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TOMM70A cDNA ORF clone, Homo sapiens (human)

Gene Symbol TOMM70A
Entrez Gene ID 9868
Full Name translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
General protein information
Preferred Names
mitochondrial import receptor subunit TOM70
Names
mitochondrial import receptor subunit TOM70
translocase of outer membrane 70 kDa subunit
mitochondrial precursor proteins import receptor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3q12.2

Summary This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. [provided by RefSeq, Oct 2011]. lac of sum
Disorder MIM:

606081


mRNA and Protein(s)

mRNA Protein Name
NM_014820 NP_055635 mitochondrial import receptor subunit TOM70



Homo sapiens (human) TOMM70A NP_055635.3
Pan troglodytes (chimpanzee) TOMM70A XP_526255.2
Macaca mulatta (Rhesus monkey) TOMM70A XP_001092332.1
Canis lupus familiaris (dog) TOMM70A XP_535719.3
Bos taurus (cattle) TOMM70A NP_001068796.1
Mus musculus (house mouse) Tomm70a NP_613065.2
Rattus norvegicus (Norway rat) Tomm70a NP_997684.1
Gallus gallus (chicken) TOMM70A XP_416605.2
Danio rerio (zebrafish) tomm70a NP_956296.1
Drosophila melanogaster (fruit fly) Tom70 NP_609536.1
Xenopus (Silurana) tropicalis (western clawed frog) tomm70a NP_001096527.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TOMM70A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TOMM70A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu09660
NM_014820 Homo sapiens translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae) (TOMM70A), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$219.50-$307.30
$439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu09660
Clone ID Related Accession (Same CDS sequence) NM_014820
Accession Version NM_014820.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1827bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product mitochondrial import receptor subunit TOM70
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC065555.1, AB018262.1 and AW044465.1. On Oct 26, 2011 this sequence version replaced gi:54607134. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: BC065555.1, AB018262.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
ATGGCCGCCT CTAAACCTGT GGAGGCAGCG GTGGTCGCAG CCGCTGTACC GAGCTCCGGG 
AGTGGGGTGG GCGGCGGCGG GACTGCGGGC CCGGGCACGG GGGGGCTGCC GCGATGGCAG
CTGGCTCTGG CGGTCGGGGC ACCCCTGCTG CTGGGCGCGG GTGCCATATA CCTGTGGAGT
CGGCAGCAAC GGCGCCGGGA GGCCAGAGGC CGGGGCGACG CCAGCGGCCT GAAGCGCAAC
AGCGAACGGA AGACCCCGGA GGGCAGGGCC AGTCCGGCCC CGGGCAGCGG ACACCCTGAA
GGTCCCGGTG CTCACTTGGA CATGAACTCT CTTGATAGAG CCCAAGCAGC CAAGAATAAA
GGCAATAAAT ATTTTAAAGC AGGAAAATAT GAACAAGCTA TTCAGTGCTA TACTGAGGCT
ATTAGCTTGT GCCCTACAGA GAAGAATGTT GACCTTTCTA CATTTTATCA AAACAGAGCT
GCTGCCTTTG AACAGTTGCA AAAATGGAAA GAAGTGGCAC AAGACTGTAC AAAAGCTGTT
GAACTTAATC CCAAATATGT GAAAGCTCTC TTTAGACGTG CAAAAGCCCA TGAGAAGCTA
GACAATAAGA AGGAATGTTT AGAAGATGTC ACTGCTGTGT GTATATTAGA AGGGTTCCAA
AATCAACAAA GCATGCTGTT AGCCGATAAA GTTCTTAAAC TCCTTGGAAA AGAGAAAGCC
AAAGAAAAAT ATAAGAATCG TGAACCTCTG ATGCCATCTC CACAGTTTAT CAAATCTTAC
TTCAGTTCTT TCACGGATGA TATCATTTCC CAGCCCATGC TTAAAGGAGA GAAATCTGAT
GAAGATAAAG ACAAGGAAGG GGAGGCTTTA GAAGTGAAAG AAAATTCTGG ATACTTAAAG
GCCAAACAGT ATATGGAAGA AGAAAACTAC GATAAAATCA TAAGTGAATG CTCAAAAGAA
ATAGATGCTG AAGGCAAATA CATGGCAGAA GCATTGCTAC TACGAGCTAC CTTCTACCTG
CTTATTGGCA ATGCCAATGC AGCCAAACCA GATTTAGATA AAGTCATCAG TTTGAAAGAA
GCTAATGTGA AGCTTCGAGC AAATGCTCTC ATCAAAAGAG GCAGCATGTA CATGCAACAG
CAGCAGCCTT TGCTGTCCAC TCAAGATTTT AACATGGCTG CTGACATCGA TCCTCAGAAT
GCAGATGTTT ATCACCACCG AGGACAGCTG AAAATACTCC TTGATCAAGT TGAAGAAGCA
GTGGCAGATT TTGATGAATG TATTAGGTTA AGACCTGAGT CTGCTCTGGC ACAAGCACAG
AAATGTTTTG CATTGTACCG CCAGGCATAT ACGGGAAACA ACTCTTCACA AATCCAAGCA
GCTATGAAAG GTTTTGAAGA GGTCATAAAG AAATTTCCAA GGTGTGCCGA AGGCTATGCA
CTATACGCCC AGGCATTAAC AGATCAACAA CAGTTTGGTA AAGCTGATGA AATGTATGAT
AAATGTATTG ATTTGGAACC AGATAATGCT ACAACATATG TTCATAAAGG TTTACTTCAA
CTTCAGTGGA AGCAAGATCT GGATAGAGGT TTGGAACTTA TCAGCAAGGC TATTGAAATT
GACAATAAAT GTGATTTTGC CTATGAAACC ATGGGAACTA TTGAAGTACA AAGAGGAAAC
ATGGAGAAAG CCATTGACAT GTTCAACAAA GCTATTAACC TGGCCAAATC GGAAATGGAG
ATGGCCCATC TGTATTCACT TTGCGATGCC GCCCATGCCC AGACAGAAGT TGCAAAGAAA
TACGGATTAA AACCACCAAC ATTATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_055635.3
CDS450..2276
Misc Feature(1)399..401(+)
Misc Feature(2)453..455(+)
Misc Feature(3)564..626(+)
Misc Feature(4)570..2252(+)
Misc Feature(5)702..704(+)
Misc Feature(6)720..722(+)
Misc Feature(7)720..722(+)
Misc Feature(8)735..737(+)
Misc Feature(9)777..779(+)
Misc Feature(10)789..890(+)
Misc Feature(11)789..887(+)
Misc Feature(12)789..875(+)
Misc Feature(13)792..1046(+)
Misc Feature(14)903..995(+)
Misc Feature(15)906..1007(+)
Misc Feature(16)1002..1004(+)
Misc Feature(17)1008..1076(+)
Misc Feature(18)1329..1430(+)
Misc Feature(19)1434..1535(+)
Misc Feature(20)1434..1520(+)
Misc Feature(21)1437..1688(+)
Misc Feature(22)1533..1637(+)
Misc Feature(23)1548..1649(+)
Misc Feature(24)1650..1751(+)
Misc Feature(25)1650..1736(+)
Misc Feature(26)1767..1874(+)
Misc Feature(27)1875..1976(+)
Misc Feature(28)1875..1961(+)
Misc Feature(29)1878..2120(+)
Misc Feature(30)1974..2069(+)
Misc Feature(31)1980..2081(+)
Misc Feature(32)2082..2183(+)
Misc Feature(33)2082..2165(+)
Exon (1)1..773
Gene:TOMM70A
Gene Synonym:
Exon (2)774..947
Gene:TOMM70A
Gene Synonym:
Exon (3)948..1074
Gene:TOMM70A
Gene Synonym:
Exon (4)1075..1184
Gene:TOMM70A
Gene Synonym:
Exon (5)1185..1333
Gene:TOMM70A
Gene Synonym:
Exon (6)1334..1541
Gene:TOMM70A
Gene Synonym:
Exon (7)1542..1676
Gene:TOMM70A
Gene Synonym:
Exon (8)1677..1784
Gene:TOMM70A
Gene Synonym:
Exon (9)1785..1901
Gene:TOMM70A
Gene Synonym:
Exon (10)1902..1999
Gene:TOMM70A
Gene Synonym:
Exon (11)2000..2122
Gene:TOMM70A
Gene Synonym:
Exon (12)2123..4381
Gene:TOMM70A
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_014820
Organism Homo sapiens (human)
Definition Homo sapiens translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae) (TOMM70A), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_014820

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
ATGGCCGCCT CTAAACCTGT GGAGGCAGCG GTGGTCGCAG CCGCTGTACC GAGCTCCGGG 
AGTGGGGTGG GCGGCGGCGG GACTGCGGGC CCGGGCACGG GGGGGCTGCC GCGATGGCAG
CTGGCTCTGG CGGTCGGGGC ACCCCTGCTG CTGGGCGCGG GTGCCATATA CCTGTGGAGT
CGGCAGCAAC GGCGCCGGGA GGCCAGAGGC CGGGGCGACG CCAGCGGCCT GAAGCGCAAC
AGCGAACGGA AGACCCCGGA GGGCAGGGCC AGTCCGGCCC CGGGCAGCGG ACACCCTGAA
GGTCCCGGTG CTCACTTGGA CATGAACTCT CTTGATAGAG CCCAAGCAGC CAAGAATAAA
GGCAATAAAT ATTTTAAAGC AGGAAAATAT GAACAAGCTA TTCAGTGCTA TACTGAGGCT
ATTAGCTTGT GCCCTACAGA GAAGAATGTT GACCTTTCTA CATTTTATCA AAACAGAGCT
GCTGCCTTTG AACAGTTGCA AAAATGGAAA GAAGTGGCAC AAGACTGTAC AAAAGCTGTT
GAACTTAATC CCAAATATGT GAAAGCTCTC TTTAGACGTG CAAAAGCCCA TGAGAAGCTA
GACAATAAGA AGGAATGTTT AGAAGATGTC ACTGCTGTGT GTATATTAGA AGGGTTCCAA
AATCAACAAA GCATGCTGTT AGCCGATAAA GTTCTTAAAC TCCTTGGAAA AGAGAAAGCC
AAAGAAAAAT ATAAGAATCG TGAACCTCTG ATGCCATCTC CACAGTTTAT CAAATCTTAC
TTCAGTTCTT TCACGGATGA TATCATTTCC CAGCCCATGC TTAAAGGAGA GAAATCTGAT
GAAGATAAAG ACAAGGAAGG GGAGGCTTTA GAAGTGAAAG AAAATTCTGG ATACTTAAAG
GCCAAACAGT ATATGGAAGA AGAAAACTAC GATAAAATCA TAAGTGAATG CTCAAAAGAA
ATAGATGCTG AAGGCAAATA CATGGCAGAA GCATTGCTAC TACGAGCTAC CTTCTACCTG
CTTATTGGCA ATGCCAATGC AGCCAAACCA GATTTAGATA AAGTCATCAG TTTGAAAGAA
GCTAATGTGA AGCTTCGAGC AAATGCTCTC ATCAAAAGAG GCAGCATGTA CATGCAACAG
CAGCAGCCTT TGCTGTCCAC TCAAGATTTT AACATGGCTG CTGACATCGA TCCTCAGAAT
GCAGATGTTT ATCACCACCG AGGACAGCTG AAAATACTCC TTGATCAAGT TGAAGAAGCA
GTGGCAGATT TTGATGAATG TATTAGGTTA AGACCTGAGT CTGCTCTGGC ACAAGCACAG
AAATGTTTTG CATTGTACCG CCAGGCATAT ACGGGAAACA ACTCTTCACA AATCCAAGCA
GCTATGAAAG GTTTTGAAGA GGTCATAAAG AAATTTCCAA GGTGTGCCGA AGGCTATGCA
CTATACGCCC AGGCATTAAC AGATCAACAA CAGTTTGGTA AAGCTGATGA AATGTATGAT
AAATGTATTG ATTTGGAACC AGATAATGCT ACAACATATG TTCATAAAGG TTTACTTCAA
CTTCAGTGGA AGCAAGATCT GGATAGAGGT TTGGAACTTA TCAGCAAGGC TATTGAAATT
GACAATAAAT GTGATTTTGC CTATGAAACC ATGGGAACTA TTGAAGTACA AAGAGGAAAC
ATGGAGAAAG CCATTGACAT GTTCAACAAA GCTATTAACC TGGCCAAATC GGAAATGGAG
ATGGCCCATC TGTATTCACT TTGCGATGCC GCCCATGCCC AGACAGAAGT TGCAAAGAAA
TACGGATTAA AACCACCAAC ATTATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Tom70 is essential for PINK1 import into mitochondria
PLoS ONE 8 (3), E58435 (2013)
Kato H, Lu Q, Rapaport D and Kozjak-Pavlovic V.


book

Translocase of outer mitochondrial membrane 70 induces interferon response and is impaired by hepatitis C virus NS3
Virus Res. 163 (1), 405-409 (2012)
Kasama Y, Saito M, Takano T, Nishimura T, Satoh M, Wang Z, Ali SN, Harada S, Kohara M and Tsukiyama-Kohara K.


book

Interaction between the human mitochondrial import receptors Tom20 and Tom70 in vitro suggests a chaperone displacement mechanism
J. Biol. Chem. 286 (37), 32208-32219 (2011)
Fan AC, Kozlov G, Hoegl A, Marcellus RC, Wong MJ, Gehring K and Young JC.


book

Stoichiometry and thermodynamics of the interaction between the C-terminus of human 90kDa heat shock protein Hsp90 and the mitochondrial translocase of outer membrane Tom70
Arch. Biochem. Biophys. 513 (2), 119-125 (2011)
Gava LM, Goncalves DC, Borges JC and Ramos CH.


book

Hsp90 functions in the targeting and outer membrane translocation steps of Tom70-mediated mitochondrial import
J. Biol. Chem. 281 (44), 33313-33324 (2006)
Fan AC, Bhangoo MK and Young JC.


book

An internal EELD domain facilitates mitochondrial targeting of Mcl-1 via a Tom70-dependent pathway
Mol. Biol. Cell 17 (9), 3952-3963 (2006)
Chou CH, Lee RS and Yang-Yen HF.


book

Dissection of the mitochondrial import and assembly pathway for human Tom40
J. Biol. Chem. 280 (12), 11535-11543 (2005)
Humphries AD, Streimann IC, Stojanovski D, Johnston AJ, Yano M, Hoogenraad NJ and Ryan MT.


book

Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70
Cell 112 (1), 41-50 (2003)
Young JC, Hoogenraad NJ and Hartl FU.


book

Characterization of a human import component of the mitochondrial outer membrane, TOMM70A
Cell Commun. Adhes. 9 (1), 15-27 (2002)
Edmonson AM, Mayfield DK, Vervoort V, DuPont BR and Argyropoulos G.


book

Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions
J. Neurochem. 73 (6), 2240-2249 (1999)
Alvarez-Dolado M, Gonzalez-Moreno M, Valencia A, Zenke M, Bernal J and Munoz A.


 
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