Antibody fragments are engineered, smaller versions of full-sized antibodies, known as immunoglobulins. These fragments maintain the crucial ability to bind to specific antigens, similar to full antibodies, but they lack certain structural components found in complete antibody molecules. Antibody fragments are highly valuable in various biomedical and therapeutic applications, particularly when the size of full antibodies may be a limitation. 1. Fab (Fragment Antigen-Binding): The Fab fragment is the essential antigen-binding region of an antibody. It encompasses one of the antibody's arms, containing the variable regions of both the heavy and light chains. Fab fragments are commonly used in scientific research and diagnostics, serving as valuable tools for capturing or detecting specific antigens. 2. F(ab')₂ (Fragment Antigen-Binding)2: F(ab')₂ fragments are larger than Fab fragments and possess two distinct antigen-binding regions. They are generated by enzymatically cleaving full antibodies, often using the enzyme pepsin. F(ab')₂ fragments are known for their enhanced stability compared to Fab fragments and are applied in diverse research and diagnostic settings. 3. Fv (Variable Fragment): The Fv fragment consists solely of the variable regions of both the heavy and light chains of an antibody. It is the smallest antibody fragment that retains its antigen-binding activity. Fv fragments are instrumental in antibody engineering and research, enabling the creation of bispecific antibodies and other customized antibody-based constructs. 4. Single-Chain Variable Fragment (scFv): scFv is a fusion of the variable regions of the heavy and light chains, connected by a short peptide linker. These scFvs are compact and stable antibody fragments that can be efficiently produced in various expression systems. They are widely used in scientific research, diagnostics, and therapeutic applications, including cancer therapy and targeted drug delivery. 5. Isolation of Panels of Llama Single-Domain Antibody Fragments Binding All Nine Neuraminidase Subtypes of Influenza A Virus.
GenSmart Optimization is a free online tool for performing codon optimization to improve gene expression. GenScript's patented algorithms are integrated into the tool to optimize the computing capability of high-performance sequence generation.
GenSmart™ Design is a free online DNA construct design tool developed by GenScript. GenSmart™ Design has two design modules, the Create Construct module for individual plasmid design and the Create Library module for DNA library design.
This online tool shows commonly used genetic codon frequency table in expression host organisms including Escherichia coli and other common host organisms.
Antibody Production Services
Comprehensive custom antibody production services including monoclonal and polyclonal antibody production services with industry leading turnaround times.
Polyclonal Antibody Services
The fastest custom polyclonal antibody production services in the industry with unmatched guarantees.
Custom Monoclonal Antibody Development Services
Developing custom monoclonal antibodies with standard or fully custom protocols including everything from antigen synthesis to antibody scale-up options.
Phospho-Specific Antibody Services
Guaranteed ELISA titer of ≥ 1:64,000 and < 10% cross reactivity with non-phospho peptide.
Immunoassay Development Services
Our custom immunoassay development service offering comprehensive high-throughput assay development with fast turnaround and high efficiency.
Large-scale Antibody Manufacturing
Our large-scale antibody manufacturing services offer polyclonal and monoclonal antibody production of gram quantities for industrial antibody yields.
COVID-19 Reagent Antibodies
On demand SARS-CoV-2 control mAbs ideal for diagnostics, therapeutic, and vaccine development.
If you know of any terms that have been omitted from this glossary that you feel would be useful to include, please send detail to the Editorial Office at GenScript: [email protected]