Ecrg4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Gene Symbol	Ecrg4
Entrez Gene ID	363225
Full Name	similar to RIKEN cDNA 1500015O10
Synonyms	Ecrg4
General protein information	Preferred Names similar to RIKEN cDNA 1500015O10 Names augurin esophageal cancer related gene 4 protein esophageal cancer-related gene 4 protein homolog
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q22

mRNA and Protein(s)

mRNA Protein Name

NM_001271051.1 NP_001257980.1 augurin precursor
Pathways from BioSystems

mRNA	Protein	Name
NM_001271051.1	NP_001257980.1	augurin precursor

Homologies

Homo sapiens (human)	C2orf40	NP_115787.1
Xenopus tropicalis (tropical clawed frog)	c2orf40	NP_001015782.2
Gallus gallus (chicken)	C1H2ORF40	XP_004938572.1
Pan troglodytes (chimpanzee)	C2AH2orf40	XP_001164223.1
	C13H2orf40	XP_001109654.1
Canis lupus familiaris (dog)	C10H2orf40	XP_853925.1
Bos taurus (cattle)	C11H2orf40	NP_001033202.1
Mus musculus (house mouse)	1500015O10Rik	NP_077245.2
Rattus norvegicus (Norway rat)	RGD1305645	NP_001257980.1
Danio rerio (zebrafish)	ecrg4b	XP_003198817.1
Danio rerio (zebrafish)	ecrg4a	NP_001017697.1

Gene Ontology
Bibliography

Related articles in PubMed

ECRG4 expression in normal rat tissues: expression study and literature review.
Porzionato A, Rucinski M, Macchi V, Sarasin G, Malendowicz LK, De Caro R
European journal of histochemistry : EJH59(2)2458(2015 May)

Ecrg4 attenuates the inflammatory proliferative response of mucosal epithelial cells to infection.
Kurabi A, Pak K, Dang X, Coimbra R, Eliceiri BP, Ryan AF, Baird A
PloS one8(4)e61394(2013)

Esophageal cancer related gene-4 is a choroid plexus-derived injury response gene: evidence for a biphasic response in early and late brain injury.
Podvin S, Gonzalez AM, Miller MC, Dang X, Botfield H, Donahue JE, Kurabi A, Boissaud-Cooke M, Rossi R, Leadbeater WE, Johanson CE, Coimbra R, Stopa EG, Eliceiri BP, Baird A
PloS one6(9)e24609(2011)

Ecrg4 expression and its product augurin in the choroid plexus: impact on fetal brain development, cerebrospinal fluid homeostasis and neuroprogenitor cell response to CNS injury.
Gonzalez AM, Podvin S, Lin SY, Miller MC, Botfield H, Leadbeater WE, Roberton A, Dang X, Knowling SE, Cardenas-Galindo E, Donahue JE, Stopa EG, Johanson CE, Coimbra R, Eliceiri BP, Baird A
Fluids and barriers of the CNS8(1)6(2011 Jan)

Esophageal cancer-related gene 4 is a secreted inducer of cell senescence expressed by aged CNS precursor cells.
Kujuro Y, Suzuki N, Kondo T
Proceedings of the National Academy of Sciences of the United States of America107(18)8259-64(2010 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ur identification of ECRG4 in many structures suggests the involvement of ECRG4 in the tumorigenesis of other organs
Title: ECRG4 expression in normal rat tissues: expression study and literature review.

Ecrg4 plays a role in coordinating the inflammatory and proliferative response to infection of mucosal epithelium suggesting a possible mechanism for its putative anti-tumor activity.
Title: Ecrg4 attenuates the inflammatory proliferative response of mucosal epithelial cells to infection.

Augurin would play a constitutive inhibitory function in normal CNS while down regulation of Ecrg4 gene expression in injury, like in cancer, dysinhibits proliferation.
Title: Esophageal cancer related gene-4 is a choroid plexus-derived injury response gene: evidence for a biphasic response in early and late brain injury.

The following Ecrg4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ecrg4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10104	NM_001271051.1 Latest version!	Rattus norvegicus ECRG4 augurin precursor (Ecrg4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ecrg4 ( NM_001271051.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001257980.1 Rattus norvegicus ECRG4 augurin precursor (Ecrg4), mRNA.

Price & Availability↑

CloneID	ORa10104
Clone ID Related Accession (Same CDS sequence)	NM_001271051.1
Accession Version	NM_001271051.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Rattus norvegicus(Norway rat)
Product	augurin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR07067512.1 and AABR07067513.1. On or before Aug 30, 2012 this sequence version replaced XM_343562.5, XM_001060972.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: DV720574.1, BG662789.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGCACCT CCTCTGCTCG GCCTGCAGTC CTGGCCCTAG CTGGGCTCGC GCTGCTCCTT 
CTGCTGTGTC TGGGTCCAGG TGACGTAAGT GGAAACAAAC TCAAGAAGAT GCTTCAGAAA 
CGAGAAGGAC CTGTTCCATC AAAGACGAAC GTAGCTGTTT CTGAGCACAC AGCAAAGGAA 
TTCCTAGGTG GCCTGAAGCG TGCCAAACGA CAGCTGTGGG ACCGTACACG ACCTGAGGTA 
CAGCAGTGGT ACCAGCAGTT CCTGTACATG GGCTTCGATG AGGCGAAATT TGAAGATGAT 
GTCAACTATT GGCTAAACAG AAACCAAAAT GGCCATGACT ACTATGGTGA CTACTACCAG 
CGTCACTATG ATGAAGATGC GGCCATTGGT CCCCGCAGCC GGGAAGGCTT TAGGCACGGA 
GCCAGTGTCA ACTATGATGA CTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001257980.1
CDS	288..734
Translation	MGTSSARPAVLALAGLALLLLLCLGPGDVSGNKLKKMLQKREGPVPSKTNVAVSEHTAKEFLGGLKRAKRQLWDRTRPEVQQWYQQFLYMGFDEAKFEDDVNYWLNRNQNGHDYYGDYYQRHYDEDAAIGPRSREGFRHGASVNYDDY

Target ORF information:

RefSeq Version	NM_001271051.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ECRG4 augurin precursor (Ecrg4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271051.1

ORF Insert Sequence:

ATGGGCACCT CCTCTGCTCG GCCTGCAGTC CTGGCCCTAG CTGGGCTCGC GCTGCTCCTT 
CTGCTGTGTC TGGGTCCAGG TGACGTAAGT GGAAACAAAC TCAAGAAGAT GCTTCAGAAA 
CGAGAAGGAC CTGTTCCATC AAAGACGAAC GTAGCTGTTT CTGAGCACAC AGCAAAGGAA 
TTCCTAGGTG GCCTGAAGCG TGCCAAACGA CAGCTGTGGG ACCGTACACG ACCTGAGGTA 
CAGCAGTGGT ACCAGCAGTT CCTGTACATG GGCTTCGATG AGGCGAAATT TGAAGATGAT 
GTCAACTATT GGCTAAACAG AAACCAAAAT GGCCATGACT ACTATGGTGA CTACTACCAG 
CGTCACTATG ATGAAGATGC GGCCATTGGT CCCCGCAGCC GGGAAGGCTT TAGGCACGGA 
GCCAGTGTCA ACTATGATGA CTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ECRG4 expression in normal rat tissues: expression study and literature review.
European journal of histochemistry : EJH59(2)2458(2015 May)
Porzionato A,Rucinski M,Macchi V,Sarasin G,Malendowicz LK,De Caro R

Ecrg4 attenuates the inflammatory proliferative response of mucosal epithelial cells to infection.
PloS one8(4)e61394(2013)
Kurabi A,Pak K,Dang X,Coimbra R,Eliceiri BP,Ryan AF,Baird A

Esophageal cancer related gene-4 is a choroid plexus-derived injury response gene: evidence for a biphasic response in early and late brain injury.
PloS one6(9)e24609(2011)
Podvin S,Gonzalez AM,Miller MC,Dang X,Botfield H,Donahue JE,Kurabi A,Boissaud-Cooke M,Rossi R,Leadbeater WE,Johanson CE,Coimbra R,Stopa EG,Eliceiri BP,Baird A

Ecrg4 expression and its product augurin in the choroid plexus: impact on fetal brain development, cerebrospinal fluid homeostasis and neuroprogenitor cell response to CNS injury.
Fluids and barriers of the CNS8(1)6(2011 Jan)
Gonzalez AM,Podvin S,Lin SY,Miller MC,Botfield H,Leadbeater WE,Roberton A,Dang X,Knowling SE,Cardenas-Galindo E,Donahue JE,Stopa EG,Johanson CE,Coimbra R,Eliceiri BP,Baird A

Esophageal cancer-related gene 4 is a secreted inducer of cell senescence expressed by aged CNS precursor cells.
Proceedings of the National Academy of Sciences of the United States of America107(18)8259-64(2010 May)
Kujuro Y,Suzuki N,Kondo T

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Ecrg4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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