Hexim1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hexim1
Entrez Gene ID	192231
Full Name	hexamethylene bis-acetamide inducible 1
Synonyms	7330426E13Rik,CLP-1,Clp1,HIS1
General protein information	Preferred Names hexamethylene bis-acetamide inducible 1 Names protein HEXIM1 cardiac lineage protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 E1

mRNA and Protein(s)

mRNA	Protein	Name
NM_138753.2	NP_620092.1	protein HEXIM1

Pathways from BioSystems

Homologies

	HEXIM1	XP_001115260.1
Pan troglodytes (chimpanzee)	HEXIM1	XP_003953030.1
Canis lupus familiaris (dog)	HEXIM1	XP_005624429.1
Mus musculus (house mouse)	Hexim1	NP_620092.1
Gallus gallus (chicken)	HEXIM1	XP_003642831.1
Bos taurus (cattle)	HEXIM1	NP_001069649.1
Homo sapiens (human)	HEXIM1	NP_006451.1
Rattus norvegicus (Norway rat)	Hexim1	NP_001020307.1

Gene Ontology
Bibliography

Related articles in PubMed

Rn7SK small nuclear RNA is involved in neuronal differentiation.
Bazi Z, Bertacchi M, Abasi M, Mohammadi-Yeganeh S, Soleimani M, Wagner N, Ghanbarian H
Journal of cellular biochemistry(2017 Nov)

Rapidly progressive course of Trypanosoma cruzi infection in mice heterozygous for hexamethylene bis-acetamide inducible 1 (Hexim1) gene.
Mascareno E, Gupta R, Martello LA, Dhar-Mascareno M, Salciccioli L, Beckles D, Walsh MG, Machado FS, Tanowitz HB, Haseeb MA
Microbes and infection(2017 Sep)

Hexim1 heterozygosity stabilizes atherosclerotic plaque and decreased steatosis in ApoE null mice fed atherogenic diet.
Dhar-Mascareno M, Rozenberg I, Iqbal J, Hussain MM, Beckles D, Mascareno E
The international journal of biochemistry & cell biology8356-64(2017 02)

Hexim1, a Novel Regulator of Leptin Function, Modulates Obesity and Glucose Disposal.
Dhar-Mascareno M, Ramirez SN, Rozenberg I, Rouille Y, Kral JG, Mascareno EJ
Molecular endocrinology (Baltimore, Md.)30(3)314-24(2016 Mar)

Down-regulation of hypoxia-inducible factor-1 alpha and vascular endothelial growth factor by HEXIM1 attenuates myocardial angiogenesis in hypoxic mice.
Yoshikawa N, Shimizu N, Ojima H, Kobayashi H, Hosono O, Tanaka H
Biochemical and biophysical research communications453(3)600-5(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Decreased Hexim-1 expression does not alter cholesterol metabolism in ApoE null background after high fat diet. However, it promotes stable atherosclerotic plaque and decreased steatosis by promoting the anti-inflammatory TGFbeta pathway and blocking the expression of the inducible and pro-inflammatory expression of SOCS3 respectively.
Title: Hexim1 heterozygosity stabilizes atherosclerotic plaque and decreased steatosis in ApoE null mice fed atherogenic diet.

Hexim1 selectively modulates leptin-mediated signal transduction pathways in the hypothalamus.
Title: Hexim1, a Novel Regulator of Leptin Function, Modulates Obesity and Glucose Disposal.

conclude that HEXIM1 could prevent RV hypertrophy, at least in part, via suppression of myocardial angiogenesis through down-regulation of HIF-1alpha and VEGF in the myocardium under hypoxic condition
Title: Down-regulation of hypoxia-inducible factor-1 alpha and vascular endothelial growth factor by HEXIM1 attenuates myocardial angiogenesis in hypoxic mice.

HEXIM1 re-expression results in the induction of angiogenesis that allows for the co-ordination of tissue growth and angiogenesis during physiological hypertrophy
Title: Inducible re-expression of HEXIM1 causes physiological cardiac hypertrophy in the adult mouse.

a crucial role for the HEXIM1/P-TEFb pathway in the regulation of satellite cell-mediated muscle regeneration and identify HEXIM1 as a potential therapeutic target for degenerative muscular diseases.
Title: HEXIM1 controls satellite cell expansion after injury to regulate skeletal muscle regeneration.

The following Hexim1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hexim1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu17616	NM_138753.2 Latest version!	Mus musculus hexamethylene bis-acetamide inducible 1 (Hexim1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hexim1 ( NM_138753.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_620092.1 Mus musculus hexamethylene bis-acetamide inducible 1 (Hexim1), mRNA.

Price & Availability↑

CloneID	OMu17616
Clone ID Related Accession (Same CDS sequence)	NM_138753.2
Accession Version	NM_138753.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1071bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	protein HEXIM1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL731805.8. On Jan 31, 2007 this sequence version replaced NM_138753.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AY090614.1 [ECO:0000345] ##Evidence-Data-END##

ATGGCCGAGC CACTCTTGAC AGAACATCAA CACCAGCCTC AAACTAGCAA CTGTACAGGT 
GCTGCTGTTG TCCATGAAGA GCATACCTCT GAGCGCCCCC CAAGCGCGGA GGAACGGGTG 
CCCAAGGAGG ACAGTAGGTG GCAATCGAGA GCGTCCTTGC AGTCCGGTAG CCGTCCAGGG 
CAGGAGGGAG AAGGGGGCCT GAAGCACCAG CTGCCCCCAT TGCAGACGAA TGCCTGTCCA 
GAATTGAGCT CCCTGGAGAA GGGCGAGAAG GGCCAGAATG GGGAGGACTT ATCCACTGGC 
GGTGCCTCCC CGTCGGCGGA GGGAGAGCCG ATGTCAGAGT CCCTCGTGCA GCCAGGTCAT 
GACTCGGAGG CCACCAAGCA GGAGGCTCCT GCCGCCGGAG GCGAGGAGCC ATGGGGACAG 
CAACAGAGAC AGCTGGGCAA GAAAAAACAT CGGAGACGCC CCTCAAAGAA GAAGCGGCAT 
TGGAAGCCCT ACTACAAGCT GACTTGGGAG GAGAAGAAAA AGTTCGACGA GAAGCAGAGC 
CTGCGAGCTT CGCGGGTTCG AGCCGAGATG TTCGCCAAGG GCCAGCCAGT TGCGCCCTAT 
AACACCACGC AGTTCCTCAT GGATGACCAC GATCAGGAGG AGCCTGATCT CAAAACCGGC 
CTTTACCCCA AGCGGGCAGC CGCCAAATCC GACGACACCA GCGATGAGGA TTTTGTGGAA 
GAAGCTGGTG AGGAAGACGG AGGCAGCGAT GGCATGGGAG GGGACGGCAG CGAGTTTCTG 
CAGCGGGACT TCTCGGAGAC GTACGAGCGG TACCACGCCG AGAGCCTGCA GAACATGAGC 
AAGCAGGAGC TCATCAAAGA GTACCTGGAG CTGGAGAAGT GCCTCTCCCG CAAGGAGGAC 
GAAAATAACC GGCTGCGGCT GGAAAGCAAG CGGCTGGGAG GCGTCGACGC GCGAGTGCGG 
GAGCTCGAGC TAGAGCTGGA CCGGCTGCGC GCTGAGAACC TCCAGCTGCT GACCGAGAAC 
GAACTGCACC GGCAGCAGGA GCGAGCGCCT CTTTCCAAGT TCGGCGACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620092.1
CDS	598..1668
Translation	MAEPLLTEHQHQPQTSNCTGAAVVHEEHTSERPPSAEERVPKEDSRWQSRASLQSGSRPGQEGEGGLKHQLPPLQTNACPELSSLEKGEKGQNGEDLSTGGASPSAEGEPMSESLVQPGHDSEATKQEAPAAGGEEPWGQQQRQLGKKKHRRRPSKKKRHWKPYYKLTWEEKKKFDEKQSLRASRVRAEMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTGLYPKRAAAKSDDTSDEDFVEEAGEEDGGSDGMGGDGSEFLQRDFSETYERYHAESLQNMSKQELIKEYLELEKCLSRKEDENNRLRLESKRLGGVDARVRELELELDRLRAENLQLLTENELHRQQERAPLSKFGD

Target ORF information:

RefSeq Version	NM_138753.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus hexamethylene bis-acetamide inducible 1 (Hexim1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138753.2

ORF Insert Sequence:

ATGGCCGAGC CACTCTTGAC AGAACATCAA CACCAGCCTC AAACTAGCAA CTGTACAGGT 
GCTGCTGTTG TCCATGAAGA GCATACCTCT GAGCGCCCCC CAAGCGCGGA GGAACGGGTG 
CCCAAGGAGG ACAGTAGGTG GCAATCGAGA GCGTCCTTGC AGTCCGGTAG CCGTCCAGGG 
CAGGAGGGAG AAGGGGGCCT GAAGCACCAG CTGCCCCCAT TGCAGACGAA TGCCTGTCCA 
GAATTGAGCT CCCTGGAGAA GGGCGAGAAG GGCCAGAATG GGGAGGACTT ATCCACTGGC 
GGTGCCTCCC CGTCGGCGGA GGGAGAGCCG ATGTCAGAGT CCCTCGTGCA GCCAGGTCAT 
GACTCGGAGG CCACCAAGCA GGAGGCTCCT GCCGCCGGAG GCGAGGAGCC ATGGGGACAG 
CAACAGAGAC AGCTGGGCAA GAAAAAACAT CGGAGACGCC CCTCAAAGAA GAAGCGGCAT 
TGGAAGCCCT ACTACAAGCT GACTTGGGAG GAGAAGAAAA AGTTCGACGA GAAGCAGAGC 
CTGCGAGCTT CGCGGGTTCG AGCCGAGATG TTCGCCAAGG GCCAGCCAGT TGCGCCCTAT 
AACACCACGC AGTTCCTCAT GGATGACCAC GATCAGGAGG AGCCTGATCT CAAAACCGGC 
CTTTACCCCA AGCGGGCAGC CGCCAAATCC GACGACACCA GCGATGAGGA TTTTGTGGAA 
GAAGCTGGTG AGGAAGACGG AGGCAGCGAT GGCATGGGAG GGGACGGCAG CGAGTTTCTG 
CAGCGGGACT TCTCGGAGAC GTACGAGCGG TACCACGCCG AGAGCCTGCA GAACATGAGC 
AAGCAGGAGC TCATCAAAGA GTACCTGGAG CTGGAGAAGT GCCTCTCCCG CAAGGAGGAC 
GAAAATAACC GGCTGCGGCT GGAAAGCAAG CGGCTGGGAG GCGTCGACGC GCGAGTGCGG 
GAGCTCGAGC TAGAGCTGGA CCGGCTGCGC GCTGAGAACC TCCAGCTGCT GACCGAGAAC 
GAACTGCACC GGCAGCAGGA GCGAGCGCCT CTTTCCAAGT TCGGCGACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Rn7SK small nuclear RNA is involved in neuronal differentiation.
Journal of cellular biochemistry(2017 Nov)
Bazi Z,Bertacchi M,Abasi M,Mohammadi-Yeganeh S,Soleimani M,Wagner N,Ghanbarian H

Rapidly progressive course of Trypanosoma cruzi infection in mice heterozygous for hexamethylene bis-acetamide inducible 1 (Hexim1) gene.
Microbes and infection(2017 Sep)
Mascareno E,Gupta R,Martello LA,Dhar-Mascareno M,Salciccioli L,Beckles D,Walsh MG,Machado FS,Tanowitz HB,Haseeb MA

Hexim1 heterozygosity stabilizes atherosclerotic plaque and decreased steatosis in ApoE null mice fed atherogenic diet.
The international journal of biochemistry & cell biology8356-64(2017 02)
Dhar-Mascareno M,Rozenberg I,Iqbal J,Hussain MM,Beckles D,Mascareno E

Hexim1, a Novel Regulator of Leptin Function, Modulates Obesity and Glucose Disposal.
Molecular endocrinology (Baltimore, Md.)30(3)314-24(2016 Mar)
Dhar-Mascareno M,Ramirez SN,Rozenberg I,Rouille Y,Kral JG,Mascareno EJ

Down-regulation of hypoxia-inducible factor-1 alpha and vascular endothelial growth factor by HEXIM1 attenuates myocardial angiogenesis in hypoxic mice.
Biochemical and biophysical research communications453(3)600-5(2014 Oct)
Yoshikawa N,Shimizu N,Ojima H,Kobayashi H,Hosono O,Tanaka H

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Hexim1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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