Aco2 cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Aco2 |
| Entrez Gene ID | 11429 |
| Full Name | aconitase 2, mitochondrial |
| Synonyms | Aco-2,Aco3,D10Wsu183e |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_080633.2 | NP_542364.1 | aconitate hydratase, mitochondrial precursor |
| Mus musculus (house mouse) | Aco2 | NP_542364.1 |
| Caenorhabditis elegans (roundworm) | aco-2 | NP_741235.1 |
| Saccharomyces cerevisiae (baker's yeast) | ACO1 | NP_013407.1 |
| Canis lupus familiaris (dog) | ACO2 | XP_849166.1 |
| Gallus gallus (chicken) | ACO2 | NP_989519.1 |
| ACO2 | XP_001105023.1 | |
| Drosophila melanogaster (fruit fly) | Acon | NP_001163030.1 |
| Bos taurus (cattle) | ACO2 | NP_776402.1 |
| Rattus norvegicus (Norway rat) | Aco2 | NP_077374.2 |
| Danio rerio (zebrafish) | aco2 | NP_944590.1 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP007852 | XP_317642.4 |
| Eremothecium gossypii | AGOS_ADL032W | NP_984065.1 |
| Schizosaccharomyces pombe (fission yeast) | SPAC24C9.06c | NP_594031.2 |
| Magnaporthe oryzae (rice blast fungus) | MGG_03521 | XP_003716398.1 |
| Neurospora crassa | NCU02366 | XP_959787.1 |
| Xenopus tropicalis (tropical clawed frog) | aco2 | NP_001011445.1 |
| Homo sapiens (human) | ACO2 | NP_001089.1 |
| Kluyveromyces lactis | KLLA0C17314g | XP_452974.1 |
Related articles in PubMed
Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.
Bulusu V, Prior N, Snaebjornsson MT, Kuehne A, Sonnen KF, Kress J, Stein F, Schultz C, Sauer U, Aulehla A
Developmental cell40(4)331-341.e4(2017 02)
Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.
Bowman CE, Zhao L, Hartung T, Wolfgang MJ
Molecular and cellular biology36(15)2089-104(2016 Aug)
Lysine Acetylation Activates Mitochondrial Aconitase in the Heart.
Fernandes J, Weddle A, Kinter CS, Humphries KM, Mather T, Szweda LI, Kinter M
Biochemistry54(25)4008-18(2015 Jun)
Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells.
Kim SJ, Cheresh P, Williams D, Cheng Y, Ridge K, Schumacker PT, Weitzman S, Bohr VA, Kamp DW
The Journal of biological chemistry289(9)6165-76(2014 Feb)
Characterization of potential S-nitrosylation sites in the myocardium.
Kohr MJ, Aponte AM, Sun J, Wang G, Murphy E, Gucek M, Steenbergen C
American journal of physiology. Heart and circulatory physiology300(4)H1327-35(2011 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Activation of mitochondrial aconitase is acetylation-dependent.
Title: Lysine Acetylation Activates Mitochondrial Aconitase in the Heart.
Ogg1 chaperoning of Aco-2 in preventing oxidant-mediated mtDNA damage and apoptosis may afford an innovative target for the molecular events underlying oxidant-induced toxicity.
Title: Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells.
aconitase activity can be regulated by at least two mechanisms: oxidation/reduction and phosphorylation/dephosphorylation
Title: Activation of aconitase in mouse fast-twitch skeletal muscle during contraction-mediated oxidative stress.
IRP-1,-2 are indispensable for regulation of mammalian iron homeostasis at the post-implantation stage of murine embryonic development
Title: Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development.
The following Aco2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Aco2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu18691 | |
| Clone ID Related Accession (Same CDS sequence) | NM_080633.2 | |
| Accession Version | NM_080633.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2343bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-24 | |
| Organism | Mus musculus(house mouse) | |
| Product | aconitate hydratase, mitochondrial precursor | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI987806.1, BY732916.1, CA750686.1, CO426953.1, CO429053.1 and BQ031215.1. On Aug 31, 2005 this sequence version replaced NM_080633.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK145511.1, BC004645.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## | |
1 | ATGGCGCCTT ACAGCCTCCT GGTCACCCGG CTGCAGAAGG CCCTGGGTGT GCGGCAGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_542364.1 |
| CDS | 51..2393 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_080633.2 |
ORF Insert Sequence:
1 | ATGGCGCCTT ACAGCCTCCT GGTCACCCGG CTGCAGAAGG CCCTGGGTGT GCGGCAGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. |
|
Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. |
|
Lysine Acetylation Activates Mitochondrial Aconitase in the Heart. |
|
Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells. |
|
Characterization of potential S-nitrosylation sites in the myocardium. |