Gene Symbol | PLSCR1 |
Entrez Gene ID | 22038 |
Full Name | phospholipid scramblase 1 |
Synonyms | MmTRA1a,MmTRA1b,Nor1,Tra1,Tra1a,Tra1b,Tras1,Tras2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(House mouse) |
Genome |
ORF » Species Summary » Mus musculus » PLSCR1 cDNA ORF clone
gRNAs
Gene Symbol | PLSCR1 |
Entrez Gene ID | 22038 |
Full Name | phospholipid scramblase 1 |
Synonyms | MmTRA1a,MmTRA1b,Nor1,Tra1,Tra1a,Tra1b,Tras1,Tras2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(House mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006511052.4 | XP_006511115.1 | phospholipid scramblase 1 isoform X1 |
NM_011636.2 | NP_035766.2 | phospholipid scramblase 1 |
XM_006511052.3 | XP_006511115.1 | phospholipid scramblase 1 isoform X1 |
XM_006511052.2 | XP_006511115.1 | phospholipid scramblase 1 isoform X1 |
Danio rerio (zebrafish) | plscr3a | NP_001098583.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP005498 | XP_001688666.1 |
Homo sapiens (human) | PLSCR1 | NP_066928.1 |
Rattus norvegicus (Norway rat) | Plscr1 | NP_476542.1 |
Drosophila melanogaster (fruit fly) | scramb1 | NP_648389.3 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP005504 | XP_001688668.1 |
Caenorhabditis elegans (roundworm) | scrm-3 | NP_503934.2 |
Xenopus tropicalis (tropical clawed frog) | LOC100489273 | XP_002938452.2 |
Pan troglodytes (chimpanzee) | PLSCR1 | XP_001135229.2 |
PLSCR1 | XP_001111222.1 | |
Mus musculus (house mouse) | Plscr1 | NP_035766.2 |
Gallus gallus (chicken) | PLSCR1 | XP_001231237.1 |
Danio rerio (zebrafish) | plscr3b | NP_998031.1 |
Caenorhabditis elegans (roundworm) | scrm-2 | NP_493321.1 |
Xenopus tropicalis (tropical clawed frog) | plscr1 | NP_001135607.1 |
Canis lupus familiaris (dog) | LOC611500 | XP_005634707.1 |
Caenorhabditis elegans (roundworm) | scrm-1 | NP_492976.2 |
Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia.
Tufail Y, Cook D, Fourgeaud L, Powers CJ, Merten K, Clark CL, Hoffman E, Ngo A, Sekiguchi KJ, O'Shea CC, Lemke G, Nimmerjahn A
Neuron93(3)574-586.e8(2017 Feb)
Phospholipid scramblase 1 amplifies anaphylactic reactions in vivo.
Kassas-Guediri A, Coudrat J, Pacreau E, Launay P, Monteiro RC, Blank U, Charles N, Benhamou M
PloS one12(3)e0173815(2017)
High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)
IgE receptor type I-dependent tyrosine phosphorylation of phospholipid scramblase.
Pastorelli C, Veiga J, Charles N, Voignier E, Moussu H, Monteiro RC, Benhamou M
The Journal of biological chemistry276(23)20407-12(2001 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Genetic knockdown of PLSCR1 activity reduces intracellular calcium dysregulation, prevents phosphatidylserine externalization, and enables months-long protection of vector-transduced, transgene-expressing cells from microglial phagocytosis.
Title: Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia.
PLSCR1 aggravates anaphylactic reactions by increasing Fc epsion RI-dependent mast cell degranulation.
Title: Phospholipid scramblase 1 amplifies anaphylactic reactions in vivo.
Phospholipid scramblase 1 regulates phosphatidylserine exposure in response to oxygen stress, leading to beta2-glycoprotein I and IgM binding and lipid-mediated, inflammatory responses.
Title: Phospholipid scramblase 1 is required for ?2-glycoprotein I binding in hypoxia and reoxygenation-induced endothelial inflammation.
Lipopolysaccharide treatment resulted in increased expression of phospholipid scramblase 1(PLSCR-1) and decrease in phospholipid scramblase 4(Plscr4 )messenger RNA demonstrating modulation of PLSCR-1 and PLSCR-4 in lipopolysaccharide-induced preterm birth
Title: Phospholipid scramblase expression in the pregnant mouse uterus in LPS-induced preterm delivery.
Study demonstrates that PLSCR1 is a TLR9-interacting protein that plays an important role in pDC's type 1 IFN responses by regulating TLR9 trafficking to the endosomal compartment.
Title: Phospholipid scramblase 1 regulates Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells.
The following PLSCR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PLSCR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu08499 | |
Clone ID Related Accession (Same CDS sequence) | XM_006511052.4 , NM_011636.2 , XM_006511052.3 , XM_006511052.2 | |
Accession Version | NM_011636.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 987bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | phospholipid scramblase 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CK788898.1, AF159593.1, AK003628.1 and CJ213207.1. On Jul 19, 2008 this sequence version replaced NM_011636.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK003628.1, AF159593.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAAAACC ACAGCAAGCA AACTGAGGCT CCCCACCCGG GAACATATAT GCCAGCTGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_035766.2 |
CDS | 182..1168 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAAAACC ACAGCAAGCA AACTGAGGCT CCCCACCCGG GAACATATAT GCCAGCTGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu08499 | |
Clone ID Related Accession (Same CDS sequence) | XM_006511052.4 , NM_011636.2 , XM_006511052.3 , XM_006511052.2 | |
Accession Version | XM_006511052.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 987bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | phospholipid scramblase 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006511052.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAAAACC ACAGCAAGCA AACTGAGGCT CCCCACCCGG GAACATATAT GCCAGCTGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006511115.1 |
CDS | 236..1222 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAAAACC ACAGCAAGCA AACTGAGGCT CCCCACCCGG GAACATATAT GCCAGCTGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu08499 | |
Clone ID Related Accession (Same CDS sequence) | XM_006511052.4 , NM_011636.2 , XM_006511052.3 , XM_006511052.2 | |
Accession Version | XM_006511052.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 987bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-02-08 | |
Organism | Mus musculus(House mouse) | |
Product | phospholipid scramblase 1 isoform X1 | |
Comment |
1 | ATGGAAAACC ACAGCAAGCA AACTGAGGCT CCCCACCCGG GAACATATAT GCCAGCTGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006511115.1 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAAAACC ACAGCAAGCA AACTGAGGCT CCCCACCCGG GAACATATAT GCCAGCTGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu08499 | |
Clone ID Related Accession (Same CDS sequence) | XM_006511052.4 , NM_011636.2 , XM_006511052.3 , XM_006511052.2 | |
Accession Version | XM_006511052.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 987bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | phospholipid scramblase 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006511052.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAAAACC ACAGCAAGCA AACTGAGGCT CCCCACCCGG GAACATATAT GCCAGCTGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006511115.1 |
CDS | 105..1091 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAAAACC ACAGCAAGCA AACTGAGGCT CCCCACCCGG GAACATATAT GCCAGCTGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia. |
Phospholipid scramblase 1 amplifies anaphylactic reactions in vivo. |
High-throughput discovery of novel developmental phenotypes. |
IgE receptor type I-dependent tyrosine phosphorylation of phospholipid scramblase. |