A cell that is useful in production of quantities of a monoclonal antibody; a fusion of a myeloma cell and a spleen lymphocyte that, like the myeloma cell, can divide in culture and, like the spleen cell, can produce antibodies. The use of HAT (hypoxanthine/ aminopterin/thymidine) medium allows selection of hybrids of myeloma cell mutants that lack hypoxanthine-guanine phosphoribosyltransferase and consequently cannot utilize hypoxanthine, with spleen cells, which do not proliferate in vitro. (see also hypoxanthine/aminopterin/thymidine (HAT) medium)
Related Biology Tools
GenSmart™ Codon Optimization
GenSmart Optimization is a free online tool for performing codon optimization to improve gene expression. GenScript's patented algorithms are integrated into the tool to optimize the computing capability of high-performance sequence generation.
DNA Construct Design Tool
GenSmart™ Design is a free online DNA construct design tool developed by GenScript. GenSmart™ Design has two design modules, the Create Construct module for individual plasmid design and the Create Library module for DNA library design.
Codon Frequency Tables
This online tool shows commonly used genetic codon frequency table in expression host organisms including Escherichia coli and other common host organisms.
Service and Products
From lentivirus packaging to generating clonal cell lines, let us assist you on your assay cell line creation project.
Assay Cell Line Development
For Drug Discovery, Toxicity Testing and Basic Research.
Research Grade Lentiviral Vector Packaging
Lentiviruses are a powerful gene delivery vector that ensures long-term expression of your target transgene.
Research Grade AAV
Our beta-testers are important to us and we are offering heavily discounted prices and additional guarantees.
If you know of any terms that have been omitted from this glossary that you feel would be useful to include, please send detail to the Editorial Office at GenScript: [email protected]