Ankrd2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Gene Symbol	Ankrd2
Entrez Gene ID	309374
Full Name	ankyrin repeat domain 2
General protein information	Preferred Names ankyrin repeat domain 2 Names ankyrin repeat domain-containing protein 2 ankyrin repeat domain 2 (stretch responsive muscle)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q54

mRNA and Protein(s)

mRNA Protein Name

NM_001107589.1 NP_001101059.1 ankyrin repeat domain-containing protein 2
Pathways from BioSystems

mRNA	Protein	Name
NM_001107589.1	NP_001101059.1	ankyrin repeat domain-containing protein 2

Homologies

Bos taurus (cattle)	ANKRD2	XP_003587918.2
Rattus norvegicus (Norway rat)	Ankrd2	NP_001101059.1
Homo sapiens (human)	ANKRD2	NP_065082.2
Mus musculus (house mouse)	Ankrd2	NP_064417.1
	ANKRD2	XP_001095517.2
Pan troglodytes (chimpanzee)	ANKRD2	XP_507964.3
Canis lupus familiaris (dog)	ANKRD2	XP_850948.2
Gallus gallus (chicken)	ANKRD2	XP_004942257.1
Danio rerio (zebrafish)	LOC101886079	XP_005157118.1
Xenopus tropicalis (tropical clawed frog)	ankrd2	NP_001090801.1

Gene Ontology
Bibliography

Related articles in PubMed

Characterization of muscle ankyrin repeat proteins in human skeletal muscle.
Wette SG, Smith HK, Lamb GD, Murphy RM
American journal of physiology. Cell physiology313(3)C327-C339(2017 Sep)

Ankrd2 is a modulator of NF-?B-mediated inflammatory responses during muscle differentiation.
Bean C, Verma NK, Yamamoto DL, Chemello F, Cenni V, Filomena MC, Chen J, Bang ML, Lanfranchi G
Cell death & disease5e1002(2014 Jan)

Ankrd1 is a transcriptional repressor for the androgen receptor that is downregulated by testosterone.
Wu Y, Ruggiero CL, Bauman WA, Cardozo C
Biochemical and biophysical research communications437(3)355-60(2013 Aug)

Ankyrin repeat domain protein 2 and inhibitor of DNA binding 3 cooperatively inhibit myoblast differentiation by physical interaction.
Mohamed JS, Lopez MA, Cox GA, Boriek AM
The Journal of biological chemistry288(34)24560-8(2013 Aug)

Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation.
Rajan S, Chu Pham Dang H, Djambazian H, Zuzan H, Fedyshyn Y, Ketela T, Moffat J, Hudson TJ, Sladek R
Physiological genomics44(2)183-97(2012 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data are not consistent with the proposal that Ankrd 2, per se, or pAnkrd 2-Ser99 mediates stretch-induced signaling in skeletal muscle, dissociating from titin and translocating to the nucleus, because the majority of these forms of Ankrd 2 are already free in the cytosol.
Title: Characterization of muscle ankyrin repeat proteins in human skeletal muscle.

Ankrd2 does not bind the human androgen receptor (AR) or alter testosterone-induced changes in reporter gene activity, indicating that it is not a direct transcriptional effector for the AR.
Title: Ankrd1 is a transcriptional repressor for the androgen receptor that is downregulated by testosterone.

assignment of Ankrd2 to rat chromosome 1q51-q53.
Title: Assignment of the murine ankyrin-repeated protein gene (Ankrd2) to mouse chromosome 19C3-->D1 and rat chromosome 1q51-->q53 by fluorescence in situ hybridization.

The following Ankrd2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ankrd2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11326	NM_001107589.1 Latest version!	Rattus norvegicus ankyrin repeat domain 2 (Ankrd2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ankrd2 ( NM_001107589.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101059.1 Rattus norvegicus ankyrin repeat domain 2 (Ankrd2), mRNA.

Price & Availability↑

CloneID	ORa11326
Clone ID Related Accession (Same CDS sequence)	NM_001107589.1
Accession Version	NM_001107589.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 987bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	ankyrin repeat domain-containing protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473986.1. On or before Oct 4, 2007 this sequence version replaced XM_001055096.1, XM_219881.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FQ216123.1, FQ216298.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMEA2689600 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGGTC CCGAGGCTGT GCAGAGAGCC ACAGAGCTCA TCGAGCAGCG GCTTGCCGAG 
GAGGAAGAGA CTGAGAAACT TCGAAGAGCC ACTCCTGGGA AGACGTCCAT GGACATGCTA 
GTGCTAGAGG ACGAGAAGCG CCTCGGGGTG CAGAGTCCTG CTTTACAAAA GGTTAAGGGC 
CAAGAGCGCG TGCGCAAGAC ATCCCTGGAC TTGCGACGTG AGATCATTGA CGTGGGCGGG 
ATCCAGAACC TCATAGAACT GAGGAAAAAA CGCAAGCAGA AAAAGCGAGA TGCCCTTGCC 
GCAGCGCAGG AACCACCTCC GGAGCCGGAG GAGATCACTG GCCCAGTAGA TGAGGAGACA 
TTCCTGAAAG CTGCGGTGGA GGGGAAAATC AAAGTCATTG ACAAGTACCT GGCAGACGGA 
GGTTCGGCAG ACACCTGTGA TGAGTTCCGT CGGACAGCAC TGCATCGGGC CTCCCTGGAG 
GGACACATGG AGATACTGGA GAAACTTCTG GAGAATGGGG CCACCGTGGA CTTCCAGGAT 
CGGCTGGACT GCACAGCCAT GCACTGGGCC TGCCGTGGAG GCCACCTGGA GGTGGTGAAA 
CTCTTGCAAA GTCGGGGGGC CAACACCGAC GTGAGAGACA AGCTACTGAG CACTCCCCTG 
CATGTGGCCG TCCGTACTGG ACACGTGGAG ATTGTGGAAC ATTTTCTCTC CCTGGGCTTG 
GATATCAATG CCAAAGACAG AGAAGGGGAC AGTGCCCTGC ATGATGCCGT GAGACTCAAC 
CGCTACAAAA TCATCAAACT GCTGCTCTTG CATGGGGCAG ACATGATGGC TAAGAATATG 
GCGGGGAAGA CCCCTACCGA CCTGGTCCAG CTGTGGCAAG CAGACACCCG GCATGCCCTG 
GAGCACCCTG AACCAGAATC AGAGCAGAAC GGATTGGAGA GGCCTGGGAG TGGCCGGGAG 
ACACCCCAGC CTGTACCAGC CCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101059.1
CDS	11..997
Translation	MEGPEAVQRATELIEQRLAEEEETEKLRRATPGKTSMDMLVLEDEKRLGVQSPALQKVKGQERVRKTSLDLRREIIDVGGIQNLIELRKKRKQKKRDALAAAQEPPPEPEEITGPVDEETFLKAAVEGKIKVIDKYLADGGSADTCDEFRRTALHRASLEGHMEILEKLLENGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSRGANTDVRDKLLSTPLHVAVRTGHVEIVEHFLSLGLDINAKDREGDSALHDAVRLNRYKIIKLLLLHGADMMAKNMAGKTPTDLVQLWQADTRHALEHPEPESEQNGLERPGSGRETPQPVPAQ

Target ORF information:

RefSeq Version	NM_001107589.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ankyrin repeat domain 2 (Ankrd2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107589.1

ORF Insert Sequence:

ATGGAGGGTC CCGAGGCTGT GCAGAGAGCC ACAGAGCTCA TCGAGCAGCG GCTTGCCGAG 
GAGGAAGAGA CTGAGAAACT TCGAAGAGCC ACTCCTGGGA AGACGTCCAT GGACATGCTA 
GTGCTAGAGG ACGAGAAGCG CCTCGGGGTG CAGAGTCCTG CTTTACAAAA GGTTAAGGGC 
CAAGAGCGCG TGCGCAAGAC ATCCCTGGAC TTGCGACGTG AGATCATTGA CGTGGGCGGG 
ATCCAGAACC TCATAGAACT GAGGAAAAAA CGCAAGCAGA AAAAGCGAGA TGCCCTTGCC 
GCAGCGCAGG AACCACCTCC GGAGCCGGAG GAGATCACTG GCCCAGTAGA TGAGGAGACA 
TTCCTGAAAG CTGCGGTGGA GGGGAAAATC AAAGTCATTG ACAAGTACCT GGCAGACGGA 
GGTTCGGCAG ACACCTGTGA TGAGTTCCGT CGGACAGCAC TGCATCGGGC CTCCCTGGAG 
GGACACATGG AGATACTGGA GAAACTTCTG GAGAATGGGG CCACCGTGGA CTTCCAGGAT 
CGGCTGGACT GCACAGCCAT GCACTGGGCC TGCCGTGGAG GCCACCTGGA GGTGGTGAAA 
CTCTTGCAAA GTCGGGGGGC CAACACCGAC GTGAGAGACA AGCTACTGAG CACTCCCCTG 
CATGTGGCCG TCCGTACTGG ACACGTGGAG ATTGTGGAAC ATTTTCTCTC CCTGGGCTTG 
GATATCAATG CCAAAGACAG AGAAGGGGAC AGTGCCCTGC ATGATGCCGT GAGACTCAAC 
CGCTACAAAA TCATCAAACT GCTGCTCTTG CATGGGGCAG ACATGATGGC TAAGAATATG 
GCGGGGAAGA CCCCTACCGA CCTGGTCCAG CTGTGGCAAG CAGACACCCG GCATGCCCTG 
GAGCACCCTG AACCAGAATC AGAGCAGAAC GGATTGGAGA GGCCTGGGAG TGGCCGGGAG 
ACACCCCAGC CTGTACCAGC CCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Characterization of muscle ankyrin repeat proteins in human skeletal muscle.
American journal of physiology. Cell physiology313(3)C327-C339(2017 Sep)
Wette SG,Smith HK,Lamb GD,Murphy RM

Ankrd2 is a modulator of NF-?B-mediated inflammatory responses during muscle differentiation.
Cell death & disease5e1002(2014 Jan)
Bean C,Verma NK,Yamamoto DL,Chemello F,Cenni V,Filomena MC,Chen J,Bang ML,Lanfranchi G

Ankrd1 is a transcriptional repressor for the androgen receptor that is downregulated by testosterone.
Biochemical and biophysical research communications437(3)355-60(2013 Aug)
Wu Y,Ruggiero CL,Bauman WA,Cardozo C

Ankyrin repeat domain protein 2 and inhibitor of DNA binding 3 cooperatively inhibit myoblast differentiation by physical interaction.
The Journal of biological chemistry288(34)24560-8(2013 Aug)
Mohamed JS,Lopez MA,Cox GA,Boriek AM

Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation.
Physiological genomics44(2)183-97(2012 Feb)
Rajan S,Chu Pham Dang H,Djambazian H,Zuzan H,Fedyshyn Y,Ketela T,Moffat J,Hudson TJ,Sladek R

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Ankrd2 cDNA ORF clone, Rattus norvegicus(Norway rat)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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