Defb19 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Defb19
Entrez Gene ID	246700
Full Name	defensin beta 19
Synonyms	BD-19,Defb24,Tdl,mBD-19
General protein information	Preferred Names defensin beta 19 Names beta-defensin 19 beta-defensin 24 testis-specific beta-defensin-like protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 H1

mRNA and Protein(s)

mRNA Protein Name

NM_145157.3 NP_660139.1 beta-defensin 19 precursor
Pathways from BioSystems

mRNA	Protein	Name
NM_145157.3	NP_660139.1	beta-defensin 19 precursor

Homologies

Bos taurus (cattle)	DEFB119	NP_001095131.1
Homo sapiens (human)	DEFB119	NP_695021.2
Pan troglodytes (chimpanzee)	DEFB119	NP_001095143.1
Canis lupus familiaris (dog)	DEFB119	XP_005634965.1
Mus musculus (house mouse)	Defb19	NP_660139.1
Rattus norvegicus (Norway rat)	Defb24	NP_001032597.1

Gene Ontology
Bibliography

Related articles in PubMed

Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway.
Correa SM, Washburn LL, Kahlon RS, Musson MC, Bouma GJ, Eicher EM, Albrecht KH
PLoS genetics8(4)e1002569(2012)

Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal.
Munger SC, Aylor DL, Syed HA, Magwene PM, Threadgill DW, Capel B
Genes & development23(21)2521-36(2009 Nov)

Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
Patil AA, Cai Y, Sang Y, Blecha F, Zhang G
Physiological genomics23(1)5-17(2005 Sep)

Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells.
Bouma GJ, Albrecht KH, Washburn LL, Recknagel AK, Churchill GA, Eicher EM
Development (Cambridge, England)132(13)3045-54(2005 Jul)

Using real time RT-PCR analysis to determine multiple gene expression patterns during XX and XY mouse fetal gonad development.
Bouma GJ, Hart GT, Washburn LL, Recknagel AK, Eicher EM
Gene expression patterns : GEP5(1)141-9(2004 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Tdl is specifically expressed in Sertoli cell-lineage in seminiferous cords in embryonic testes, but not in embryonic ovaries after 12.5dpc when the sexual differentiation of gonads is initiated.
Title: Testis-specific expression of a novel mouse defensin-like gene, Tdl.

The following Defb19 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Defb19 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11367	NM_145157.3 Latest version!	Mus musculus defensin beta 19 (Defb19), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Defb19 ( NM_145157.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_660139.1 Mus musculus defensin beta 19 (Defb19), mRNA.

Price & Availability↑

CloneID	OMu11367
Clone ID Related Accession (Same CDS sequence)	NM_145157.3
Accession Version	NM_145157.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 252bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	beta-defensin 19 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DQ012035.1 and AF532614.1. On Nov 22, 2008 this sequence version replaced NM_145157.2. ##Evidence-Data-START## Transcript exon combination :: BC049701.1, AY098993.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGCTGG CTCTCCTGCT TCTTGCCATA CTTGTGGCAA CGGAACTGGT CGTGTCTGGC 
AAAAATCCTA TCCTTCAATG CATGGGTAAC AGAGGATTCT GTAGGTCTTC CTGCAAAAAG 
AGTGAACAGG CCTACTTCTA CTGCAGAACT TTCCAGATGT GCTGCCTCCA GTCCTACGTG 
AGGATCAGCC TCACAGGAGT AGATGACAAC ACTAACTGGT CTTACGAGAA GCACTGGCCA 
AGAATACCGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_660139.1
CDS	66..317
Translation	MRLALLLLAILVATELVVSGKNPILQCMGNRGFCRSSCKKSEQAYFYCRTFQMCCLQSYVRISLTGVDDNTNWSYEKHWPRIP

Target ORF information:

RefSeq Version	NM_145157.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus defensin beta 19 (Defb19), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145157.3

ORF Insert Sequence:

ATGAGGCTGG CTCTCCTGCT TCTTGCCATA CTTGTGGCAA CGGAACTGGT CGTGTCTGGC 
AAAAATCCTA TCCTTCAATG CATGGGTAAC AGAGGATTCT GTAGGTCTTC CTGCAAAAAG 
AGTGAACAGG CCTACTTCTA CTGCAGAACT TTCCAGATGT GCTGCCTCCA GTCCTACGTG 
AGGATCAGCC TCACAGGAGT AGATGACAAC ACTAACTGGT CTTACGAGAA GCACTGGCCA 
AGAATACCGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway.
PLoS genetics8(4)e1002569(2012)
Correa SM,Washburn LL,Kahlon RS,Musson MC,Bouma GJ,Eicher EM,Albrecht KH

Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal.
Genes & development23(21)2521-36(2009 Nov)
Munger SC,Aylor DL,Syed HA,Magwene PM,Threadgill DW,Capel B

Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
Physiological genomics23(1)5-17(2005 Sep)
Patil AA,Cai Y,Sang Y,Blecha F,Zhang G

Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells.
Development (Cambridge, England)132(13)3045-54(2005 Jul)
Bouma GJ,Albrecht KH,Washburn LL,Recknagel AK,Churchill GA,Eicher EM

Using real time RT-PCR analysis to determine multiple gene expression patterns during XX and XY mouse fetal gonad development.
Gene expression patterns : GEP5(1)141-9(2004 Nov)
Bouma GJ,Hart GT,Washburn LL,Recknagel AK,Eicher EM

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Defb19 cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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