Gene Symbol | Fech |
Entrez Gene ID | 14151 |
Full Name | ferrochelatase |
Synonyms | AI894116,Fcl,fch |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Fech cDNA ORF clone
gRNAs
Gene Symbol | Fech |
Entrez Gene ID | 14151 |
Full Name | ferrochelatase |
Synonyms | AI894116,Fcl,fch |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_017317829.1 | XP_017173318.1 | ferrochelatase, mitochondrial isoform X1 |
NM_001348055.1 | NP_001334984.1 | ferrochelatase, mitochondrial isoform 2 |
NM_007998.7 | NP_032024.2 | ferrochelatase, mitochondrial isoform 1 |
Gallus gallus (chicken) | FECH | NP_989527.1 |
Kluyveromyces lactis | KLLA0F20141g | XP_455984.1 |
Eremothecium gossypii | AGOS_AGR272W | NP_986938.1 |
Schizosaccharomyces pombe (fission yeast) | hem15 | NP_587720.1 |
Xenopus tropicalis (tropical clawed frog) | fech | XP_002934473.1 |
FECH | XP_002800996.1 | |
Canis lupus familiaris (dog) | FECH | XP_852936.1 |
Saccharomyces cerevisiae (baker's yeast) | HEM15 | NP_014819.3 |
Neurospora crassa | NCU08291 | XP_962504.1 |
Oryza sativa (rice) | Os05g0361200 | NP_001055309.1 |
Homo sapiens (human) | FECH | NP_000131.2 |
Pan troglodytes (chimpanzee) | FECH | NP_001033101.1 |
Mus musculus (house mouse) | Fech | NP_032024.2 |
Rattus norvegicus (Norway rat) | Fech | NP_001101904.1 |
Danio rerio (zebrafish) | fech | NP_571706.1 |
Drosophila melanogaster (fruit fly) | ferrochelatase | NP_524613.1 |
Arabidopsis thaliana (thale cress) | FC2 | NP_001189639.1 |
Bos taurus (cattle) | FECH | NP_776479.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP003719 | XP_310249.3 |
Magnaporthe oryzae (rice blast fungus) | MGG_15723 | XP_003714486.1 |
Ferrochelatase is a therapeutic target for ocular neovascularization.
Basavarajappa HD, Sulaiman RS, Qi X, Shetty T, Sheik Pran Babu S, Sishtla KL, Lee B, Quigley J, Alkhairy S, Briggs CM, Gupta K, Tang B, Shadmand M, Grant MB, Boulton ME, Seo SY, Corson TW
EMBO molecular medicine9(6)786-801(2017 Jun)
Modeling the ferrochelatase c.315-48C modifier mutation for erythropoietic protoporphyria (EPP) in mice.
Barman-Aks?zen J, C Wiek P, Bansode VB, Koentgen F, Tr?b J, Pelczar P, Cinelli P, Schneider-Yin X, Sch?mperli D, Minder EI
Disease models & mechanisms10(3)225-233(2017 03)
A Novel Role for Progesterone Receptor Membrane Component 1 (PGRMC1): A Partner and Regulator of Ferrochelatase.
Piel RB 3rd, Shiferaw MT, Vashisht AA, Marcero JR, Praissman JL, Phillips JD, Wohlschlegel JA, Medlock AE
Biochemistry55(37)5204-17(2016 09)
Structure and transcriptional regulation of the mouse ferrochelatase gene.
Taketani S, Mohri T, Hioki K, Tokunaga R, Kohno H
Gene227(2)117-24(1999 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
5-aza-2'-deoxycytidine activates iron uptake and heme biosynthesis by increasing c-Myc nuclear localization and binding to the E-boxes of transferrin receptor 1 (TfR1) and ferrochelatase (Fech) genes.
Title: 5-aza-2'-deoxycytidine activates iron uptake and heme biosynthesis by increasing c-Myc nuclear localization and binding to the E-boxes of transferrin receptor 1 (TfR1) and ferrochelatase (Fech) genes.
analysis of the inhibitory metal ion-binding site in ferrochelatase
Title: Identification and characterization of an inhibitory metal ion-binding site in ferrochelatase.
Fech forms an oligomeric complex with Mfrn1 and Abcb10 to synergistically integrate mitochondrial iron importation and use for heme biosynthesis.
Title: Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis.
Ferrochelatase activity and protein levels were dramatically decreased in Irp2(-/-) spleens, whereas ferrochelatase mRNA levels were increased, demonstrating posttranscriptional regulation of ferrochelatase in vivo
Title: Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery.
ferrochelatase localizes to both the mitochondrial outer and inner membranes, and the change in the equilibrium position of the forward and reverse activities may be regulated by the phosphorylation of ferrochelatase
Title: Dual mitochondrial localization and different roles of the reversible reaction of mammalian ferrochelatase.
The following Fech gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fech cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu16268 | |
Clone ID Related Accession (Same CDS sequence) | NM_007998.7 | |
Accession Version | NM_007998.7 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1269bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-28 | |
Organism | Mus musculus(house mouse) | |
Product | ferrochelatase, mitochondrial isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC102268.11, BY754052.1, AK018738.2, AC102106.14 and BP766542.1. On Jan 11, 2017 this sequence version replaced NM_007998.6. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCTTTCGG CCAGCGCCAA CATGGCTGCG GCCCTGCGGG CTGCGGGCGC TCTGCTCCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_032024.2 |
CDS | 132..1400 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCTTTCGG CCAGCGCCAA CATGGCTGCG GCCCTGCGGG CTGCGGGCGC TCTGCTCCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu79762 | |
Clone ID Related Accession (Same CDS sequence) | XM_017317829.1 , NM_001348055.1 | |
Accession Version | NM_001348055.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-28 | |
Organism | Mus musculus(house mouse) | |
Product | ferrochelatase, mitochondrial isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC102268.11, BC096770.1, AK018738.2, AC102106.14 and BP766542.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks an in-frame portion of the 5' coding region, and uses a downstream start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849382, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTTAAACA TGGGAGGCCC CGAAACCCTT GGAGAAGTTC AAGACTTTCT TCAGAGGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001334984.1 |
CDS | 221..1276 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTTAAACA TGGGAGGCCC CGAAACCCTT GGAGAAGTTC AAGACTTTCT TCAGAGGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu79762 | |
Clone ID Related Accession (Same CDS sequence) | XM_017317829.1 , NM_001348055.1 | |
Accession Version | XM_017317829.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | ferrochelatase, mitochondrial isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000084.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTAAACA TGGGAGGCCC CGAAACCCTT GGAGAAGTTC AAGACTTTCT TCAGAGGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017173318.1 |
CDS | 220..1275 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTTAAACA TGGGAGGCCC CGAAACCCTT GGAGAAGTTC AAGACTTTCT TCAGAGGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Ferrochelatase is a therapeutic target for ocular neovascularization. |
Modeling the ferrochelatase c.315-48C modifier mutation for erythropoietic protoporphyria (EPP) in mice. |
A Novel Role for Progesterone Receptor Membrane Component 1 (PGRMC1): A Partner and Regulator of Ferrochelatase. |
Structure and transcriptional regulation of the mouse ferrochelatase gene. |