ARHGAP18 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ARHGAP18
Entrez Gene ID	93663
Full Name	Rho GTPase activating protein 18
Synonyms	MacGAP,SENEX,bA307O14.2
General protein information	Preferred Names Rho GTPase activating protein 18 Names rho GTPase-activating protein 18 rho-type GTPase-activating protein 18
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q22.33
Summary	ARHGAP18 belongs to a family of Rho (see MIM 165390) GTPase-activating proteins that modulate cell signaling (Potkin et al., 2009 [PubMed 19065146]).[supplied by OMIM, Apr 2010].
Disorder MIM:	613351

mRNA and Protein(s)

mRNA	Protein	Name
NM_033515.3	NP_277050.2	rho GTPase-activating protein 18
XM_005267212.2	XP_005267269.2	rho GTPase-activating protein 18 isoform X1
XM_017011494.1	XP_016866983.1	rho GTPase-activating protein 18 isoform X2
XM_005267213.1	XP_005267270.1	rho GTPase-activating protein 18 isoform X3
NM_033515.2	NP_277050.2	rho GTPase-activating protein 18

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ARHGAP18	NP_001104242.1
Mus musculus (house mouse)	Arhgap18	NP_789807.1
	ARHGAP18	XP_001105288.1
Canis lupus familiaris (dog)	ARHGAP18	XP_533497.3
Gallus gallus (chicken)	ARHGAP18	XP_419743.3
Xenopus tropicalis (tropical clawed frog)	arhgap18	NP_001072336.1
Rattus norvegicus (Norway rat)	Arhgap18	NP_001164046.1
Homo sapiens (human)	ARHGAP18	NP_277050.2
Danio rerio (zebrafish)	LOC100004252	XP_001343601.5
Pan troglodytes (chimpanzee)	ARHGAP18	XP_001168191.2
Xenopus tropicalis (tropical clawed frog)	LOC101734415	XP_004920294.1

Gene Ontology
Bibliography

Related articles in PubMed

Activation of human gonadotropin-releasing hormone receptor promotes down regulation of ARHGAP18 and regulates the cell invasion of MDA-MB-231?cells.
Aguilar-Rojas A, Maya-N??ez G, Huerta-Reyes M, P?rez-Solis MA, Silva-Garc?a R, Guill?n N, Olivo-Marin JC
Molecular and cellular endocrinology46094-103(2018 Jan)

ARHGAP18 is a novel gene under positive natural selection that influences HbF levels in ?-thalassaemia.
He Y, Luo J, Chen Y, Zhou X, Yu S, Jin L, Xiao X, Jia S, Liu Q
Molecular genetics and genomics : MGG(2017 Oct)

ARHGAP18 Downregulation by miR-200b Suppresses Metastasis of Triple-Negative Breast Cancer by Enhancing Activation of RhoA.
Humphries B, Wang Z, Li Y, Jhan JR, Jiang Y, Yang C
Cancer research77(15)4051-4064(2017 Aug)

Association of ARHGAP18 polymorphisms with schizophrenia in the Chinese-Han population.
Guo W, Cai Y, Zhang H, Yang Y, Yang G, Wang X, Zhao J, Lin J, Zhu J, Li W, Lv L
PloS one12(4)e0175209(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these results define opposing roles for oncogenic ARHGAP18 and tumor suppressive miR-200b in determining triple-negative breast cancer cell migration and metastatic prowess
Title: ARHGAP18 Downregulation by miR-200b Suppresses Metastasis of Triple-Negative Breast Cancer by Enhancing Activation of RhoA.

In endothelial cells, ARHGAP18 may act as a significant regulator of vascular homeostasis.
Title: The RhoGAP protein ARHGAP18/SENEX localizes to microtubules and regulates their stability in endothelial cells.

data suggest the ARHGAP18 may confer vulnerability to SZ in the Chinese Han population, providing additional evidence for the involvement of neurodevelopmental dysfunction in the pathogenesis of schizophrenia
Title: Association of ARHGAP18 polymorphisms with schizophrenia in the Chinese-Han population.

Our results show that miR-181a is down-regulated in glioblastoma multiforme (GBM) patients. The three target genes, ANGPT2, ARHGAP18 and LAMC1, are negatively correlated with the expression of miR-181a. Moreover, high expression of ANGPT2 or LAMC1 together with large size of GBM is correlated with a shorter median overall survival
Title: The correlation of microRNA-181a and target genes with poor prognosis of glioblastoma patients.

Results describe ARHGAP18 as a novel negative regulator of sprouting by acting dualistically to limit tip cell formation and to maintain junctional integrity.
Title: ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions.

The following ARHGAP18 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ARHGAP18 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08910	NM_033515.3 Latest version!	Homo sapiens Rho GTPase activating protein 18 (ARHGAP18), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu41021	XM_005267213.1 Latest version!	Homo sapiens Rho GTPase activating protein 18 (ARHGAP18), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu96914	XM_005267212.2 Latest version!	Homo sapiens Rho GTPase activating protein 18 (ARHGAP18), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OHu96915	XM_017011494.1 Latest version!	Homo sapiens Rho GTPase activating protein 18 (ARHGAP18), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OHu08910	NM_033515.2	Homo sapiens Rho GTPase activating protein 18 (ARHGAP18), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ARHGAP18 ( NM_033515.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_277050.2 Homo sapiens Rho GTPase activating protein 18 (ARHGAP18), mRNA.

Price & Availability↑

CloneID	OHu08910
Clone ID Related Accession (Same CDS sequence)	NM_033515.3 , NM_033515.2
Accession Version	NM_033515.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1992bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	rho GTPase-activating protein 18
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB149638.1, BM557223.1, AB053293.1 and AL450310.18. On Nov 22, 2018 this sequence version replaced NM_033515.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.158316.1, SRR1803614.93837.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000368149.3/ ENSP00000357131.2 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCTGGC TCTCCAGTTC CCAGGGAGTG GTACTAACAG CCTACCACCC CAGCGGCAAG 
GACCAGACCG TCGGGAACAG CCATGCAAAG GCAGGGGAGG AAGCCACCTC GAGTCGCAGA 
TATGGCCAGT ACACTATGAA CCAGGAAAGC ACCACCATCA AAGTTATGGA GAAGCCTCCA 
TTTGATCGAT CAATTTCCCA GGATTCTTTG GATGAACTAT CTATGGAAGA CTATTGGATA 
GAACTAGAAA ACATCAAGAA ATCTAGTGAA AACAGCCAAG AAGATCAAGA GGTGGTTGTT 
GTCAAAGAGC CTGATGAGGG AGAATTGGAA GAAGAGTGGC TTAAAGAGGC CGGTTTATCC 
AATCTCTTCG GAGAGTCTGC TGGAGATCCA CAGGAAAGCA TTGTGTTTTT ATCAACATTG 
ACGCGGACCC AGGCAGCAGC AGTTCAGAAG CGAGTAGAGA CGGTCTCCCA GACCTTGAGG 
AAAAAAAACA AACAGTACCA GATTCCTGAC GTCAGAGACA TATTTGCTCA ACAGAGAGAA 
TCAAAAGAAA CAGCTCCAGG TGGCACTGAA TCGCAGTCAC TTAGAACAAA TGAAAACAAA 
TACCAAGGAA GAGATGACGA GGCATCTAAC CTTGTTGGTG AAGAGAAGCT GATCCCACCT 
GAGGAGACGC CTGCCCCTGA AACAGACATC AACCTGGAGG TATCATTTGC CGAGCAAGCA 
CTCAATCAGA AAGAGAGCTC CAAGGAGAAA ATCCAGAAGA GCAAAGGCGA TGATGCCACA 
TTACCTAGTT TCAGATTGCC AAAAGACAAA ACGGGTACCA CAAGGATTGG TGACCTCGCA 
CCCCAGGACA TGAAGAAAGT TTGCCATTTA GCCCTAATTG AGCTGACTGC CCTCTATGAT 
GTATTGGGTA TTGAGCTGAA ACAACAAAAA GCTGTGAAAA TCAAAACAAA AGATTCTGGT 
CTTTTTTGCG TTCCATTGAC AGCGCTATTA GAACAAGATC AGAGGAAAGT ACCAGGAATG 
CGAATACCCT TGATCTTTCA AAAACTGATT TCTCGAATTG AAGAGAGAGG TTTGGAAACA 
GAAGGCCTCT TACGGATCCC TGGAGCTGCC ATTAGAATCA AGAATCTTTG CCAAGAACTA 
GAAGCAAAGT TTTATGAAGG GACTTTTAAT TGGGAAAGTG TCAAACAGCA TGATGCCGCC 
AGCCTGCTGA AGCTCTTCAT TCGGGAGTTG CCCCAGCCAC TGCTCAGTGT GGAGTATCTC 
AAAGCCTTTC AGGCTGTCCA GAATCTTCCA ACCAAGAAGC AGCAACTACA GGCTTTGAAC 
CTTCTTGTCA TCCTCCTACC TGATGCAAAC AGGGACACAC TGAAGGCCCT TCTTGAATTT 
CTCCAAAGAG TAATAGATAA TAAAGAAAAA AATAAAATGA CAGTCATGAA TGTAGCAATG 
GTCATGGCCC CGAATCTCTT TATGTGTCAT GCATTGGGAT TGAAGTCCAG TGAACAGCGA 
GAATTTGTAA TGGCAGCTGG GACAGCAAAT ACCATGCACT TATTGATTAA GTACCAAAAA 
CTTCTGTGGA CAATTCCCAA GTTTATTGTA AACCAAGTGA GGAAGCAAAA CACGGAAAAT 
CATAAAAAGG ATAAAAGAGC CATGAAGAAA TTGCTGAAGA AAATGGCTTA TGACCGAGAA 
AAATATGAAA AGCAAGATAA GAGTACAAAT GATGCTGACG TTCCTCAGGG AGTGATTCGA 
GTGCAAGCTC CCCATCTTTC GAAAGTTTCC ATGGCAATAC AGCTAACTGA AGAACTAAAA 
GCCAGTGATG TACTTGCCAG GTTTCTCAGC CAAGAAAGTG GGGTTGCCCA GACTCTCAAG 
AAAGGAGAAG TTTTTTTGTA TGAAATTGGA GGAAATATTG GGGAACGCTG CCTTGATGAT 
GACACTTACA TGAAGGATTT ATATCAGCTT AACCCAAATG CTGAGTGGGT TATAAAGTCA 
AAGCCATTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_277050.2
CDS	42..2033
Translation	MSWLSSSQGVVLTAYHPSGKDQTVGNSHAKAGEEATSSRRYGQYTMNQESTTIKVMEKPPFDRSISQDSLDELSMEDYWIELENIKKSSENSQEDQEVVVVKEPDEGELEEEWLKEAGLSNLFGESAGDPQESIVFLSTLTRTQAAAVQKRVETVSQTLRKKNKQYQIPDVRDIFAQQRESKETAPGGTESQSLRTNENKYQGRDDEASNLVGEEKLIPPEETPAPETDINLEVSFAEQALNQKESSKEKIQKSKGDDATLPSFRLPKDKTGTTRIGDLAPQDMKKVCHLALIELTALYDVLGIELKQQKAVKIKTKDSGLFCVPLTALLEQDQRKVPGMRIPLIFQKLISRIEERGLETEGLLRIPGAAIRIKNLCQELEAKFYEGTFNWESVKQHDAASLLKLFIRELPQPLLSVEYLKAFQAVQNLPTKKQQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTVMNVAMVMAPNLFMCHALGLKSSEQREFVMAAGTANTMHLLIKYQKLLWTIPKFIVNQVRKQNTENHKKDKRAMKKLLKKMAYDREKYEKQDKSTNDADVPQGVIRVQAPHLSKVSMAIQLTEELKASDVLARFLSQESGVAQTLKKGEVFLYEIGGNIGERCLDDDTYMKDLYQLNPNAEWVIKSKPL

Target ORF information:

RefSeq Version	NM_033515.3
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho GTPase activating protein 18 (ARHGAP18), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033515.3

ORF Insert Sequence:

ATGAGCTGGC TCTCCAGTTC CCAGGGAGTG GTACTAACAG CCTACCACCC CAGCGGCAAG 
GACCAGACCG TCGGGAACAG CCATGCAAAG GCAGGGGAGG AAGCCACCTC GAGTCGCAGA 
TATGGCCAGT ACACTATGAA CCAGGAAAGC ACCACCATCA AAGTTATGGA GAAGCCTCCA 
TTTGATCGAT CAATTTCCCA GGATTCTTTG GATGAACTAT CTATGGAAGA CTATTGGATA 
GAACTAGAAA ACATCAAGAA ATCTAGTGAA AACAGCCAAG AAGATCAAGA GGTGGTTGTT 
GTCAAAGAGC CTGATGAGGG AGAATTGGAA GAAGAGTGGC TTAAAGAGGC CGGTTTATCC 
AATCTCTTCG GAGAGTCTGC TGGAGATCCA CAGGAAAGCA TTGTGTTTTT ATCAACATTG 
ACGCGGACCC AGGCAGCAGC AGTTCAGAAG CGAGTAGAGA CGGTCTCCCA GACCTTGAGG 
AAAAAAAACA AACAGTACCA GATTCCTGAC GTCAGAGACA TATTTGCTCA ACAGAGAGAA 
TCAAAAGAAA CAGCTCCAGG TGGCACTGAA TCGCAGTCAC TTAGAACAAA TGAAAACAAA 
TACCAAGGAA GAGATGACGA GGCATCTAAC CTTGTTGGTG AAGAGAAGCT GATCCCACCT 
GAGGAGACGC CTGCCCCTGA AACAGACATC AACCTGGAGG TATCATTTGC CGAGCAAGCA 
CTCAATCAGA AAGAGAGCTC CAAGGAGAAA ATCCAGAAGA GCAAAGGCGA TGATGCCACA 
TTACCTAGTT TCAGATTGCC AAAAGACAAA ACGGGTACCA CAAGGATTGG TGACCTCGCA 
CCCCAGGACA TGAAGAAAGT TTGCCATTTA GCCCTAATTG AGCTGACTGC CCTCTATGAT 
GTATTGGGTA TTGAGCTGAA ACAACAAAAA GCTGTGAAAA TCAAAACAAA AGATTCTGGT 
CTTTTTTGCG TTCCATTGAC AGCGCTATTA GAACAAGATC AGAGGAAAGT ACCAGGAATG 
CGAATACCCT TGATCTTTCA AAAACTGATT TCTCGAATTG AAGAGAGAGG TTTGGAAACA 
GAAGGCCTCT TACGGATCCC TGGAGCTGCC ATTAGAATCA AGAATCTTTG CCAAGAACTA 
GAAGCAAAGT TTTATGAAGG GACTTTTAAT TGGGAAAGTG TCAAACAGCA TGATGCCGCC 
AGCCTGCTGA AGCTCTTCAT TCGGGAGTTG CCCCAGCCAC TGCTCAGTGT GGAGTATCTC 
AAAGCCTTTC AGGCTGTCCA GAATCTTCCA ACCAAGAAGC AGCAACTACA GGCTTTGAAC 
CTTCTTGTCA TCCTCCTACC TGATGCAAAC AGGGACACAC TGAAGGCCCT TCTTGAATTT 
CTCCAAAGAG TAATAGATAA TAAAGAAAAA AATAAAATGA CAGTCATGAA TGTAGCAATG 
GTCATGGCCC CGAATCTCTT TATGTGTCAT GCATTGGGAT TGAAGTCCAG TGAACAGCGA 
GAATTTGTAA TGGCAGCTGG GACAGCAAAT ACCATGCACT TATTGATTAA GTACCAAAAA 
CTTCTGTGGA CAATTCCCAA GTTTATTGTA AACCAAGTGA GGAAGCAAAA CACGGAAAAT 
CATAAAAAGG ATAAAAGAGC CATGAAGAAA TTGCTGAAGA AAATGGCTTA TGACCGAGAA 
AAATATGAAA AGCAAGATAA GAGTACAAAT GATGCTGACG TTCCTCAGGG AGTGATTCGA 
GTGCAAGCTC CCCATCTTTC GAAAGTTTCC ATGGCAATAC AGCTAACTGA AGAACTAAAA 
GCCAGTGATG TACTTGCCAG GTTTCTCAGC CAAGAAAGTG GGGTTGCCCA GACTCTCAAG 
AAAGGAGAAG TTTTTTTGTA TGAAATTGGA GGAAATATTG GGGAACGCTG CCTTGATGAT 
GACACTTACA TGAAGGATTT ATATCAGCTT AACCCAAATG CTGAGTGGGT TATAAAGTCA 
AAGCCATTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARHGAP18 ( NM_033515.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_277050.2 Homo sapiens Rho GTPase activating protein 18 (ARHGAP18), mRNA.

Price & Availability↑

CloneID	OHu08910
Clone ID Related Accession (Same CDS sequence)	NM_033515.3 , NM_033515.2
Accession Version	NM_033515.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1992bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	rho GTPase-activating protein 18
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB149638.1, BM557223.1, AB053293.1 and AI337078.1. On Dec 16, 2003 this sequence version replaced NM_033515.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.52579.1, SRR1660803.24302.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGAGCTGGC TCTCCAGTTC CCAGGGAGTG GTACTAACAG CCTACCACCC CAGCGGCAAG 
GACCAGACCG TCGGGAACAG CCATGCAAAG GCAGGGGAGG AAGCCACCTC GAGTCGCAGA 
TATGGCCAGT ACACTATGAA CCAGGAAAGC ACCACCATCA AAGTTATGGA GAAGCCTCCA 
TTTGATCGAT CAATTTCCCA GGATTCTTTG GATGAACTAT CTATGGAAGA CTATTGGATA 
GAACTAGAAA ACATCAAGAA ATCTAGTGAA AACAGCCAAG AAGATCAAGA GGTGGTTGTT 
GTCAAAGAGC CTGATGAGGG AGAATTGGAA GAAGAGTGGC TTAAAGAGGC CGGTTTATCC 
AATCTCTTCG GAGAGTCTGC TGGAGATCCA CAGGAAAGCA TTGTGTTTTT ATCAACATTG 
ACGCGGACCC AGGCAGCAGC AGTTCAGAAG CGAGTAGAGA CGGTCTCCCA GACCTTGAGG 
AAAAAAAACA AACAGTACCA GATTCCTGAC GTCAGAGACA TATTTGCTCA ACAGAGAGAA 
TCAAAAGAAA CAGCTCCAGG TGGCACTGAA TCGCAGTCAC TTAGAACAAA TGAAAACAAA 
TACCAAGGAA GAGATGACGA GGCATCTAAC CTTGTTGGTG AAGAGAAGCT GATCCCACCT 
GAGGAGACGC CTGCCCCTGA AACAGACATC AACCTGGAGG TATCATTTGC CGAGCAAGCA 
CTCAATCAGA AAGAGAGCTC CAAGGAGAAA ATCCAGAAGA GCAAAGGCGA TGATGCCACA 
TTACCTAGTT TCAGATTGCC AAAAGACAAA ACGGGTACCA CAAGGATTGG TGACCTCGCA 
CCCCAGGACA TGAAGAAAGT TTGCCATTTA GCCCTAATTG AGCTGACTGC CCTCTATGAT 
GTATTGGGTA TTGAGCTGAA ACAACAAAAA GCTGTGAAAA TCAAAACAAA AGATTCTGGT 
CTTTTTTGCG TTCCATTGAC AGCGCTATTA GAACAAGATC AGAGGAAAGT ACCAGGAATG 
CGAATACCCT TGATCTTTCA AAAACTGATT TCTCGAATTG AAGAGAGAGG TTTGGAAACA 
GAAGGCCTCT TACGGATCCC TGGAGCTGCC ATTAGAATCA AGAATCTTTG CCAAGAACTA 
GAAGCAAAGT TTTATGAAGG GACTTTTAAT TGGGAAAGTG TCAAACAGCA TGATGCCGCC 
AGCCTGCTGA AGCTCTTCAT TCGGGAGTTG CCCCAGCCAC TGCTCAGTGT GGAGTATCTC 
AAAGCCTTTC AGGCTGTCCA GAATCTTCCA ACCAAGAAGC AGCAACTACA GGCTTTGAAC 
CTTCTTGTCA TCCTCCTACC TGATGCAAAC AGGGACACAC TGAAGGCCCT TCTTGAATTT 
CTCCAAAGAG TAATAGATAA TAAAGAAAAA AATAAAATGA CAGTCATGAA TGTAGCAATG 
GTCATGGCCC CGAATCTCTT TATGTGTCAT GCATTGGGAT TGAAGTCCAG TGAACAGCGA 
GAATTTGTAA TGGCAGCTGG GACAGCAAAT ACCATGCACT TATTGATTAA GTACCAAAAA 
CTTCTGTGGA CAATTCCCAA GTTTATTGTA AACCAAGTGA GGAAGCAAAA CACGGAAAAT 
CATAAAAAGG ATAAAAGAGC CATGAAGAAA TTGCTGAAGA AAATGGCTTA TGACCGAGAA 
AAATATGAAA AGCAAGATAA GAGTACAAAT GATGCTGACG TTCCTCAGGG AGTGATTCGA 
GTGCAAGCTC CCCATCTTTC GAAAGTTTCC ATGGCAATAC AGCTAACTGA AGAACTAAAA 
GCCAGTGATG TACTTGCCAG GTTTCTCAGC CAAGAAAGTG GGGTTGCCCA GACTCTCAAG 
AAAGGAGAAG TTTTTTTGTA TGAAATTGGA GGAAATATTG GGGAACGCTG CCTTGATGAT 
GACACTTACA TGAAGGATTT ATATCAGCTT AACCCAAATG CTGAGTGGGT TATAAAGTCA 
AAGCCATTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_277050.2
CDS	90..2081
Translation	MSWLSSSQGVVLTAYHPSGKDQTVGNSHAKAGEEATSSRRYGQYTMNQESTTIKVMEKPPFDRSISQDSLDELSMEDYWIELENIKKSSENSQEDQEVVVVKEPDEGELEEEWLKEAGLSNLFGESAGDPQESIVFLSTLTRTQAAAVQKRVETVSQTLRKKNKQYQIPDVRDIFAQQRESKETAPGGTESQSLRTNENKYQGRDDEASNLVGEEKLIPPEETPAPETDINLEVSFAEQALNQKESSKEKIQKSKGDDATLPSFRLPKDKTGTTRIGDLAPQDMKKVCHLALIELTALYDVLGIELKQQKAVKIKTKDSGLFCVPLTALLEQDQRKVPGMRIPLIFQKLISRIEERGLETEGLLRIPGAAIRIKNLCQELEAKFYEGTFNWESVKQHDAASLLKLFIRELPQPLLSVEYLKAFQAVQNLPTKKQQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTVMNVAMVMAPNLFMCHALGLKSSEQREFVMAAGTANTMHLLIKYQKLLWTIPKFIVNQVRKQNTENHKKDKRAMKKLLKKMAYDREKYEKQDKSTNDADVPQGVIRVQAPHLSKVSMAIQLTEELKASDVLARFLSQESGVAQTLKKGEVFLYEIGGNIGERCLDDDTYMKDLYQLNPNAEWVIKSKPL

Target ORF information:

RefSeq Version	NM_033515.2
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho GTPase activating protein 18 (ARHGAP18), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033515.2

ORF Insert Sequence:

ATGAGCTGGC TCTCCAGTTC CCAGGGAGTG GTACTAACAG CCTACCACCC CAGCGGCAAG 
GACCAGACCG TCGGGAACAG CCATGCAAAG GCAGGGGAGG AAGCCACCTC GAGTCGCAGA 
TATGGCCAGT ACACTATGAA CCAGGAAAGC ACCACCATCA AAGTTATGGA GAAGCCTCCA 
TTTGATCGAT CAATTTCCCA GGATTCTTTG GATGAACTAT CTATGGAAGA CTATTGGATA 
GAACTAGAAA ACATCAAGAA ATCTAGTGAA AACAGCCAAG AAGATCAAGA GGTGGTTGTT 
GTCAAAGAGC CTGATGAGGG AGAATTGGAA GAAGAGTGGC TTAAAGAGGC CGGTTTATCC 
AATCTCTTCG GAGAGTCTGC TGGAGATCCA CAGGAAAGCA TTGTGTTTTT ATCAACATTG 
ACGCGGACCC AGGCAGCAGC AGTTCAGAAG CGAGTAGAGA CGGTCTCCCA GACCTTGAGG 
AAAAAAAACA AACAGTACCA GATTCCTGAC GTCAGAGACA TATTTGCTCA ACAGAGAGAA 
TCAAAAGAAA CAGCTCCAGG TGGCACTGAA TCGCAGTCAC TTAGAACAAA TGAAAACAAA 
TACCAAGGAA GAGATGACGA GGCATCTAAC CTTGTTGGTG AAGAGAAGCT GATCCCACCT 
GAGGAGACGC CTGCCCCTGA AACAGACATC AACCTGGAGG TATCATTTGC CGAGCAAGCA 
CTCAATCAGA AAGAGAGCTC CAAGGAGAAA ATCCAGAAGA GCAAAGGCGA TGATGCCACA 
TTACCTAGTT TCAGATTGCC AAAAGACAAA ACGGGTACCA CAAGGATTGG TGACCTCGCA 
CCCCAGGACA TGAAGAAAGT TTGCCATTTA GCCCTAATTG AGCTGACTGC CCTCTATGAT 
GTATTGGGTA TTGAGCTGAA ACAACAAAAA GCTGTGAAAA TCAAAACAAA AGATTCTGGT 
CTTTTTTGCG TTCCATTGAC AGCGCTATTA GAACAAGATC AGAGGAAAGT ACCAGGAATG 
CGAATACCCT TGATCTTTCA AAAACTGATT TCTCGAATTG AAGAGAGAGG TTTGGAAACA 
GAAGGCCTCT TACGGATCCC TGGAGCTGCC ATTAGAATCA AGAATCTTTG CCAAGAACTA 
GAAGCAAAGT TTTATGAAGG GACTTTTAAT TGGGAAAGTG TCAAACAGCA TGATGCCGCC 
AGCCTGCTGA AGCTCTTCAT TCGGGAGTTG CCCCAGCCAC TGCTCAGTGT GGAGTATCTC 
AAAGCCTTTC AGGCTGTCCA GAATCTTCCA ACCAAGAAGC AGCAACTACA GGCTTTGAAC 
CTTCTTGTCA TCCTCCTACC TGATGCAAAC AGGGACACAC TGAAGGCCCT TCTTGAATTT 
CTCCAAAGAG TAATAGATAA TAAAGAAAAA AATAAAATGA CAGTCATGAA TGTAGCAATG 
GTCATGGCCC CGAATCTCTT TATGTGTCAT GCATTGGGAT TGAAGTCCAG TGAACAGCGA 
GAATTTGTAA TGGCAGCTGG GACAGCAAAT ACCATGCACT TATTGATTAA GTACCAAAAA 
CTTCTGTGGA CAATTCCCAA GTTTATTGTA AACCAAGTGA GGAAGCAAAA CACGGAAAAT 
CATAAAAAGG ATAAAAGAGC CATGAAGAAA TTGCTGAAGA AAATGGCTTA TGACCGAGAA 
AAATATGAAA AGCAAGATAA GAGTACAAAT GATGCTGACG TTCCTCAGGG AGTGATTCGA 
GTGCAAGCTC CCCATCTTTC GAAAGTTTCC ATGGCAATAC AGCTAACTGA AGAACTAAAA 
GCCAGTGATG TACTTGCCAG GTTTCTCAGC CAAGAAAGTG GGGTTGCCCA GACTCTCAAG 
AAAGGAGAAG TTTTTTTGTA TGAAATTGGA GGAAATATTG GGGAACGCTG CCTTGATGAT 
GACACTTACA TGAAGGATTT ATATCAGCTT AACCCAAATG CTGAGTGGGT TATAAAGTCA 
AAGCCATTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARHGAP18 ( XM_005267213.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_005267270.1 Homo sapiens Rho GTPase activating protein 18 (ARHGAP18), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu41021
Clone ID Related Accession (Same CDS sequence)	XM_005267213.1
Accession Version	XM_005267213.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1758bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	rho GTPase-activating protein 18 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCTGGC TCTCCAGTTC CCAGGGAGTG GTACTAACAG CCTACCACCC CAGCGGCAAG 
GACCAGACCG TCGGGAACAG CCATGCAAAG GCAGGGGAGG AAGCCACCTC GAGTCGCAGA 
TATGGCCAGT ACACTATGAA CCAGGAAAGC ACCACCATCA AAGTTATGGA GAAGCCTCCA 
TTTGATCGAT CAATTTCCCA GGATTCTTTG GATGAACTAT CTATGGAAGA CTATTGGATA 
GAACTAGAAA ACATCAAGAA ATCTAGTGAA AACAGCCAAG AAGATCAAGA GGTGGTTGTT 
GTCAAAGAGC CTGATGAGGG AGAATTGGAA GAAGAGTGGC TTAAAGAGGC CGGTTTATCC 
AATCTCTTCG GAGAGTCTGC TGGAGATCCA CAGGAAAGCA TTGTGTTTTT ATCAACATTG 
ACGCGGACCC AGGCAGCAGC AGTTCAGAAG CGAGTAGAGA CGGTCTCCCA GACCTTGAGG 
AAAAAAAACA AACAGTACCA GATTCCTGAC GTCAGAGACA TATTTGCTCA ACAGAGAGAA 
TCAAAAGAAA CAGCTCCAGG TGGCACTGAA TCGCAGTCAC TTAGAACAAA TGAAAACAAA 
TACCAAGGAA GAGATGACGA GGCATCTAAC CTTGTTGGTG AAGAGAAGCT GATCCCACCT 
GAGGAGACGC CTGCCCCTGA AACAGACATC AACCTGGAGG TATCATTTGC CGAGCAAGCA 
CTCAATCAGA AAGAGAGCTC CAAGGAGAAA ATCCAGAAGA GCAAAGGCGA TGATGCCACA 
TTACCTAGTT TCAGATTGCC AAAAGACAAA ACGGGTACCA CAAGGATTGG TGACCTCGCA 
CCCCAGGACA TGAAGAAAGT TTGCCATTTA GCCCTAATTG AGCTGACTGC CCTCTATGAT 
GTATTGGGTA TTGAGCTGAA ACAACAAAAA GCTGTGAAAA TCAAAACAAA AGATTCTGGT 
CTTTTTTGCG TTCCATTGAC AGCGCTATTA GAACAAGATC AGAGGAAAGT ACCAGGAATG 
CGAATACCCT TGATCTTTCA AAAACTGATT TCTCGAATTG AAGAGAGAGG TTTGGAAACA 
GAAGGCCTCT TACGGATCCC TGGAGCTGCC ATTAGAATCA AGAATCTTTG CCAAGAACTA 
GAAGCAAAGT TTTATGAAGG GACTTTTAAT TGGGAAAGTG TCAAACAGCA TGATGCCGCC 
AGCCTGCTGA AGCTCTTCAT TCGGGAGTTG CCCCAGCCAC TGCTCAGTGT GGAGTATCTC 
AAAGCCTTTC AGGCTGTCCA GAATCTTCCA ACCAAGAAGC AGCAACTACA GGCTTTGAAC 
CTTCTTGTCA TCCTCCTACC TGATGCAAAC AGGGACACAC TGAAGGCCCT TCTTGAATTT 
CTCCAAAGAG TAATAGATAA TAAAGAAAAA AATAAAATGA CAGTCATGAA TGTAGCAATG 
GTCATGGCCC CGAATCTCTT TATGTGTCAT GCATTGGGAT TGAAGTCCAG TGAACAGCGA 
GAATTTGTAA TGGCAGCTGG GACAGCAAAT ACCATGCACT TATTGATTAA GTACCAAAAA 
CTTCTGTGGA CAATTCCCAA GTTTATTGTA AACCAAGTGA GGAAGCAAAA CACGGAAAAT 
CATAAAAAGG ATAAAAGAGC CATGAAGAAA TTGCTGAAGA AAATGGCTTA TGACCGAGAA 
AAATATGAAA AGCAAGATAA GAGTACAAAT GATTGGGGTT GCCCAGACTC TCAAGAAAGG 
AGAAGTTTTT TTGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005267270.1
CDS	90..1847
Translation	MSWLSSSQGVVLTAYHPSGKDQTVGNSHAKAGEEATSSRRYGQYTMNQESTTIKVMEKPPFDRSISQDSLDELSMEDYWIELENIKKSSENSQEDQEVVVVKEPDEGELEEEWLKEAGLSNLFGESAGDPQESIVFLSTLTRTQAAAVQKRVETVSQTLRKKNKQYQIPDVRDIFAQQRESKETAPGGTESQSLRTNENKYQGRDDEASNLVGEEKLIPPEETPAPETDINLEVSFAEQALNQKESSKEKIQKSKGDDATLPSFRLPKDKTGTTRIGDLAPQDMKKVCHLALIELTALYDVLGIELKQQKAVKIKTKDSGLFCVPLTALLEQDQRKVPGMRIPLIFQKLISRIEERGLETEGLLRIPGAAIRIKNLCQELEAKFYEGTFNWESVKQHDAASLLKLFIRELPQPLLSVEYLKAFQAVQNLPTKKQQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTVMNVAMVMAPNLFMCHALGLKSSEQREFVMAAGTANTMHLLIKYQKLLWTIPKFIVNQVRKQNTENHKKDKRAMKKLLKKMAYDREKYEKQDKSTNDWGCPDSQERRSFFV

Target ORF information:

RefSeq Version	XM_005267213.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho GTPase activating protein 18 (ARHGAP18), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005267213.1

ORF Insert Sequence:

ATGAGCTGGC TCTCCAGTTC CCAGGGAGTG GTACTAACAG CCTACCACCC CAGCGGCAAG 
GACCAGACCG TCGGGAACAG CCATGCAAAG GCAGGGGAGG AAGCCACCTC GAGTCGCAGA 
TATGGCCAGT ACACTATGAA CCAGGAAAGC ACCACCATCA AAGTTATGGA GAAGCCTCCA 
TTTGATCGAT CAATTTCCCA GGATTCTTTG GATGAACTAT CTATGGAAGA CTATTGGATA 
GAACTAGAAA ACATCAAGAA ATCTAGTGAA AACAGCCAAG AAGATCAAGA GGTGGTTGTT 
GTCAAAGAGC CTGATGAGGG AGAATTGGAA GAAGAGTGGC TTAAAGAGGC CGGTTTATCC 
AATCTCTTCG GAGAGTCTGC TGGAGATCCA CAGGAAAGCA TTGTGTTTTT ATCAACATTG 
ACGCGGACCC AGGCAGCAGC AGTTCAGAAG CGAGTAGAGA CGGTCTCCCA GACCTTGAGG 
AAAAAAAACA AACAGTACCA GATTCCTGAC GTCAGAGACA TATTTGCTCA ACAGAGAGAA 
TCAAAAGAAA CAGCTCCAGG TGGCACTGAA TCGCAGTCAC TTAGAACAAA TGAAAACAAA 
TACCAAGGAA GAGATGACGA GGCATCTAAC CTTGTTGGTG AAGAGAAGCT GATCCCACCT 
GAGGAGACGC CTGCCCCTGA AACAGACATC AACCTGGAGG TATCATTTGC CGAGCAAGCA 
CTCAATCAGA AAGAGAGCTC CAAGGAGAAA ATCCAGAAGA GCAAAGGCGA TGATGCCACA 
TTACCTAGTT TCAGATTGCC AAAAGACAAA ACGGGTACCA CAAGGATTGG TGACCTCGCA 
CCCCAGGACA TGAAGAAAGT TTGCCATTTA GCCCTAATTG AGCTGACTGC CCTCTATGAT 
GTATTGGGTA TTGAGCTGAA ACAACAAAAA GCTGTGAAAA TCAAAACAAA AGATTCTGGT 
CTTTTTTGCG TTCCATTGAC AGCGCTATTA GAACAAGATC AGAGGAAAGT ACCAGGAATG 
CGAATACCCT TGATCTTTCA AAAACTGATT TCTCGAATTG AAGAGAGAGG TTTGGAAACA 
GAAGGCCTCT TACGGATCCC TGGAGCTGCC ATTAGAATCA AGAATCTTTG CCAAGAACTA 
GAAGCAAAGT TTTATGAAGG GACTTTTAAT TGGGAAAGTG TCAAACAGCA TGATGCCGCC 
AGCCTGCTGA AGCTCTTCAT TCGGGAGTTG CCCCAGCCAC TGCTCAGTGT GGAGTATCTC 
AAAGCCTTTC AGGCTGTCCA GAATCTTCCA ACCAAGAAGC AGCAACTACA GGCTTTGAAC 
CTTCTTGTCA TCCTCCTACC TGATGCAAAC AGGGACACAC TGAAGGCCCT TCTTGAATTT 
CTCCAAAGAG TAATAGATAA TAAAGAAAAA AATAAAATGA CAGTCATGAA TGTAGCAATG 
GTCATGGCCC CGAATCTCTT TATGTGTCAT GCATTGGGAT TGAAGTCCAG TGAACAGCGA 
GAATTTGTAA TGGCAGCTGG GACAGCAAAT ACCATGCACT TATTGATTAA GTACCAAAAA 
CTTCTGTGGA CAATTCCCAA GTTTATTGTA AACCAAGTGA GGAAGCAAAA CACGGAAAAT 
CATAAAAAGG ATAAAAGAGC CATGAAGAAA TTGCTGAAGA AAATGGCTTA TGACCGAGAA 
AAATATGAAA AGCAAGATAA GAGTACAAAT GATTGGGGTT GCCCAGACTC TCAAGAAAGG 
AGAAGTTTTT TTGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARHGAP18 ( XM_005267212.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005267269.2 Homo sapiens Rho GTPase activating protein 18 (ARHGAP18), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu96914
Clone ID Related Accession (Same CDS sequence)	XM_005267212.2
Accession Version	XM_005267212.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2142bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	rho GTPase-activating protein 18 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005267212.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTTTTTA ATCATTTGGC ATCTAGCATG GAGCCTTCAG AGAGTATTAT GCCTCAGAGA 
GCTGCAGCTT GCGTGGATCT TGGGAGGGGC CCTTGGTTTC AGGGGCTTTG TGTTCTGTGT 
GTGTGTGTGT GTGTGGCAAC ACCAGGTAGT GACAACAGTG TCACCTGGGA AACAGAGGAC 
ACAGATGACT GCTTGGTGGA CTTGAAACCA GCTCTAAACA GCTGTTGGGT TCTGAACAAA 
ACTCCAGGAA AATTGTTCGC TGGTCGCAGA TATGGCCAGT ACACTATGAA CCAGGAAAGC 
ACCACCATCA AAGTTATGGA GAAGCCTCCA TTTGATCGAT CAATTTCCCA GGATTCTTTG 
GATGAACTAT CTATGGAAGA CTATTGGATA GAACTAGAAA ACATCAAGAA ATCTAGTGAA 
AACAGCCAAG AAGATCAAGA GGTGGTTGTT GTCAAAGAGC CTGATGAGGG AGAATTGGAA 
GAAGAGTGGC TTAAAGAGGC CGGTTTATCC AATCTCTTCG GAGAGTCTGC TGGAGATCCA 
CAGGAAAGCA TTGTGTTTTT ATCAACATTG ACGCGGACCC AGGCAGCAGC AGTTCAGAAG 
CGAGTAGAGA CGGTCTCCCA GACCTTGAGG AAAAAAAACA AACAGTACCA GATTCCTGAC 
GTCAGAGACA TATTTGCTCA ACAGAGAGAA TCAAAAGAAA CAGCTCCAGG TGGCACTGAA 
TCGCAGTCAC TTAGAACAAA TGAAAACAAA TACCAAGGAA GAGATGACGA GGCATCTAAC 
CTTGTTGGTG AAGAGAAGCT GATCCCACCT GAGGAGACGC CTGCCCCTGA AACAGACATC 
AACCTGGAGG TATCATTTGC CGAGCAAGCA CTCAATCAGA AAGAGAGCTC CAAGGAGAAA 
ATCCAGAAGA GCAAAGGCGA TGATGCCACA TTACCTAGTT TCAGATTGCC AAAAGACAAA 
ACGGGTACCA CAAGGATTGG TGACCTCGCA CCCCAGGACA TGAAGAAAGT TTGCCATTTA 
GCCCTAATTG AGCTGACTGC CCTCTATGAT GTATTGGGTA TTGAGCTGAA ACAACAAAAA 
GCTGTGAAAA TCAAAACAAA AGATTCTGGT CTTTTTTGCG TTCCATTGAC AGCGCTATTA 
GAACAAGATC AGAGGAAAGT ACCAGGAATG CGAATACCCT TGATCTTTCA AAAACTGATT 
TCTCGAATTG AAGAGAGAGG TTTGGAAACA GAAGGCCTCT TACGGATCCC TGGAGCTGCC 
ATTAGAATCA AGAATCTTTG CCAAGAACTA GAAGCAAAGT TTTATGAAGG GACTTTTAAT 
TGGGAAAGTG TCAAACAGCA TGATGCCGCC AGCCTGCTGA AGCTCTTCAT TCGGGAGTTG 
CCCCAGCCAC TGCTCAGTGT GGAGTATCTC AAAGCCTTTC AGGCTGTCCA GAATCTTCCA 
ACCAAGAAGC AGCAACTACA GGCTTTGAAC CTTCTTGTCA TCCTCCTACC TGATGCAAAC 
AGGGACACAC TGAAGGCCCT TCTTGAATTT CTCCAAAGAG TAATAGATAA TAAAGAAAAA 
AATAAAATGA CAGTCATGAA TGTAGCAATG GTCATGGCCC CGAATCTCTT TATGTGTCAT 
GCATTGGGAT TGAAGTCCAG TGAACAGCGA GAATTTGTAA TGGCAGCTGG GACAGCAAAT 
ACCATGCACT TATTGATTAA GTACCAAAAA CTTCTGTGGA CAATTCCCAA GTTTATTGTA 
AACCAAGTGA GGAAGCAAAA CACGGAAAAT CATAAAAAGG ATAAAAGAGC CATGAAGAAA 
TTGCTGAAGA AAATGGCTTA TGACCGAGAA AAATATGAAA AGCAAGATAA GAGTACAAAT 
GATGCTGACG TTCCTCAGGG AGTGATTCGA GTGCAAGCTC CCCATCTTTC GAAAGTTTCC 
ATGGCAATAC AGCTAACTGA AGAACTAAAA GCCAGTGATG TACTTGCCAG GTTTCTCAGC 
CAAGAAAGTG GGGTTGCCCA GACTCTCAAG AAAGGAGAAG TTTTTTTGTA TGAAATTGGA 
GGAAATATTG GGGAACGCTG CCTTGATGAT GACACTTACA TGAAGGATTT ATATCAGCTT 
AACCCAAATG CTGAGTGGGT TATAAAGTCA AAGCCATTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005267269.2
CDS	16..2157
Translation	MVFNHLASSMEPSESIMPQRAAACVDLGRGPWFQGLCVLCVCVCVATPGSDNSVTWETEDTDDCLVDLKPALNSCWVLNKTPGKLFAGRRYGQYTMNQESTTIKVMEKPPFDRSISQDSLDELSMEDYWIELENIKKSSENSQEDQEVVVVKEPDEGELEEEWLKEAGLSNLFGESAGDPQESIVFLSTLTRTQAAAVQKRVETVSQTLRKKNKQYQIPDVRDIFAQQRESKETAPGGTESQSLRTNENKYQGRDDEASNLVGEEKLIPPEETPAPETDINLEVSFAEQALNQKESSKEKIQKSKGDDATLPSFRLPKDKTGTTRIGDLAPQDMKKVCHLALIELTALYDVLGIELKQQKAVKIKTKDSGLFCVPLTALLEQDQRKVPGMRIPLIFQKLISRIEERGLETEGLLRIPGAAIRIKNLCQELEAKFYEGTFNWESVKQHDAASLLKLFIRELPQPLLSVEYLKAFQAVQNLPTKKQQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTVMNVAMVMAPNLFMCHALGLKSSEQREFVMAAGTANTMHLLIKYQKLLWTIPKFIVNQVRKQNTENHKKDKRAMKKLLKKMAYDREKYEKQDKSTNDADVPQGVIRVQAPHLSKVSMAIQLTEELKASDVLARFLSQESGVAQTLKKGEVFLYEIGGNIGERCLDDDTYMKDLYQLNPNAEWVIKSKPL

Target ORF information:

RefSeq Version	XM_005267212.2
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho GTPase activating protein 18 (ARHGAP18), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005267212.2

ORF Insert Sequence:

ATGGTTTTTA ATCATTTGGC ATCTAGCATG GAGCCTTCAG AGAGTATTAT GCCTCAGAGA 
GCTGCAGCTT GCGTGGATCT TGGGAGGGGC CCTTGGTTTC AGGGGCTTTG TGTTCTGTGT 
GTGTGTGTGT GTGTGGCAAC ACCAGGTAGT GACAACAGTG TCACCTGGGA AACAGAGGAC 
ACAGATGACT GCTTGGTGGA CTTGAAACCA GCTCTAAACA GCTGTTGGGT TCTGAACAAA 
ACTCCAGGAA AATTGTTCGC TGGTCGCAGA TATGGCCAGT ACACTATGAA CCAGGAAAGC 
ACCACCATCA AAGTTATGGA GAAGCCTCCA TTTGATCGAT CAATTTCCCA GGATTCTTTG 
GATGAACTAT CTATGGAAGA CTATTGGATA GAACTAGAAA ACATCAAGAA ATCTAGTGAA 
AACAGCCAAG AAGATCAAGA GGTGGTTGTT GTCAAAGAGC CTGATGAGGG AGAATTGGAA 
GAAGAGTGGC TTAAAGAGGC CGGTTTATCC AATCTCTTCG GAGAGTCTGC TGGAGATCCA 
CAGGAAAGCA TTGTGTTTTT ATCAACATTG ACGCGGACCC AGGCAGCAGC AGTTCAGAAG 
CGAGTAGAGA CGGTCTCCCA GACCTTGAGG AAAAAAAACA AACAGTACCA GATTCCTGAC 
GTCAGAGACA TATTTGCTCA ACAGAGAGAA TCAAAAGAAA CAGCTCCAGG TGGCACTGAA 
TCGCAGTCAC TTAGAACAAA TGAAAACAAA TACCAAGGAA GAGATGACGA GGCATCTAAC 
CTTGTTGGTG AAGAGAAGCT GATCCCACCT GAGGAGACGC CTGCCCCTGA AACAGACATC 
AACCTGGAGG TATCATTTGC CGAGCAAGCA CTCAATCAGA AAGAGAGCTC CAAGGAGAAA 
ATCCAGAAGA GCAAAGGCGA TGATGCCACA TTACCTAGTT TCAGATTGCC AAAAGACAAA 
ACGGGTACCA CAAGGATTGG TGACCTCGCA CCCCAGGACA TGAAGAAAGT TTGCCATTTA 
GCCCTAATTG AGCTGACTGC CCTCTATGAT GTATTGGGTA TTGAGCTGAA ACAACAAAAA 
GCTGTGAAAA TCAAAACAAA AGATTCTGGT CTTTTTTGCG TTCCATTGAC AGCGCTATTA 
GAACAAGATC AGAGGAAAGT ACCAGGAATG CGAATACCCT TGATCTTTCA AAAACTGATT 
TCTCGAATTG AAGAGAGAGG TTTGGAAACA GAAGGCCTCT TACGGATCCC TGGAGCTGCC 
ATTAGAATCA AGAATCTTTG CCAAGAACTA GAAGCAAAGT TTTATGAAGG GACTTTTAAT 
TGGGAAAGTG TCAAACAGCA TGATGCCGCC AGCCTGCTGA AGCTCTTCAT TCGGGAGTTG 
CCCCAGCCAC TGCTCAGTGT GGAGTATCTC AAAGCCTTTC AGGCTGTCCA GAATCTTCCA 
ACCAAGAAGC AGCAACTACA GGCTTTGAAC CTTCTTGTCA TCCTCCTACC TGATGCAAAC 
AGGGACACAC TGAAGGCCCT TCTTGAATTT CTCCAAAGAG TAATAGATAA TAAAGAAAAA 
AATAAAATGA CAGTCATGAA TGTAGCAATG GTCATGGCCC CGAATCTCTT TATGTGTCAT 
GCATTGGGAT TGAAGTCCAG TGAACAGCGA GAATTTGTAA TGGCAGCTGG GACAGCAAAT 
ACCATGCACT TATTGATTAA GTACCAAAAA CTTCTGTGGA CAATTCCCAA GTTTATTGTA 
AACCAAGTGA GGAAGCAAAA CACGGAAAAT CATAAAAAGG ATAAAAGAGC CATGAAGAAA 
TTGCTGAAGA AAATGGCTTA TGACCGAGAA AAATATGAAA AGCAAGATAA GAGTACAAAT 
GATGCTGACG TTCCTCAGGG AGTGATTCGA GTGCAAGCTC CCCATCTTTC GAAAGTTTCC 
ATGGCAATAC AGCTAACTGA AGAACTAAAA GCCAGTGATG TACTTGCCAG GTTTCTCAGC 
CAAGAAAGTG GGGTTGCCCA GACTCTCAAG AAAGGAGAAG TTTTTTTGTA TGAAATTGGA 
GGAAATATTG GGGAACGCTG CCTTGATGAT GACACTTACA TGAAGGATTT ATATCAGCTT 
AACCCAAATG CTGAGTGGGT TATAAAGTCA AAGCCATTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARHGAP18 ( XM_017011494.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016866983.1 Homo sapiens Rho GTPase activating protein 18 (ARHGAP18), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu96915
Clone ID Related Accession (Same CDS sequence)	XM_017011494.1
Accession Version	XM_017011494.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1908bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	rho GTPase-activating protein 18 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTTTTTA ATCATTTGGC ATCTAGCATG GAGCCTTCAG AGAGTATTAT GCCTCAGAGA 
GCTGCAGCTT GCGTGGATCT TGGGAGGGGC CCTTGGTTTC AGGGGCTTTG TGTTCTGTGT 
GTGTGTGTGT GTGTGGCAAC ACCAGGTAGT GACAACAGTG TCACCTGGGA AACAGAGGAC 
ACAGATGACT GCTTGGTGGA CTTGAAACCA GCTCTAAACA GCTGTTGGGT TCTGAACAAA 
ACTCCAGGAA AATTGTTCGC TGGTCGCAGA TATGGCCAGT ACACTATGAA CCAGGAAAGC 
ACCACCATCA AAGTTATGGA GAAGCCTCCA TTTGATCGAT CAATTTCCCA GGATTCTTTG 
GATGAACTAT CTATGGAAGA CTATTGGATA GAACTAGAAA ACATCAAGAA ATCTAGTGAA 
AACAGCCAAG AAGATCAAGA GGTGGTTGTT GTCAAAGAGC CTGATGAGGG AGAATTGGAA 
GAAGAGTGGC TTAAAGAGGC CGGTTTATCC AATCTCTTCG GAGAGTCTGC TGGAGATCCA 
CAGGAAAGCA TTGTGTTTTT ATCAACATTG ACGCGGACCC AGGCAGCAGC AGTTCAGAAG 
CGAGTAGAGA CGGTCTCCCA GACCTTGAGG AAAAAAAACA AACAGTACCA GATTCCTGAC 
GTCAGAGACA TATTTGCTCA ACAGAGAGAA TCAAAAGAAA CAGCTCCAGG TGGCACTGAA 
TCGCAGTCAC TTAGAACAAA TGAAAACAAA TACCAAGGAA GAGATGACGA GGCATCTAAC 
CTTGTTGGTG AAGAGAAGCT GATCCCACCT GAGGAGACGC CTGCCCCTGA AACAGACATC 
AACCTGGAGG TATCATTTGC CGAGCAAGCA CTCAATCAGA AAGAGAGCTC CAAGGAGAAA 
ATCCAGAAGA GCAAAGGCGA TGATGCCACA TTACCTAGTT TCAGATTGCC AAAAGACAAA 
ACGGGTACCA CAAGGATTGG TGACCTCGCA CCCCAGGACA TGAAGAAAGT TTGCCATTTA 
GCCCTAATTG AGCTGACTGC CCTCTATGAT GTATTGGGTA TTGAGCTGAA ACAACAAAAA 
GCTGTGAAAA TCAAAACAAA AGATTCTGGT CTTTTTTGCG TTCCATTGAC AGCGCTATTA 
GAACAAGATC AGAGGAAAGT ACCAGGAATG CGAATACCCT TGATCTTTCA AAAACTGATT 
TCTCGAATTG AAGAGAGAGG TTTGGAAACA GAAGGCCTCT TACGGATCCC TGGAGCTGCC 
ATTAGAATCA AGAATCTTTG CCAAGAACTA GAAGCAAAGT TTTATGAAGG GACTTTTAAT 
TGGGAAAGTG TCAAACAGCA TGATGCCGCC AGCCTGCTGA AGCTCTTCAT TCGGGAGTTG 
CCCCAGCCAC TGCTCAGTGT GGAGTATCTC AAAGCCTTTC AGGCTGTCCA GAATCTTCCA 
ACCAAGAAGC AGCAACTACA GGCTTTGAAC CTTCTTGTCA TCCTCCTACC TGATGCAAAC 
AGGGACACAC TGAAGGCCCT TCTTGAATTT CTCCAAAGAG TAATAGATAA TAAAGAAAAA 
AATAAAATGA CAGTCATGAA TGTAGCAATG GTCATGGCCC CGAATCTCTT TATGTGTCAT 
GCATTGGGAT TGAAGTCCAG TGAACAGCGA GAATTTGTAA TGGCAGCTGG GACAGCAAAT 
ACCATGCACT TATTGATTAA GTACCAAAAA CTTCTGTGGA CAATTCCCAA GTTTATTGTA 
AACCAAGTGA GGAAGCAAAA CACGGAAAAT CATAAAAAGG ATAAAAGAGC CATGAAGAAA 
TTGCTGAAGA AAATGGCTTA TGACCGAGAA AAATATGAAA AGCAAGATAA GAGTACAAAT 
GATTGGGGTT GCCCAGACTC TCAAGAAAGG AGAAGTTTTT TTGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016866983.1
CDS	16..1923
Translation	MVFNHLASSMEPSESIMPQRAAACVDLGRGPWFQGLCVLCVCVCVATPGSDNSVTWETEDTDDCLVDLKPALNSCWVLNKTPGKLFAGRRYGQYTMNQESTTIKVMEKPPFDRSISQDSLDELSMEDYWIELENIKKSSENSQEDQEVVVVKEPDEGELEEEWLKEAGLSNLFGESAGDPQESIVFLSTLTRTQAAAVQKRVETVSQTLRKKNKQYQIPDVRDIFAQQRESKETAPGGTESQSLRTNENKYQGRDDEASNLVGEEKLIPPEETPAPETDINLEVSFAEQALNQKESSKEKIQKSKGDDATLPSFRLPKDKTGTTRIGDLAPQDMKKVCHLALIELTALYDVLGIELKQQKAVKIKTKDSGLFCVPLTALLEQDQRKVPGMRIPLIFQKLISRIEERGLETEGLLRIPGAAIRIKNLCQELEAKFYEGTFNWESVKQHDAASLLKLFIRELPQPLLSVEYLKAFQAVQNLPTKKQQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTVMNVAMVMAPNLFMCHALGLKSSEQREFVMAAGTANTMHLLIKYQKLLWTIPKFIVNQVRKQNTENHKKDKRAMKKLLKKMAYDREKYEKQDKSTNDWGCPDSQERRSFFV

Target ORF information:

RefSeq Version	XM_017011494.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho GTPase activating protein 18 (ARHGAP18), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017011494.1

ORF Insert Sequence:

ATGGTTTTTA ATCATTTGGC ATCTAGCATG GAGCCTTCAG AGAGTATTAT GCCTCAGAGA 
GCTGCAGCTT GCGTGGATCT TGGGAGGGGC CCTTGGTTTC AGGGGCTTTG TGTTCTGTGT 
GTGTGTGTGT GTGTGGCAAC ACCAGGTAGT GACAACAGTG TCACCTGGGA AACAGAGGAC 
ACAGATGACT GCTTGGTGGA CTTGAAACCA GCTCTAAACA GCTGTTGGGT TCTGAACAAA 
ACTCCAGGAA AATTGTTCGC TGGTCGCAGA TATGGCCAGT ACACTATGAA CCAGGAAAGC 
ACCACCATCA AAGTTATGGA GAAGCCTCCA TTTGATCGAT CAATTTCCCA GGATTCTTTG 
GATGAACTAT CTATGGAAGA CTATTGGATA GAACTAGAAA ACATCAAGAA ATCTAGTGAA 
AACAGCCAAG AAGATCAAGA GGTGGTTGTT GTCAAAGAGC CTGATGAGGG AGAATTGGAA 
GAAGAGTGGC TTAAAGAGGC CGGTTTATCC AATCTCTTCG GAGAGTCTGC TGGAGATCCA 
CAGGAAAGCA TTGTGTTTTT ATCAACATTG ACGCGGACCC AGGCAGCAGC AGTTCAGAAG 
CGAGTAGAGA CGGTCTCCCA GACCTTGAGG AAAAAAAACA AACAGTACCA GATTCCTGAC 
GTCAGAGACA TATTTGCTCA ACAGAGAGAA TCAAAAGAAA CAGCTCCAGG TGGCACTGAA 
TCGCAGTCAC TTAGAACAAA TGAAAACAAA TACCAAGGAA GAGATGACGA GGCATCTAAC 
CTTGTTGGTG AAGAGAAGCT GATCCCACCT GAGGAGACGC CTGCCCCTGA AACAGACATC 
AACCTGGAGG TATCATTTGC CGAGCAAGCA CTCAATCAGA AAGAGAGCTC CAAGGAGAAA 
ATCCAGAAGA GCAAAGGCGA TGATGCCACA TTACCTAGTT TCAGATTGCC AAAAGACAAA 
ACGGGTACCA CAAGGATTGG TGACCTCGCA CCCCAGGACA TGAAGAAAGT TTGCCATTTA 
GCCCTAATTG AGCTGACTGC CCTCTATGAT GTATTGGGTA TTGAGCTGAA ACAACAAAAA 
GCTGTGAAAA TCAAAACAAA AGATTCTGGT CTTTTTTGCG TTCCATTGAC AGCGCTATTA 
GAACAAGATC AGAGGAAAGT ACCAGGAATG CGAATACCCT TGATCTTTCA AAAACTGATT 
TCTCGAATTG AAGAGAGAGG TTTGGAAACA GAAGGCCTCT TACGGATCCC TGGAGCTGCC 
ATTAGAATCA AGAATCTTTG CCAAGAACTA GAAGCAAAGT TTTATGAAGG GACTTTTAAT 
TGGGAAAGTG TCAAACAGCA TGATGCCGCC AGCCTGCTGA AGCTCTTCAT TCGGGAGTTG 
CCCCAGCCAC TGCTCAGTGT GGAGTATCTC AAAGCCTTTC AGGCTGTCCA GAATCTTCCA 
ACCAAGAAGC AGCAACTACA GGCTTTGAAC CTTCTTGTCA TCCTCCTACC TGATGCAAAC 
AGGGACACAC TGAAGGCCCT TCTTGAATTT CTCCAAAGAG TAATAGATAA TAAAGAAAAA 
AATAAAATGA CAGTCATGAA TGTAGCAATG GTCATGGCCC CGAATCTCTT TATGTGTCAT 
GCATTGGGAT TGAAGTCCAG TGAACAGCGA GAATTTGTAA TGGCAGCTGG GACAGCAAAT 
ACCATGCACT TATTGATTAA GTACCAAAAA CTTCTGTGGA CAATTCCCAA GTTTATTGTA 
AACCAAGTGA GGAAGCAAAA CACGGAAAAT CATAAAAAGG ATAAAAGAGC CATGAAGAAA 
TTGCTGAAGA AAATGGCTTA TGACCGAGAA AAATATGAAA AGCAAGATAA GAGTACAAAT 
GATTGGGGTT GCCCAGACTC TCAAGAAAGG AGAAGTTTTT TTGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Activation of human gonadotropin-releasing hormone receptor promotes down regulation of ARHGAP18 and regulates the cell invasion of MDA-MB-231?cells.
Molecular and cellular endocrinology46094-103(2018 Jan)
Aguilar-Rojas A,Maya-N??ez G,Huerta-Reyes M,P?rez-Solis MA,Silva-Garc?a R,Guill?n N,Olivo-Marin JC

ARHGAP18 is a novel gene under positive natural selection that influences HbF levels in ?-thalassaemia.
Molecular genetics and genomics : MGG(2017 Oct)
He Y,Luo J,Chen Y,Zhou X,Yu S,Jin L,Xiao X,Jia S,Liu Q

ARHGAP18 Downregulation by miR-200b Suppresses Metastasis of Triple-Negative Breast Cancer by Enhancing Activation of RhoA.
Cancer research77(15)4051-4064(2017 Aug)
Humphries B,Wang Z,Li Y,Jhan JR,Jiang Y,Yang C

Association of ARHGAP18 polymorphisms with schizophrenia in the Chinese-Han population.
PloS one12(4)e0175209(2017)
Guo W,Cai Y,Zhang H,Yang Y,Yang G,Wang X,Zhao J,Lin J,Zhu J,Li W,Lv L

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ARHGAP18 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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