGGCGAGGAG AATTTTTTGA ACTTATAAGA AAAAATCAAT TCAATTTGGA AGATCCTCAT CAAAAGGAGT TGTTTTTGGC AATGCTGATG ACAGCTTGTG ATCTTTCTGC AATTACAAAA CCCTGGCCTA TTCAACAACG GATAGCAGAA CTTGTAGCAA CTGAATTTTT TGATCAAGGA GACAGAGAGA GAAAAGAACT CAACATAGAA CCCACTGATC TAATGAACAG GGAGAAGAAA AACAAAATCC CAAGTATGCA AGTTGGGTTC ATAGATGCCA TCTGCTTGCA ACTGTATGAG GCCCTGACCC ACGTGTCAGA GGACTGTTTC CCTTTGCTAG ATGGCTGCAG AAAGAACAGG CAGAAATGGC AGGCCCTTGC AGAACAGCAG GAGAAGATGC TGATTAATGG GGAAAGCGGC CAGGCCAAGC GGAACTGA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
CloneID
OHu05453
Clone ID Related Accession (Same CDS sequence)
NM_033430.3
, NM_033430.2
Accession Version
NM_033430.3 Latest version!
Documents for ORF clone product in default vector
Sequence Information
ORF Nucleotide Sequence (Length: 2502bp)
Protein sequence
SNP
Vector
pcDNA3.1+ /C-(K)DYK or customized vector
User Manual
Clone information
Clone Map
MSDS
Tag on pcDNA3.1+ /C-(K)DYK
C terminal DYKDDDDK tags
ORF Insert Method
CloneEZ™ Seamless cloning technology
Insert Structure
linear
Update Date
2019-12-03
Organism
Homo sapiens(human)
Product
cGMP-specific 3',5'-cyclic phosphodiesterase isoform 2
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC080089.5, AF043732.1, AY264918.1, AC093752.2 and BM978332.1. On Jun 1, 2019 this sequence version replaced NM_033430.2.
Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (2, also known as PDE5A2) has a distinct and shorter N-terminus, compared to isoform 1.
Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1660805.247788.1, SRR1660805.155004.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA2467148 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 1381 1441 1501 1561 1621 1681 1741 1801 1861 1921 1981 2041 2101 2161 2221 2281 2341 2401 2461 ATGTTGCCCT TTGGAGACAA AACAAGAGAA ATGGTCAATG CATGGTTTGC TGAGAGAGTT CACACCATCC CTGTGTGCAA GGAAGGTATC AGAGGCCACA CCGAATCTTG CTCTTGTCCC TTGCAGCAGA GTCCTCGTGC AGATAACAGT GCCCCTGGAA CACCAACCAG GAAAATCTCT GCCTCTGAAT TTGACCGGCC TCTTAGACCC ATTGTTGTCA AGGATTCTGA GGGAACTGTG AGCTTCCTCT CTGACTCAGA AAAGAAGGAA CAGATGCCTC TAACCCCTCC AAGGTTTGAT CATGATGAAG GGGACCAGTG CTCAAGACTC TTGGAATTAG TGAAGGATAT TTCTAGTCAT TTGGATGTCA CAGCCTTATG TCACAAAATT TTCTTGCATA TCCATGGACT GATATCTGCT GACCGCTATT CCCTGTTCCT TGTCTGTGAA GACAGCTCCA ATGACAAGTT TCTTATCAGC CGCCTCTTTG ATGTTGCTGA AGGTTCAACA CTGGAAGAAG TTTCAAATAA CTGTATCCGC TTAGAATGGA ACAAAGGCAT TGTGGGACAT GTGGCAGCGC TTGGTGAGCC CTTGAACATC AAAGATGCAT ATGAGGATCC TCGGTTCAAT GCAGAAGTTG ACCAAATTAC AGGCTACAAG ACACAAAGCA TTCTTTGTAT GCCAATTAAG AATCATAGGG AAGAGGTTGT TGGTGTAGCC CAGGCCATCA ACAAGAAATC AGGAAACGGT GGGACATTTA CTGAAAAAGA TGAAAAGGAC TTTGCTGCTT ATTTGGCATT TTGTGGTATT GTTCTTCATA ATGCTCAGCT CTATGAGACT TCACTGCTGG AGAACAAGAG AAATCAGGTG CTGCTTGACC TTGCTAGTTT AATTTTTGAA GAACAACAAT CATTAGAAGT AATTTTGAAG AAAATAGCTG CCACTATTAT CTCTTTCATG CAAGTGCAGA AATGCACCAT TTTCATAGTG GATGAAGATT GCTCCGATTC TTTTTCTAGT GTGTTTCACA TGGAGTGTGA GGAATTAGAA AAATCATCTG ATACATTAAC AAGGGAACAT GATGCAAACA AAATCAATTA CATGTATGCT CAGTATGTCA AAAATACTAT GGAACCACTT AATATCCCAG ATGTCAGTAA GGATAAAAGA TTTCCCTGGA CAACTGAAAA TACAGGAAAT GTAAACCAGC AGTGCATTAG AAGTTTGCTT TGTACACCTA TAAAAAATGG AAAGAAGAAT AAAGTTATAG GGGTTTGCCA ACTTGTTAAT AAGATGGAGG AGAATACTGG CAAGGTTAAG CCTTTCAACC GAAATGACGA ACAGTTTCTG GAAGCTTTTG TCATCTTTTG TGGCTTGGGG ATCCAGAACA CGCAGATGTA TGAAGCAGTG GAGAGAGCCA TGGCCAAGCA AATGGTCACA TTGGAGGTTC TGTCGTATCA TGCTTCAGCA GCAGAGGAAG AAACAAGAGA GCTACAGTCG TTAGCGGCTG CTGTGGTGCC ATCTGCCCAG ACCCTTAAAA TTACTGACTT TAGCTTCAGT GACTTTGAGC TGTCTGATCT GGAAACAGCA CTGTGTACAA TTCGGATGTT TACTGACCTC AACCTTGTGC AGAACTTCCA GATGAAACAT GAGGTTCTTT GCAGATGGAT TTTAAGTGTT AAGAAGAATT ATCGGAAGAA TGTTGCCTAT CATAATTGGA GACATGCCTT TAATACAGCT CAGTGCATGT TTGCTGCTCT AAAAGCAGGC AAAATTCAGA ACAAGCTGAC TGACCTGGAG ATACTTGCAT TGCTGATTGC TGCACTAAGC CACGATTTGG ATCACCGTGG TGTGAATAAC TCTTACATAC AGCGAAGTGA ACATCCACTT GCCCAGCTTT ACTGCCATTC AATCATGGAA CACCATCATT TTGACCAGTG CCTGATGATT CTTAATAGTC CAGGCAATCA GATTCTCAGT GGCCTCTCCA TTGAAGAATA TAAGACCACG TTGAAAATAA TCAAGCAAGC TATTTTAGCT ACAGACCTAG CACTGTACAT TAAGAGGCGA GGAGAATTTT TTGAACTTAT AAGAAAAAAT CAATTCAATT TGGAAGATCC TCATCAAAAG GAGTTGTTTT TGGCAATGCT GATGACAGCT TGTGATCTTT CTGCAATTAC AAAACCCTGG CCTATTCAAC AACGGATAGC AGAACTTGTA GCAACTGAAT TTTTTGATCA AGGAGACAGA GAGAGAAAAG AACTCAACAT AGAACCCACT GATCTAATGA ACAGGGAGAA GAAAAACAAA ATCCCAAGTA TGCAAGTTGG GTTCATAGAT GCCATCTGCT TGCAACTGTA TGAGGCCCTG ACCCACGTGT CAGAGGACTG TTTCCCTTTG CTAGATGGCT GCAGAAAGAA CAGGCAGAAA TGGCAGGCCC TTGCAGAACA GCAGGAGAAG ATGCTGATTA ATGGGGAAAG CGGCCAGGCC AAGCGGAACT GA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
RefSeq
NP_236914.2
CDS 563..3064
Translation
Target ORF information:
RefSeq Version NM_033430.3
Organism Homo sapiens(human)
Definition Homo sapiens phosphodiesterase 5A (PDE5A), transcript variant 2, mRNA.
Target ORF information:
Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+ /C-(K)DYK
NM_033430.3
ORF Insert Sequence:
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 1381 1441 1501 1561 1621 1681 1741 1801 1861 1921 1981 2041 2101 2161 2221 2281 2341 2401 2461 ATGTTGCCCT TTGGAGACAA AACAAGAGAA ATGGTCAATG CATGGTTTGC TGAGAGAGTT CACACCATCC CTGTGTGCAA GGAAGGTATC AGAGGCCACA CCGAATCTTG CTCTTGTCCC TTGCAGCAGA GTCCTCGTGC AGATAACAGT GCCCCTGGAA CACCAACCAG GAAAATCTCT GCCTCTGAAT TTGACCGGCC TCTTAGACCC ATTGTTGTCA AGGATTCTGA GGGAACTGTG AGCTTCCTCT CTGACTCAGA AAAGAAGGAA CAGATGCCTC TAACCCCTCC AAGGTTTGAT CATGATGAAG GGGACCAGTG CTCAAGACTC TTGGAATTAG TGAAGGATAT TTCTAGTCAT TTGGATGTCA CAGCCTTATG TCACAAAATT TTCTTGCATA TCCATGGACT GATATCTGCT GACCGCTATT CCCTGTTCCT TGTCTGTGAA GACAGCTCCA ATGACAAGTT TCTTATCAGC CGCCTCTTTG ATGTTGCTGA AGGTTCAACA CTGGAAGAAG TTTCAAATAA CTGTATCCGC TTAGAATGGA ACAAAGGCAT TGTGGGACAT GTGGCAGCGC TTGGTGAGCC CTTGAACATC AAAGATGCAT ATGAGGATCC TCGGTTCAAT GCAGAAGTTG ACCAAATTAC AGGCTACAAG ACACAAAGCA TTCTTTGTAT GCCAATTAAG AATCATAGGG AAGAGGTTGT TGGTGTAGCC CAGGCCATCA ACAAGAAATC AGGAAACGGT GGGACATTTA CTGAAAAAGA TGAAAAGGAC TTTGCTGCTT ATTTGGCATT TTGTGGTATT GTTCTTCATA ATGCTCAGCT CTATGAGACT TCACTGCTGG AGAACAAGAG AAATCAGGTG CTGCTTGACC TTGCTAGTTT AATTTTTGAA GAACAACAAT CATTAGAAGT AATTTTGAAG AAAATAGCTG CCACTATTAT CTCTTTCATG CAAGTGCAGA AATGCACCAT TTTCATAGTG GATGAAGATT GCTCCGATTC TTTTTCTAGT GTGTTTCACA TGGAGTGTGA GGAATTAGAA AAATCATCTG ATACATTAAC AAGGGAACAT GATGCAAACA AAATCAATTA CATGTATGCT CAGTATGTCA AAAATACTAT GGAACCACTT AATATCCCAG ATGTCAGTAA GGATAAAAGA TTTCCCTGGA CAACTGAAAA TACAGGAAAT GTAAACCAGC AGTGCATTAG AAGTTTGCTT TGTACACCTA TAAAAAATGG AAAGAAGAAT AAAGTTATAG GGGTTTGCCA ACTTGTTAAT AAGATGGAGG AGAATACTGG CAAGGTTAAG CCTTTCAACC GAAATGACGA ACAGTTTCTG GAAGCTTTTG TCATCTTTTG TGGCTTGGGG ATCCAGAACA CGCAGATGTA TGAAGCAGTG GAGAGAGCCA TGGCCAAGCA AATGGTCACA TTGGAGGTTC TGTCGTATCA TGCTTCAGCA GCAGAGGAAG AAACAAGAGA GCTACAGTCG TTAGCGGCTG CTGTGGTGCC ATCTGCCCAG ACCCTTAAAA TTACTGACTT TAGCTTCAGT GACTTTGAGC TGTCTGATCT GGAAACAGCA CTGTGTACAA TTCGGATGTT TACTGACCTC AACCTTGTGC AGAACTTCCA GATGAAACAT GAGGTTCTTT GCAGATGGAT TTTAAGTGTT AAGAAGAATT ATCGGAAGAA TGTTGCCTAT CATAATTGGA GACATGCCTT TAATACAGCT CAGTGCATGT TTGCTGCTCT AAAAGCAGGC AAAATTCAGA ACAAGCTGAC TGACCTGGAG ATACTTGCAT TGCTGATTGC TGCACTAAGC CACGATTTGG ATCACCGTGG TGTGAATAAC TCTTACATAC AGCGAAGTGA ACATCCACTT GCCCAGCTTT ACTGCCATTC AATCATGGAA CACCATCATT TTGACCAGTG CCTGATGATT CTTAATAGTC CAGGCAATCA GATTCTCAGT GGCCTCTCCA TTGAAGAATA TAAGACCACG TTGAAAATAA TCAAGCAAGC TATTTTAGCT ACAGACCTAG CACTGTACAT TAAGAGGCGA GGAGAATTTT TTGAACTTAT AAGAAAAAAT CAATTCAATT TGGAAGATCC TCATCAAAAG GAGTTGTTTT TGGCAATGCT GATGACAGCT TGTGATCTTT CTGCAATTAC AAAACCCTGG CCTATTCAAC AACGGATAGC AGAACTTGTA GCAACTGAAT TTTTTGATCA AGGAGACAGA GAGAGAAAAG AACTCAACAT AGAACCCACT GATCTAATGA ACAGGGAGAA GAAAAACAAA ATCCCAAGTA TGCAAGTTGG GTTCATAGAT GCCATCTGCT TGCAACTGTA TGAGGCCCTG ACCCACGTGT CAGAGGACTG TTTCCCTTTG CTAGATGGCT GCAGAAAGAA CAGGCAGAAA TGGCAGGCCC TTGCAGAACA GCAGGAGAAG ATGCTGATTA ATGGGGAAAG CGGCCAGGCC AAGCGGAACT GA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
CloneID
OHu05453
Clone ID Related Accession (Same CDS sequence)
NM_033430.3
, NM_033430.2
Accession Version
NM_033430.2
Documents for ORF clone product in default vector
Sequence Information
ORF Nucleotide Sequence (Length: 2502bp)
Protein sequence
SNP
Vector
pcDNA3.1+ /C-(K)DYK or customized vector
User Manual
Clone information
Clone Map
MSDS
Tag on pcDNA3.1+ /C-(K)DYK
C terminal DYKDDDDK tags
ORF Insert Method
CloneEZ™ Seamless cloning technology
Insert Structure
linear
Update Date
2018-06-22
Organism
Homo sapiens(human)
Product
cGMP-specific 3',5'-cyclic phosphodiesterase isoform 2
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF043732.1, AY264918.1, AC093752.2 and BM978332.1. On Mar 24, 2005 this sequence version replaced NM_033430.1.
Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (2, also known as PDE5A2) has a distinct and shorter N-terminus, compared to isoform 1.
Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1660805.247788.1, SRR1660805.155004.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA2467148 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 1381 1441 1501 1561 1621 1681 1741 1801 1861 1921 1981 2041 2101 2161 2221 2281 2341 2401 2461 ATGTTGCCCT TTGGAGACAA AACAAGAGAA ATGGTCAATG CATGGTTTGC TGAGAGAGTT CACACCATCC CTGTGTGCAA GGAAGGTATC AGAGGCCACA CCGAATCTTG CTCTTGTCCC TTGCAGCAGA GTCCTCGTGC AGATAACAGT GCCCCTGGAA CACCAACCAG GAAAATCTCT GCCTCTGAAT TTGACCGGCC TCTTAGACCC ATTGTTGTCA AGGATTCTGA GGGAACTGTG AGCTTCCTCT CTGACTCAGA AAAGAAGGAA CAGATGCCTC TAACCCCTCC AAGGTTTGAT CATGATGAAG GGGACCAGTG CTCAAGACTC TTGGAATTAG TGAAGGATAT TTCTAGTCAT TTGGATGTCA CAGCCTTATG TCACAAAATT TTCTTGCATA TCCATGGACT GATATCTGCT GACCGCTATT CCCTGTTCCT TGTCTGTGAA GACAGCTCCA ATGACAAGTT TCTTATCAGC CGCCTCTTTG ATGTTGCTGA AGGTTCAACA CTGGAAGAAG TTTCAAATAA CTGTATCCGC TTAGAATGGA ACAAAGGCAT TGTGGGACAT GTGGCAGCGC TTGGTGAGCC CTTGAACATC AAAGATGCAT ATGAGGATCC TCGGTTCAAT GCAGAAGTTG ACCAAATTAC AGGCTACAAG ACACAAAGCA TTCTTTGTAT GCCAATTAAG AATCATAGGG AAGAGGTTGT TGGTGTAGCC CAGGCCATCA ACAAGAAATC AGGAAACGGT GGGACATTTA CTGAAAAAGA TGAAAAGGAC TTTGCTGCTT ATTTGGCATT TTGTGGTATT GTTCTTCATA ATGCTCAGCT CTATGAGACT TCACTGCTGG AGAACAAGAG AAATCAGGTG CTGCTTGACC TTGCTAGTTT AATTTTTGAA GAACAACAAT CATTAGAAGT AATTTTGAAG AAAATAGCTG CCACTATTAT CTCTTTCATG CAAGTGCAGA AATGCACCAT TTTCATAGTG GATGAAGATT GCTCCGATTC TTTTTCTAGT GTGTTTCACA TGGAGTGTGA GGAATTAGAA AAATCATCTG ATACATTAAC AAGGGAACAT GATGCAAACA AAATCAATTA CATGTATGCT CAGTATGTCA AAAATACTAT GGAACCACTT AATATCCCAG ATGTCAGTAA GGATAAAAGA TTTCCCTGGA CAACTGAAAA TACAGGAAAT GTAAACCAGC AGTGCATTAG AAGTTTGCTT TGTACACCTA TAAAAAATGG AAAGAAGAAT AAAGTTATAG GGGTTTGCCA ACTTGTTAAT AAGATGGAGG AGAATACTGG CAAGGTTAAG CCTTTCAACC GAAATGACGA ACAGTTTCTG GAAGCTTTTG TCATCTTTTG TGGCTTGGGG ATCCAGAACA CGCAGATGTA TGAAGCAGTG GAGAGAGCCA TGGCCAAGCA AATGGTCACA TTGGAGGTTC TGTCGTATCA TGCTTCAGCA GCAGAGGAAG AAACAAGAGA GCTACAGTCG TTAGCGGCTG CTGTGGTGCC ATCTGCCCAG ACCCTTAAAA TTACTGACTT TAGCTTCAGT GACTTTGAGC TGTCTGATCT GGAAACAGCA CTGTGTACAA TTCGGATGTT TACTGACCTC AACCTTGTGC AGAACTTCCA GATGAAACAT GAGGTTCTTT GCAGATGGAT TTTAAGTGTT AAGAAGAATT ATCGGAAGAA TGTTGCCTAT CATAATTGGA GACATGCCTT TAATACAGCT CAGTGCATGT TTGCTGCTCT AAAAGCAGGC AAAATTCAGA ACAAGCTGAC TGACCTGGAG ATACTTGCAT TGCTGATTGC TGCACTAAGC CACGATTTGG ATCACCGTGG TGTGAATAAC TCTTACATAC AGCGAAGTGA ACATCCACTT GCCCAGCTTT ACTGCCATTC AATCATGGAA CACCATCATT TTGACCAGTG CCTGATGATT CTTAATAGTC CAGGCAATCA GATTCTCAGT GGCCTCTCCA TTGAAGAATA TAAGACCACG TTGAAAATAA TCAAGCAAGC TATTTTAGCT ACAGACCTAG CACTGTACAT TAAGAGGCGA GGAGAATTTT TTGAACTTAT AAGAAAAAAT CAATTCAATT TGGAAGATCC TCATCAAAAG GAGTTGTTTT TGGCAATGCT GATGACAGCT TGTGATCTTT CTGCAATTAC AAAACCCTGG CCTATTCAAC AACGGATAGC AGAACTTGTA GCAACTGAAT TTTTTGATCA AGGAGACAGA GAGAGAAAAG AACTCAACAT AGAACCCACT GATCTAATGA ACAGGGAGAA GAAAAACAAA ATCCCAAGTA TGCAAGTTGG GTTCATAGAT GCCATCTGCT TGCAACTGTA TGAGGCCCTG ACCCACGTGT CAGAGGACTG TTTCCCTTTG CTAGATGGCT GCAGAAAGAA CAGGCAGAAA TGGCAGGCCC TTGCAGAACA GCAGGAGAAG ATGCTGATTA ATGGGGAAAG CGGCCAGGCC AAGCGGAACT GA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
RefSeq
NP_236914.2
CDS 113..2614
Translation
Target ORF information:
RefSeq Version NM_033430.2
Organism Homo sapiens(human)
Definition Homo sapiens phosphodiesterase 5A (PDE5A), transcript variant 2, mRNA.
Target ORF information:
Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+ /C-(K)DYK
NM_033430.2
ORF Insert Sequence:
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 1381 1441 1501 1561 1621 1681 1741 1801 1861 1921 1981 2041 2101 2161 2221 2281 2341 2401 2461 ATGTTGCCCT TTGGAGACAA AACAAGAGAA ATGGTCAATG CATGGTTTGC TGAGAGAGTT CACACCATCC CTGTGTGCAA GGAAGGTATC AGAGGCCACA CCGAATCTTG CTCTTGTCCC TTGCAGCAGA GTCCTCGTGC AGATAACAGT GCCCCTGGAA CACCAACCAG GAAAATCTCT GCCTCTGAAT TTGACCGGCC TCTTAGACCC ATTGTTGTCA AGGATTCTGA GGGAACTGTG AGCTTCCTCT CTGACTCAGA AAAGAAGGAA CAGATGCCTC TAACCCCTCC AAGGTTTGAT CATGATGAAG GGGACCAGTG CTCAAGACTC TTGGAATTAG TGAAGGATAT TTCTAGTCAT TTGGATGTCA CAGCCTTATG TCACAAAATT TTCTTGCATA TCCATGGACT GATATCTGCT GACCGCTATT CCCTGTTCCT TGTCTGTGAA GACAGCTCCA ATGACAAGTT TCTTATCAGC CGCCTCTTTG ATGTTGCTGA AGGTTCAACA CTGGAAGAAG TTTCAAATAA CTGTATCCGC TTAGAATGGA ACAAAGGCAT TGTGGGACAT GTGGCAGCGC TTGGTGAGCC CTTGAACATC AAAGATGCAT ATGAGGATCC TCGGTTCAAT GCAGAAGTTG ACCAAATTAC AGGCTACAAG ACACAAAGCA TTCTTTGTAT GCCAATTAAG AATCATAGGG AAGAGGTTGT TGGTGTAGCC CAGGCCATCA ACAAGAAATC AGGAAACGGT GGGACATTTA CTGAAAAAGA TGAAAAGGAC TTTGCTGCTT ATTTGGCATT TTGTGGTATT GTTCTTCATA ATGCTCAGCT CTATGAGACT TCACTGCTGG AGAACAAGAG AAATCAGGTG CTGCTTGACC TTGCTAGTTT AATTTTTGAA GAACAACAAT CATTAGAAGT AATTTTGAAG AAAATAGCTG CCACTATTAT CTCTTTCATG CAAGTGCAGA AATGCACCAT TTTCATAGTG GATGAAGATT GCTCCGATTC TTTTTCTAGT GTGTTTCACA TGGAGTGTGA GGAATTAGAA AAATCATCTG ATACATTAAC AAGGGAACAT GATGCAAACA AAATCAATTA CATGTATGCT CAGTATGTCA AAAATACTAT GGAACCACTT AATATCCCAG ATGTCAGTAA GGATAAAAGA TTTCCCTGGA CAACTGAAAA TACAGGAAAT GTAAACCAGC AGTGCATTAG AAGTTTGCTT TGTACACCTA TAAAAAATGG AAAGAAGAAT AAAGTTATAG GGGTTTGCCA ACTTGTTAAT AAGATGGAGG AGAATACTGG CAAGGTTAAG CCTTTCAACC GAAATGACGA ACAGTTTCTG GAAGCTTTTG TCATCTTTTG TGGCTTGGGG ATCCAGAACA CGCAGATGTA TGAAGCAGTG GAGAGAGCCA TGGCCAAGCA AATGGTCACA TTGGAGGTTC TGTCGTATCA TGCTTCAGCA GCAGAGGAAG AAACAAGAGA GCTACAGTCG TTAGCGGCTG CTGTGGTGCC ATCTGCCCAG ACCCTTAAAA TTACTGACTT TAGCTTCAGT GACTTTGAGC TGTCTGATCT GGAAACAGCA CTGTGTACAA TTCGGATGTT TACTGACCTC AACCTTGTGC AGAACTTCCA GATGAAACAT GAGGTTCTTT GCAGATGGAT TTTAAGTGTT AAGAAGAATT ATCGGAAGAA TGTTGCCTAT CATAATTGGA GACATGCCTT TAATACAGCT CAGTGCATGT TTGCTGCTCT AAAAGCAGGC AAAATTCAGA ACAAGCTGAC TGACCTGGAG ATACTTGCAT TGCTGATTGC TGCACTAAGC CACGATTTGG ATCACCGTGG TGTGAATAAC TCTTACATAC AGCGAAGTGA ACATCCACTT GCCCAGCTTT ACTGCCATTC AATCATGGAA CACCATCATT TTGACCAGTG CCTGATGATT CTTAATAGTC CAGGCAATCA GATTCTCAGT GGCCTCTCCA TTGAAGAATA TAAGACCACG TTGAAAATAA TCAAGCAAGC TATTTTAGCT ACAGACCTAG CACTGTACAT TAAGAGGCGA GGAGAATTTT TTGAACTTAT AAGAAAAAAT CAATTCAATT TGGAAGATCC TCATCAAAAG GAGTTGTTTT TGGCAATGCT GATGACAGCT TGTGATCTTT CTGCAATTAC AAAACCCTGG CCTATTCAAC AACGGATAGC AGAACTTGTA GCAACTGAAT TTTTTGATCA AGGAGACAGA GAGAGAAAAG AACTCAACAT AGAACCCACT GATCTAATGA ACAGGGAGAA GAAAAACAAA ATCCCAAGTA TGCAAGTTGG GTTCATAGAT GCCATCTGCT TGCAACTGTA TGAGGCCCTG ACCCACGTGT CAGAGGACTG TTTCCCTTTG CTAGATGGCT GCAGAAAGAA CAGGCAGAAA TGGCAGGCCC TTGCAGAACA GCAGGAGAAG ATGCTGATTA ATGGGGAAAG CGGCCAGGCC AAGCGGAACT GA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
CloneID
OHu95522
Clone ID Related Accession (Same CDS sequence)
XM_017008791.2
, XM_017008791.1
Accession Version
XM_017008791.2 Latest version!
Documents for ORF clone product in default vector
Sequence Information
ORF Nucleotide Sequence (Length: 1932bp)
Protein sequence
SNP
Vector
pcDNA3.1+ /C-(K)DYK or customized vector
User Manual
Clone information
Clone Map
MSDS
Tag on pcDNA3.1+ /C-(K)DYK
C terminal DYKDDDDK tags
ORF Insert Method
CloneEZ™ Seamless cloning technology
Insert Structure
linear
Update Date
2019-12-05
Organism
Homo sapiens(human)
Product
cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1
Comment
Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process
On Mar 26, 2018 this sequence version replaced XM_017008791.1.
##Genome-Annotation-Data-START##
Annotation Provider :: NCBI
Annotation Status :: Updated annotation
Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205
Annotation Version :: 109.20191205
Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline
Annotation Software Version :: 8.3
Annotation Method :: Best-placed RefSeq; propagated RefSeq model
Features Annotated :: Gene; mRNA; CDS; ncRNA
##Genome-Annotation-Data-END##
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 1381 1441 1501 1561 1621 1681 1741 1801 1861 1921 ATGGAGCGGG CCGGCCCCAG CTTCGGGCAG CAGCGACAGC AGCAGCAGCC CCAGCAGCAG AAGCAGCAGC AGAGGGATCA GGACTCGGTC GAAGCATGGC TGGACGATCA CTGGGACTTT ACCTTCTCAT ACTTTGTTAG AAAAGCCACC AGAGAAATGG TCAATGCATG GTTTGCTGAG AGAGTTCACA CCATCCCTGT GTGCAAGGAA GGTATCAGAG GCCACACCGA ATCTTGCTCT TGTCCCTTGC AGCAGAGTCC TCGTGCAGAT AACAGTGCCC CTGGAACACC AACCAGGAAA ATCTCTGCCT CTGAATTTGA CCGGCCTCTT AGACCCATTG TTGTCAAGGA TTCTGAGGGA ACTGTGAGCT TCCTCTCTGA CTCAGAAAAG AAGGAACAGA TGCCTCTAAC CCCTCCAAGG TTTGATCATG ATGAAGGGGA CCAGTGCTCA AGACTCTTGG AATTAGTGAA GGATATTTCT AGTCATTTGG ATGTCACAGC CTTATGTCAC AAAATTTTCT TGCATATCCA TGGACTGATA TCTGCTGACC GCTATTCCCT GTTCCTTGTC TGTGAAGACA GCTCCAATGA CAAGTTTCTT ATCAGCCGCC TCTTTGATGT TGCTGAAGGT TCAACACTGG AAGAAGTTTC AAATAACTGT ATCCGCTTAG AATGGAACAA AGGCATTGTG GGACATGTGG CAGCGCTTGG TGAGCCCTTG AACATCAAAG ATGCATATGA GGATCCTCGG TTCAATGCAG AAGTTGACCA AATTACAGGC TACAAGACAC AAAGCATTCT TTGTATGCCA ATTAAGAATC ATAGGGAAGA GGTTGTTGGT GTAGCCCAGG CCATCAACAA GAAATCAGGA AACGGTGGGA CATTTACTGA AAAAGATGAA AAGGACTTTG CTGCTTATTT GGCATTTTGT GGTATTGTTC TTCATAATGC TCAGCTCTAT GAGACTTCAC TGCTGGAGAA CAAGAGAAAT CAGGTGCTGC TTGACCTTGC TAGTTTAATT TTTGAAGAAC AACAATCATT AGAAGTAATT TTGAAGAAAA TAGCTGCCAC TATTATCTCT TTCATGCAAG TGCAGAAATG CACCATTTTC ATAGTGGATG AAGATTGCTC CGATTCTTTT TCTAGTGTGT TTCACATGGA GTGTGAGGAA TTAGAAAAAT CATCTGATAC ATTAACAAGG GAACATGATG CAAACAAAAT CAATTACATG TATGCTCAGT ATGTCAAAAA TACTATGGAA CCACTTAATA TCCCAGATGT CAGTAAGGAT AAAAGATTTC CCTGGACAAC TGAAAATACA GGAAATGTAA ACCAGCAGTG CATTAGAAGT TTGCTTTGTA CACCTATAAA AAATGGAAAG AAGAATAAAG TTATAGGGGT TTGCCAACTT GTTAATAAGA TGGAGGAGAA TACTGGCAAG GTTAAGCCTT TCAACCGAAA TGACGAACAG TTTCTGGAAG CTTTTGTCAT CTTTTGTGGC TTGGGGATCC AGAACACGCA GATGTATGAA GCAGTGGAGA GAGCCATGGC CAAGCAAATG GTCACATTGG AGGTTCTGTC GTATCATGCT TCAGCAGCAG AGGAAGAAAC AAGAGAGCTA CAGTCGTTAG CGGCTGCTGT GGTGCCATCT GCCCAGACCC TTAAAATTAC TGACTTTAGC TTCAGTGACT TTGAGCTGTC TGATCTGGAA ACAGCACTGT GTACAATTCG GATGTTTACT GACCTCAACC TTGTGCAGAA CTTCCAGATG AAACATGAGG TTCTTTGCAG ATGGATTTTA AGTGTTAAGA AGAATTATCG GAAGAATGTT GCCTATCATA ATTGGAGACA TGCCTTTAAT ACAGCTCAGT GCATGTTTGC TGCTCTAAAA GCAGGCAAAA TTCAGATTCT AACTTCAGTG GGAATCGACT AG
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
RefSeq
XP_016864280.1
CDS 37..1968
Translation
Target ORF information:
RefSeq Version XM_017008791.2
Organism Homo sapiens(human)
Definition Homo sapiens phosphodiesterase 5A (PDE5A), transcript variant X1, mRNA.
Target ORF information:
Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+ /C-(K)DYK
XM_017008791.2
ORF Insert Sequence:
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 1381 1441 1501 1561 1621 1681 1741 1801 1861 1921 ATGGAGCGGG CCGGCCCCAG CTTCGGGCAG CAGCGACAGC AGCAGCAGCC CCAGCAGCAG AAGCAGCAGC AGAGGGATCA GGACTCGGTC GAAGCATGGC TGGACGATCA CTGGGACTTT ACCTTCTCAT ACTTTGTTAG AAAAGCCACC AGAGAAATGG TCAATGCATG GTTTGCTGAG AGAGTTCACA CCATCCCTGT GTGCAAGGAA GGTATCAGAG GCCACACCGA ATCTTGCTCT TGTCCCTTGC AGCAGAGTCC TCGTGCAGAT AACAGTGCCC CTGGAACACC AACCAGGAAA ATCTCTGCCT CTGAATTTGA CCGGCCTCTT AGACCCATTG TTGTCAAGGA TTCTGAGGGA ACTGTGAGCT TCCTCTCTGA CTCAGAAAAG AAGGAACAGA TGCCTCTAAC CCCTCCAAGG TTTGATCATG ATGAAGGGGA CCAGTGCTCA AGACTCTTGG AATTAGTGAA GGATATTTCT AGTCATTTGG ATGTCACAGC CTTATGTCAC AAAATTTTCT TGCATATCCA TGGACTGATA TCTGCTGACC GCTATTCCCT GTTCCTTGTC TGTGAAGACA GCTCCAATGA CAAGTTTCTT ATCAGCCGCC TCTTTGATGT TGCTGAAGGT TCAACACTGG AAGAAGTTTC AAATAACTGT ATCCGCTTAG AATGGAACAA AGGCATTGTG GGACATGTGG CAGCGCTTGG TGAGCCCTTG AACATCAAAG ATGCATATGA GGATCCTCGG TTCAATGCAG AAGTTGACCA AATTACAGGC TACAAGACAC AAAGCATTCT TTGTATGCCA ATTAAGAATC ATAGGGAAGA GGTTGTTGGT GTAGCCCAGG CCATCAACAA GAAATCAGGA AACGGTGGGA CATTTACTGA AAAAGATGAA AAGGACTTTG CTGCTTATTT GGCATTTTGT GGTATTGTTC TTCATAATGC TCAGCTCTAT GAGACTTCAC TGCTGGAGAA CAAGAGAAAT CAGGTGCTGC TTGACCTTGC TAGTTTAATT TTTGAAGAAC AACAATCATT AGAAGTAATT TTGAAGAAAA TAGCTGCCAC TATTATCTCT TTCATGCAAG TGCAGAAATG CACCATTTTC ATAGTGGATG AAGATTGCTC CGATTCTTTT TCTAGTGTGT TTCACATGGA GTGTGAGGAA TTAGAAAAAT CATCTGATAC ATTAACAAGG GAACATGATG CAAACAAAAT CAATTACATG TATGCTCAGT ATGTCAAAAA TACTATGGAA CCACTTAATA TCCCAGATGT CAGTAAGGAT AAAAGATTTC CCTGGACAAC TGAAAATACA GGAAATGTAA ACCAGCAGTG CATTAGAAGT TTGCTTTGTA CACCTATAAA AAATGGAAAG AAGAATAAAG TTATAGGGGT TTGCCAACTT GTTAATAAGA TGGAGGAGAA TACTGGCAAG GTTAAGCCTT TCAACCGAAA TGACGAACAG TTTCTGGAAG CTTTTGTCAT CTTTTGTGGC TTGGGGATCC AGAACACGCA GATGTATGAA GCAGTGGAGA GAGCCATGGC CAAGCAAATG GTCACATTGG AGGTTCTGTC GTATCATGCT TCAGCAGCAG AGGAAGAAAC AAGAGAGCTA CAGTCGTTAG CGGCTGCTGT GGTGCCATCT GCCCAGACCC TTAAAATTAC TGACTTTAGC TTCAGTGACT TTGAGCTGTC TGATCTGGAA ACAGCACTGT GTACAATTCG GATGTTTACT GACCTCAACC TTGTGCAGAA CTTCCAGATG AAACATGAGG TTCTTTGCAG ATGGATTTTA AGTGTTAAGA AGAATTATCG GAAGAATGTT GCCTATCATA ATTGGAGACA TGCCTTTAAT ACAGCTCAGT GCATGTTTGC TGCTCTAAAA GCAGGCAAAA TTCAGATTCT AACTTCAGTG GGAATCGACT AG
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
CloneID
OHu95522
Clone ID Related Accession (Same CDS sequence)
XM_017008791.2
, XM_017008791.1
Accession Version
XM_017008791.1
Documents for ORF clone product in default vector
Sequence Information
ORF Nucleotide Sequence (Length: 1932bp)
Protein sequence
SNP
Vector
pcDNA3.1+ /C-(K)DYK or customized vector
User Manual
Clone information
Clone Map
MSDS
Tag on pcDNA3.1+ /C-(K)DYK
C terminal DYKDDDDK tags
ORF Insert Method
CloneEZ™ Seamless cloning technology
Insert Structure
linear
Update Date
2016-06-05
Organism
Homo sapiens(human)
Product
cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1
Comment
Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process
##Genome-Annotation-Data-START##
Annotation Provider :: NCBI
Annotation Status :: Full annotation
Annotation Version :: Homo sapiens Annotation Release 108
Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline
Annotation Software Version :: 7.0
Annotation Method :: Best-placed RefSeq; Gnomon
Features Annotated :: Gene; mRNA; CDS; ncRNA
##Genome-Annotation-Data-END##
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 1381 1441 1501 1561 1621 1681 1741 1801 1861 1921 ATGGAGCGGG CCGGCCCCAG CTTCGGGCAG CAGCGACAGC AGCAGCAGCC CCAGCAGCAG AAGCAGCAGC AGAGGGATCA GGACTCGGTC GAAGCATGGC TGGACGATCA CTGGGACTTT ACCTTCTCAT ACTTTGTTAG AAAAGCCACC AGAGAAATGG TCAATGCATG GTTTGCTGAG AGAGTTCACA CCATCCCTGT GTGCAAGGAA GGTATCAGAG GCCACACCGA ATCTTGCTCT TGTCCCTTGC AGCAGAGTCC TCGTGCAGAT AACAGTGCCC CTGGAACACC AACCAGGAAA ATCTCTGCCT CTGAATTTGA CCGGCCTCTT AGACCCATTG TTGTCAAGGA TTCTGAGGGA ACTGTGAGCT TCCTCTCTGA CTCAGAAAAG AAGGAACAGA TGCCTCTAAC CCCTCCAAGG TTTGATCATG ATGAAGGGGA CCAGTGCTCA AGACTCTTGG AATTAGTGAA GGATATTTCT AGTCATTTGG ATGTCACAGC CTTATGTCAC AAAATTTTCT TGCATATCCA TGGACTGATA TCTGCTGACC GCTATTCCCT GTTCCTTGTC TGTGAAGACA GCTCCAATGA CAAGTTTCTT ATCAGCCGCC TCTTTGATGT TGCTGAAGGT TCAACACTGG AAGAAGTTTC AAATAACTGT ATCCGCTTAG AATGGAACAA AGGCATTGTG GGACATGTGG CAGCGCTTGG TGAGCCCTTG AACATCAAAG ATGCATATGA GGATCCTCGG TTCAATGCAG AAGTTGACCA AATTACAGGC TACAAGACAC AAAGCATTCT TTGTATGCCA ATTAAGAATC ATAGGGAAGA GGTTGTTGGT GTAGCCCAGG CCATCAACAA GAAATCAGGA AACGGTGGGA CATTTACTGA AAAAGATGAA AAGGACTTTG CTGCTTATTT GGCATTTTGT GGTATTGTTC TTCATAATGC TCAGCTCTAT GAGACTTCAC TGCTGGAGAA CAAGAGAAAT CAGGTGCTGC TTGACCTTGC TAGTTTAATT TTTGAAGAAC AACAATCATT AGAAGTAATT TTGAAGAAAA TAGCTGCCAC TATTATCTCT TTCATGCAAG TGCAGAAATG CACCATTTTC ATAGTGGATG AAGATTGCTC CGATTCTTTT TCTAGTGTGT TTCACATGGA GTGTGAGGAA TTAGAAAAAT CATCTGATAC ATTAACAAGG GAACATGATG CAAACAAAAT CAATTACATG TATGCTCAGT ATGTCAAAAA TACTATGGAA CCACTTAATA TCCCAGATGT CAGTAAGGAT AAAAGATTTC CCTGGACAAC TGAAAATACA GGAAATGTAA ACCAGCAGTG CATTAGAAGT TTGCTTTGTA CACCTATAAA AAATGGAAAG AAGAATAAAG TTATAGGGGT TTGCCAACTT GTTAATAAGA TGGAGGAGAA TACTGGCAAG GTTAAGCCTT TCAACCGAAA TGACGAACAG TTTCTGGAAG CTTTTGTCAT CTTTTGTGGC TTGGGGATCC AGAACACGCA GATGTATGAA GCAGTGGAGA GAGCCATGGC CAAGCAAATG GTCACATTGG AGGTTCTGTC GTATCATGCT TCAGCAGCAG AGGAAGAAAC AAGAGAGCTA CAGTCGTTAG CGGCTGCTGT GGTGCCATCT GCCCAGACCC TTAAAATTAC TGACTTTAGC TTCAGTGACT TTGAGCTGTC TGATCTGGAA ACAGCACTGT GTACAATTCG GATGTTTACT GACCTCAACC TTGTGCAGAA CTTCCAGATG AAACATGAGG TTCTTTGCAG ATGGATTTTA AGTGTTAAGA AGAATTATCG GAAGAATGTT GCCTATCATA ATTGGAGACA TGCCTTTAAT ACAGCTCAGT GCATGTTTGC TGCTCTAAAA GCAGGCAAAA TTCAGATTCT AACTTCAGTG GGAATCGACT AG
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
RefSeq
XP_016864280.1
CDS 410..2341
Translation
Target ORF information:
RefSeq Version XM_017008791.1
Organism Homo sapiens(human)
Definition Homo sapiens phosphodiesterase 5A (PDE5A), transcript variant X1, mRNA.
Target ORF information:
Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+ /C-(K)DYK
XM_017008791.1
ORF Insert Sequence:
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 1381 1441 1501 1561 1621 1681 1741 1801 1861 1921 ATGGAGCGGG CCGGCCCCAG CTTCGGGCAG CAGCGACAGC AGCAGCAGCC CCAGCAGCAG AAGCAGCAGC AGAGGGATCA GGACTCGGTC GAAGCATGGC TGGACGATCA CTGGGACTTT ACCTTCTCAT ACTTTGTTAG AAAAGCCACC AGAGAAATGG TCAATGCATG GTTTGCTGAG AGAGTTCACA CCATCCCTGT GTGCAAGGAA GGTATCAGAG GCCACACCGA ATCTTGCTCT TGTCCCTTGC AGCAGAGTCC TCGTGCAGAT AACAGTGCCC CTGGAACACC AACCAGGAAA ATCTCTGCCT CTGAATTTGA CCGGCCTCTT AGACCCATTG TTGTCAAGGA TTCTGAGGGA ACTGTGAGCT TCCTCTCTGA CTCAGAAAAG AAGGAACAGA TGCCTCTAAC CCCTCCAAGG TTTGATCATG ATGAAGGGGA CCAGTGCTCA AGACTCTTGG AATTAGTGAA GGATATTTCT AGTCATTTGG ATGTCACAGC CTTATGTCAC AAAATTTTCT TGCATATCCA TGGACTGATA TCTGCTGACC GCTATTCCCT GTTCCTTGTC TGTGAAGACA GCTCCAATGA CAAGTTTCTT ATCAGCCGCC TCTTTGATGT TGCTGAAGGT TCAACACTGG AAGAAGTTTC AAATAACTGT ATCCGCTTAG AATGGAACAA AGGCATTGTG GGACATGTGG CAGCGCTTGG TGAGCCCTTG AACATCAAAG ATGCATATGA GGATCCTCGG TTCAATGCAG AAGTTGACCA AATTACAGGC TACAAGACAC AAAGCATTCT TTGTATGCCA ATTAAGAATC ATAGGGAAGA GGTTGTTGGT GTAGCCCAGG CCATCAACAA GAAATCAGGA AACGGTGGGA CATTTACTGA AAAAGATGAA AAGGACTTTG CTGCTTATTT GGCATTTTGT GGTATTGTTC TTCATAATGC TCAGCTCTAT GAGACTTCAC TGCTGGAGAA CAAGAGAAAT CAGGTGCTGC TTGACCTTGC TAGTTTAATT TTTGAAGAAC AACAATCATT AGAAGTAATT TTGAAGAAAA TAGCTGCCAC TATTATCTCT TTCATGCAAG TGCAGAAATG CACCATTTTC ATAGTGGATG AAGATTGCTC CGATTCTTTT TCTAGTGTGT TTCACATGGA GTGTGAGGAA TTAGAAAAAT CATCTGATAC ATTAACAAGG GAACATGATG CAAACAAAAT CAATTACATG TATGCTCAGT ATGTCAAAAA TACTATGGAA CCACTTAATA TCCCAGATGT CAGTAAGGAT AAAAGATTTC CCTGGACAAC TGAAAATACA GGAAATGTAA ACCAGCAGTG CATTAGAAGT TTGCTTTGTA CACCTATAAA AAATGGAAAG AAGAATAAAG TTATAGGGGT TTGCCAACTT GTTAATAAGA TGGAGGAGAA TACTGGCAAG GTTAAGCCTT TCAACCGAAA TGACGAACAG TTTCTGGAAG CTTTTGTCAT CTTTTGTGGC TTGGGGATCC AGAACACGCA GATGTATGAA GCAGTGGAGA GAGCCATGGC CAAGCAAATG GTCACATTGG AGGTTCTGTC GTATCATGCT TCAGCAGCAG AGGAAGAAAC AAGAGAGCTA CAGTCGTTAG CGGCTGCTGT GGTGCCATCT GCCCAGACCC TTAAAATTAC TGACTTTAGC TTCAGTGACT TTGAGCTGTC TGATCTGGAA ACAGCACTGT GTACAATTCG GATGTTTACT GACCTCAACC TTGTGCAGAA CTTCCAGATG AAACATGAGG TTCTTTGCAG ATGGATTTTA AGTGTTAAGA AGAATTATCG GAAGAATGTT GCCTATCATA ATTGGAGACA TGCCTTTAAT ACAGCTCAGT GCATGTTTGC TGCTCTAAAA GCAGGCAAAA TTCAGATTCT AACTTCAGTG GGAATCGACT AG
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
Type 5 phosphodiesterase regulates glioblastoma multiforme aggressiveness and clinical outcome.
Oncotarget8(8)13223-13239(2017 Feb)
Cesarini V,Martini M,Vitiani LR,Gravina GL,Di Agostino S,Graziani G,D'Alessandris QG,Pallini R,Larocca LM,Rossi P,Jannini EA,Dolci S