Fscn2 cDNA ORF clone, Rattus norvegicus(Norway rat)
| Gene Symbol | Fscn2 |
| Entrez Gene ID | 303741 |
| Full Name | fascin actin-bundling protein 2, retinal |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_001107072.1 | NP_001100542.1 | fascin-2 |
| XM_008768476.2 | XP_008766698.1 | fascin-2 isoform X1 |
| Canis lupus familiaris (dog) | FSCN2 | XP_003435223.1 |
| Rattus norvegicus (Norway rat) | Fscn2 | NP_001100542.1 |
| Drosophila melanogaster (fruit fly) | sn | NP_001162696.1 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP012991 | XP_003437121.1 |
| Pan troglodytes (chimpanzee) | FSCN2 | XP_003953273.1 |
| Gallus gallus (chicken) | FSCN2 | NP_001171209.1 |
| Danio rerio (zebrafish) | fscn2a | NP_001116988.1 |
| Homo sapiens (human) | FSCN2 | NP_001070650.1 |
| FSCN2 | XP_001110926.2 | |
| Mus musculus (house mouse) | Fscn2 | NP_766390.2 |
| Danio rerio (zebrafish) | fscn2b | NP_957064.2 |
| Xenopus tropicalis (tropical clawed frog) | fscn2 | NP_001093724.1 |
| Bos taurus (cattle) | FSCN2 | NP_788806.1 |
Related articles in PubMed
Fascin2 regulates cisplatin-induced apoptosis in NRK-52E cells.
Wang X, Nichols L, Grunz-Borgmann EA, Sun Z, Meininger GA, Domeier TL, Baines CP, Parrish AR
Toxicology letters26656-64(2017 Jan)
HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2.
Ramakrishnan NA, Drescher MJ, Khan KM, Hatfield JS, Drescher DG
The Journal of biological chemistry287(45)37628-46(2012 Nov)
The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice.
Shin JB, Longo-Guess CM, Gagnon LH, Saylor KW, Dumont RA, Spinelli KJ, Pagana JM, Wilmarth PA, David LL, Gillespie PG, Johnson KR
The Journal of neuroscience : the official journal of the Society for Neuroscience30(29)9683-94(2010 Jul)
Targeted disruption of FSCN2 gene induces retinopathy in mice.
Yokokura S, Wada Y, Nakai S, Sato H, Yao R, Yamanaka H, Ito S, Sagara Y, Takahashi M, Nakamura Y, Tamai M, Noda T
Investigative ophthalmology & visual science46(8)2905-15(2005 Aug)
Mutation of human retinal fascin gene (FSCN2) causes autosomal dominant retinitis pigmentosa.
Wada Y, Abe T, Takeshita T, Sato H, Yanashima K, Tamai M
Investigative ophthalmology & visual science42(10)2395-400(2001 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These data demonstrate that fascin2, a putative target of alpha(E)-catenin, may play important role in preventing cisplatin-induced acute kidney injury.
Title: Fascin2 regulates cisplatin-induced apoptosis in NRK-52E cells.
The following Fscn2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fscn2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa13736 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001107072.1 | |
| Accession Version | NM_001107072.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1479bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2018-05-27 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | fascin-2 | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473948.1. On or before Oct 4, 2007 this sequence version replaced XM_221196.3, XM_001081803.1. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGCCAACCA ACGGCTTGCA CCAGGTGCTG AAGATCCAGT TTGGCCTTGT GAACGATGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001100542.1 |
| CDS | 169..1647 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001107072.1 |
ORF Insert Sequence:
1 | ATGCCAACCA ACGGCTTGCA CCAGGTGCTG AAGATCCAGT TTGGCCTTGT GAACGATGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa46069 | |
| Clone ID Related Accession (Same CDS sequence) | XM_008768476.2 | |
| Accession Version | XM_008768476.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1548bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | fascin-2 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008768476.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGCCAACCA ACGGCTTGCA CCAGGTGCTG AAGATCCAGT TTGGCCTTGT GAACGATGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_008766698.1 |
| CDS | 5349..6896 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_008768476.2 |
ORF Insert Sequence:
1 | ATGCCAACCA ACGGCTTGCA CCAGGTGCTG AAGATCCAGT TTGGCCTTGT GAACGATGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Fascin2 regulates cisplatin-induced apoptosis in NRK-52E cells. |
|
HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2. |
|
The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice. |
|
Targeted disruption of FSCN2 gene induces retinopathy in mice. |
|
Mutation of human retinal fascin gene (FSCN2) causes autosomal dominant retinitis pigmentosa. |