Gene Symbol | Dand5 |
Entrez Gene ID | 23863 |
Full Name | DAN domain family member 5, BMP antagonist |
Synonyms | Cerl-2,Cerr2,Dte,GREM3,coco |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Dand5 cDNA ORF clone
Gene Symbol | Dand5 |
Entrez Gene ID | 23863 |
Full Name | DAN domain family member 5, BMP antagonist |
Synonyms | Cerl-2,Cerr2,Dte,GREM3,coco |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_201227.3 | NP_957679.1 | DAN domain family member 5 precursor |
Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways.
Sigg MA, Menchen T, Lee C, Johnson J, Jungnickel MK, Choksi SP, Garcia G 3rd, Busengdal H, Dougherty GW, Pennekamp P, Werner C, Rentzsch F, Florman HM, Krogan N, Wallingford JB, Omran H, Reiter JF
Developmental cell43(6)744-762.e11(2017 12)
Mechanism for generation of left isomerism in Ccdc40 mutant embryos.
Sugrue KF, Zohn IE
PloS one12(2)e0171180(2017)
PIERCE1 is critical for specification of left-right asymmetry in mice.
Sung YH, Baek IJ, Kim YH, Gho YS, Oh SP, Lee YJ, Lee HW
Scientific reports627932(2016 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Cerl2 plays an important role during heart development.
Title: Targeted inactivation of Cerberus like-2 leads to left ventricular cardiac hyperplasia and systolic dysfunction in the mouse.
The consequent prolonged Nodal activity in the node by the absence of Cerl2 affects local Nodal expression and prolongs its expression in the lateral plate mesoderm.
Title: The dynamic right-to-left translocation of Cerl2 is involved in the regulation and termination of Nodal activity in the mouse node.
Study shows the cilia protein Arl13b is required for left right axis specification as its absence results in heterotaxia; the defect originates in the node where Cerl2 is not downregulated and asymmetric expression of Nodal is not maintained resulting in symmetric expression of both genes.
Title: Defective Nodal and Cerl2 expression in the Arl13b(hnn) mutant node underlie its heterotaxia.
Decay of Cerl2 mRNA on the left is initiated by the leftward flow and further enhanced by the operation of Wnt-Cerl2 interlinked feedback loops.
Title: Fluid flow and interlinked feedback loops establish left-right asymmetric decay of Cerl2 mRNA.
cCer and mouse Cerl-2 have evolved distinct regulatory mechanisms but retained a conserved function in left-right development, which is to restrict Nodal activity to the left side of the embryo.
Title: Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo.
The following Dand5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dand5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu09510 | |
Clone ID Related Accession (Same CDS sequence) | NM_201227.3 | |
Accession Version | NM_201227.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | DAN domain family member 5 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC155163.4, AY387409.1 and AK143395.1. On Dec 12, 2009 this sequence version replaced NM_201227.2. Transcript Variant: This variant (1) represents the longer transcript and is the protein-coding transcript. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY387409.1, BC115659.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164136 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTTCCGTA GCCAGTTCAC CACGCTGCTG GGTCTGTTCA GTGGGGCCTG GCTACCCACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_957679.1 |
CDS | 144..701 |
Translation |
Target ORF information:
Target ORF information:
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NM_201227.3 |
1 | ATGTTCCGTA GCCAGTTCAC CACGCTGCTG GGTCTGTTCA GTGGGGCCTG GCTACCCACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways. |
Mechanism for generation of left isomerism in Ccdc40 mutant embryos. |
PIERCE1 is critical for specification of left-right asymmetry in mice. |