Gene Symbol | Por |
Entrez Gene ID | 18984 |
Full Name | P450 (cytochrome) oxidoreductase |
Synonyms | 4933424M13Rik,CPR,CYPOR,P450R |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Por cDNA ORF clone
gRNAs
Gene Symbol | Por |
Entrez Gene ID | 18984 |
Full Name | P450 (cytochrome) oxidoreductase |
Synonyms | 4933424M13Rik,CPR,CYPOR,P450R |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006504399.1 | XP_006504462.1 | NADPH--cytochrome P450 reductase isoform X1 |
XM_006504398.1 | XP_006504461.1 | NADPH--cytochrome P450 reductase isoform X1 |
NM_008898.2 | NP_032924.1 | NADPH--cytochrome P450 reductase |
Canis lupus familiaris (dog) | POR | NP_001171276.1 |
Gallus gallus (chicken) | POR | NP_001182725.1 |
Kluyveromyces lactis | KLLA0D08712g | XP_453451.1 |
Homo sapiens (human) | POR | NP_000932.3 |
Pan troglodytes (chimpanzee) | POR | XP_001155755.2 |
POR | XP_001109664.1 | |
Drosophila melanogaster (fruit fly) | Cpr | NP_001260128.1 |
Caenorhabditis elegans (roundworm) | emb-8 | NP_498103.1 |
Oryza sativa (rice) | Os09g0558900 | NP_001063914.1 |
Oryza sativa (rice) | Os08g0243500 | NP_001061346.1 |
Rattus norvegicus (Norway rat) | Por | NP_113764.1 |
Eremothecium gossypii | AGOS_AAL121C | NP_982421.1 |
Schizosaccharomyces pombe (fission yeast) | ccr1 | NP_596046.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_07117 | XP_003715306.1 |
Danio rerio (zebrafish) | por | NP_001030154.1 |
Bos taurus (cattle) | POR | NP_001030467.1 |
Mus musculus (house mouse) | Por | NP_032924.1 |
Saccharomyces cerevisiae (baker's yeast) | NCP1 | NP_011908.1 |
Neurospora crassa | NCU09741 | XP_964443.1 |
Arabidopsis thaliana (thale cress) | ATR2 | NP_849472.2 |
Xenopus tropicalis (tropical clawed frog) | por | XP_002933864.1 |
A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism.
Barzi M, Pankowicz FP, Zorman B, Liu X, Legras X, Yang D, Borowiak M, Bissig-Choisat B, Sumazin P, Li F, Bissig KD
Nature communications8(1)39(2017 06)
Cytochrome P450 enzymes but not NADPH oxidases are the source of the NADPH-dependent lucigenin chemiluminescence in membrane assays.
Rezende F, Prior KK, L?we O, Wittig I, Strecker V, Moll F, Helfinger V, Schn?tgen F, Kurrle N, Wempe F, Walter M, Zukunft S, Luck B, Fleming I, Weissmann N, Brandes RP, Schr?der K
Free radical biology & medicine10257-66(2017 Jan)
Oscillating primary transcripts harbor miRNAs with circadian functions.
Wang H, Fan Z, Zhao M, Li J, Lu M, Liu W, Ying H, Liu M, Yan J
Scientific reports621598(2016 Feb)
Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability.
Henderson CJ, McLaughlin LA, Osuna-Cabello M, Taylor M, Gilbert I, McLaren AW, Wolf CR
The Biochemical journal465(3)479-88(2015 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Knockout of the cytochrome P450 reductase by CRISPR/Cas9 technology (POR(-/-)) in HEK293 cells overexpressing Nox4 or Nox5 did not interfere with ROS production in intact cells. However, POR(-/-) abolished the signal in NADPH-stimulated assays using membrane fractions from the very same cells. Moreover, membranes of rat smooth muscle cells treated with angiotensin II showed an increased NADPH-dependent signal with lucigen
Title: Cytochrome P450 enzymes but not NADPH oxidases are the source of the NADPH-dependent lucigenin chemiluminescence in membrane assays.
we observed that miR-378 modulates the oscillation amplitudes of Cdkn1a in the control of cell cycle and Por in the regulation of oxidation reduction by forming partnership with different circadian transcription factors
Title: Oscillating primary transcripts harbor miRNAs with circadian functions.
Results are the first to show that some forms of opioid-mediated stress-induced analgesia require brain neuronal P450 activity.
Title: Significance of neuronal cytochrome P450 activity in opioid-mediated stress-induced analgesia.
Immunological and metabolic changes resulting from a genetic deficiency in CPR expression in the intestine in mice.
Title: Mice deficient in intestinal epithelium cytochrome P450 reductase are prone to acute toxin-induced mucosal damage.
An apparent link exists between the cytochrome p450 reductase and FGF signaling pathways.
Title: Conditional deletion of cytochrome p450 reductase in osteoprogenitor cells affects long bone and skull development in mice recapitulating antley-bixler syndrome: role of a redox enzyme in development.
The following Por gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Por cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu19095 | |
Clone ID Related Accession (Same CDS sequence) | XM_006504399.1 , XM_006504398.1 , NM_008898.2 | |
Accession Version | NM_008898.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2037bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-28 | |
Organism | Mus musculus(house mouse) | |
Product | NADPH--cytochrome P450 reductase | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC083948.3. On May 5, 2015 this sequence version replaced NM_008898.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC031463.1, D17571.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGGGACT CTCACGAAGA CACCAGTGCC ACAGTGCCTG AGGCAGTGGC TGAAGAAGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_032924.1 |
CDS | 122..2158 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGGGACT CTCACGAAGA CACCAGTGCC ACAGTGCCTG AGGCAGTGGC TGAAGAAGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu19095 | |
Clone ID Related Accession (Same CDS sequence) | XM_006504399.1 , XM_006504398.1 , NM_008898.2 | |
Accession Version | XM_006504399.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2037bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | NADPH--cytochrome P450 reductase isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGGGACT CTCACGAAGA CACCAGTGCC ACAGTGCCTG AGGCAGTGGC TGAAGAAGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006504462.1 |
CDS | 91..2127 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGGGACT CTCACGAAGA CACCAGTGCC ACAGTGCCTG AGGCAGTGGC TGAAGAAGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu19095 | |
Clone ID Related Accession (Same CDS sequence) | XM_006504399.1 , XM_006504398.1 , NM_008898.2 | |
Accession Version | XM_006504398.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2037bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | NADPH--cytochrome P450 reductase isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGGGACT CTCACGAAGA CACCAGTGCC ACAGTGCCTG AGGCAGTGGC TGAAGAAGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006504461.1 |
CDS | 86..2122 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGGGACT CTCACGAAGA CACCAGTGCC ACAGTGCCTG AGGCAGTGGC TGAAGAAGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism. |
Cytochrome P450 enzymes but not NADPH oxidases are the source of the NADPH-dependent lucigenin chemiluminescence in membrane assays. |
Oscillating primary transcripts harbor miRNAs with circadian functions. |
Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability. |