Gene Symbol | Ddc |
Entrez Gene ID | 13195 |
Full Name | dopa decarboxylase |
Synonyms | Aadc |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Ddc cDNA ORF clone
Gene Symbol | Ddc |
Entrez Gene ID | 13195 |
Full Name | dopa decarboxylase |
Synonyms | Aadc |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006514488.4 | XP_006514551.1 | aromatic-L-amino-acid decarboxylase isoform X2 |
XM_006514486.1 | XP_006514549.1 | aromatic-L-amino-acid decarboxylase isoform X1 |
XM_006514487.4 | XP_006514550.1 | aromatic-L-amino-acid decarboxylase isoform X2 |
XM_006514489.2 | XP_006514552.1 | aromatic-L-amino-acid decarboxylase isoform X2 |
NM_016672.4 | NP_057881.1 | aromatic-L-amino-acid decarboxylase |
XM_006514487.3 | XP_006514550.1 | aromatic-L-amino-acid decarboxylase isoform X2 |
NM_001190448.1 | NP_001177377.1 | aromatic-L-amino-acid decarboxylase |
XM_006514488.3 | XP_006514551.1 | aromatic-L-amino-acid decarboxylase isoform X2 |
DDC | XP_001082132.1 | |
Mus musculus (house mouse) | Ddc | NP_001177377.1 |
Rattus norvegicus (Norway rat) | Ddc | NP_036677.1 |
Danio rerio (zebrafish) | ddc | NP_998507.1 |
Homo sapiens (human) | DDC | NP_000781.1 |
Bos taurus (cattle) | DDC | NP_776332.1 |
Gallus gallus (chicken) | DDC | XP_419032.3 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP009091 | XP_319841.3 |
Arabidopsis thaliana (thale cress) | AT2G20340 | NP_849999.1 |
Oryza sativa (rice) | Os07g0437500 | NP_001059509.1 |
Drosophila melanogaster (fruit fly) | Ddc | NP_724163.1 |
Pan troglodytes (chimpanzee) | DDC | XP_519096.2 |
Canis lupus familiaris (dog) | DDC | XP_848285.2 |
Neurospora crassa | NCU08275 | XP_961903.1 |
Xenopus tropicalis (tropical clawed frog) | ddc | NP_001011289.1 |
A pathogenic S250F missense mutation results in a mouse model of mild aromatic l-amino acid decarboxylase (AADC) deficiency.
Caine C, Shohat M, Kim JK, Nakanishi K, Homma S, Mosharov EV, Monani UR
Human molecular genetics26(22)4406-4415(2017 Nov)
A novel floor plate boundary defined by adjacent En1 and Dbx1 microdomains distinguishes midbrain dopamine and hypothalamic neurons.
Nouri N, Awatramani R
Development (Cambridge, England)144(5)916-927(2017 03)
Plasma membrane transporters of serotonin, dopamine, and norepinephrine mediate serotonin accumulation in atypical locations in the developing brain of monoamine oxidase A knock-outs.
Cases O, Lebrand C, Giros B, Vitalis T, De Maeyer E, Caron MG, Price DJ, Gaspar P, Seif I
The Journal of neuroscience : the official journal of the Society for Neuroscience18(17)6914-27(1998 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
We found that only the modified U1 snRNA (IVS-AAA) that completely matched both the intronic and exonic U1 binding sequences of the mutated DDC gene could correct splicing errors of either the mutated human DDC minigene or the mouse artificial splicing construct in vitro
Title: Mutation-adapted U1 snRNA corrects a splicing error of the dopa decarboxylase gene.
The data show that endothelial AADC plays an important role in cardiac synthesis of 5-HT and possibly in 5-HT-dependent regulation of nitric oxide generation.
Title: Role of endothelial AADC in cardiac synthesis of serotonin and nitrates accumulation.
Mash1 plays an important role in regulating the expression of AADC in type III cells in taste buds.
Title: Mash1 is required for the differentiation of AADC-positive type III cells in mouse taste buds.
evidence for PKGIalpha-dependent phosphorylation and activation of neuronal AAAD in vitro, and introduce AAAD as a putative PKGIalpha substrate.
Title: Aromatic L-amino acid decarboxylase phosphorylation and activation by PKGIalpha in vitro.
the fact that renal DDC inversely correlated with renal sodium reabsorption suggest that renal and intestinal gender dimorphism in DDC could be related to sex-related differences in sodium balance observed between males and females
Title: Opposite sexual dimorphism of 3,4-dihydroxyphenylalanine decarboxylase in the kidney and small intestine of mice.
The following Ddc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ddc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu15577 | |
Clone ID Related Accession (Same CDS sequence) | XM_006514488.4 , XM_006514487.4 , XM_006514489.2 , NM_016672.4 , XM_006514487.3 , NM_001190448.1 , XM_006514488.3 | |
Accession Version | NM_016672.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | aromatic-L-amino-acid decarboxylase | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY129740.1, AK149141.1 and AA986109.1. On Jun 25, 2010 this sequence version replaced NM_016672.3. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK149141.1, SRR1660813.215718.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGATTCCC GTGAATTCCG GAGGAGAGGC AAGGAGATGG TGGATTATAT AGCTGACTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_057881.1 |
CDS | 80..1522 |
Translation |
Target ORF information:
Target ORF information:
|
NM_016672.4 |
1 | ATGGATTCCC GTGAATTCCG GAGGAGAGGC AAGGAGATGG TGGATTATAT AGCTGACTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu15577 | |
Clone ID Related Accession (Same CDS sequence) | XM_006514488.4 , XM_006514487.4 , XM_006514489.2 , NM_016672.4 , XM_006514487.3 , NM_001190448.1 , XM_006514488.3 | |
Accession Version | NM_001190448.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | aromatic-L-amino-acid decarboxylase | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL645803.19 and AL596450.8. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC060989.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGATTCCC GTGAATTCCG GAGGAGAGGC AAGGAGATGG TGGATTATAT AGCTGACTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001177377.1 |
CDS | 142..1584 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001190448.1 |
1 | ATGGATTCCC GTGAATTCCG GAGGAGAGGC AAGGAGATGG TGGATTATAT AGCTGACTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu15577 | |
Clone ID Related Accession (Same CDS sequence) | XM_006514488.4 , XM_006514487.4 , XM_006514489.2 , NM_016672.4 , XM_006514487.3 , NM_001190448.1 , XM_006514488.3 | |
Accession Version | XM_006514489.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | aromatic-L-amino-acid decarboxylase isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006514489.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATTCCC GTGAATTCCG GAGGAGAGGC AAGGAGATGG TGGATTATAT AGCTGACTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006514552.1 |
CDS | 29..1471 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006514489.2 |
1 | ATGGATTCCC GTGAATTCCG GAGGAGAGGC AAGGAGATGG TGGATTATAT AGCTGACTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu15577 | |
Clone ID Related Accession (Same CDS sequence) | XM_006514488.4 , XM_006514487.4 , XM_006514489.2 , NM_016672.4 , XM_006514487.3 , NM_001190448.1 , XM_006514488.3 | |
Accession Version | XM_006514487.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | aromatic-L-amino-acid decarboxylase isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006514487.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATTCCC GTGAATTCCG GAGGAGAGGC AAGGAGATGG TGGATTATAT AGCTGACTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006514550.1 |
CDS | 106..1548 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006514487.3 |
1 | ATGGATTCCC GTGAATTCCG GAGGAGAGGC AAGGAGATGG TGGATTATAT AGCTGACTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu15577 | |
Clone ID Related Accession (Same CDS sequence) | XM_006514488.4 , XM_006514487.4 , XM_006514489.2 , NM_016672.4 , XM_006514487.3 , NM_001190448.1 , XM_006514488.3 | |
Accession Version | XM_006514488.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | aromatic-L-amino-acid decarboxylase isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006514488.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATTCCC GTGAATTCCG GAGGAGAGGC AAGGAGATGG TGGATTATAT AGCTGACTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006514551.1 |
CDS | 110..1552 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006514488.3 |
1 | ATGGATTCCC GTGAATTCCG GAGGAGAGGC AAGGAGATGG TGGATTATAT AGCTGACTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu45062 | |
Clone ID Related Accession (Same CDS sequence) | XM_006514486.1 | |
Accession Version | XM_006514486.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1542bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | aromatic-L-amino-acid decarboxylase isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAATCG CATCCTCTGT GTCTTTTAAC TGTCACCAAG GAGAGAGAGA GAGCAAGAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006514549.1 |
CDS | 66..1607 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006514486.1 |
1 | ATGGCAATCG CATCCTCTGT GTCTTTTAAC TGTCACCAAG GAGAGAGAGA GAGCAAGAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu15577 | |
Clone ID Related Accession (Same CDS sequence) | XM_006514488.4 , XM_006514487.4 , XM_006514489.2 , NM_016672.4 , XM_006514487.3 , NM_001190448.1 , XM_006514488.3 | |
Accession Version | XM_006514488.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | aromatic-L-amino-acid decarboxylase isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006514488.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATTCCC GTGAATTCCG GAGGAGAGGC AAGGAGATGG TGGATTATAT AGCTGACTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006514551.1 |
CDS | 107..1549 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006514488.4 |
1 | ATGGATTCCC GTGAATTCCG GAGGAGAGGC AAGGAGATGG TGGATTATAT AGCTGACTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu15577 | |
Clone ID Related Accession (Same CDS sequence) | XM_006514488.4 , XM_006514487.4 , XM_006514489.2 , NM_016672.4 , XM_006514487.3 , NM_001190448.1 , XM_006514488.3 | |
Accession Version | XM_006514487.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | aromatic-L-amino-acid decarboxylase isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006514487.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATTCCC GTGAATTCCG GAGGAGAGGC AAGGAGATGG TGGATTATAT AGCTGACTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006514550.1 |
CDS | 105..1547 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006514487.4 |
1 | ATGGATTCCC GTGAATTCCG GAGGAGAGGC AAGGAGATGG TGGATTATAT AGCTGACTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
A pathogenic S250F missense mutation results in a mouse model of mild aromatic l-amino acid decarboxylase (AADC) deficiency. |
A novel floor plate boundary defined by adjacent En1 and Dbx1 microdomains distinguishes midbrain dopamine and hypothalamic neurons. |
Plasma membrane transporters of serotonin, dopamine, and norepinephrine mediate serotonin accumulation in atypical locations in the developing brain of monoamine oxidase A knock-outs. |