Gene Symbol | Yes1 |
Entrez Gene ID | 22612 |
Full Name | YES proto-oncogene 1, Src family tyrosine kinase |
Synonyms | Yes,p61-Yes |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Yes1 cDNA ORF clone
gRNAs
Gene Symbol | Yes1 |
Entrez Gene ID | 22612 |
Full Name | YES proto-oncogene 1, Src family tyrosine kinase |
Synonyms | Yes,p61-Yes |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001205132.1 | NP_001192061.1 | tyrosine-protein kinase Yes |
NM_001205133.1 | NP_001192062.1 | tyrosine-protein kinase Yes |
NM_009535.3 | NP_033561.1 | tyrosine-protein kinase Yes |
Pan troglodytes (chimpanzee) | YES1 | XP_001148240.1 |
YES1 | XP_001088280.1 | |
Bos taurus (cattle) | YES1 | NP_001094530.1 |
Gallus gallus (chicken) | YES1 | NP_990632.1 |
Canis lupus familiaris (dog) | YES1 | XP_005623082.1 |
Mus musculus (house mouse) | Yes1 | NP_001192062.1 |
Xenopus tropicalis (tropical clawed frog) | yes1 | NP_001008186.1 |
Homo sapiens (human) | YES1 | NP_005424.1 |
Rattus norvegicus (Norway rat) | Yes1 | NP_150640.1 |
Danio rerio (zebrafish) | yes1 | NP_001013288.2 |
Integrin signalling regulates YAP and TAZ to control skin homeostasis.
Elbediwy A, Vincent-Mistiaen ZI, Spencer-Dene B, Stone RK, Boeing S, Wculek SK, Cordero J, Tan EH, Ridgway R, Brunton VG, Sahai E, Gerhardt H, Behrens A, Malanchi I, Sansom OJ, Thompson BJ
Development (Cambridge, England)143(10)1674-87(2016 05)
A phosphotyrosine switch regulates organic cation transporters.
Sprowl JA, Ong SS, Gibson AA, Hu S, Du G, Lin W, Li L, Bharill S, Ness RA, Stecula A, Offer SM, Diasio RB, Nies AT, Schwab M, Cavaletti G, Schlatter E, Ciarimboli G, Schellens JH, Isacoff EY, Sali A, Chen T, Baker SD, Sparreboom A, Pabla N
Nature communications710880(2016 Mar)
Ganglioside GD3 Enhances Invasiveness of Gliomas by Forming a Complex with Platelet-derived Growth Factor Receptor ? and Yes Kinase.
Ohkawa Y, Momota H, Kato A, Hashimoto N, Tsuda Y, Kotani N, Honke K, Suzumura A, Furukawa K, Ohmi Y, Natsume A, Wakabayashi T, Furukawa K
The Journal of biological chemistry290(26)16043-58(2015 Jun)
Serum Inter-?-inhibitor activates the Yes tyrosine kinase and YAP/TEAD transcriptional complex in mouse embryonic stem cells.
Pijuan-Galit? S, Tamm C, Anner?n C
The Journal of biological chemistry289(48)33492-502(2014 Nov)
Palatal adhesion is dependent on Src family kinases and p38MAPK.
Kitase Y, Shuler CF
The International journal of developmental biology58(5)335-41(2014)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Ganglioside GD3 enhances invasiveness of gliomas by forming a complex with PDGFRalpha and Yes Kinase.
Title: Ganglioside GD3 Enhances Invasiveness of Gliomas by Forming a Complex with Platelet-derived Growth Factor Receptor ? and Yes Kinase.
serum also activates TEAD-dependent transcription in a time- and dose-dependent manner and we identify Inter-alpha-inhibitor (IalphaI) as a component in serum capable of activating the Yes/YAP/TEAD pathway
Title: Serum Inter-?-inhibitor activates the Yes tyrosine kinase and YAP/TEAD transcriptional complex in mouse embryonic stem cells.
Differentiation of embryonic stem cells is driven by c-Src is antagonized by c-Yes.
Title: c-Yes tyrosine kinase is a potent suppressor of ES cell differentiation and antagonizes the actions of its closest phylogenetic relative, c-Src.
The antiapoptotic effect of YES1 activation in response to testicular heat insult may mediate via the regulation of extracellular signal-regulated kinase (ERK)/metastasis-associated 1 (MTA1) cascade.
Title: YES1 activation elicited by heat stress is anti-apoptotic in mouse pachytene spermatocytes.
Results suggest that LKB1 inactivation in the context of RAS activation facilitates metastasis by inducing an SFK-dependent expansion of a prometastatic, CD24(+) tumor subpopulation.
Title: LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma.
The following Yes1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Yes1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu02864 | |
Clone ID Related Accession (Same CDS sequence) | NM_001205132.1 , NM_001205133.1 , NM_009535.3 | |
Accession Version | NM_001205132.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1626bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-20 | |
Organism | Mus musculus(house mouse) | |
Product | tyrosine-protein kinase Yes | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC091274.11 and AC166934.3. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK052478.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGCTGCA TTAAAAGTAA AGAAAACAAA AGTCCAGCCA TAAAATACAC ACCGGAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001192061.1 |
CDS | 214..1839 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGGCTGCA TTAAAAGTAA AGAAAACAAA AGTCCAGCCA TAAAATACAC ACCGGAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu02864 | |
Clone ID Related Accession (Same CDS sequence) | NM_001205132.1 , NM_001205133.1 , NM_009535.3 | |
Accession Version | NM_001205133.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1626bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-20 | |
Organism | Mus musculus(house mouse) | |
Product | tyrosine-protein kinase Yes | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC091274.11 and AC166934.3. Transcript Variant: This variant (3) differs in both the 5' UTR and 3' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC010594.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849380 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGCTGCA TTAAAAGTAA AGAAAACAAA AGTCCAGCCA TAAAATACAC ACCGGAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001192062.1 |
CDS | 214..1839 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGCTGCA TTAAAAGTAA AGAAAACAAA AGTCCAGCCA TAAAATACAC ACCGGAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu02864 | |
Clone ID Related Accession (Same CDS sequence) | NM_001205132.1 , NM_001205133.1 , NM_009535.3 | |
Accession Version | NM_009535.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1626bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-20 | |
Organism | Mus musculus(house mouse) | |
Product | tyrosine-protein kinase Yes | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC091274.11, AK167420.1 and AC166934.3. On Mar 25, 2011 this sequence version replaced NM_009535.2. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X67677.1, AK035612.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGCTGCA TTAAAAGTAA AGAAAACAAA AGTCCAGCCA TAAAATACAC ACCGGAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_033561.1 |
CDS | 676..2301 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGCTGCA TTAAAAGTAA AGAAAACAAA AGTCCAGCCA TAAAATACAC ACCGGAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Integrin signalling regulates YAP and TAZ to control skin homeostasis. |
A phosphotyrosine switch regulates organic cation transporters. |
Ganglioside GD3 Enhances Invasiveness of Gliomas by Forming a Complex with Platelet-derived Growth Factor Receptor ? and Yes Kinase. |
Serum Inter-?-inhibitor activates the Yes tyrosine kinase and YAP/TEAD transcriptional complex in mouse embryonic stem cells. |
Palatal adhesion is dependent on Src family kinases and p38MAPK. |