Gene Symbol | otx2 |
Entrez Gene ID | 548931 |
Full Name | orthodenticle homeobox 2 |
Synonyms | Xotx-2,Xotx2,mcops5,otx-2,otx2-a,otx2-b,otxA |
General protein information |
|
Gene Type | protein-coding |
Organism | Xenopus tropicalis(tropical clawed frog) |
ORF » Species Summary » Xenopus tropicalis » otx2 cDNA ORF clone
Gene Symbol | otx2 |
Entrez Gene ID | 548931 |
Full Name | orthodenticle homeobox 2 |
Synonyms | Xotx-2,Xotx2,mcops5,otx-2,otx2-a,otx2-b,otxA |
General protein information |
|
Gene Type | protein-coding |
Organism | Xenopus tropicalis(tropical clawed frog) |
mRNA | Protein | Name |
---|---|---|
XM_012968372.2 | XP_012823826.1 | homeobox protein OTX2 isoform X1 |
XM_012968372.3 | XP_012823826.1 | homeobox protein OTX2 isoform X1 |
NM_001016177.2 | NP_001016177.1 | homeobox protein OTX2 |
Occupancy of tissue-specific cis-regulatory modules by Otx2 and TLE/Groucho for embryonic head specification.
Yasuoka Y, Suzuki Y, Takahashi S, Someya H, Sudou N, Haramoto Y, Cho KW, Asashima M, Sugano S, Taira M
Nature communications54322(2014 Jul)
Convergence of a head-field selector Otx2 and Notch signaling: a mechanism for lens specification.
Ogino H, Fisher M, Grainger RM
Development (Cambridge, England)135(2)249-58(2008 Jan)
A specific box switches the cell fate determining activity of XOTX2 and XOTX5b in the Xenopus retina.
Onorati M, Cremisi F, Liu Y, He RQ, Barsacchi G, Vignali R
Neural development212(2007 Jun)
Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative.
Klein SL, Strausberg RL, Wagner L, Pontius J, Clifton SW, Richardson P
Developmental dynamics : an official publication of the American Association of Anatomists225(4)384-91(2002 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Otx2 upregulate or downregulate a large battery of target genes in the head organizer.
Title: Occupancy of tissue-specific cis-regulatory modules by Otx2 and TLE/Groucho for embryonic head specification.
The obligate integration of inputs of a field-selector (Otx2) and localized signaling (Notch) within target cis-regulatory elements might be a general mechanism of organ-field specification in vertebrates (as it is in Drosophila).
Title: Convergence of a head-field selector Otx2 and Notch signaling: a mechanism for lens specification.
A small 'specificity box' is necessary to confer on XOTX2 and XOTX5b their distinct activities in the developing frog retina and to convert the neutral orthologous OTD protein of Drosophila into a positive and specific XOTX-like retinal regulator.
Title: A specific box switches the cell fate determining activity of XOTX2 and XOTX5b in the Xenopus retina.
The following otx2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the otx2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OXa00648 | |
Clone ID Related Accession (Same CDS sequence) | NM_001016177.2 | |
Accession Version | NM_001016177.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 870bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-26 | |
Organism | Xenopus tropicalis(tropical clawed frog) | |
Product | homeobox protein OTX2 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CR761863.2. On Oct 14, 2005 this sequence version replaced NM_001016177.1. ##Evidence-Data-START## Transcript exon combination :: CR761863.2, CR414285.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00028290, SAMD00028291 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGATGTCTT ATCTCAAGCA ACCGCCATAT GCCGTGAATG GGCTCAGCCT GACTACCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001016177.1 |
CDS | 126..995 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001016177.2 |
1 | ATGATGTCTT ATCTCAAGCA ACCGCCATAT GCCGTGAATG GGCTCAGCCT GACTACCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OXa27582 | |
Clone ID Related Accession (Same CDS sequence) | XM_012968372.2 , XM_012968372.3 | |
Accession Version | XM_012968372.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 921bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-09-07 | |
Organism | Xenopus tropicalis(tropical clawed frog) | |
Product | homeobox protein OTX2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_030684.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2016 this sequence version replaced XM_012968372.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Xenopus tropicalis Annotation Release 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATGTCTT ATCTCAAGCA ACCGCCATAT GCCGTGAATG GGCTCAGCCT GACTACCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_012823826.1 |
CDS | 1303..2223 |
Translation |
Target ORF information:
Target ORF information:
|
XM_012968372.2 |
1 | ATGATGTCTT ATCTCAAGCA ACCGCCATAT GCCGTGAATG GGCTCAGCCT GACTACCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OXa27582 | |
Clone ID Related Accession (Same CDS sequence) | XM_012968372.2 , XM_012968372.3 | |
Accession Version | XM_012968372.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 921bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-17 | |
Organism | Xenopus tropicalis(tropical clawed frog) | |
Product | homeobox protein OTX2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_030684.2) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 18, 2019 this sequence version replaced XM_012968372.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Xenopus tropicalis Annotation Release 104 Annotation Version :: 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATGTCTT ATCTCAAGCA ACCGCCATAT GCCGTGAATG GGCTCAGCCT GACTACCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_012823826.1 |
CDS | 389..1309 |
Translation |
Target ORF information:
Target ORF information:
|
XM_012968372.3 |
1 | ATGATGTCTT ATCTCAAGCA ACCGCCATAT GCCGTGAATG GGCTCAGCCT GACTACCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Occupancy of tissue-specific cis-regulatory modules by Otx2 and TLE/Groucho for embryonic head specification. |
Convergence of a head-field selector Otx2 and Notch signaling: a mechanism for lens specification. |
A specific box switches the cell fate determining activity of XOTX2 and XOTX5b in the Xenopus retina. |
Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. |