| Gene Symbol | RYR2 |
| Entrez Gene ID | 100009536 |
| Full Name | ryanodine receptor 2 |
| Synonyms | RYR-2 |
| Gene Type | protein-coding |
| Organism | Oryctolagus cuniculus(rabbit) |
IVD Raw Materials
ORF » Species Summary » Oryctolagus cuniculus » RYR2 cDNA ORF clone
| Gene Symbol | RYR2 |
| Entrez Gene ID | 100009536 |
| Full Name | ryanodine receptor 2 |
| Synonyms | RYR-2 |
| Gene Type | protein-coding |
| Organism | Oryctolagus cuniculus(rabbit) |
| mRNA | Protein | Name |
|---|---|---|
| NM_001082757.1 | NP_001076226.1 | ryanodine receptor 2 |
A cryo-EM-based model of phosphorylation- and FKBP12.6-mediated allosterism of the cardiac ryanodine receptor.
Dhindwal S, Lobo J, Cabra V, Santiago DJ, Nayak AR, Dryden K, Sams? M
Science signaling10(480)(2017 May)
Two regions of the ryanodine receptor calcium channel are involved in Ca(2+)-dependent inactivation.
Gomez AC, Yamaguchi N
Biochemistry53(8)1373-9(2014 Mar)
Postnatal development of transmural gradients in expression of ion channels and Ca??-handling proteins in the ventricle.
Abd Allah ES, Aslanidi OV, Tellez JO, Yanni J, Billeter R, Zhang H, Dobrzynski H, Boyett MR
Journal of molecular and cellular cardiology53(2)145-55(2012 Aug)
Proteins within the intracellular calcium store determine cardiac RyR channel activity and cardiac output.
Dulhunty AF, Wium E, Li L, Hanna AD, Mirza S, Talukder S, Ghazali NA, Beard NA
Clinical and experimental pharmacology & physiology39(5)477-84(2012 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Study determined the three-dimensional structure of rabbit RyR2 in complex with the regulatory protein FKBP12.6 in the closed state at 11.8 A resolution using cryo-electron microscopy and built an atomic model of RyR2.
Title: A cryo-EM-based model of phosphorylation- and FKBP12.6-mediated allosterism of the cardiac ryanodine receptor.
Two regions of the ryanodine receptor calcium channel are involved in Ca(2+)-dependent inactivation
Title: Two regions of the ryanodine receptor calcium channel are involved in Ca(2+)-dependent inactivation.
There were substantial transmural gradients in Cav1.2, KChIP2, ERG, KvLQT1, Kir2.1, NCX1, SERCA2a and RyR2 at the mRNA and, in some cases, protein level-in every case the mRNA or protein was more abundant in the epicardium than the endocardium.
Title: Postnatal development of transmural gradients in expression of ion channels and Ca??-handling proteins in the ventricle.
[REVIEW] The efficacy of divalent calcium ion (Ca2+) release in the myocardium depends on the amount of Ca2+ loaded into the Ca2+ store and the way in which this Ca2* load influences the activity of the ryanodine receptor Ca2+ release channel (RyR2).
Title: Proteins within the intracellular calcium store determine cardiac RyR channel activity and cardiac output.
comparison of key domains in InsP3 and ryanodine receptors
Title: Structural and functional conservation of key domains in InsP3 and ryanodine receptors.
The following RYR2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RYR2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OOb30169 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001082757.1 | |
| Accession Version | NM_001082757.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 14907bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-30 | |
| Organism | Oryctolagus cuniculus(rabbit) | |
| Product | ryanodine receptor 2 | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U50465.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U50465.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00013651, SAMN03328706 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGCTGATG GGGGCGAAGG CGAGGATGAG ATCCAGTTCC TGCGAACTGA TGATGAAGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001076226.1 |
| CDS | 314..15220 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001082757.1 |
1 | ATGGCTGATG GGGGCGAAGG CGAGGATGAG ATCCAGTTCC TGCGAACTGA TGATGAAGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
A cryo-EM-based model of phosphorylation- and FKBP12.6-mediated allosterism of the cardiac ryanodine receptor. |
Two regions of the ryanodine receptor calcium channel are involved in Ca(2+)-dependent inactivation. |
Postnatal development of transmural gradients in expression of ion channels and Ca??-handling proteins in the ventricle. |
Proteins within the intracellular calcium store determine cardiac RyR channel activity and cardiac output. |