Socs3 cDNA ORF clone, Rattus norvegicus(Norway rat)
| Gene Symbol | Socs3 |
| Entrez Gene ID | 89829 |
| Full Name | suppressor of cytokine signaling 3 |
| Synonyms | Cish3,Socs-3,Ssi-3 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | regulates cytokine levels to modulate inflammation [RGD, Feb 2006]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| XM_008768398.1 | XP_008766620.1 | suppressor of cytokine signaling 3 isoform X1 |
| NM_053565.1 | NP_446017.1 | suppressor of cytokine signaling 3 |
| Bos taurus (cattle) | SOCS3 | NP_776891.1 |
| Mus musculus (house mouse) | Socs3 | NP_031733.1 |
| Danio rerio (zebrafish) | socs3a | NP_956244.1 |
| Xenopus tropicalis (tropical clawed frog) | socs3 | NP_001005696.1 |
| Canis lupus familiaris (dog) | SOCS3 | NP_001026801.1 |
| Rattus norvegicus (Norway rat) | Socs3 | NP_446017.1 |
| Pan troglodytes (chimpanzee) | SOCS3 | XP_001157032.1 |
| Homo sapiens (human) | SOCS3 | NP_003946.3 |
| SOCS3 | XP_001106015.2 | |
| Gallus gallus (chicken) | SOCS3 | NP_989931.1 |
| Danio rerio (zebrafish) | socs3b | NP_998469.1 |
Related articles in PubMed
Momordica charantia extracts ameliorate insulin resistance by regulating the expression of SOCS-3 and JNK in type 2 diabetes mellitus rats.
Ma C, Yu H, Xiao Y, Wang H
Pharmaceutical biology55(1)2170-2177(2017 Dec)
Activation of PI3K in response to high glucose leads to regulation of SOCS-3 and STAT1/3 signals and induction of glomerular mesangial extracellular matrix formation.
Sheu ML, Shen CC, Jheng JR, Chiang CK
Oncotarget8(10)16925-16938(2017 Mar)
Overexpression of suppressor of cytokine signaling 3 in dorsal root ganglion attenuates cancer-induced pain in rats.
Wei J, Li M, Wang D, Zhu H, Kong X, Wang S, Zhou YL, Ju Z, Xu GY, Jiang GQ
Molecular pain131744806916688901(2017 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The phosphatidylinositol 3-Kinases (PI3K)/signal transducer and activator of transcription 1 and 3 (STAT1/3) signaling pathway mediated high glucose (HG)-triggered extracellular matrix (ECM) accumulation and suppressor of cytokine signaling-3 (SOCS-3) upregulation in mesangial cells (RMCs).
Title: Activation of PI3K in response to high glucose leads to regulation of SOCS-3 and STAT1/3 signals and induction of glomerular mesangial extracellular matrix formation.
Using cultured primary neurons, JEV efficiently replicated in embryonic neurons rather than adult neurons, and the preference was accompanied by higher SOCS3 expression and protein tyrosine phosphatase activity.
Title: Susceptibility of na?ve and differentiated PC12 cells to Japanese encephalitis virus infection.
These results suggest that SOCS3 might be a key molecular involved in the development of complicated cancer pain and that overexpression of SOCS3 might be an important strategy for treatment for mechanical allodynia associated with bone cancer.
Title: Overexpression of suppressor of cytokine signaling 3 in dorsal root ganglion attenuates cancer-induced pain in rats.
SOCS3 induces neurite differentiation and promotes neuronal cell survival.SOCS3-induced neurite differentiation was mediated via the PI3 kinase pathway.
Title: SOCS3 induces neurite differentiation and promotes neuronal cell survival.
results suggest that knocking down of SOCS3 enhances dendritic regeneration and prevents demyelination after SCI
Title: Effects of Reducing Suppressors of Cytokine Signaling-3 (SOCS3) Expression on Dendritic Outgrowth and Demyelination after Spinal Cord Injury.
The following Socs3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Socs3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa13203 | |
| Clone ID Related Accession (Same CDS sequence) | NM_053565.1 | |
| Accession Version | NM_053565.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 678bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-22 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | suppressor of cytokine signaling 3 | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF075383.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF075383.1 [ECO:0000332] ##Evidence-Data-END## | |
1 | ATGGTCACCC ACAGCAAGTT TCCCGCCGCC GGGATGAGCC GCCCCCTGGA CACCAGCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_446017.1 |
| CDS | 18..695 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_053565.1 |
ORF Insert Sequence:
1 | ATGGTCACCC ACAGCAAGTT TCCCGCCGCC GGGATGAGCC GCCCCCTGGA CACCAGCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa33983 | |
| Clone ID Related Accession (Same CDS sequence) | XM_008768398.1 | |
| Accession Version | XM_008768398.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 678bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | suppressor of cytokine signaling 3 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGTCACCC ACAGCAAGTT TCCCGCCGCC GGGATGAGCC GCCCCCTGGA CACCAGCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_008766620.1 |
| CDS | 386..1063 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_008768398.1 |
ORF Insert Sequence:
1 | ATGGTCACCC ACAGCAAGTT TCCCGCCGCC GGGATGAGCC GCCCCCTGGA CACCAGCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Momordica charantia extracts ameliorate insulin resistance by regulating the expression of SOCS-3 and JNK in type 2 diabetes mellitus rats. |
|
Activation of PI3K in response to high glucose leads to regulation of SOCS-3 and STAT1/3 signals and induction of glomerular mesangial extracellular matrix formation. |
|
Overexpression of suppressor of cytokine signaling 3 in dorsal root ganglion attenuates cancer-induced pain in rats. |