Gene Symbol | Daxx |
Entrez Gene ID | 13163 |
Full Name | Fas death domain-associated protein |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Daxx cDNA ORF clone
Gene Symbol | Daxx |
Entrez Gene ID | 13163 |
Full Name | Fas death domain-associated protein |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006523581.2 | XP_006523644.1 | death domain-associated protein 6 isoform X1 |
XM_006523582.2 | XP_006523645.1 | death domain-associated protein 6 isoform X1 |
NM_001199733.1 | NP_001186662.1 | death domain-associated protein 6 |
XM_006523580.2 | XP_006523643.1 | death domain-associated protein 6 isoform X1 |
NM_001355704.1 | NP_001342633.1 | death domain-associated protein 6 |
NM_007829.4 | NP_031855.3 | death domain-associated protein 6 |
XM_006523581.3 | XP_006523644.1 | death domain-associated protein 6 isoform X1 |
XM_006523582.3 | XP_006523645.1 | death domain-associated protein 6 isoform X1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP009432 | XP_001687821.1 |
Pan troglodytes (chimpanzee) | DAXX | XP_001170728.2 |
Canis lupus familiaris (dog) | DAXX | XP_005627258.1 |
Rattus norvegicus (Norway rat) | Daxx | NP_543167.2 |
DAXX | XP_001109244.2 | |
Mus musculus (house mouse) | Daxx | NP_001186662.1 |
Homo sapiens (human) | DAXX | NP_001341.1 |
Bos taurus (cattle) | DAXX | NP_001068623.1 |
Myogenic differentiation triggers PML nuclear body loss and DAXX relocalization to chromocentres.
Salsman J, Rapkin LM, Margam NN, Duncan R, Bazett-Jones DP, Dellaire G
Cell death & disease8(3)e2724(2017 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
data support a model in which activation of myogenic differentiation results in PML NB loss, chromatin reorganization and DAXX relocalization, and provides a paradigm for understanding the consequence of PML loss in other cellular contexts, such as during cancer development and progression
Title: Myogenic differentiation triggers PML nuclear body loss and DAXX relocalization to chromocentres.
This study provides important details regarding the expression and post-translational modifications of DAXX in aging in the entire organism and provides reference data for the deregulation observed in age-associated diseases.
Title: Age-dependent differential expression of death-associated protein 6 (Daxx) in various peripheral tissues and different brain regions of C57BL/6 male mice.
This is a promising novel therapeutic approach because it appears to be effective in a model producing severe injury by interfering with an array of proximal signals and effectors of the ischemic cascade, upstream of JNK, caspases, and BIM and BAX activation.
Title: Interaction of ARC and Daxx: A Novel Endogenous Target to Preserve Motor Function and Cell Loss after Focal Brain Ischemia in Mice.
The protein levels of Daxx is reduced in Stella-null oocytes and embryos.
Title: Stella controls chromocenter formation through regulation of Daxx expression in 2-cell embryos.
Daxx and Atrx safeguard the genome by silencing repetitive elements when DNA methylation levels are low.
Title: The Daxx/Atrx Complex Protects Tandem Repetitive Elements during DNA Hypomethylation by Promoting H3K9 Trimethylation.
The following Daxx gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Daxx cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu23050 | |
Clone ID Related Accession (Same CDS sequence) | XM_006523581.2 , XM_006523582.2 , NM_001199733.1 , XM_006523580.2 , NM_001355704.1 , NM_007829.4 , XM_006523581.3 , XM_006523582.3 | |
Accession Version | NM_001199733.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2223bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-26 | |
Organism | Mus musculus(house mouse) | |
Product | death domain-associated protein 6 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR974462.5, AK145906.1 and BQ176437.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK156425.1, AK172616.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCCACCG ATGACAGCAT CATTGTACTT GATGATGACG ATGAAGATGA AGCTGCTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001186662.1 |
CDS | 271..2493 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001199733.1 |
1 | ATGGCCACCG ATGACAGCAT CATTGTACTT GATGATGACG ATGAAGATGA AGCTGCTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu23050 | |
Clone ID Related Accession (Same CDS sequence) | XM_006523581.2 , XM_006523582.2 , NM_001199733.1 , XM_006523580.2 , NM_001355704.1 , NM_007829.4 , XM_006523581.3 , XM_006523582.3 | |
Accession Version | NM_001355704.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2223bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-29 | |
Organism | Mus musculus(house mouse) | |
Product | death domain-associated protein 6 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR974462.5 and CO041718.1. On Sep 26, 2017 this sequence version replaced XM_006523580.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660817.224688.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCCACCG ATGACAGCAT CATTGTACTT GATGATGACG ATGAAGATGA AGCTGCTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001342633.1 |
CDS | 216..2438 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001355704.1 |
1 | ATGGCCACCG ATGACAGCAT CATTGTACTT GATGATGACG ATGAAGATGA AGCTGCTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu23050 | |
Clone ID Related Accession (Same CDS sequence) | XM_006523581.2 , XM_006523582.2 , NM_001199733.1 , XM_006523580.2 , NM_001355704.1 , NM_007829.4 , XM_006523581.3 , XM_006523582.3 | |
Accession Version | NM_007829.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2223bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | death domain-associated protein 6 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR974462.5, AK145906.1 and BQ176437.1. On Dec 14, 2010 this sequence version replaced NM_007829.3. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK145906.1, AK151279.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCCACCG ATGACAGCAT CATTGTACTT GATGATGACG ATGAAGATGA AGCTGCTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_031855.3 |
CDS | 171..2393 |
Translation |
Target ORF information:
Target ORF information:
|
NM_007829.4 |
1 | ATGGCCACCG ATGACAGCAT CATTGTACTT GATGATGACG ATGAAGATGA AGCTGCTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu23050 | |
Clone ID Related Accession (Same CDS sequence) | XM_006523581.2 , XM_006523582.2 , NM_001199733.1 , XM_006523580.2 , NM_001355704.1 , NM_007829.4 , XM_006523581.3 , XM_006523582.3 | |
Accession Version | XM_006523581.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2223bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | death domain-associated protein 6 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006523581.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCCACCG ATGACAGCAT CATTGTACTT GATGATGACG ATGAAGATGA AGCTGCTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006523644.1 |
CDS | 98..2320 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006523581.2 |
1 | ATGGCCACCG ATGACAGCAT CATTGTACTT GATGATGACG ATGAAGATGA AGCTGCTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu23050 | |
Clone ID Related Accession (Same CDS sequence) | XM_006523581.2 , XM_006523582.2 , NM_001199733.1 , XM_006523580.2 , NM_001355704.1 , NM_007829.4 , XM_006523581.3 , XM_006523582.3 | |
Accession Version | XM_006523582.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2223bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | death domain-associated protein 6 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006523582.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCCACCG ATGACAGCAT CATTGTACTT GATGATGACG ATGAAGATGA AGCTGCTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006523645.1 |
CDS | 100..2322 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006523582.2 |
1 | ATGGCCACCG ATGACAGCAT CATTGTACTT GATGATGACG ATGAAGATGA AGCTGCTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu23050 | |
Clone ID Related Accession (Same CDS sequence) | XM_006523581.2 , XM_006523582.2 , NM_001199733.1 , XM_006523580.2 , NM_001355704.1 , NM_007829.4 , XM_006523581.3 , XM_006523582.3 | |
Accession Version | XM_006523580.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2223bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(House mouse) | |
Product | death domain-associated protein 6 isoform X1 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006523580.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCCACCG ATGACAGCAT CATTGTACTT GATGATGACG ATGAAGATGA AGCTGCTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006523643.1 |
CDS | 216..2438 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006523580.2 |
1 | ATGGCCACCG ATGACAGCAT CATTGTACTT GATGATGACG ATGAAGATGA AGCTGCTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu23050 | |
Clone ID Related Accession (Same CDS sequence) | XM_006523581.2 , XM_006523582.2 , NM_001199733.1 , XM_006523580.2 , NM_001355704.1 , NM_007829.4 , XM_006523581.3 , XM_006523582.3 | |
Accession Version | XM_006523581.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2223bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | death domain-associated protein 6 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006523581.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCCACCG ATGACAGCAT CATTGTACTT GATGATGACG ATGAAGATGA AGCTGCTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006523644.1 |
CDS | 74..2296 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006523581.3 |
1 | ATGGCCACCG ATGACAGCAT CATTGTACTT GATGATGACG ATGAAGATGA AGCTGCTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu23050 | |
Clone ID Related Accession (Same CDS sequence) | XM_006523581.2 , XM_006523582.2 , NM_001199733.1 , XM_006523580.2 , NM_001355704.1 , NM_007829.4 , XM_006523581.3 , XM_006523582.3 | |
Accession Version | XM_006523582.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2223bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | death domain-associated protein 6 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006523582.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCCACCG ATGACAGCAT CATTGTACTT GATGATGACG ATGAAGATGA AGCTGCTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006523645.1 |
CDS | 77..2299 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006523582.3 |
1 | ATGGCCACCG ATGACAGCAT CATTGTACTT GATGATGACG ATGAAGATGA AGCTGCTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Myogenic differentiation triggers PML nuclear body loss and DAXX relocalization to chromocentres. |