Gene Symbol | Cyp4a14 |
Entrez Gene ID | 13119 |
Full Name | cytochrome P450, family 4, subfamily a, polypeptide 14 |
Synonyms | AI314743 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Cyp4a14 cDNA ORF clone
Gene Symbol | Cyp4a14 |
Entrez Gene ID | 13119 |
Full Name | cytochrome P450, family 4, subfamily a, polypeptide 14 |
Synonyms | AI314743 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006502724.2 | XP_006502787.2 | cytochrome P450 4A14 isoform X2 |
XM_017319946.2 | XP_017175435.1 | cytochrome P450 4A14 isoform X1 |
NM_007822.2 | NP_031848.1 | cytochrome P450 4A14 |
XM_017319946.1 | XP_017175435.1 | cytochrome P450 4A14 isoform X1 |
XM_006502724.3 | XP_006502787.2 | cytochrome P450 4A14 isoform X2 |
Oryza sativa (rice) | Os01g0627400 | NP_001043631.1 |
Rattus norvegicus (Norway rat) | Cyp4a2 | NP_001038235.1 |
Rattus norvegicus (Norway rat) | Cyp4a3 | NP_786936.1 |
Oryza sativa (rice) | Os01g0627900 | NP_001043635.1 |
Oryza sativa (rice) | Os01g0728300 | NP_001044129.1 |
Oryza sativa (rice) | Os05g0372300 | NP_001055361.1 |
Oryza sativa (rice) | Os01g0627800 | NP_001043634.1 |
Mus musculus (house mouse) | Cyp4a14 | NP_031848.1 |
Oryza sativa (rice) | Os01g0602400 | NP_001043498.1 |
Oryza sativa (rice) | Os01g0602500 | NP_001043499.1 |
Oryza sativa (rice) | Os01g0628900 | NP_001043638.1 |
Oryza sativa (rice) | Os01g0627933 | NP_001172471.1 |
Oryza sativa (rice) | Os01g0627500 | NP_001043632.1 |
The Blood Pressure-Lowering Effect of 20-HETE Blockade in
Pandey V, Garcia V, Gilani A, Mishra P, Zhang FF, Paudyal MP, Falck JR, Nasjletti A, Wang WH, Schwartzman ML
The Journal of pharmacology and experimental therapeutics363(3)412-418(2017 Dec)
Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice.
Zhou Y, Yu J, Liu J, Cao R, Su W, Li S, Ye S, Zhu C, Zhang X, Xu H, Chen H, Zhang X, Guan Y
Biochimica et biophysica acta1864(3)860-870(2017 Dec)
Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis.
Zhang X, Li S, Zhou Y, Su W, Ruan X, Wang B, Zheng F, Warner M, Gustafsson J?, Guan Y
Proceedings of the National Academy of Sciences of the United States of America114(12)3181-3185(2017 Mar)
Altered inflammatory responses to Citrobacter rodentium infection, but not bacterial lipopolysaccharide, in mice lacking the Cyp4a10 or Cyp4a14 genes.
Nyagode BA, Williams IR, Morgan ET
Inflammation37(3)893-907(2014 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Hypertension in Cyp4a14(-/-) male mice was accompanied by decreased renal perfusion and reduced glomerular filtration rates
Title: The Blood Pressure-Lowering Effect of 20-HETE Blockade in
These results implicate Cyp4a10 and Cyp4a14 in the regulation of the host inflammatory response to enteropathogenic bacterial infection but not to acute aseptic inflammation.
Title: Altered inflammatory responses to Citrobacter rodentium infection, but not bacterial lipopolysaccharide, in mice lacking the Cyp4a10 or Cyp4a14 genes.
DEHP exposure did not influence lipase activity, whereas it slightly enhanced UGT activity and exclusively increased CYP4A14 levels in pregnant and/or postpartum dams.
Title: Differences in metabolite burden of di(2-ethylhexyl)phthalate in pregnant and postpartum dams and their offspring in relation to drug-metabolizing enzymes in mice.
Deletion of the Cyp4a gene conferred a prohypertensive status via increased 20-HETE synthesis and eNOS uncoupling leading to increased oxidative stress, enhanced vasoconstriction but diminished vasodilation as well as a defect in renal excretory capacity.
Title: Renal function and vasomotor activity in mice lacking the Cyp4a14 gene.
Hypertension in the Cyp4a14 knockout mice appears to be driven by excessive fluid reabsorption in the proximal tubule, which is secondary to overexpression of NHE3.
Title: Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice.
The following Cyp4a14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cyp4a14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu00860 | |
Clone ID Related Accession (Same CDS sequence) | NM_007822.2 | |
Accession Version | NM_007822.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1524bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-19 | |
Organism | Mus musculus(house mouse) | |
Product | cytochrome P450 4A14 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC089609.1, AK165452.1 and BF322553.1. On Jan 9, 2008 this sequence version replaced NM_007822.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC089609.1, AK098088.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGTTTTT TTTTATTTAG CCCTACAAGG TACTTGGATG GTATCTCTGG GTTCTTCCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_031848.1 |
CDS | 29..1552 |
Translation |
Target ORF information:
Target ORF information:
|
NM_007822.2 |
1 | ATGGGTTTTT TTTTATTTAG CCCTACAAGG TACTTGGATG GTATCTCTGG GTTCTTCCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu67505 | |
Clone ID Related Accession (Same CDS sequence) | XM_006502724.2 , XM_006502724.3 | |
Accession Version | XM_006502724.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1284bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | cytochrome P450 4A14 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006502724.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGTTTTT TTTTATTTAG CCCTACAAGG TACTTGGATG GTATCTCTGG GTTCTTCCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006502787.2 |
CDS | 47..1330 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006502724.2 |
1 | ATGGGTTTTT TTTTATTTAG CCCTACAAGG TACTTGGATG GTATCTCTGG GTTCTTCCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu67505 | |
Clone ID Related Accession (Same CDS sequence) | XM_006502724.2 , XM_006502724.3 | |
Accession Version | XM_006502724.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1284bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | cytochrome P450 4A14 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006502724.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGTTTTT TTTTATTTAG CCCTACAAGG TACTTGGATG GTATCTCTGG GTTCTTCCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006502787.2 |
CDS | 46..1329 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006502724.3 |
1 | ATGGGTTTTT TTTTATTTAG CCCTACAAGG TACTTGGATG GTATCTCTGG GTTCTTCCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu80827 | |
Clone ID Related Accession (Same CDS sequence) | XM_017319946.2 , XM_017319946.1 | |
Accession Version | XM_017319946.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1395bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | cytochrome P450 4A14 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017319946.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGTTTTT TTTTATTTAG CCCTACAAGG TACTTGGATG GTATCTCTGG GTTCTTCCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017175435.1 |
CDS | 45..1439 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017319946.2 |
1 | ATGGGTTTTT TTTTATTTAG CCCTACAAGG TACTTGGATG GTATCTCTGG GTTCTTCCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu80827 | |
Clone ID Related Accession (Same CDS sequence) | XM_017319946.2 , XM_017319946.1 | |
Accession Version | XM_017319946.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1395bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | cytochrome P450 4A14 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGTTTTT TTTTATTTAG CCCTACAAGG TACTTGGATG GTATCTCTGG GTTCTTCCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017175435.1 |
CDS | 46..1440 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017319946.1 |
1 | ATGGGTTTTT TTTTATTTAG CCCTACAAGG TACTTGGATG GTATCTCTGG GTTCTTCCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The Blood Pressure-Lowering Effect of 20-HETE Blockade in |
Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice. |
Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis. |
Altered inflammatory responses to Citrobacter rodentium infection, but not bacterial lipopolysaccharide, in mice lacking the Cyp4a10 or Cyp4a14 genes. |