Hsp90aa1 cDNA ORF clone, Rattus norvegicus(Norway rat)
| Gene Symbol | Hsp90aa1 |
| Entrez Gene ID | 299331 |
| Full Name | heat shock protein 90, alpha (cytosolic), class A member 1 |
| Synonyms | Hsp86,Hsp90,Hspca |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | a molecular chaperone; involved in sequestering damaged proteins and in ATP-dependent folding of proteins [RGD, Feb 2006]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_175761.2 | NP_786937.1 | heat shock protein HSP 90-alpha |
| Canis lupus familiaris (dog) | HSP90AA1 | XP_005623992.1 |
| Arabidopsis thaliana (thale cress) | HSP81-3 | NP_200412.1 |
| Arabidopsis thaliana (thale cress) | HSP81-2 | NP_200414.1 |
| Oryza sativa (rice) | Os09g0482100 | NP_001063500.1 |
| HSP90AA1 | XP_002805263.1 | |
| Arabidopsis thaliana (thale cress) | Hsp81.4 | NP_200411.1 |
| Oryza sativa (rice) | Os09g0482400 | NP_001063503.1 |
| Pan troglodytes (chimpanzee) | HSP90AA1 | NP_001092042.1 |
| Mus musculus (house mouse) | Hsp90aa1 | NP_034610.1 |
| Rattus norvegicus (Norway rat) | Hsp90aa1 | NP_786937.1 |
| Bos taurus (cattle) | HSP90AA1 | NP_001012688.1 |
| Gallus gallus (chicken) | HSP90AA1 | NP_001103255.1 |
| Oryza sativa (rice) | Os09g0482610 | NP_001175894.1 |
| Homo sapiens (human) | HSP90AA1 | NP_001017963.2 |
| Danio rerio (zebrafish) | hsp90aa1.2 | NP_001038538.1 |
| Danio rerio (zebrafish) | hsp90aa1.1 | NP_571403.1 |
| Xenopus tropicalis (tropical clawed frog) | hsp90aa1.1 | NP_001016282.1 |
Related articles in PubMed
Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.
Woodford MR, Sager RA, Marris E, Dunn DM, Blanden AR, Murphy RL, Rensing N, Shapiro O, Panaretou B, Prodromou C, Loh SN, Gutmann DH, Bourboulia D, Bratslavsky G, Wong M, Mollapour M
The EMBO journal36(24)3650-3665(2017 12)
Antipsychotics promote GABAergic interneuron genesis in the adult rat brain: Role of heat-shock protein production.
Kaneta H, Ukai W, Tsujino H, Furuse K, Kigawa Y, Tayama M, Ishii T, Hashimoto E, Kawanishi C
Journal of psychiatric research92108-118(2017 Sep)
Myocyte-Derived Hsp90 Modulates Collagen Upregulation via Biphasic Activation of STAT-3 in Fibroblasts during Cardiac Hypertrophy.
Datta R, Bansal T, Rana S, Datta K, Datta Chaudhuri R, Chawla-Sarkar M, Sarkar S
Molecular and cellular biology37(6)(2017 Mar)
Calpain-1 resident in lipid raft/caveolin-1 membrane microdomains plays a protective role in endothelial cells.
Martines A, Stifanese R, Faelli EL, Perasso L, Melloni I, Ruggeri P, Averna M
Biochimie13320-27(2017 Feb)
Novel Functional Role of Heat Shock Protein 90 in Mitochondrial Connexin 43-Mediated Hypoxic Postconditioning.
Tu RH, Li QJ, Huang Z, He Y, Meng JJ, Zheng HL, Zeng ZY, Zhong GQ
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology44(3)982-997(2017)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
myocyte-derived exosomes and myocyte-secreted IL-6 are responsible in unison for the biphasic activation of STAT-3 signaling in cardiac fibroblasts that culminates in excess collagen synthesis, leading to severely compromised cardiac function during cardiac hypertrophy.
Title: Myocyte-Derived Hsp90 Modulates Collagen Upregulation via Biphasic Activation of STAT-3 in Fibroblasts during Cardiac Hypertrophy.
hese results suggest that the protein adjustments observed in lipid raft/caveolin-1 microdomains could be visualized as a process required to protect the cells against NO overproduction and aberrant calpain activation. Alterations in eNOS, calpain-1 and HSP90 levels have been observed in aorta of Zucker Diabetic Rats (ZDR).
Title: Calpain-1 resident in lipid raft/caveolin-1 membrane microdomains plays a protective role in endothelial cells.
Blocking the function of HSP90 with the HSP90 inhibitor geldanamycin or siRNA targeting HSP90 prevented the protection of HPC and the HPC-induced association of Cx43, indicating that mitochondrial HSP90 was important for mitochondrial translocation of Cx43 during HPC.
Title: Novel Functional Role of Heat Shock Protein 90 in Mitochondrial Connexin 43-Mediated Hypoxic Postconditioning.
adenosine-induced translocation of PKCepsilon to mitochondria is mediated by a caveolin-3-dependent mechanism and this process is age-related, possibly in part, through regulation of HSP90 and TOM70 expression
Title: Regulation of protein kinase C-epsilon and its age-dependence.
These results reveal that Hsp90aa1 is a novel target of miR-1, and repression of miR-1 may contribute to the recovery of Hsp90aa1 during myocardial ischemia/reperfusion.
Title: Hsp90aa1: a novel target gene of miR-1 in cardiac ischemia/reperfusion injury.
The following Hsp90aa1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hsp90aa1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa13487 | |
| Clone ID Related Accession (Same CDS sequence) | NM_175761.2 | |
| Accession Version | NM_175761.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2202bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-11-14 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | heat shock protein HSP 90-alpha | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ428213.1. On Mar 12, 2003 this sequence version replaced NM_175761.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ428213.1, BC072489.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGCCTGAGG AAACCCAGAC CCAAGACCAA CCAATGGAGG AAGAGGAGGT CGAAACCTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_786937.1 |
| CDS | 59..2260 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_175761.2 |
ORF Insert Sequence:
1 | ATGCCTGAGG AAACCCAGAC CCAAGACCAA CCAATGGAGG AAGAGGAGGT CGAAACCTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients. |
|
Antipsychotics promote GABAergic interneuron genesis in the adult rat brain: Role of heat-shock protein production. |
|
Myocyte-Derived Hsp90 Modulates Collagen Upregulation via Biphasic Activation of STAT-3 in Fibroblasts during Cardiac Hypertrophy. |
|
Calpain-1 resident in lipid raft/caveolin-1 membrane microdomains plays a protective role in endothelial cells. |
|
Novel Functional Role of Heat Shock Protein 90 in Mitochondrial Connexin 43-Mediated Hypoxic Postconditioning. |