| Gene Symbol | Spg7 |
| Entrez Gene ID | 353231 |
| Full Name | SPG7, paraplegin matrix AAA peptidase subunit |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome |
gRNAs
The following Spg7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Spg7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa47647 | |
| Clone ID Related Accession (Same CDS sequence) | XM_008772621.2 | |
| Accession Version | XM_008772621.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1938bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | paraplegin isoform X3 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005118.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008772621.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGTACCGGG AGAGGCTGCG CACCTTGTTC ATCATCGCCA TCGTGATGAG CCTGCTCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_008770843.1 |
| CDS | 361..2298 |
| Translation |
Target ORF information:
Target ORF information:
|
 XM_008772621.2 |
1 | ATGTACCGGG AGAGGCTGCG CACCTTGTTC ATCATCGCCA TCGTGATGAG CCTGCTCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa12810 | |
| Clone ID Related Accession (Same CDS sequence) | NM_181388.2 | |
| Accession Version | NM_181388.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2235bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-18 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | paraplegin | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY278739.1. On Jun 3, 2003 this sequence version replaced NM_181388.1. ##Evidence-Data-START## Transcript exon combination :: AY278739.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## | |
1 | ATGGCGGCCG CGTTGCTGCT GCTTCGCGCG CTCCGCCAGA GCCCGGAGCC CGGGCCCTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_852053.1 |
| CDS | 52..2286 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_181388.2 |
1 | ATGGCGGCCG CGTTGCTGCT GCTTCGCGCG CTCCGCCAGA GCCCGGAGCC CGGGCCCTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa47645 | |
| Clone ID Related Accession (Same CDS sequence) | XM_008772619.2 | |
| Accession Version | XM_008772619.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2346bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | paraplegin isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005118.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008772619.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGCGGCCG CGTTGCTGCT GCTTCGCGCG CTCCGCCAGA GCCCGGAGCC CGGGCCCTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_008770841.1 |
| CDS | 64..2409 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_008772619.2 |
1 | ATGGCGGCCG CGTTGCTGCT GCTTCGCGCG CTCCGCCAGA GCCCGGAGCC CGGGCCCTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa59450 | |
| Clone ID Related Accession (Same CDS sequence) | XM_017601307.1 | |
| Accession Version | XM_017601307.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1977bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | paraplegin isoform X2 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005118.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGCGGCCG CGTTGCTGCT GCTTCGCGCG CTCCGCCAGA GCCCGGAGCC CGGGCCCTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_017456796.1 |
| CDS | 43..2019 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_017601307.1 |
1 | ATGGCGGCCG CGTTGCTGCT GCTTCGCGCG CTCCGCCAGA GCCCGGAGCC CGGGCCCTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore. |
Autocatalytic processing of m-AAA protease subunits in mitochondria. |
Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport. |
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. |
Molecular and functional analyses of the human and mouse genes encoding AFG3L1, a mitochondrial metalloprotease homologous to the human spastic paraplegia protein. |
