Gene Symbol | OTX2 |
Entrez Gene ID | 395191 |
Full Name | orthodenticle homeobox 2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Gallus gallus(chicken) |
ORF » Species Summary » Gallus gallus » OTX2 cDNA ORF clone
Gene Symbol | OTX2 |
Entrez Gene ID | 395191 |
Full Name | orthodenticle homeobox 2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Gallus gallus(chicken) |
mRNA | Protein | Name |
---|---|---|
XM_015287272.1 | XP_015142758.1 | homeobox protein OTX2 isoform X1 |
NM_204520.2 | NP_989851.2 | homeobox protein OTX2 |
XM_015287272.2 | XP_015142758.1 | homeobox protein OTX2 isoform X1 |
Otx2 and Onecut1 promote the fates of cone photoreceptors and horizontal cells and repress rod photoreceptors.
Emerson MM, Surzenko N, Goetz JJ, Trimarchi J, Cepko CL
Developmental cell26(1)59-72(2013 Jul)
Mutual repression between Gbx2 and Otx2 in sensory placodes reveals a general mechanism for ectodermal patterning.
Steventon B, Mayor R, Streit A
Developmental biology367(1)55-65(2012 Jul)
MiR-206 regulates neural cells proliferation and apoptosis via Otx2.
Wang R, Hu Y, Song G, Hao CJ, Cui Y, Xia HF, Ma X
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology29(3-4)381-90(2012)
Otx2 is involved in the regional specification of the developing retinal pigment epithelium by preventing the expression of sox2 and fgf8, factors that induce neural retina differentiation.
Nishihara D, Yajima I, Tabata H, Nakai M, Tsukiji N, Katahira T, Takeda K, Shibahara S, Nakamura H, Yamamoto H
PloS one7(11)e48879(2012)
Evolutionary origin of the Otx2 enhancer for its expression in visceral endoderm.
Kurokawa D, Ohmura T, Ogino H, Takeuchi M, Inoue A, Inoue F, Suda Y, Aizawa S
Developmental biology342(1)110-20(2010 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Otx2 and Onecut1 are coexpressed in retinal progenitors and coregulate cis-regulatory module for the thyroid hormone receptor beta gene.
Title: Otx2 and Onecut1 promote the fates of cone photoreceptors and horizontal cells and repress rod photoreceptors.
Otx2 and Gbx2 provide a global mechanism for patterning of the embryonic ectoderm and ensure the coordinated development of the central and peripheral nervous system in the head.
Title: Mutual repression between Gbx2 and Otx2 in sensory placodes reveals a general mechanism for ectodermal patterning.
OTX2 is down-regulated in chick embryos in sodium arsenite-induced neural tube defects.
Title: MiR-206 regulates neural cells proliferation and apoptosis via Otx2.
Otx2 prevents the presumptive retinal pigment epithelium region from forming the neural retina (NR) by repressing the expression of both Fgf8 and Sox2 which induce the NR cell fate.
Title: Otx2 is involved in the regional specification of the developing retinal pigment epithelium by preventing the expression of sox2 and fgf8, factors that induce neural retina differentiation.
Results suggest that the interaction between Otx2 and Gbx2 in developing inner ear defines Fgf10 expression domain to induce the cochlear ganglion.
Title: Role of Gbx2 and Otx2 in the formation of cochlear ganglion and endolymphatic duct.
The following OTX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OTX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OGa26651 | |
Clone ID Related Accession (Same CDS sequence) | NM_204520.2 , XM_015287272.2 | |
Accession Version | NM_204520.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 870bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-20 | |
Organism | Gallus gallus(chicken) | |
Product | homeobox protein OTX2 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY600957.1. On Mar 13, 2005 this sequence version replaced NM_204520.1. ##Evidence-Data-START## Transcript exon combination :: AY600957.1 [ECO:0000332] ##Evidence-Data-END## |
1 | ATGATGTCTT ATCTTAAGCA ACCACCTTAC GCAGTCAATG GCCTGAGTCT CACCACCTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_989851.2 |
CDS | 30..899 |
Translation |
Target ORF information:
Target ORF information:
|
NM_204520.2 |
1 | ATGATGTCTT ATCTTAAGCA ACCACCTTAC GCAGTCAATG GCCTGAGTCT CACCACCTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OGa26651 | |
Clone ID Related Accession (Same CDS sequence) | NM_204520.2 , XM_015287272.2 | |
Accession Version | XM_015287272.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 870bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-16 | |
Organism | Gallus gallus(chicken) | |
Product | homeobox protein OTX2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006092.5) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 17, 2018 this sequence version replaced XM_015287272.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 104 Annotation Version :: 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATGTCTT ATCTTAAGCA ACCACCTTAC GCAGTCAATG GCCTGAGTCT CACCACCTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_015142758.1 |
CDS | 373..1242 |
Translation |
Target ORF information:
Target ORF information:
|
XM_015287272.2 |
1 | ATGATGTCTT ATCTTAAGCA ACCACCTTAC GCAGTCAATG GCCTGAGTCT CACCACCTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OGa36749 | |
Clone ID Related Accession (Same CDS sequence) | XM_015287272.1 | |
Accession Version | XM_015287272.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 870bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-01-03 | |
Organism | Gallus gallus(chicken) | |
Product | homeobox protein OTX2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_455885.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Gallus gallus Annotation Release 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATGTCTT ATCTTAAGCA ACCACCTTAC GCAGTCAATG GCCTGAGTCT CACCACCTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_015142758.1 |
CDS | 326..1195 |
Translation |
Target ORF information:
Target ORF information:
|
XM_015287272.1 |
1 | ATGATGTCTT ATCTTAAGCA ACCACCTTAC GCAGTCAATG GCCTGAGTCT CACCACCTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Otx2 and Onecut1 promote the fates of cone photoreceptors and horizontal cells and repress rod photoreceptors. |
Mutual repression between Gbx2 and Otx2 in sensory placodes reveals a general mechanism for ectodermal patterning. |
MiR-206 regulates neural cells proliferation and apoptosis via Otx2. |
Otx2 is involved in the regional specification of the developing retinal pigment epithelium by preventing the expression of sox2 and fgf8, factors that induce neural retina differentiation. |
Evolutionary origin of the Otx2 enhancer for its expression in visceral endoderm. |