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ISX cDNA ORF clone, Homo sapiens(Human)

Gene Symbol ISX
Entrez Gene ID 91464
Full Name intestine specific homeobox
Synonyms Pix-1,RAXLX
General protein information
Preferred Names

intestine specific homeobox

Names

intestine-specific homeobox
RAX-like homeobox
pancreas-intestine homeodomain transcription factor

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

22

22q12.3

Summary Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the RAXLX homeobox gene family. [provided by RefSeq, Jul 2008].
Disorder MIM:

612019


mRNA and Protein(s)

mRNA Protein Name
NM_001303508.1 NP_001290437.1 intestine-specific homeobox



Pan troglodytes (chimpanzee) ISX XP_001154843.1
Canis lupus familiaris (dog) ISX XP_853196.2
Homo sapiens (human) ISX NP_001008494.1
Mus musculus (house mouse) Isx NP_082113.2
Rattus norvegicus (Norway rat) Isx XP_006255209.1
Gallus gallus (chicken) ISX XP_004937856.1
Macaca mulatta (rhesus monkey) ISX XP_001113063.1
Bos taurus (cattle) ISX XP_003586145.1


Related articles in PubMed

Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX.
Lobo GP, Amengual J, Baus D, Shivdasani RA, Taylor D, von Lintig J
The Journal of biological chemistry288(13)9017-27(2013 Mar)

Proinflammatory homeobox gene, ISX, regulates tumor growth and survival in hepatocellular carcinoma.
Hsu SH, Wang LT, Lee KT, Chen YL, Liu KY, Suen JL, Chai CY, Wang SN
Cancer research73(2)508-18(2013 Jan)

Isx participates in the maintenance of vitamin A metabolism by regulation of beta-carotene 15,15'-monooxygenase (Bcmo1) expression.
Seino Y, Miki T, Kiyonari H, Abe T, Fujimoto W, Kimura K, Takeuchi A, Takahashi Y, Oiso Y, Iwanaga T, Seino S
The Journal of biological chemistry283(8)4905-11(2008 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ISX expression induced by H. pylori infection may lead to intestinal metaplasia and hyperproliferation of gastric mucosa through CDX1/2 and cyclinD1 expression, contributing to gastric carcinogenesis.
Title: Intestine-specific homeobox (ISX) induces intestinal metaplasia and cell proliferation to contribute to gastric carcinogenesis.

Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX
Title: Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX.

our results highlight ISX as an important regulator in hepatoma progression with significant potential as a prognostic and therapeutic target in HCCs.
Title: Proinflammatory homeobox gene, ISX, regulates tumor growth and survival in hepatocellular carcinoma.

The following ISX gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ISX cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu30776 NM_001303508.1
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Homo sapiens intestine specific homeobox (ISX), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu30776
Clone ID Related Accession (Same CDS sequence) NM_001303508.1
Accession Version NM_001303508.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 738bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-08-28
Organism Homo sapiens(Human)
Product intestine-specific homeobox
Comment VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR749372.1, Z83853.2, AL024494.1 and AK025181.1. ##Evidence-Data-START## Transcript exon combination :: CR749372.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGTGTGCTG AGGTGGGCCC TGCTCTCTGC AGGGGTATGG AGAGAAATAG CTTGGGGTGC 
TGTGAGGCCC CGAAGAAGCT GAGCCTGTCC TTCTCCATTG AGGCGATCCT AAAGAGGCCT
GCCAGGAGGA GTGATATGGA CAGACCAGAA GGGCCAGGTG AAGAGGGCCC CGGAGAAGCT
GCGGCCTCAG GCTCTGGGCT AGAAAAGCCT CCAAAGGACC AGCCCCAGGA AGGAAGGAAG
AGCAAGCGGA GGGTTCGTAC CACCTTCACC ACTGAGCAGC TGCATGAGCT GGAGAAGATC
TTCCACTTTA CCCACTACCC AGACGTTCAC ATCCGCAGCC AGCTGGCAGC CAGGATCAAC
CTCCCAGAAG CTCGGGTGCA GATCTGGTTC CAGAATCAGC GAGCCAAGTG GCGGAAGCAG
GAGAAGATTG GCAACCTGGG GGCTCCACAG CAGCTGAGTG AAGCCAGTGT GGCCCTGCCC
ACAAATCTGG ATGTGGCTGG GCCCACGTGG ACATCCACTG CTCTGCGCAG GCTGGCTCCT
CCCACGAGCT GTTGTCCATC GGCTCAAGAT CAGCTGGCCT CTGCCTGGTT CCCTGCCTGG
ATCACCCTCC TCCCAGCGCA CCCATGGGAA ACACAGCCTG TCCCAGGTCT TCCCATCCAT
CAAACTTGCA TCCCTGTGCT ATGCATCCTT CCACCTCCAC ACCCCAAATG GGGCAGCATC
TGTGCTACTT CAACATAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001290437.1
CDS664..1401
Misc Feature(1)538..540
Exon (1)1..327
Exon (2)328..892
Translation

Target ORF information:

RefSeq Version NM_001303508.1
Organism Homo sapiens(Human)
Definition Homo sapiens intestine specific homeobox (ISX), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001303508.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGTGTGCTG AGGTGGGCCC TGCTCTCTGC AGGGGTATGG AGAGAAATAG CTTGGGGTGC 
TGTGAGGCCC CGAAGAAGCT GAGCCTGTCC TTCTCCATTG AGGCGATCCT AAAGAGGCCT
GCCAGGAGGA GTGATATGGA CAGACCAGAA GGGCCAGGTG AAGAGGGCCC CGGAGAAGCT
GCGGCCTCAG GCTCTGGGCT AGAAAAGCCT CCAAAGGACC AGCCCCAGGA AGGAAGGAAG
AGCAAGCGGA GGGTTCGTAC CACCTTCACC ACTGAGCAGC TGCATGAGCT GGAGAAGATC
TTCCACTTTA CCCACTACCC AGACGTTCAC ATCCGCAGCC AGCTGGCAGC CAGGATCAAC
CTCCCAGAAG CTCGGGTGCA GATCTGGTTC CAGAATCAGC GAGCCAAGTG GCGGAAGCAG
GAGAAGATTG GCAACCTGGG GGCTCCACAG CAGCTGAGTG AAGCCAGTGT GGCCCTGCCC
ACAAATCTGG ATGTGGCTGG GCCCACGTGG ACATCCACTG CTCTGCGCAG GCTGGCTCCT
CCCACGAGCT GTTGTCCATC GGCTCAAGAT CAGCTGGCCT CTGCCTGGTT CCCTGCCTGG
ATCACCCTCC TCCCAGCGCA CCCATGGGAA ACACAGCCTG TCCCAGGTCT TCCCATCCAT
CAAACTTGCA TCCCTGTGCT ATGCATCCTT CCACCTCCAC ACCCCAAATG GGGCAGCATC
TGTGCTACTT CAACATAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX.
The Journal of biological chemistry288(13)9017-27(2013 Mar)
Lobo GP,Amengual J,Baus D,Shivdasani RA,Taylor D,von Lintig J


book

Proinflammatory homeobox gene, ISX, regulates tumor growth and survival in hepatocellular carcinoma.
Cancer research73(2)508-18(2013 Jan)
Hsu SH,Wang LT,Lee KT,Chen YL,Liu KY,Suen JL,Chai CY,Wang SN


book

Isx participates in the maintenance of vitamin A metabolism by regulation of beta-carotene 15,15'-monooxygenase (Bcmo1) expression.
The Journal of biological chemistry283(8)4905-11(2008 Feb)
Seino Y,Miki T,Kiyonari H,Abe T,Fujimoto W,Kimura K,Takeuchi A,Takahashi Y,Oiso Y,Iwanaga T,Seino S


 
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