Gene Symbol | Mnt |
Entrez Gene ID | 17428 |
Full Name | max binding protein |
Synonyms | Rox,bHLHd3 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Mnt cDNA ORF clone
gRNAs
Gene Symbol | Mnt |
Entrez Gene ID | 17428 |
Full Name | max binding protein |
Synonyms | Rox,bHLHd3 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006532402.4 | XP_006532465.1 | max-binding protein MNT isoform X1 |
XM_006532403.3 | XP_006532466.1 | max-binding protein MNT isoform X2 |
XM_006532402.3 | XP_006532465.1 | max-binding protein MNT isoform X1 |
NM_010813.3 | NP_034943.3 | max-binding protein MNT |
XM_006532403.2 | XP_006532466.1 | max-binding protein MNT isoform X2 |
Homo sapiens (human) | MNT | NP_064706.1 |
Pan troglodytes (chimpanzee) | MNT | XP_523532.2 |
Gallus gallus (chicken) | MNT | XP_425414.2 |
Canis lupus familiaris (dog) | MNT | XP_854059.3 |
Bos taurus (cattle) | MNT | NP_001193828.1 |
Xenopus tropicalis (tropical clawed frog) | mnt | NP_001135494.1 |
Mus musculus (house mouse) | Mnt | NP_034943.3 |
Mnt modulates Myc-driven lymphomagenesis.
Campbell KJ, Vandenberg CJ, Anstee NS, Hurlin PJ, Cory S
Cell death and differentiation24(12)2117-2126(2017 Dec)
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)
A critical role for Mnt in Myc-driven T-cell proliferation and oncogenesis.
Link JM, Ota S, Zhou ZQ, Daniel CJ, Sears RC, Hurlin PJ
Proceedings of the National Academy of Sciences of the United States of America109(48)19685-90(2012 Nov)
Regulation of lung endoderm progenitor cell behavior by miR302/367.
Tian Y, Zhang Y, Hurd L, Hannenhalli S, Liu F, Lu MM, Morrisey EE
Development (Cambridge, England)138(7)1235-45(2011 Apr)
OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival.
Vasilevsky NA, Ruby CE, Hurlin PJ, Weinberg AD
European journal of immunology41(4)1024-34(2011 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
results redefine the physiological relationship between Mnt and Myc and requirements for Myc-driven oncogenesis
Title: A critical role for Mnt in Myc-driven T-cell proliferation and oncogenesis.
Mxd4 and Mnt upregulation following OX40 engagement most likely increases T-cell survival
Title: OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival.
The switch from Mnt-Max to Myc-Max during bile duct ligation (cholestasis) and in hepatocytes treated with lithocholic acid is responsible for the induction in p53 and cyclin D1 expression and contributes to apoptosis.
Title: Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes.
Mnt functions as a tumor suppressor and reveal a critical and surprising role for Mnt in the regulation of T-cell development and in T-cell-dependent immune homeostasis.
Title: Inflammatory disease and lymphomagenesis caused by deletion of the Myc antagonist Mnt in T cells.
Mnt is expressed both in growth-arrested and proliferating mouse fibroblasts and is phosphorylated when resting cells are induced to re-enter the cell cycle
Title: Mnt transcriptional repressor is functionally regulated during cell cycle progression.
The following Mnt gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mnt cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu06944 | |
Clone ID Related Accession (Same CDS sequence) | NM_010813.3 | |
Accession Version | NM_010813.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1776bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-18 | |
Organism | Mus musculus(house mouse) | |
Product | max-binding protein MNT | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CA327080.1, BC054534.1 and AW491765.1. On Dec 11, 2007 this sequence version replaced NM_010813.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U77356.1, AK147933.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAGCATAG AGACGCTACT GGAGGCGGCC CGCTTCCTGG AATGGCAAGC GCAGCAACAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_034943.3 |
CDS | 406..2181 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAGCATAG AGACGCTACT GGAGGCGGCC CGCTTCCTGG AATGGCAAGC GCAGCAACAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu45680 | |
Clone ID Related Accession (Same CDS sequence) | XM_006532402.4 , XM_006532402.3 | |
Accession Version | XM_006532402.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1734bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | max-binding protein MNT isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006532402.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGCATAG AGACGCTACT GGAGGCGGCC CGCTTCCTGG AATGGCAAGC GCAGCAACAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006532465.1 |
CDS | 549..2282 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAGCATAG AGACGCTACT GGAGGCGGCC CGCTTCCTGG AATGGCAAGC GCAGCAACAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu45681 | |
Clone ID Related Accession (Same CDS sequence) | XM_006532403.3 , XM_006532403.2 | |
Accession Version | XM_006532403.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 927bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | max-binding protein MNT isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006532403.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGCGCC TTGCGCGGGA GAAGATCGCC ACCCAGCAGC GGCTGGCAGA GCTCAAGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006532466.1 |
CDS | 1813..2739 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAGCGCC TTGCGCGGGA GAAGATCGCC ACCCAGCAGC GGCTGGCAGA GCTCAAGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu45681 | |
Clone ID Related Accession (Same CDS sequence) | XM_006532403.3 , XM_006532403.2 | |
Accession Version | XM_006532403.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 927bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | max-binding protein MNT isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006532403.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGCGCC TTGCGCGGGA GAAGATCGCC ACCCAGCAGC GGCTGGCAGA GCTCAAGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006532466.1 |
CDS | 1806..2732 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAGCGCC TTGCGCGGGA GAAGATCGCC ACCCAGCAGC GGCTGGCAGA GCTCAAGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu45680 | |
Clone ID Related Accession (Same CDS sequence) | XM_006532402.4 , XM_006532402.3 | |
Accession Version | XM_006532402.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1734bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | max-binding protein MNT isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006532402.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGCATAG AGACGCTACT GGAGGCGGCC CGCTTCCTGG AATGGCAAGC GCAGCAACAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006532465.1 |
CDS | 524..2257 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAGCATAG AGACGCTACT GGAGGCGGCC CGCTTCCTGG AATGGCAAGC GCAGCAACAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Mnt modulates Myc-driven lymphomagenesis. |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
A critical role for Mnt in Myc-driven T-cell proliferation and oncogenesis. |
Regulation of lung endoderm progenitor cell behavior by miR302/367. |
OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival. |