Gene Symbol | Spint2 |
Entrez Gene ID | 292770 |
Full Name | serine peptidase inhibitor, Kunitz type, 2 |
Synonyms | HAI-2,Pb |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Spint2 cDNA ORF clone
Gene Symbol | Spint2 |
Entrez Gene ID | 292770 |
Full Name | serine peptidase inhibitor, Kunitz type, 2 |
Synonyms | HAI-2,Pb |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001082549.1 | NP_001076018.1 | kunitz-type protease inhibitor 2 isoform a precursor |
NM_199087.1 | NP_954518.1 | kunitz-type protease inhibitor 2 isoform b precursor |
SPINT2 | XP_001106508.1 | |
Mus musculus (house mouse) | Spint2 | NP_035594.1 |
Xenopus tropicalis (tropical clawed frog) | spint2 | NP_001039077.1 |
Bos taurus (cattle) | SPINT2 | NP_001039436.1 |
Canis lupus familiaris (dog) | SPINT2 | XP_853537.1 |
Rattus norvegicus (Norway rat) | Spint2 | NP_001076018.1 |
Danio rerio (zebrafish) | spint2 | NP_001070718.2 |
Homo sapiens (human) | SPINT2 | NP_066925.1 |
Hepatocyte growth factor activator inhibitor-1 is induced by bone morphogenetic proteins and regulates proliferation and cell fate of neural progenitor cells.
Koivuniemi R, M?kel? J, Hokkanen ME, Bruelle C, Ho TH, Ola R, Korhonen L, Schr?der J, Kataoka H, Lindholm D
PloS one8(2)e56117(2013)
Persistent elevation of hepatocyte growth factor activator inhibitors in cholangiopathies affects liver fibrosis and differentiation.
Huang HP, Chang MH, Chen YT, Hsu HY, Chiang CL, Cheng TS, Wu YM, Wu MZ, Hsu YC, Shen CC, Lee CN, Chuang YH, Hong CL, Jeng YM, Chen PH, Chen HL, Lee MS
Hepatology (Baltimore, Md.)55(1)161-72(2012 Jan)
Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice.
Szabo R, Hobson JP, Christoph K, Kosa P, List K, Bugge TH
Development (Cambridge, England)136(15)2653-63(2009 Aug)
Mutations in SPINT2 cause a syndromic form of congenital sodium diarrhea.
Heinz-Erian P, M?ller T, Krabichler B, Schranz M, Becker C, R?schendorf F, N?rnberg P, Rossier B, Vujic M, Booth IW, Holmberg C, Wijmenga C, Grigelioniene G, Kneepkens CM, Rosipal S, Mistrik M, Kappler M, Michaud L, D?czy LC, Siu VM, Krantz M, Zoller H, Utermann G, Janecke AR
American journal of human genetics84(2)188-96(2009 Feb)
Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes.
Itoh H, Kataoka H, Yamauchi M, Naganuma S, Akiyama Y, Nuki Y, Shimomura T, Miyazawa K, Kitamura N, Koono M
Biochemical and biophysical research communications288(2)390-9(2001 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The following Spint2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Spint2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa04836 | |
Clone ID Related Accession (Same CDS sequence) | NM_199087.1 | |
Accession Version | NM_199087.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-30 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | kunitz-type protease inhibitor 2 isoform b precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC061768.1. On Jan 1, 2004 this sequence version replaced XM_214891.2. ##Evidence-Data-START## Transcript exon combination :: BC061768.1, EV776248.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGCAGC TATGTGAGCC GCGGCGGGGC CGGGCGCTTC TCGCCCTGTT AGCCTCGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_954518.1 |
CDS | 286..867 |
Translation |
Target ORF information:
Target ORF information:
|
NM_199087.1 |
1 | ATGGCGCAGC TATGTGAGCC GCGGCGGGGC CGGGCGCTTC TCGCCCTGTT AGCCTCGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa10871 | |
Clone ID Related Accession (Same CDS sequence) | NM_001082549.1 | |
Accession Version | NM_001082549.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 753bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-01 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | kunitz-type protease inhibitor 2 isoform a precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DN934634.1 and BC061768.1. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGCAGC TATGTGAGCC GCGGCGGGGC CGGGCGCTTC TCGCCCTGTT AGCCTCGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001076018.1 |
CDS | 286..1038 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001082549.1 |
1 | ATGGCGCAGC TATGTGAGCC GCGGCGGGGC CGGGCGCTTC TCGCCCTGTT AGCCTCGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Hepatocyte growth factor activator inhibitor-1 is induced by bone morphogenetic proteins and regulates proliferation and cell fate of neural progenitor cells. |
Persistent elevation of hepatocyte growth factor activator inhibitors in cholangiopathies affects liver fibrosis and differentiation. |
Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice. |
Mutations in SPINT2 cause a syndromic form of congenital sodium diarrhea. |
Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes. |