OTX2 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	OTX2
Entrez Gene ID	395191
Full Name	orthodenticle homeobox 2
General protein information	Preferred Names orthodenticle homeobox 2 Names homeobox protein OTX2 orthodenticle homolog 2
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
XM_015287272.1	XP_015142758.1	homeobox protein OTX2 isoform X1
NM_204520.2	NP_989851.2	homeobox protein OTX2
XM_015287272.2	XP_015142758.1	homeobox protein OTX2 isoform X1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	OTX2	NP_989851.2
Rattus norvegicus (Norway rat)	Otx2	NP_001094036.1
Xenopus tropicalis (tropical clawed frog)	otx2	NP_001016177.1

Gene Ontology
Bibliography

Related articles in PubMed

Otx2 and Onecut1 promote the fates of cone photoreceptors and horizontal cells and repress rod photoreceptors.
Emerson MM, Surzenko N, Goetz JJ, Trimarchi J, Cepko CL
Developmental cell26(1)59-72(2013 Jul)

Mutual repression between Gbx2 and Otx2 in sensory placodes reveals a general mechanism for ectodermal patterning.
Steventon B, Mayor R, Streit A
Developmental biology367(1)55-65(2012 Jul)

MiR-206 regulates neural cells proliferation and apoptosis via Otx2.
Wang R, Hu Y, Song G, Hao CJ, Cui Y, Xia HF, Ma X
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology29(3-4)381-90(2012)

Otx2 is involved in the regional specification of the developing retinal pigment epithelium by preventing the expression of sox2 and fgf8, factors that induce neural retina differentiation.
Nishihara D, Yajima I, Tabata H, Nakai M, Tsukiji N, Katahira T, Takeda K, Shibahara S, Nakamura H, Yamamoto H
PloS one7(11)e48879(2012)

Evolutionary origin of the Otx2 enhancer for its expression in visceral endoderm.
Kurokawa D, Ohmura T, Ogino H, Takeuchi M, Inoue A, Inoue F, Suda Y, Aizawa S
Developmental biology342(1)110-20(2010 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Otx2 and Onecut1 are coexpressed in retinal progenitors and coregulate cis-regulatory module for the thyroid hormone receptor beta gene.
Title: Otx2 and Onecut1 promote the fates of cone photoreceptors and horizontal cells and repress rod photoreceptors.

Otx2 and Gbx2 provide a global mechanism for patterning of the embryonic ectoderm and ensure the coordinated development of the central and peripheral nervous system in the head.
Title: Mutual repression between Gbx2 and Otx2 in sensory placodes reveals a general mechanism for ectodermal patterning.

OTX2 is down-regulated in chick embryos in sodium arsenite-induced neural tube defects.
Title: MiR-206 regulates neural cells proliferation and apoptosis via Otx2.

Otx2 prevents the presumptive retinal pigment epithelium region from forming the neural retina (NR) by repressing the expression of both Fgf8 and Sox2 which induce the NR cell fate.
Title: Otx2 is involved in the regional specification of the developing retinal pigment epithelium by preventing the expression of sox2 and fgf8, factors that induce neural retina differentiation.

Results suggest that the interaction between Otx2 and Gbx2 in developing inner ear defines Fgf10 expression domain to induce the cochlear ganglion.
Title: Role of Gbx2 and Otx2 in the formation of cochlear ganglion and endolymphatic duct.

The following OTX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OTX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OGa26651	NM_204520.2 Latest version!	Gallus gallus orthodenticle homeobox 2 (OTX2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OGa26651	XM_015287272.2 Latest version!	Gallus gallus orthodenticle homeobox 2 (OTX2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OGa36749	XM_015287272.1 Latest version!	Gallus gallus orthodenticle homeobox 2 (OTX2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OTX2 ( NM_204520.2 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_989851.2 Gallus gallus orthodenticle homeobox 2 (OTX2), mRNA.

Price & Availability↑

CloneID	OGa26651
Clone ID Related Accession (Same CDS sequence)	NM_204520.2 , XM_015287272.2
Accession Version	NM_204520.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 870bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-20
Organism	Gallus gallus(chicken)
Product	homeobox protein OTX2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY600957.1. On Mar 13, 2005 this sequence version replaced NM_204520.1. ##Evidence-Data-START## Transcript exon combination :: AY600957.1 [ECO:0000332] ##Evidence-Data-END##

ATGATGTCTT ATCTTAAGCA ACCACCTTAC GCAGTCAATG GCCTGAGTCT CACCACCTCG 
GGCATGGATT TGTTGCATCC GTCCGTCGGT TATCCCGCCA CCCCCCGAAA GCAGCGGCGG 
GAGCGCACCA CCTTCACCCG GGCGCAGCTG GACGTGCTGG AGGCCCTGTT CGCCAAGACC 
CGCTACCCCG ACATCTTCAT GCGGGAGGAG GTGGCCTTGA AAATCAACCT GCCCGAGTCC 
AGAGTGCAGG TGTGGTTCAA AAACCGCCGG GCCAAGTGCC GGCAGCAGCA GCAGCAGCAG 
CAGAACGGGG GCCAGAACAA GGTGAGGCCG GCCAAAAAGA AGAACTCGCC GGCCCGGGAA 
GTGAGCTCGG AGAGCGGGAC CAGCGGGCAG TTCACACCCC CCTCCAGCAC CTCGGTCCCC 
ACCATTTCCA GCAGCAGTGC CCCCGTGTCC ATCTGGAGCC CGGCGTCCAT CTCCCCGCTC 
TCCGATCCCC TGTCCACTTC TTCCTCCTGC ATGCAGAGGT CCTACCCCAT GACCTACACC 
CAGGCATCAG GTTACAGCCA AGGATATGCC GGCTCGACCT CCTATTTCGG AGGGATGGAC 
TGTGGATCTT ATTTGACCCC TATGCACCAC CAGCTCCCCG GACCGGGGGC CACCCTGAGT 
CCCATGGGTG CCAATGCGGT CACCAGCCAC CTCAACCAGT CTCCAGCCTC CCTCTCCACC 
CAGGGCTATG GAGCCTCCAG TTTGGGCTTT AACTCGACCA CCGATTGCTT GGATTATAAA 
GACCAAACCG CCTCCTGGAA GTTAAACTTC AATGCTGACT GCTTGGATTA TAAAGACCAG 
ACATCCTCAT GGAAGTTCCA GGTTTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_989851.2
CDS	30..899
Translation	MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPATPRKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAKKKNSPAREVSSESGTSGQFTPPSSTSVPTISSSSAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLPGPGATLSPMGANAVTSHLNQSPASLSTQGYGASSLGFNSTTDCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL

Target ORF information:

RefSeq Version	NM_204520.2
Organism	Gallus gallus(chicken)
Definition	Gallus gallus orthodenticle homeobox 2 (OTX2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_204520.2

ORF Insert Sequence:

ATGATGTCTT ATCTTAAGCA ACCACCTTAC GCAGTCAATG GCCTGAGTCT CACCACCTCG 
GGCATGGATT TGTTGCATCC GTCCGTCGGT TATCCCGCCA CCCCCCGAAA GCAGCGGCGG 
GAGCGCACCA CCTTCACCCG GGCGCAGCTG GACGTGCTGG AGGCCCTGTT CGCCAAGACC 
CGCTACCCCG ACATCTTCAT GCGGGAGGAG GTGGCCTTGA AAATCAACCT GCCCGAGTCC 
AGAGTGCAGG TGTGGTTCAA AAACCGCCGG GCCAAGTGCC GGCAGCAGCA GCAGCAGCAG 
CAGAACGGGG GCCAGAACAA GGTGAGGCCG GCCAAAAAGA AGAACTCGCC GGCCCGGGAA 
GTGAGCTCGG AGAGCGGGAC CAGCGGGCAG TTCACACCCC CCTCCAGCAC CTCGGTCCCC 
ACCATTTCCA GCAGCAGTGC CCCCGTGTCC ATCTGGAGCC CGGCGTCCAT CTCCCCGCTC 
TCCGATCCCC TGTCCACTTC TTCCTCCTGC ATGCAGAGGT CCTACCCCAT GACCTACACC 
CAGGCATCAG GTTACAGCCA AGGATATGCC GGCTCGACCT CCTATTTCGG AGGGATGGAC 
TGTGGATCTT ATTTGACCCC TATGCACCAC CAGCTCCCCG GACCGGGGGC CACCCTGAGT 
CCCATGGGTG CCAATGCGGT CACCAGCCAC CTCAACCAGT CTCCAGCCTC CCTCTCCACC 
CAGGGCTATG GAGCCTCCAG TTTGGGCTTT AACTCGACCA CCGATTGCTT GGATTATAAA 
GACCAAACCG CCTCCTGGAA GTTAAACTTC AATGCTGACT GCTTGGATTA TAAAGACCAG 
ACATCCTCAT GGAAGTTCCA GGTTTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OTX2 ( XM_015287272.2 ) cDNA ORF clone, Gallus gallus(chicken) -> XP_015142758.1 Gallus gallus orthodenticle homeobox 2 (OTX2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OGa26651
Clone ID Related Accession (Same CDS sequence)	NM_204520.2 , XM_015287272.2
Accession Version	XM_015287272.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 870bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-16
Organism	Gallus gallus(chicken)
Product	homeobox protein OTX2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006092.5) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 17, 2018 this sequence version replaced XM_015287272.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 104 Annotation Version :: 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGTCTT ATCTTAAGCA ACCACCTTAC GCAGTCAATG GCCTGAGTCT CACCACCTCG 
GGCATGGATT TGTTGCATCC GTCCGTCGGT TATCCCGCCA CCCCCCGAAA GCAGCGGCGG 
GAGCGCACCA CCTTCACCCG GGCGCAGCTG GACGTGCTGG AGGCCCTGTT CGCCAAGACC 
CGCTACCCCG ACATCTTCAT GCGGGAGGAG GTGGCCTTGA AAATCAACCT GCCCGAGTCC 
AGAGTGCAGG TGTGGTTCAA AAACCGCCGG GCCAAGTGCC GGCAGCAGCA GCAGCAGCAG 
CAGAACGGGG GCCAGAACAA GGTGAGGCCG GCCAAAAAGA AGAACTCGCC GGCCCGGGAA 
GTGAGCTCGG AGAGCGGGAC CAGCGGGCAG TTCACACCCC CCTCCAGCAC CTCGGTCCCC 
ACCATTTCCA GCAGCAGTGC CCCCGTGTCC ATCTGGAGCC CGGCGTCCAT CTCCCCGCTC 
TCCGATCCCC TGTCCACTTC TTCCTCCTGC ATGCAGAGGT CCTACCCCAT GACCTACACC 
CAGGCATCAG GTTACAGCCA AGGATATGCC GGCTCGACCT CCTATTTCGG AGGGATGGAC 
TGTGGATCTT ATTTGACCCC TATGCACCAC CAGCTCCCCG GACCGGGGGC CACCCTGAGT 
CCCATGGGTG CCAATGCGGT CACCAGCCAC CTCAACCAGT CTCCAGCCTC CCTCTCCACC 
CAGGGCTATG GAGCCTCCAG TTTGGGCTTT AACTCGACCA CCGATTGCTT GGATTATAAA 
GACCAAACCG CCTCCTGGAA GTTAAACTTC AATGCTGACT GCTTGGATTA TAAAGACCAG 
ACATCCTCAT GGAAGTTCCA GGTTTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_015142758.1
CDS	373..1242
Translation	MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPATPRKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAKKKNSPAREVSSESGTSGQFTPPSSTSVPTISSSSAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLPGPGATLSPMGANAVTSHLNQSPASLSTQGYGASSLGFNSTTDCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL

Target ORF information:

RefSeq Version	XM_015287272.2
Organism	Gallus gallus(chicken)
Definition	Gallus gallus orthodenticle homeobox 2 (OTX2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_015287272.2

ORF Insert Sequence:

ATGATGTCTT ATCTTAAGCA ACCACCTTAC GCAGTCAATG GCCTGAGTCT CACCACCTCG 
GGCATGGATT TGTTGCATCC GTCCGTCGGT TATCCCGCCA CCCCCCGAAA GCAGCGGCGG 
GAGCGCACCA CCTTCACCCG GGCGCAGCTG GACGTGCTGG AGGCCCTGTT CGCCAAGACC 
CGCTACCCCG ACATCTTCAT GCGGGAGGAG GTGGCCTTGA AAATCAACCT GCCCGAGTCC 
AGAGTGCAGG TGTGGTTCAA AAACCGCCGG GCCAAGTGCC GGCAGCAGCA GCAGCAGCAG 
CAGAACGGGG GCCAGAACAA GGTGAGGCCG GCCAAAAAGA AGAACTCGCC GGCCCGGGAA 
GTGAGCTCGG AGAGCGGGAC CAGCGGGCAG TTCACACCCC CCTCCAGCAC CTCGGTCCCC 
ACCATTTCCA GCAGCAGTGC CCCCGTGTCC ATCTGGAGCC CGGCGTCCAT CTCCCCGCTC 
TCCGATCCCC TGTCCACTTC TTCCTCCTGC ATGCAGAGGT CCTACCCCAT GACCTACACC 
CAGGCATCAG GTTACAGCCA AGGATATGCC GGCTCGACCT CCTATTTCGG AGGGATGGAC 
TGTGGATCTT ATTTGACCCC TATGCACCAC CAGCTCCCCG GACCGGGGGC CACCCTGAGT 
CCCATGGGTG CCAATGCGGT CACCAGCCAC CTCAACCAGT CTCCAGCCTC CCTCTCCACC 
CAGGGCTATG GAGCCTCCAG TTTGGGCTTT AACTCGACCA CCGATTGCTT GGATTATAAA 
GACCAAACCG CCTCCTGGAA GTTAAACTTC AATGCTGACT GCTTGGATTA TAAAGACCAG 
ACATCCTCAT GGAAGTTCCA GGTTTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OTX2 ( XM_015287272.1 ) cDNA ORF clone, Gallus gallus(chicken) -> XP_015142758.1 Gallus gallus orthodenticle homeobox 2 (OTX2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OGa36749
Clone ID Related Accession (Same CDS sequence)	XM_015287272.1
Accession Version	XM_015287272.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 870bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-01-03
Organism	Gallus gallus(chicken)
Product	homeobox protein OTX2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_455885.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Gallus gallus Annotation Release 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGTCTT ATCTTAAGCA ACCACCTTAC GCAGTCAATG GCCTGAGTCT CACCACCTCG 
GGCATGGATT TGTTGCATCC GTCCGTCGGT TATCCCGCCA CCCCCCGAAA GCAGCGCCGG 
GAGCGCACCA CCTTCACCCG GGCGCAGCTG GACGTGCTGG AGGCCCTGTT CGCCAAGACC 
CGCTACCCCG ACATCTTCAT GCGGGAGGAG GTGGCCTTGA AAATCAACCT GCCCGAGTCC 
AGAGTGCAGG TGTGGTTCAA AAACCGCCGG GCCAAGTGCC GGCAGCAGCA GCAGCAGCAG 
CAGAACGGGG GCCAGAACAA GGTGAGGCCG GCCAAAAAGA AGAACTCGCC GGCCCGGGAA 
GTGAGCTCGG AGAGCGGGAC CAGCGGGCAG TTCACACCCC CCTCCAGCAC CTCGGTCCCC 
ACCATTTCCA GCAGCAGTGC CCCCGTGTCC ATCTGGAGCC CGGCGTCCAT CTCCCCGCTC 
TCCGATCCCC TGTCCACTTC TTCCTCCTGC ATGCAGAGGT CCTACCCCAT GACCTACACC 
CAGGCATCAG GTTACAGCCA AGGATATGCC GGCTCGACCT CCTATTTCGG AGGGATGGAC 
TGTGGATCTT ATTTGACCCC TATGCACCAC CAGCTCCCCG GACCGGGGGC CACCCTGAGT 
CCCATGGGTG CCAATGCGGT CACCAGCCAC CTCAACCAGT CTCCAGCCTC CCTCTCCACC 
CAGGGCTATG GAGCCTCCAG TTTGGGCTTT AACTCGACCA CCGATTGCTT GGATTATAAA 
GACCAAACCG CCTCCTGGAA GTTAAACTTC AATGCTGACT GCTTGGATTA TAAAGACCAG 
ACATCCTCAT GGAAGTTCCA GGTTTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_015142758.1
CDS	326..1195
Translation	MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPATPRKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAKKKNSPAREVSSESGTSGQFTPPSSTSVPTISSSSAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLPGPGATLSPMGANAVTSHLNQSPASLSTQGYGASSLGFNSTTDCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL

Target ORF information:

RefSeq Version	XM_015287272.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus orthodenticle homeobox 2 (OTX2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_015287272.1

ORF Insert Sequence:

ATGATGTCTT ATCTTAAGCA ACCACCTTAC GCAGTCAATG GCCTGAGTCT CACCACCTCG 
GGCATGGATT TGTTGCATCC GTCCGTCGGT TATCCCGCCA CCCCCCGAAA GCAGCGCCGG 
GAGCGCACCA CCTTCACCCG GGCGCAGCTG GACGTGCTGG AGGCCCTGTT CGCCAAGACC 
CGCTACCCCG ACATCTTCAT GCGGGAGGAG GTGGCCTTGA AAATCAACCT GCCCGAGTCC 
AGAGTGCAGG TGTGGTTCAA AAACCGCCGG GCCAAGTGCC GGCAGCAGCA GCAGCAGCAG 
CAGAACGGGG GCCAGAACAA GGTGAGGCCG GCCAAAAAGA AGAACTCGCC GGCCCGGGAA 
GTGAGCTCGG AGAGCGGGAC CAGCGGGCAG TTCACACCCC CCTCCAGCAC CTCGGTCCCC 
ACCATTTCCA GCAGCAGTGC CCCCGTGTCC ATCTGGAGCC CGGCGTCCAT CTCCCCGCTC 
TCCGATCCCC TGTCCACTTC TTCCTCCTGC ATGCAGAGGT CCTACCCCAT GACCTACACC 
CAGGCATCAG GTTACAGCCA AGGATATGCC GGCTCGACCT CCTATTTCGG AGGGATGGAC 
TGTGGATCTT ATTTGACCCC TATGCACCAC CAGCTCCCCG GACCGGGGGC CACCCTGAGT 
CCCATGGGTG CCAATGCGGT CACCAGCCAC CTCAACCAGT CTCCAGCCTC CCTCTCCACC 
CAGGGCTATG GAGCCTCCAG TTTGGGCTTT AACTCGACCA CCGATTGCTT GGATTATAAA 
GACCAAACCG CCTCCTGGAA GTTAAACTTC AATGCTGACT GCTTGGATTA TAAAGACCAG 
ACATCCTCAT GGAAGTTCCA GGTTTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Otx2 and Onecut1 promote the fates of cone photoreceptors and horizontal cells and repress rod photoreceptors.
Developmental cell26(1)59-72(2013 Jul)
Emerson MM,Surzenko N,Goetz JJ,Trimarchi J,Cepko CL

Mutual repression between Gbx2 and Otx2 in sensory placodes reveals a general mechanism for ectodermal patterning.
Developmental biology367(1)55-65(2012 Jul)
Steventon B,Mayor R,Streit A

MiR-206 regulates neural cells proliferation and apoptosis via Otx2.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology29(3-4)381-90(2012)
Wang R,Hu Y,Song G,Hao CJ,Cui Y,Xia HF,Ma X

Otx2 is involved in the regional specification of the developing retinal pigment epithelium by preventing the expression of sox2 and fgf8, factors that induce neural retina differentiation.
PloS one7(11)e48879(2012)
Nishihara D,Yajima I,Tabata H,Nakai M,Tsukiji N,Katahira T,Takeda K,Shibahara S,Nakamura H,Yamamoto H

Evolutionary origin of the Otx2 enhancer for its expression in visceral endoderm.
Developmental biology342(1)110-20(2010 Jun)
Kurokawa D,Ohmura T,Ogino H,Takeuchi M,Inoue A,Inoue F,Suda Y,Aizawa S

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OTX2 cDNA ORF clone, Gallus gallus(chicken)

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Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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