List by Alphabet: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

signaling pathway

A signaling pathway, also known as a signal transduction pathway, is a sequence of molecular events and interactions occurring within a cell. These pathways enable the cell to respond to external or internal signals or stimuli by transmitting information from the cell's surface or environment to its interior. This transmission ultimately leads to specific cellular responses and processes.

The core components and characteristics of signaling pathways include:

1. Receptors: Signaling initiates with the binding of a ligand or signaling molecule to a specific receptor on the cell surface or within the cell. Ligands can encompass hormones, neurotransmitters, growth factors, or other signaling molecules.

2. Transduction: Upon ligand-receptor binding, a cascade of intracellular events is triggered. These events often involve protein-protein interactions, chemical modifications, or changes in protein conformation, facilitating the transmission of the signal from the receptor to downstream components.

3. Amplification: Signaling pathways frequently include steps that amplify the initial signal. A single ligand-receptor interaction can activate multiple downstream signaling molecules, intensifying the cellular response.

4. Signal Integration: Cells can simultaneously receive multiple signals, and these signals may merge and interact within the cell. Signal integration allows the cell to coordinate its response based on various input sources.

5. Effector Proteins: Effector proteins are typically the downstream elements of signaling pathways responsible for specific functions. These functions may involve altering gene expression, modifying cell behavior, activating enzymes, or regulating ion channels.

6. Cellular Response: The ultimate objective of a signaling pathway is to elicit a specific cellular response. This response can be diverse, including processes such as cell growth, differentiation, migration, apoptosis (cell death), secretion, or changes in metabolism.

7. Feedback Regulation: Signaling pathways often incorporate feedback mechanisms to maintain cellular equilibrium. Feedback can be either positive, amplifying the signal, or negative, mitigating or terminating the signal.

Signaling pathways are pivotal for various biological processes, encompassing cell growth and proliferation, immune responses, neurotransmission, metabolic control, development and differentiation, and hormonal regulation.

Dysregulation of signaling pathways can contribute to the development of numerous diseases, including cancer, autoimmune disorders, and metabolic conditions. Consequently, comprehending these pathways is essential for advancing basic biological research and developing therapeutic strategies in medicine.

Related Service

• GenScript offers: p38 MAPK Signaling Pathway (Downstream), MAPK signaling pathway, Olfactory Signaling Pathway


Related Biology Tools

  • GenSmart™ Codon Optimization

    GenSmart Optimization is a free online tool for performing codon optimization to improve gene expression. GenScript's patented algorithms are integrated into the tool to optimize the computing capability of high-performance sequence generation.

    Learn More

  • DNA Construct Design Tool

    GenSmart™ Design is a free online DNA construct design tool developed by GenScript. GenSmart™ Design has two design modules, the Create Construct module for individual plasmid design and the Create Library module for DNA library design.

    Learn More

  • Codon Frequency Tables

    This online tool shows commonly used genetic codon frequency table in expression host organisms including Escherichia coli and other common host organisms.

    Learn More

Service and Products

Antibody Production Services

Comprehensive custom antibody production services including monoclonal and polyclonal antibody production services with industry leading turnaround times.

Polyclonal Antibody Services

The fastest custom polyclonal antibody production services in the industry with unmatched guarantees.

Custom Monoclonal Antibody Development Services

Developing custom monoclonal antibodies with standard or fully custom protocols including everything from antigen synthesis to antibody scale-up options.

Phospho-Specific Antibody Services

Guaranteed ELISA titer of ≥ 1:64,000 and < 10% cross reactivity with non-phospho peptide.

Immunoassay Development Services

Our custom immunoassay development service offering comprehensive high-throughput assay development with fast turnaround and high efficiency.

Large-scale Antibody Manufacturing

Our large-scale antibody manufacturing services offer polyclonal and monoclonal antibody production of gram quantities for industrial antibody yields.

COVID-19 Reagent Antibodies

On demand SARS-CoV-2 control mAbs ideal for diagnostics, therapeutic, and vaccine development.

If you know of any terms that have been omitted from this glossary that you feel would be useful to include, please send detail to the Editorial Office at GenScript: [email protected]

If your term is adopted, we will send 1,000 EzCoupon points to your GenScript account.

Do you like the current new website?

Hate

Dislike

Neutral

Like

Love

*