Hsp90aa1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Gene Symbol	Hsp90aa1
Entrez Gene ID	299331
Full Name	heat shock protein 90, alpha (cytosolic), class A member 1
Synonyms	Hsp86,Hsp90,Hspca
General protein information	Preferred Names heat shock protein 90, alpha (cytosolic), class A member 1 Names heat shock protein HSP 90-alpha HSP 86 heat shock 86 kDa heat shock protein 1, alpha heat shock protein 86
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q32
Summary	a molecular chaperone; involved in sequestering damaged proteins and in ATP-dependent folding of proteins [RGD, Feb 2006].

mRNA and Protein(s)

mRNA Protein Name

NM_175761.2 NP_786937.1 heat shock protein HSP 90-alpha
Pathways from BioSystems

mRNA	Protein	Name
NM_175761.2	NP_786937.1	heat shock protein HSP 90-alpha

Homologies

Canis lupus familiaris (dog)	HSP90AA1	XP_005623992.1
Arabidopsis thaliana (thale cress)	HSP81-3	NP_200412.1
Arabidopsis thaliana (thale cress)	HSP81-2	NP_200414.1
Oryza sativa (rice)	Os09g0482100	NP_001063500.1
	HSP90AA1	XP_002805263.1
Arabidopsis thaliana (thale cress)	Hsp81.4	NP_200411.1
Oryza sativa (rice)	Os09g0482400	NP_001063503.1
Pan troglodytes (chimpanzee)	HSP90AA1	NP_001092042.1
Mus musculus (house mouse)	Hsp90aa1	NP_034610.1
Rattus norvegicus (Norway rat)	Hsp90aa1	NP_786937.1
Bos taurus (cattle)	HSP90AA1	NP_001012688.1
Gallus gallus (chicken)	HSP90AA1	NP_001103255.1
Oryza sativa (rice)	Os09g0482610	NP_001175894.1
Homo sapiens (human)	HSP90AA1	NP_001017963.2
Danio rerio (zebrafish)	hsp90aa1.2	NP_001038538.1
Danio rerio (zebrafish)	hsp90aa1.1	NP_571403.1
Xenopus tropicalis (tropical clawed frog)	hsp90aa1.1	NP_001016282.1

Gene Ontology
Bibliography

Related articles in PubMed

Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.
Woodford MR, Sager RA, Marris E, Dunn DM, Blanden AR, Murphy RL, Rensing N, Shapiro O, Panaretou B, Prodromou C, Loh SN, Gutmann DH, Bourboulia D, Bratslavsky G, Wong M, Mollapour M
The EMBO journal36(24)3650-3665(2017 12)

Antipsychotics promote GABAergic interneuron genesis in the adult rat brain: Role of heat-shock protein production.
Kaneta H, Ukai W, Tsujino H, Furuse K, Kigawa Y, Tayama M, Ishii T, Hashimoto E, Kawanishi C
Journal of psychiatric research92108-118(2017 Sep)

Myocyte-Derived Hsp90 Modulates Collagen Upregulation via Biphasic Activation of STAT-3 in Fibroblasts during Cardiac Hypertrophy.
Datta R, Bansal T, Rana S, Datta K, Datta Chaudhuri R, Chawla-Sarkar M, Sarkar S
Molecular and cellular biology37(6)(2017 Mar)

Calpain-1 resident in lipid raft/caveolin-1 membrane microdomains plays a protective role in endothelial cells.
Martines A, Stifanese R, Faelli EL, Perasso L, Melloni I, Ruggeri P, Averna M
Biochimie13320-27(2017 Feb)

Novel Functional Role of Heat Shock Protein 90 in Mitochondrial Connexin 43-Mediated Hypoxic Postconditioning.
Tu RH, Li QJ, Huang Z, He Y, Meng JJ, Zheng HL, Zeng ZY, Zhong GQ
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology44(3)982-997(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

myocyte-derived exosomes and myocyte-secreted IL-6 are responsible in unison for the biphasic activation of STAT-3 signaling in cardiac fibroblasts that culminates in excess collagen synthesis, leading to severely compromised cardiac function during cardiac hypertrophy.
Title: Myocyte-Derived Hsp90 Modulates Collagen Upregulation via Biphasic Activation of STAT-3 in Fibroblasts during Cardiac Hypertrophy.

hese results suggest that the protein adjustments observed in lipid raft/caveolin-1 microdomains could be visualized as a process required to protect the cells against NO overproduction and aberrant calpain activation. Alterations in eNOS, calpain-1 and HSP90 levels have been observed in aorta of Zucker Diabetic Rats (ZDR).
Title: Calpain-1 resident in lipid raft/caveolin-1 membrane microdomains plays a protective role in endothelial cells.

Blocking the function of HSP90 with the HSP90 inhibitor geldanamycin or siRNA targeting HSP90 prevented the protection of HPC and the HPC-induced association of Cx43, indicating that mitochondrial HSP90 was important for mitochondrial translocation of Cx43 during HPC.
Title: Novel Functional Role of Heat Shock Protein 90 in Mitochondrial Connexin 43-Mediated Hypoxic Postconditioning.

adenosine-induced translocation of PKCepsilon to mitochondria is mediated by a caveolin-3-dependent mechanism and this process is age-related, possibly in part, through regulation of HSP90 and TOM70 expression
Title: Regulation of protein kinase C-epsilon and its age-dependence.

These results reveal that Hsp90aa1 is a novel target of miR-1, and repression of miR-1 may contribute to the recovery of Hsp90aa1 during myocardial ischemia/reperfusion.
Title: Hsp90aa1: a novel target gene of miR-1 in cardiac ischemia/reperfusion injury.

The following Hsp90aa1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hsp90aa1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13487	NM_175761.2 Latest version!	Rattus norvegicus heat shock protein 90 alpha family class A member 1 (Hsp90aa1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hsp90aa1 ( NM_175761.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_786937.1 Rattus norvegicus heat shock protein 90 alpha family class A member 1 (Hsp90aa1), mRNA.

Price & Availability↑

CloneID	ORa13487
Clone ID Related Accession (Same CDS sequence)	NM_175761.2
Accession Version	NM_175761.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2202bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-14
Organism	Rattus norvegicus(Norway rat)
Product	heat shock protein HSP 90-alpha
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ428213.1. On Mar 12, 2003 this sequence version replaced NM_175761.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ428213.1, BC072489.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCTGAGG AAACCCAGAC CCAAGACCAA CCAATGGAGG AAGAGGAGGT CGAAACCTTT 
GCCTTTCAGG CAGAAATTGC CCAGTTAATG TCCTTGATCA TCAACACTTT CTACTCGAAC 
AAAGAGATCT TTCTGAGGGA GCTCATTTCC AACTCCTCAG ACGCTCTGGA TAAGATCAGA 
TACGAGAGCT TGACCGACCC TAGTAAACTG GACTCGGGGA AGGAGCTGCA CATTAATCTC 
ATTCCCAACA AGCAAGACCG AACCCTCACT ATTGTGGATA CTGGCATTGG AATGACCAAG 
GCTGACTTGA TCAATAACCT TGGCACTATT GCCAAGTCAG GCACCAAAGC CTTCATGGAG 
GCTTTGCAGG CTGGTGCAGA TATCTCTATG ATTGGCCAGT TTGGTGTTGG TTTTTACTCT 
GCGTATTTGG TTGCTGAGAA AGTGACTGTC ATCACCAAGC ATAATGATGA CGAGCAGTAC 
GCCTGGGAGT CCTCAGCTGG AGGATCCTTC ACTGTGAGGA CAGACACAGG TGAACCAATG 
GGTCGTGGAA CAAAGGTTAT CTTGCATCTA AAAGAAGACC AAACTGAGTA TTTGGAGGAA 
AGGAGAATAA AAGAAATTGT GAAGAAACAT TCTCAGTTTA TTGGCTACCC CATTACTCTC 
TTTGTGGAGA AGGAACGTGA CAAGGAAGTC AGTGATGATG AGGCTGAAGA AAAGGAAGAG 
AAAGAGGAAG AGAAAGAAAA AGAAGAAAAG GAGTCTGATG ACAAGCCTGA AATAGAAGAT 
GTTGGTTCTG ATGAAGAAGA AGAAGAGAAG AAGGATGGTG ACAAGAAGAA AAAGAAGAAG 
ATAAAGGAAA AGTACATTGA TCAAGAAGAA CTCAACAAAA CAAAGCCGAT CTGGACCAGA 
AATCCTGATG ACATTACGAA TGAAGAATAC GGAGAGTTCT ACAAGAGCTT AACCAACGAC 
TGGGAAGAAC ATTTGGCAGT AAAGCATTTT TCTGTTGAAG GACAATTAGA ATTCCGGGCT 
CTTCTTTTTG TCCCAAGACG CGCTCCTTTT GATCTATTTG AAAACAGAAA GAAAAAGAAC 
AACATCAAGT TGTATGTTCG CAGAGTTTTT ATCATGGATA ACTGTGAGGA GTTAATCCCC 
GAGTATCTGA ATTTCATCAG AGGGGTGGTG GATTCTGAGG ATCTCCCTCT AAATATTTCC 
CGTGAAATGC TGCAACAAAG CAAAATTCTG AAAGTTATCA GGAAGAATTT GGTCAAGAAA 
TGCCTAGAAC TATTTACTGA ACTGGCTGAA GATAAAGAGA ACTACAAAAA GTTTTATGAG 
CAGTTCTCAA AAAATATAAA GCTTGGAATT CATGAAGACT CTCAAAATCG GAAGAAGCTT 
TCAGAGCTGT TGAGATACTA CACATCTGCT TCTGGGGATG AGATGGTTTC TCTGAAGGAC 
TACTGCACCA GAATGAAGGA AAACCAGAAG CACATCTATT TTATCACAGG TGAGACCAAG 
GACCAGGTTG CTAACTCAGC CTTTGTGGAA CGTCTCCGAA AGCATGGCTT AGAAGTAATC 
TATATGATTG AGCCCATTGA TGAGTATTGT GTGCAACAGC TGAAGGAATT TGAGGGCAAG 
ACCTTGGTGT CAGTTACCAA AGAAGGACTG GAACTTCCAG AAGATGAAGA GGAAAAGAAG 
AAACAGGAAG AGAAAAAGAC AAAATTTGAG AACCTCTGCA AAATTATGAA GGATATTTTA 
GAGAAAAAGG TTGAAAAGGT GGTTGTGTCA AACCGATTGG TGACATCCCC ATGCTGTATT 
GTCACAAGCA CATATGGCTG GACAGCAAAC ATGGAGAGAA TCATGAAAGC TCAAGCCCTC 
AGAGACAACT CAACAATGGG TTACATGGCA GCAAAGAAAC ACCTGGAGAT AAACCCTGAT 
CACTCCATTA TTGAAACCTT AAGGCAAAAG GCAGAGGCTG ACAAGAATGA CAAGTCTGTG 
AAAGATCTGG TCATCTTGCT GTACGAAACA GCACTCCTGT CTTCCGGCTT CAGTCTGGAA 
GATCCCCAGA CCCATGCTAA CAGGATCTAC AGGATGATCA AGCTTGGTCT AGGTATTGAT 
GAGGATGATC CTACTGTGGA TGATACCAGT GCTGCTGTAA CTGAAGAAAT GCCACCCCTG 
GAAGGAGATG ATGACACATC ACGCATGGAA GAAGTAGACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_786937.1
CDS	59..2260
Translation	MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEEKEEEKEKEEKESDDKPEIEDVGSDEEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEEHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYFITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTVDDTSAAVTEEMPPLEGDDDTSRMEEVD

Target ORF information:

RefSeq Version	NM_175761.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus heat shock protein 90 alpha family class A member 1 (Hsp90aa1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175761.2

ORF Insert Sequence:

ATGCCTGAGG AAACCCAGAC CCAAGACCAA CCAATGGAGG AAGAGGAGGT CGAAACCTTT 
GCCTTTCAGG CAGAAATTGC CCAGTTAATG TCCTTGATCA TCAACACTTT CTACTCGAAC 
AAAGAGATCT TTCTGAGGGA GCTCATTTCC AACTCCTCAG ACGCTCTGGA TAAGATCAGA 
TACGAGAGCT TGACCGACCC TAGTAAACTG GACTCGGGGA AGGAGCTGCA CATTAATCTC 
ATTCCCAACA AGCAAGACCG AACCCTCACT ATTGTGGATA CTGGCATTGG AATGACCAAG 
GCTGACTTGA TCAATAACCT TGGCACTATT GCCAAGTCAG GCACCAAAGC CTTCATGGAG 
GCTTTGCAGG CTGGTGCAGA TATCTCTATG ATTGGCCAGT TTGGTGTTGG TTTTTACTCT 
GCGTATTTGG TTGCTGAGAA AGTGACTGTC ATCACCAAGC ATAATGATGA CGAGCAGTAC 
GCCTGGGAGT CCTCAGCTGG AGGATCCTTC ACTGTGAGGA CAGACACAGG TGAACCAATG 
GGTCGTGGAA CAAAGGTTAT CTTGCATCTA AAAGAAGACC AAACTGAGTA TTTGGAGGAA 
AGGAGAATAA AAGAAATTGT GAAGAAACAT TCTCAGTTTA TTGGCTACCC CATTACTCTC 
TTTGTGGAGA AGGAACGTGA CAAGGAAGTC AGTGATGATG AGGCTGAAGA AAAGGAAGAG 
AAAGAGGAAG AGAAAGAAAA AGAAGAAAAG GAGTCTGATG ACAAGCCTGA AATAGAAGAT 
GTTGGTTCTG ATGAAGAAGA AGAAGAGAAG AAGGATGGTG ACAAGAAGAA AAAGAAGAAG 
ATAAAGGAAA AGTACATTGA TCAAGAAGAA CTCAACAAAA CAAAGCCGAT CTGGACCAGA 
AATCCTGATG ACATTACGAA TGAAGAATAC GGAGAGTTCT ACAAGAGCTT AACCAACGAC 
TGGGAAGAAC ATTTGGCAGT AAAGCATTTT TCTGTTGAAG GACAATTAGA ATTCCGGGCT 
CTTCTTTTTG TCCCAAGACG CGCTCCTTTT GATCTATTTG AAAACAGAAA GAAAAAGAAC 
AACATCAAGT TGTATGTTCG CAGAGTTTTT ATCATGGATA ACTGTGAGGA GTTAATCCCC 
GAGTATCTGA ATTTCATCAG AGGGGTGGTG GATTCTGAGG ATCTCCCTCT AAATATTTCC 
CGTGAAATGC TGCAACAAAG CAAAATTCTG AAAGTTATCA GGAAGAATTT GGTCAAGAAA 
TGCCTAGAAC TATTTACTGA ACTGGCTGAA GATAAAGAGA ACTACAAAAA GTTTTATGAG 
CAGTTCTCAA AAAATATAAA GCTTGGAATT CATGAAGACT CTCAAAATCG GAAGAAGCTT 
TCAGAGCTGT TGAGATACTA CACATCTGCT TCTGGGGATG AGATGGTTTC TCTGAAGGAC 
TACTGCACCA GAATGAAGGA AAACCAGAAG CACATCTATT TTATCACAGG TGAGACCAAG 
GACCAGGTTG CTAACTCAGC CTTTGTGGAA CGTCTCCGAA AGCATGGCTT AGAAGTAATC 
TATATGATTG AGCCCATTGA TGAGTATTGT GTGCAACAGC TGAAGGAATT TGAGGGCAAG 
ACCTTGGTGT CAGTTACCAA AGAAGGACTG GAACTTCCAG AAGATGAAGA GGAAAAGAAG 
AAACAGGAAG AGAAAAAGAC AAAATTTGAG AACCTCTGCA AAATTATGAA GGATATTTTA 
GAGAAAAAGG TTGAAAAGGT GGTTGTGTCA AACCGATTGG TGACATCCCC ATGCTGTATT 
GTCACAAGCA CATATGGCTG GACAGCAAAC ATGGAGAGAA TCATGAAAGC TCAAGCCCTC 
AGAGACAACT CAACAATGGG TTACATGGCA GCAAAGAAAC ACCTGGAGAT AAACCCTGAT 
CACTCCATTA TTGAAACCTT AAGGCAAAAG GCAGAGGCTG ACAAGAATGA CAAGTCTGTG 
AAAGATCTGG TCATCTTGCT GTACGAAACA GCACTCCTGT CTTCCGGCTT CAGTCTGGAA 
GATCCCCAGA CCCATGCTAA CAGGATCTAC AGGATGATCA AGCTTGGTCT AGGTATTGAT 
GAGGATGATC CTACTGTGGA TGATACCAGT GCTGCTGTAA CTGAAGAAAT GCCACCCCTG 
GAAGGAGATG ATGACACATC ACGCATGGAA GAAGTAGACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.
The EMBO journal36(24)3650-3665(2017 12)
Woodford MR,Sager RA,Marris E,Dunn DM,Blanden AR,Murphy RL,Rensing N,Shapiro O,Panaretou B,Prodromou C,Loh SN,Gutmann DH,Bourboulia D,Bratslavsky G,Wong M,Mollapour M

Antipsychotics promote GABAergic interneuron genesis in the adult rat brain: Role of heat-shock protein production.
Journal of psychiatric research92108-118(2017 Sep)
Kaneta H,Ukai W,Tsujino H,Furuse K,Kigawa Y,Tayama M,Ishii T,Hashimoto E,Kawanishi C

Myocyte-Derived Hsp90 Modulates Collagen Upregulation via Biphasic Activation of STAT-3 in Fibroblasts during Cardiac Hypertrophy.
Molecular and cellular biology37(6)(2017 Mar)
Datta R,Bansal T,Rana S,Datta K,Datta Chaudhuri R,Chawla-Sarkar M,Sarkar S

Calpain-1 resident in lipid raft/caveolin-1 membrane microdomains plays a protective role in endothelial cells.
Biochimie13320-27(2017 Feb)
Martines A,Stifanese R,Faelli EL,Perasso L,Melloni I,Ruggeri P,Averna M

Novel Functional Role of Heat Shock Protein 90 in Mitochondrial Connexin 43-Mediated Hypoxic Postconditioning.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology44(3)982-997(2017)
Tu RH,Li QJ,Huang Z,He Y,Meng JJ,Zheng HL,Zeng ZY,Zhong GQ

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Hsp90aa1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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