Gene Symbol | Tfr2 |
Entrez Gene ID | 288562 |
Full Name | transferrin receptor 2 |
Synonyms | Trfr2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Tfr2 cDNA ORF clone
gRNAs
Gene Symbol | Tfr2 |
Entrez Gene ID | 288562 |
Full Name | transferrin receptor 2 |
Synonyms | Trfr2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006249116.3 | XP_006249178.1 | transferrin receptor protein 2 isoform X1 |
XM_006249117.2 | XP_006249179.1 | transferrin receptor protein 2 isoform X2 |
XM_008769127.2 | XP_008767349.1 | transferrin receptor protein 2 isoform X3 |
NM_001105916.1 | NP_001099386.1 | transferrin receptor protein 2 |
XM_008769126.1 | XP_008767348.1 | transferrin receptor protein 2 isoform X2 |
XM_008769125.2 | XP_008767347.1 | transferrin receptor protein 2 isoform X2 |
XM_006249118.1 | XP_006249180.1 | transferrin receptor protein 2 isoform X2 |
XM_008769128.2 | XP_008767350.1 | transferrin receptor protein 2 isoform X4 |
Bos taurus (cattle) | TFR2 | NP_001171212.1 |
Rattus norvegicus (Norway rat) | Tfr2 | NP_001099386.1 |
Mus musculus (house mouse) | Tfr2 | NP_056614.3 |
Homo sapiens (human) | TFR2 | NP_003218.2 |
Pan troglodytes (chimpanzee) | TFR2 | XP_003318698.1 |
TFR2 | XP_001113151.1 | |
Canis lupus familiaris (dog) | TFR2 | XP_005621095.1 |
Danio rerio (zebrafish) | tfr2 | NP_001009916.1 |
CD81 promotes both the degradation of transferrin receptor 2 (TfR2) and the Tfr2-mediated maintenance of hepcidin expression.
Chen J, Enns CA
The Journal of biological chemistry290(12)7841-50(2015 Mar)
A novel rat model of hereditary hemochromatosis due to a mutation in transferrin receptor 2.
Bartnikas TB, Wildt SJ, Wineinger AE, Schmitz-Abe K, Markianos K, Cooper DM, Fleming MD
Comparative medicine63(2)143-55(2013 Apr)
Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload.
Vuji? Spasi? M, Sparla R, Mleczko-Sanecka K, Migas MC, Breitkopf-Heinlein K, Dooley S, Vaulont S, Fleming RE, Muckenthaler MU
Biochimica et biophysica acta1832(1)76-84(2013 Jan)
The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation.
D'Alessio F, Hentze MW, Muckenthaler MU
Journal of hepatology57(5)1052-60(2012 Nov)
Comparison of changes in gene expression of transferrin receptor-1 and other iron-regulatory proteins in rat liver and brain during acute-phase response.
Malik IA, Naz N, Sheikh N, Khan S, Moriconi F, Blaschke M, Ramadori G
Cell and tissue research344(2)299-312(2011 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
A mutation with the Tfr2 gene causes hemochromatosis in the rat.
Title: A novel rat model of hereditary hemochromatosis due to a mutation in transferrin receptor 2.
we have discovered a novel mitochondrial iron transport system that goes awry in Parkinson's disease, and which may provide a new target for therapeutic intervention.
Title: A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease.
hemojuvelin and TfR2 were predominantly localized to the basolateral membrane domain of hepatocytes; localization of Hjv and TfR2 at the same membrane domain renders a functional interaction of these two proteins in iron homeostasis possible
Title: Localization of the iron-regulatory proteins hemojuvelin and transferrin receptor 2 to the basolateral membrane domain of hepatocytes.
The following Tfr2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tfr2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa11664 | |
Clone ID Related Accession (Same CDS sequence) | XM_006249117.2 , NM_001105916.1 , XM_008769126.1 , XM_008769125.2 , XM_006249118.1 | |
Accession Version | NM_001105916.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2397bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-05 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | transferrin receptor protein 2 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473973.1. On or before Oct 3, 2007 this sequence version replaced XM_222022.4, XM_001068938.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BC166451.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMN01906355 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGAACAAC GTTGGGGTCT ACTTCGGAAA GTGCAACAGT GGTCCCCAAG ACCCTCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001099386.1 |
CDS | 193..2589 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAACAAC GTTGGGGTCT ACTTCGGAAA GTGCAACAGT GGTCCCCAAG ACCCTCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa11664 | |
Clone ID Related Accession (Same CDS sequence) | XM_006249117.2 , NM_001105916.1 , XM_008769126.1 , XM_008769125.2 , XM_006249118.1 | |
Accession Version | XM_006249117.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2397bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | transferrin receptor protein 2 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006249117.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAACAAC GTTGGGGTCT ACTTCGGAAA GTGCAACAGT GGTCCCCAAG ACCCTCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006249179.1 |
CDS | 159..2555 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAACAAC GTTGGGGTCT ACTTCGGAAA GTGCAACAGT GGTCCCCAAG ACCCTCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa11664 | |
Clone ID Related Accession (Same CDS sequence) | XM_006249117.2 , NM_001105916.1 , XM_008769126.1 , XM_008769125.2 , XM_006249118.1 | |
Accession Version | XM_008769126.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2397bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | transferrin receptor protein 2 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAACAAC GTTGGGGTCT ACTTCGGAAA GTGCAACAGT GGTCCCCAAG ACCCTCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_008767348.1 |
CDS | 104..2500 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAACAAC GTTGGGGTCT ACTTCGGAAA GTGCAACAGT GGTCCCCAAG ACCCTCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa11664 | |
Clone ID Related Accession (Same CDS sequence) | XM_006249117.2 , NM_001105916.1 , XM_008769126.1 , XM_008769125.2 , XM_006249118.1 | |
Accession Version | XM_008769125.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2397bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | transferrin receptor protein 2 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008769125.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAACAAC GTTGGGGTCT ACTTCGGAAA GTGCAACAGT GGTCCCCAAG ACCCTCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_008767347.1 |
CDS | 269..2665 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAACAAC GTTGGGGTCT ACTTCGGAAA GTGCAACAGT GGTCCCCAAG ACCCTCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa11664 | |
Clone ID Related Accession (Same CDS sequence) | XM_006249117.2 , NM_001105916.1 , XM_008769126.1 , XM_008769125.2 , XM_006249118.1 | |
Accession Version | XM_006249118.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2397bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | transferrin receptor protein 2 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAACAAC GTTGGGGTCT ACTTCGGAAA GTGCAACAGT GGTCCCCAAG ACCCTCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006249180.1 |
CDS | 164..2560 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAACAAC GTTGGGGTCT ACTTCGGAAA GTGCAACAGT GGTCCCCAAG ACCCTCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa34745 | |
Clone ID Related Accession (Same CDS sequence) | XM_006249116.3 | |
Accession Version | XM_006249116.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2517bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | transferrin receptor protein 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006249116.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGTCCAAG AAATCCAGAG ACCTGTTGCT GAGTTGAACT TGGCTGCTGT GTCTTCCCAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006249178.1 |
CDS | 22..2538 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGTCCAAG AAATCCAGAG ACCTGTTGCT GAGTTGAACT TGGCTGCTGT GTCTTCCCAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa44698 | |
Clone ID Related Accession (Same CDS sequence) | XM_008769127.2 | |
Accession Version | XM_008769127.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2289bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | transferrin receptor protein 2 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008769127.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGTCCAAG AAATCCAGAG ACCTGTTGCT GAGTTGAACT TGGCTGCTGT GTCTTCCCAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_008767349.1 |
CDS | 22..2310 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGTCCAAG AAATCCAGAG ACCTGTTGCT GAGTTGAACT TGGCTGCTGT GTCTTCCCAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa44699 | |
Clone ID Related Accession (Same CDS sequence) | XM_008769128.2 | |
Accession Version | XM_008769128.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2256bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | transferrin receptor protein 2 isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008769128.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGTCCAAG AAATCCAGAG ACCTGTTGCT GAGTTGAACT TGGCTGCTGT GTCTTCCCAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_008767350.1 |
CDS | 22..2277 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGTCCAAG AAATCCAGAG ACCTGTTGCT GAGTTGAACT TGGCTGCTGT GTCTTCCCAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CD81 promotes both the degradation of transferrin receptor 2 (TfR2) and the Tfr2-mediated maintenance of hepcidin expression. |
A novel rat model of hereditary hemochromatosis due to a mutation in transferrin receptor 2. |
Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload. |
The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation. |
Comparison of changes in gene expression of transferrin receptor-1 and other iron-regulatory proteins in rat liver and brain during acute-phase response. |